The network for 'positive regulation of metaphase anaphase transition of cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of metaphase anaphase transition of cell cycle

Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle.

NameDescriptionProbabilityFunc Analog Organism
CycACyclin A0.642
idaimaginal discs arrested0.552
Mcm10Sensitized chromosome inheritance modifier 190.530
dupdouble parked0.451
BubR1Bub1-related kinase0.356
ncdnon-claret disjunctional0.243
Cenp-CCG31258 gene product from transcript CG31258-RA0.240
l(1)dd4lethal (1) discs degenerate 40.222
tefutelomere fusion0.208
bratbrain tumor0.156
poloCG12306 gene product from transcript CG12306-RA0.099
Orc2Origin recognition complex subunit 20.092
Cdc27CG8610 gene product from transcript CG8610-RA0.091
CycBCyclin B0.088
Nuf2CG8902 gene product from transcript CG8902-RA0.085
CycB3Cyclin B30.071
Klp61FKinesin-like protein at 61F0.064
marsCG17064 gene product from transcript CG17064-RB0.062
IncenpInner centromere protein0.057
MybMyb oncogene-like0.050
CG9772CG9772 gene product from transcript CG9772-RB0.049
Klp3AKinesin-like protein at 3A0.045
ParpPoly-(ADP-ribose) polymerase0.040
DNApol-alpha60DNA polymerase alpha 60kD0.040
Cap-GCG34438 gene product from transcript CG34438-RF0.040
Psf2CG18013 gene product from transcript CG18013-RA0.040
rapretina aberrant in pattern0.036
Fcp1CG12252 gene product from transcript CG12252-RA0.036
weeCG4488 gene product from transcript CG4488-RA0.036
nbsCG6754 gene product from transcript CG6754-RC0.036
Mis12CG18156 gene product from transcript CG18156-RA0.031
CG4680CG4680 gene product from transcript CG4680-RA0.030
SMC2CG10212 gene product from transcript CG10212-RA0.029
Ndc80CG9938 gene product from transcript CG9938-RA0.028
Rca1Regulator of cyclin A10.027
Nipped-ACG33554 gene product from transcript CG33554-RE0.026
thrthree rows0.025
pitaCG3941 gene product from transcript CG3941-RA0.024
l(1)G0148lethal (1) G01480.024
Su(var)2-10Suppressor of variegation 2-100.022
Cks30ACyclin-dependent kinase subunit 30A0.022
pashapartner of drosha0.022
mus304mutagen-sensitive 3040.022
PtenCG5671 gene product from transcript CG5671-RB0.021
Orc5Origin recognition complex subunit 50.020
Kmn1kinetochore Mis12-Ndc80 network component 10.019
Su(H)Suppressor of Hairless0.018
Top1Topoisomerase 10.018
cidcentromere identifier0.017
aspabnormal spindle0.017
Aats-metMethionyl-tRNA synthetase0.017
Uch-L3Ubiquitin C-terminal hydrolase0.016
Nek2CG17256 gene product from transcript CG17256-RA0.014
Cdc37CG12019 gene product from transcript CG12019-RA0.014
DrefDNA replication-related element factor0.013
l(1)G0469lethal (1) G04690.013
Cks85ACyclin-dependent kinase subunit 85A0.013
jubAjuba LIM protein0.012
Spc25CG7242 gene product from transcript CG7242-RA0.012
Orc6Origin recognition complex subunit 60.011
Klp10ACG1453 gene product from transcript CG1453-RA0.011
RbfRetinoblastoma-family protein0.010
Dap160Dynamin associated protein 1600.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDC27cell division cycle 27 homolog (S. cerevisiae)1.000
CDC20cell division cycle 20 homolog (S. cerevisiae)1.000
ANAPC4anaphase promoting complex subunit 40.999
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.979
ANAPC7anaphase promoting complex subunit 70.973
ANAPC1anaphase promoting complex subunit 10.935
CDC16cell division cycle 16 homolog (S. cerevisiae)0.857
CDC23cell division cycle 23 homolog (S. cerevisiae)0.826
VHLvon Hippel-Lindau tumor suppressor0.668
ANAPC5anaphase promoting complex subunit 50.609
RB1retinoblastoma 10.493
CDC26cell division cycle 26 homolog (S. cerevisiae)0.358
TCEB2transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)0.282
CCNA2cyclin A20.224
COMMD1copper metabolism (Murr1) domain containing 10.179
CUL1cullin 10.162
ANAPC11anaphase promoting complex subunit 110.102
CCNB1cyclin B10.087
RBBP8retinoblastoma binding protein 80.076
CUL4Acullin 4A0.076
CDK2cyclin-dependent kinase 20.073
SKP2S-phase kinase-associated protein 2 (p45)0.068
PLK1polo-like kinase 10.067
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.047
RBL1retinoblastoma-like 1 (p107)0.044
PTTG1pituitary tumor-transforming 10.044
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.040
CUL5cullin 50.026
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.025
CDKN3cyclin-dependent kinase inhibitor 30.024
FBXO5F-box protein 50.024
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.020
SKP1S-phase kinase-associated protein 10.020
SMC6structural maintenance of chromosomes 60.017
ANAPC13anaphase promoting complex subunit 130.014
E2F4E2F transcription factor 4, p107/p130-binding0.013
E2F5E2F transcription factor 5, p130-binding0.013
LIN54lin-54 homolog (C. elegans)0.012
PKMYT1protein kinase, membrane associated tyrosine/threonine 10.012
RBL2retinoblastoma-like 2 (p130)0.011
NEK2NIMA (never in mitosis gene a)-related kinase 20.011
SIRT2sirtuin 20.011
ANAPC10anaphase promoting complex subunit 100.010
ANAPC16anaphase promoting complex subunit 160.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.971
Trp53transformation related protein 530.968
Kif22kinesin family member 220.718
Prc1protein regulator of cytokinesis 10.687
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.401
Ptenphosphatase and tensin homolog0.390
Ccnb2cyclin B20.373
Hmmrhyaluronan mediated motility receptor (RHAMM)0.361
Apcadenomatosis polyposis coli0.306
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.301
Dlgap5discs, large (Drosophila) homolog-associated protein 50.281
H2afxH2A histone family, member X0.273
Plk1polo-like kinase 1 (Drosophila)0.194
Cdk1cyclin-dependent kinase 10.190
Ccna2cyclin A20.174
Ccnb1cyclin B10.128
Cdkn1bcyclin-dependent kinase inhibitor 1B0.121
Prmt5protein arginine N-methyltransferase 50.112
Axin1axin 10.105
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.104
Mki67antigen identified by monoclonal antibody Ki 670.072
Gtse1G two S phase expressed protein 10.071
Ccnfcyclin F0.065
Cdc25ccell division cycle 25 homolog C (S. pombe)0.064
Cdca8cell division cycle associated 80.064
Aurkbaurora kinase B0.057
Kif20akinesin family member 20A0.056
Mdm2transformed mouse 3T3 cell double minute 20.053
Birc5baculoviral IAP repeat-containing 50.053
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.052
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.050
Spag5sperm associated antigen 50.050
Apoeapolipoprotein E0.047
Ckap2cytoskeleton associated protein 20.044
Cdca5cell division cycle associated 50.043
Rb1retinoblastoma 10.041
Psen1presenilin 10.041
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.039
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.036
Cdkn3cyclin-dependent kinase inhibitor 30.036
Ckap2lcytoskeleton associated protein 2-like0.034
Kitkit oncogene0.033
Usp9xubiquitin specific peptidase 9, X chromosome0.032
Melkmaternal embryonic leucine zipper kinase0.031
Cenpacentromere protein A0.031
Cenpfcentromere protein F0.030
Smad4MAD homolog 4 (Drosophila)0.028
Kif2ckinesin family member 2C0.027
E2f1E2F transcription factor 10.027
Kif4kinesin family member 40.026
Cenpncentromere protein N0.025
Atf2activating transcription factor 20.024
Hif1ahypoxia inducible factor 1, alpha subunit0.024
Ube2cubiquitin-conjugating enzyme E2C0.024
Espl1extra spindle poles-like 1 (S. cerevisiae)0.024
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.023
Nf2neurofibromatosis 20.023
BrafBraf transforming gene0.022
Aurkaaurora kinase A0.021
Tk1thymidine kinase 10.021
Lmnb1lamin B10.021
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.020
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.020
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.020
Brca1breast cancer 10.019
Notch1Notch gene homolog 1 (Drosophila)0.019
Nuf2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.019
Gsg2germ cell-specific gene 20.019
Racgap1Rac GTPase-activating protein 10.019
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.019
E130306D19RikRIKEN cDNA E130306D19 gene0.018
Rrm2ribonucleotide reductase M20.018
Aaasachalasia, adrenocortical insufficiency, alacrimia0.018
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.018
Lrp6low density lipoprotein receptor-related protein 60.017
Klhl7kelch-like 7 (Drosophila)0.016
Ncapd2non-SMC condensin I complex, subunit D20.016
Ptch1patched homolog 10.015
Kif23kinesin family member 230.014
Itgb1integrin beta 1 (fibronectin receptor beta)0.014
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.014
Dlg1discs, large homolog 1 (Drosophila)0.014
Tsc1tuberous sclerosis 10.014
StilScl/Tal1 interrupting locus0.014
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.014
Spc24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.014
Cdc25bcell division cycle 25 homolog B (S. pombe)0.014
Incenpinner centromere protein0.014
Kif11kinesin family member 110.013
Prr11proline rich 110.013
Tpx2TPX2, microtubule-associated protein homolog (Xenopus laevis)0.013
Dazap1DAZ associated protein 10.013
Sgol1shugoshin-like 1 (S. pombe)0.013
Ranbp9RAN binding protein 90.013
Depdc1bDEP domain containing 1B0.013
Ptpn11protein tyrosine phosphatase, non-receptor type 110.013
Tcf3transcription factor 30.012
Fam64afamily with sequence similarity 64, member A0.012
Ncaphnon-SMC condensin I complex, subunit H0.012
Kitlkit ligand0.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism