The network for 'dna modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna modification

The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties.

Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Su(var)205Suppressor of variegation 2050.908
eggeggless0.577
Su(var)3-7Suppressor of variegation 3-70.295
spn-Espindle E0.244
Rrp42CG8395 gene product from transcript CG8395-RA0.068
E(var)3-9Enhancer of variegation 3-90.057
ash1absent, small, or homeotic discs 10.044
piwiCG6122 gene product from transcript CG6122-RA0.039
RpL37bRibosomal protein L37b0.025
fs(1)Ybfemale sterile (1) Yb0.025
krimpkrimper0.019
CG7006CG7006 gene product from transcript CG7006-RA0.017
CG13581CG13581 gene product from transcript CG13581-RA0.015
gppgrappa0.014
CG4771CG4771 gene product from transcript CG4771-RA0.013
D19ACG10269 gene product from transcript CG10269-RA0.012
armiarmitage0.011
CG11660CG11660 gene product from transcript CG11660-RA0.011
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.011
otuovarian tumor0.011
CstF-50CG2261 gene product from transcript CG2261-RA0.011
Su(var)3-3Suppressor of variegation 3-30.010
CG9667CG9667 gene product from transcript CG9667-RA0.010
magomago nashi0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pgal-1Protein PGAL-10.044
asb-2Protein ASB-20.028
sucl-1Protein SUCL-10.027
C09E8.1Protein C09E8.10.026
haf-4Protein HAF-40.025
ifb-2Protein IFB-20.022
egl-44Protein EGL-440.022
scav-1Protein SCAV-10.020
inx-15Protein INX-150.019
T12D8.9Protein T12D8.90.019
acs-5Protein ACS-50.017
sma-4Protein SMA-40.017
H36L18.2Protein H36L18.20.017
CELE_T27C4.1Protein T27C4.10.016
C46G7.1Protein C46G7.10.015
soc-2Protein SOC-20.014
gst-36Protein GST-360.014
fah-1Protein FAH-10.014
lec-9Protein LEC-90.014
H43E16.1Protein H43E16.10.014
skr-3Protein SKR-30.014
C48E7.1Protein C48E7.10.013
ugt-23Protein UGT-230.013
acox-1Protein ACOX-10.012
F52H3.5Protein F52H3.50.011
T01H8.2Protein T01H8.20.011
ram-2Protein RAM-20.011
col-125Protein COL-1250.011
eef-1A.2Protein EEF-1A.20.011
CELE_R102.4Protein R102.40.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dnmt7DNA (cytosine-5-)-methyltransferase 70.621
marcksbmyristoylated alanine rich protein kinase C substrate b0.446
whsc1Wolf-Hirschhorn syndrome candidate 10.193
suv39h1bsuppressor of variegation 3-9 homolog 1b0.145
dnmt1DNA (cytosine-5-)-methyltransferase 10.136
cbx1achromobox homolog 1a (HP1 beta homolog Drosophila)0.132
smc3structural maintenance of chromosomes 30.112
pola1polymerase (DNA directed), alpha 10.098
mpxmyeloid-specific peroxidase0.087
rbb4retinoblastoma binding protein 40.086
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.085
usp1ubiquitin specific protease 10.082
sephs1selenophosphate synthetase 10.082
ssbp3bsingle stranded DNA binding protein 3b0.078
orgoogenesis-related gene0.072
ezh2enhancer of zeste homolog 2 (Drosophila)0.070
lcp1lymphocyte cytosolic plastin 10.070
suv420h2suppressor of variegation 4-20 homolog 2 (Drosophila)0.068
suv39h1asuppressor of variegation 3-9 homolog 1a0.061
sass6spindle assembly 6 homolog (C. elegans)0.059
eomesaeomesodermin homolog a0.058
epb4.1l4erythrocyte protein band 4.1-like 40.056
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.055
tmpoathymopoietin a0.052
sox19bSRY-box containing gene 19b0.052
spdyaspeedy homolog A (Xenopus laevis)0.052
sinupsiaz-interacting nuclear protein0.051
si:ch211-1n9.7si:ch211-1n9.70.050
hnf1baHNF1 homeobox Ba0.049
dnmt5DNA (cytosine-5-)-methyltransferase 50.047
rpa1replication protein A10.047
ndr1nodal-related 10.044
lmnb1lamin B10.043
tra2btransformer 2 beta homolog (Drosophila)0.042
rif1RAP1 interacting factor homolog (yeast)0.042
ssrp1astructure specific recognition protein 1a0.041
hcfc1ahost cell factor C1a0.041
otulOTU like protein0.040
lhx1bLIM homeobox 1b0.038
anp32aacidic (leucine-rich) nuclear phosphoprotein 32 family, member A0.036
brd4bromodomain containing 40.036
chaf1bchromatin assembly factor 1, subunit B0.035
smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.034
hcfc1bhost cell factor C1b0.032
chek2CHK2 checkpoint homolog (S. pombe)0.032
wnt8awingless-type MMTV integration site family, member 8a0.031
adora2aaadenosine A2a receptor a0.031
sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.030
cbx5chromobox homolog 5 (HP1 alpha homolog, Drosophila)0.030
gata2aGATA-binding protein 2a0.029
mmp13amatrix metalloproteinase 13a0.027
dnmt3DNA (cytosine-5-)-methyltransferase 30.026
dnmt8DNA (cytosine-5-)-methyltransferase 80.025
srrtserrate RNA effector molecule homolog (Arabidopsis)0.024
lyzlysozyme0.024
zgc:158604zgc:1586040.024
mosv-mos Moloney murine sarcoma viral oncogene homolog0.024
whsc1l1Wolf-Hirschhorn syndrome candidate 1-like 10.024
prim1primase polypeptide 10.023
snrnp35small nuclear ribonucleoprotein 35 (U11/U12)0.022
gh1growth hormone 10.022
ehmt2euchromatic histone-lysine N-methyltransferase 20.021
top2atopoisomerase (DNA) II alpha0.021
msh2mutS homolog 2 (E. coli)0.021
zgc:55468zgc:554680.021
LOC567638hypothetical LOC5676380.020
setd6SET domain containing 60.020
ahctf1AT hook containing transcription factor 10.019
pcdh2acprotocadherin 2 alpha c0.019
dazldaz-like gene0.019
ncf1neutrophil cytosolic factor 10.019
chek1CHK1 checkpoint homolog (S. pombe)0.019
rnf2ring finger protein 20.017
foxe3forkhead box E30.017
zgc:111944zgc:1119440.017
rnf17ring finger protein 170.016
ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.016
zgc:154063zgc:1540630.016
setd8aSET domain containing (lysine methyltransferase) 8a0.016
e2f5E2F transcription factor 50.016
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.015
sb:cb81sb:cb810.015
drldraculin0.015
hirip3HIRA interacting protein 30.015
setdb1bSET domain, bifurcated 1b0.014
sox11bSRY-box containing gene 11b0.014
dtldenticleless homolog (Drosophila)0.014
lsm14bLSM14B, SCD6 homolog B (S. cerevisiae)0.014
zc4h2zinc finger, C4H2 domain containing0.014
gcm2glial cells missing homolog 2 (Drosophila)0.014
meis2.2myeloid ecotropic viral integration site 2.20.014
her2hairy-related 20.014
mybl2myeloblastosis oncogene-like 20.013
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.013
polr2apolymerase (RNA) II (DNA directed) polypeptide A0.013
coro1acoronin, actin binding protein, 1A0.013
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.013
mycl1av-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) a0.012
rhogbras homolog gene family, member Gb0.012
mmp9matrix metalloproteinase 90.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DNMT1DNA (cytosine-5-)-methyltransferase 10.975
UHRF1ubiquitin-like with PHD and ring finger domains 10.940
CBX5chromobox homolog 50.838
EXOSC10exosome component 100.807
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.684
EXOSC2exosome component 20.490
EXOSC3exosome component 30.470
HMGA1high mobility group AT-hook 10.465
EEDembryonic ectoderm development0.445
EXOSC1exosome component 10.332
WDR5WD repeat domain 50.332
HDAC1histone deacetylase 10.318
MBD1methyl-CpG binding domain protein 10.313
DIS3LDIS3 mitotic control homolog (S. cerevisiae)-like0.291
SP1Sp1 transcription factor0.256
CHD4chromodomain helicase DNA binding protein 40.251
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.243
PARP1poly (ADP-ribose) polymerase 10.230
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.194
LBRlamin B receptor0.164
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.151
EXOSC7exosome component 70.147
MPHOSPH8M-phase phosphoprotein 80.102
CBX1chromobox homolog 10.094
RPA2replication protein A2, 32kDa0.091
SUZ12suppressor of zeste 12 homolog (Drosophila)0.091
EXOSC9exosome component 90.081
HIST1H3Bhistone cluster 1, H3b0.074
IRS1insulin receptor substrate 10.069
EHMT1euchromatic histone-lysine N-methyltransferase 10.063
SETD1ASET domain containing 1A0.055
POGZpogo transposable element with ZNF domain0.051
ADNPactivity-dependent neuroprotector homeobox0.049
AXIN1axin 10.044
AFF1AF4/FMR2 family, member 10.044
EXOSC5exosome component 50.042
MACF1microtubule-actin crosslinking factor 10.041
CDK4cyclin-dependent kinase 40.040
PRRC2Bproline-rich coiled-coil 2B0.039
CHD8chromodomain helicase DNA binding protein 80.037
MTA3metastasis associated 1 family, member 30.036
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.036
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.034
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.031
MAGEA2melanoma antigen family A, 20.031
NRIP1nuclear receptor interacting protein 10.030
CBX3chromobox homolog 30.029
AFF4AF4/FMR2 family, member 40.029
MEN1multiple endocrine neoplasia I0.027
E2F3E2F transcription factor 30.027
CMIPc-Maf-inducing protein0.026
REREarginine-glutamic acid dipeptide (RE) repeats0.025
OTUD6BOTU domain containing 6B0.025
CCNT1cyclin T10.024
SMAD4SMAD family member 40.023
SETDB1SET domain, bifurcated 10.023
HCFC1host cell factor C1 (VP16-accessory protein)0.023
ACTL6Aactin-like 6A0.022
SKILSKI-like oncogene0.022
CHAF1Achromatin assembly factor 1, subunit A (p150)0.021
MTA1metastasis associated 10.021
LRIF1ligand dependent nuclear receptor interacting factor 10.020
ZNF518Azinc finger protein 518A0.019
USP11ubiquitin specific peptidase 110.019
MCM7minichromosome maintenance complex component 70.019
TRIM27tripartite motif containing 270.017
ARRB1arrestin, beta 10.017
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.017
TRIM28tripartite motif containing 280.017
SKIv-ski sarcoma viral oncogene homolog (avian)0.016
PTNpleiotrophin0.016
YY1YY1 transcription factor0.015
PCNAproliferating cell nuclear antigen0.015
TCL1AT-cell leukemia/lymphoma 1A0.015
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.014
CDYLchromodomain protein, Y-like0.014
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.014
EPG5ectopic P-granules autophagy protein 5 homolog (C. elegans)0.014
MPHOSPH6M-phase phosphoprotein 60.013
APTXaprataxin0.013
APEX1APEX nuclease (multifunctional DNA repair enzyme) 10.013
THAP7THAP domain containing 70.013
MCM5minichromosome maintenance complex component 50.013
ANP32Aacidic (leucine-rich) nuclear phosphoprotein 32 family, member A0.012
ZNF350zinc finger protein 3500.012
SMC1Astructural maintenance of chromosomes 1A0.012
RPA1replication protein A1, 70kDa0.012
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.012
RBBP4retinoblastoma binding protein 40.012
RARAretinoic acid receptor, alpha0.012
WDR82WD repeat domain 820.012
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.012
THAP11THAP domain containing 110.012
CADcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.012
CTCFCCCTC-binding factor (zinc finger protein)0.011
SP3Sp3 transcription factor0.011
DTLdenticleless homolog (Drosophila)0.011
METTL13methyltransferase like 130.011
NCOA2nuclear receptor coactivator 20.011
DCP1BDCP1 decapping enzyme homolog B (S. cerevisiae)0.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ezh2enhancer of zeste homolog 2 (Drosophila)0.999
Rnf2ring finger protein 20.997
Jarid2jumonji, AT rich interactive domain 20.992
Suz12suppressor of zeste 12 homolog (Drosophila)0.987
Dnmt3bDNA methyltransferase 3B0.983
RybpRING1 and YY1 binding protein0.976
Eedembryonic ectoderm development0.970
Dnmt3aDNA methyltransferase 3A0.942
Mtf2metal response element binding transcription factor 20.919
Hdac1histone deacetylase 10.861
Hdac2histone deacetylase 20.853
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.849
Arid1aAT rich interactive domain 1A (SWI-like)0.830
Rbbp4retinoblastoma binding protein 40.826
Pou5f1POU domain, class 5, transcription factor 10.771
Trim28tripartite motif-containing 280.744
Sall4sal-like 4 (Drosophila)0.739
CblCasitas B-lineage lymphoma0.707
Mta1metastasis associated 10.707
Stk38serine/threonine kinase 380.701
Hellshelicase, lymphoid specific0.693
Trim24tripartite motif-containing 240.605
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.590
Aebp2AE binding protein 20.552
Sin3atranscriptional regulator, SIN3A (yeast)0.533
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.517
Arid1bAT rich interactive domain 1B (SWI-like)0.512
Gm5806predicted gene 58060.418
Rbbp7retinoblastoma binding protein 70.403
Stat3signal transducer and activator of transcription 30.364
L3mbtl2l(3)mbt-like 2 (Drosophila)0.351
Dnmt3lDNA (cytosine-5-)-methyltransferase 3-like0.324
Dnmt1DNA methyltransferase (cytosine-5) 10.304
Cbx5chromobox homolog 5 (Drosophila HP1a)0.294
Kdm2blysine (K)-specific demethylase 2B0.289
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.279
CrebbpCREB binding protein0.207
Ighimmunoglobulin heavy chain complex0.198
Setxsenataxin0.197
Morc3microrchidia 30.192
Apcadenomatosis polyposis coli0.191
Arid4aAT rich interactive domain 4A (RBP1-like)0.187
Cbfbcore binding factor beta0.170
Mecp2methyl CpG binding protein 20.168
Brca2breast cancer 20.162
Kdm1alysine (K)-specific demethylase 1A0.154
MgaMAX gene associated0.151
Zbtb33zinc finger and BTB domain containing 330.139
Piwil1piwi-like homolog 1 (Drosophila)0.137
Runx1runt related transcription factor 10.136
Piwil2piwi-like homolog 2 (Drosophila)0.132
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.125
Bptfbromodomain PHD finger transcription factor0.124
NanogNanog homeobox0.122
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.121
Tcfcp2l1transcription factor CP2-like 10.119
Arid4bAT rich interactive domain 4B (RBP1-like)0.113
Maelmaelstrom homolog (Drosophila)0.110
Ring1ring finger protein 10.104
Rbl2retinoblastoma-like 20.104
Cbx8chromobox homolog 8 (Drosophila Pc class)0.104
Mll3myeloid/lymphoid or mixed-lineage leukemia 30.103
Ncoa3nuclear receptor coactivator 30.102
Chd4chromodomain helicase DNA binding protein 40.102
Tubb5tubulin, beta 50.102
Bcl6B-cell leukemia/lymphoma 60.102
Rbm5RNA binding motif protein 50.098
Mdm4transformed mouse 3T3 cell double minute 40.098
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.097
Cbx7chromobox homolog 70.097
Ncor1nuclear receptor co-repressor 10.096
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.095
Tdrd1tudor domain containing 10.093
Ilf3interleukin enhancer binding factor 30.093
Tbl1xr1transducin (beta)-like 1X-linked receptor 10.087
Phc1polyhomeotic-like 1 (Drosophila)0.085
Pik3r3phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)0.085
Arid2AT rich interactive domain 2 (ARID, RFX-like)0.083
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.082
Rnps1ribonucleic acid binding protein S10.081
Rsf1remodeling and spacing factor 10.081
Pcgf6polycomb group ring finger 60.080
Cxcr4chemokine (C-X-C motif) receptor 40.080
Brd4bromodomain containing 40.077
Csnk2a1casein kinase 2, alpha 1 polypeptide0.076
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.075
Cdk4cyclin-dependent kinase 40.074
Ehmt1euchromatic histone methyltransferase 10.073
Msh2mutS homolog 2 (E. coli)0.073
Smarcc2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.072
Pcp2Purkinje cell protein 2 (L7)0.072
Thrathyroid hormone receptor alpha0.071
Dmtf1cyclin D binding myb-like transcription factor 10.071
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.071
Gdf3growth differentiation factor 30.068
Bmi1Bmi1 polycomb ring finger oncogene0.068
Dckdeoxycytidine kinase0.068
A530054K11RikRIKEN cDNA A530054K11 gene0.067
Ubtfupstream binding transcription factor, RNA polymerase I0.066
Msl1male-specific lethal 1 homolog (Drosophila)0.065
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ssrp1structure specific recognition protein 10.316
Errfi1ERBB receptor feedback inhibitor 10.097
Gtf2igeneral transcription factor II I0.071
Sf3b2splicing factor 3b, subunit 20.047
Prpf8PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)0.042
Rbm42RNA binding motif protein 420.036
Gsta3glutathione S-transferase A30.034
Dhx30DEAH (Asp-Glu-Ala-His) box polypeptide 300.030
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.030
Hnrpmheterogeneous nuclear ribonucleoprotein M0.029
Bat1HLA-B associated transcript 10.028
Cherpcalcium homeostasis endoplasmic reticulum protein0.027
Gstt1glutathione S-transferase theta 10.025
Mrpl45mitochondrial ribosomal protein L450.024
Mgst1microsomal glutathione S-transferase 10.023
Safbscaffold attachment factor B0.022
Csnk2a2casein kinase 2, alpha prime polypeptide0.017
Chd4chromodomain helicase DNA binding protein 40.017
Tcf4transcription factor 40.017
Cpsf1cleavage and polyadenylation specific factor 10.015
Ep400E1A binding protein p4000.015
Tgs1trimethylguanosine synthase homolog (S. cerevisiae)0.015
Lrrc47leucine rich repeat containing 470.015
Ctbp1C-terminal binding protein 10.015
CtcfCCCTC-binding factor (zinc finger protein)0.014
Hnrnplheterogeneous nuclear ribonucleoprotein L0.014
Sec24bSEC24 family, member B (S. cerevisiae)0.014
Cobra1cofactor of BRCA10.013
Idh1isocitrate dehydrogenase 1 (NADP+), soluble0.013
Thop1thimet oligopeptidase 10.013
Anapc5anaphase-promoting complex subunit 50.013
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.013
Sart3squamous cell carcinoma antigen recognized by T-cells 30.013
Trim28tripartite motif-containing 280.013
Rnf10ring finger protein 100.012
Puf60poly-U binding splicing factor 600.012
Phf12PHD finger protein 120.012
Art1ADP-ribosyltransferase 10.012
Ciz1CDKN1A interacting zinc finger protein 10.012
Ipo4importin 40.012
Ehmt2euchromatic histone lysine N-methyltransferase 20.012
Casp2caspase 20.011
Ephx1epoxide hydrolase 1, microsomal0.011
Fam40afamily with sequence similarity 40, member A0.010
Hdgf2hepatoma-derived growth factor-related protein 20.010
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CSL4Csl4p0.010