The network for 'negative regulation of intrinsic apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of intrinsic apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
Rpb5CG11979 gene product from transcript CG11979-RA0.092
Ras85DRas oncogene at 85D0.056
Moca-cypCG1866 gene product from transcript CG1866-RA0.051
RpII215RNA polymerase II 215kD subunit0.049
Srp19Signal recognition particle protein 190.047
CG5720CG5720 gene product from transcript CG5720-RA0.044
l(2)gllethal (2) giant larvae0.041
CG6610CG6610 gene product from transcript CG6610-RA0.040
AtpalphaNa pump alpha subunit0.039
BicDBicaudal D0.039
Cp190Centrosomal protein 190kD0.038
CG11970CG11970 gene product from transcript CG11970-RA0.036
mspsmini spindles0.034
Aos1CG12276 gene product from transcript CG12276-RA0.034
CG11267CG11267 gene product from transcript CG11267-RA0.034
gemininCG3183 gene product from transcript CG3183-RA0.034
MED22Mediator complex subunit 220.033
CG3353CG3353 gene product from transcript CG3353-RA0.033
Nup358Nucleoporin 3580.032
CG1542CG1542 gene product from transcript CG1542-RA0.032
RanGapRan GTPase activating protein0.031
CG9740CG9740 gene product from transcript CG9740-RA0.030
Prp8pre-mRNA processing factor 80.030
EcREcdysone receptor0.030
CG2021CG2021 gene product from transcript CG2021-RA0.029
CG8928CG8928 gene product from transcript CG8928-RA0.029
EgfrEpidermal growth factor receptor0.029
CG5515CG5515 gene product from transcript CG5515-RA0.028
Rpb11CG6840 gene product from transcript CG6840-RA0.028
Tif-IACG3278 gene product from transcript CG3278-RA0.027
Tim9aCG1660 gene product from transcript CG1660-RA0.026
Nedd8CG10679 gene product from transcript CG10679-RA0.026
mtSSBmitochondrial single stranded DNA-binding protein0.026
SmFSmall ribonucleoprotein particle protein SmF0.026
LSm7CG13277 gene product from transcript CG13277-RA0.025
Art1Arginine methyltransferase 10.024
CG5800CG5800 gene product from transcript CG5800-RA0.024
SsrpStructure specific recognition protein0.024
ebiCG4063 gene product from transcript CG4063-RA0.024
phlpole hole0.024
CG5220CG5220 gene product from transcript CG5220-RA0.024
CG9922CG9922 gene product from transcript CG9922-RA0.024
CG15019CG15019 gene product from transcript CG15019-RB0.024
ublubiquitin like0.024
CG13993CG13993 gene product from transcript CG13993-RA0.024
aopanterior open0.024
CG9603CG9603 gene product from transcript CG9603-RA0.023
Vps35Vacuolar protein sorting 350.023
CG7519CG7519 gene product from transcript CG7519-RA0.023
CG14464CG14464 gene product from transcript CG14464-RC0.022
eIF-4EEukaryotic initiation factor 4E0.022
AbiAbelson interacting protein0.022
FK506-bp2FK506-binding protein 20.022
CG32708CG32708 gene product from transcript CG32708-RA0.021
mRpL49mitochondrial ribosomal protein L490.021
CG11943CG11943 gene product from transcript CG11943-RB0.021
ctpcut up0.021
LanALaminin A0.021
CG9797CG9797 gene product from transcript CG9797-RA0.021
AdamCG12131 gene product from transcript CG12131-RA0.021
CG10635CG10635 gene product from transcript CG10635-RA0.020
sanseparation anxiety0.020
Sra-1specifically Rac1-associated protein 10.020
Fcp1CG12252 gene product from transcript CG12252-RA0.020
CG6459CG6459 gene product from transcript CG6459-RA0.020
CG11985CG11985 gene product from transcript CG11985-RA0.020
CG7993CG7993 gene product from transcript CG7993-RA0.019
CG10418CG10418 gene product from transcript CG10418-RA0.019
mbomembers only0.019
bafbarrier to autointegration factor0.019
CG8860CG8860 gene product from transcript CG8860-RA0.019
MED10Mediator complex subunit 100.019
CG5602CG5602 gene product from transcript CG5602-RA0.018
Ssb-c31aSingle stranded-binding protein c31A0.018
RpII140RNA polymerase II 140kD subunit0.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mcl1amyeloid cell leukemia sequence 1a0.330
baxabcl2-associated X protein, a0.324
aldh1a2aldehyde dehydrogenase 1 family, member A20.284
ctbp2lC-terminal binding protein 2, like0.166
bcl2l1bcl2-like 10.162
cx43.4connexin 43.40.136
ptgs2aprostaglandin-endoperoxide synthase 2a0.111
vax2ventral anterior homeobox 20.109
mcl1bmyeloid cell leukemia sequence 1b0.109
tbx2bT-box 2b0.080
rp2retinitis pigmentosa 2 (X-linked recessive)0.068
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.065
znf703zinc finger protein 7030.058
nrg1neuregulin 10.055
cxcr4bchemokine (C-X-C motif), receptor 4b0.052
dusp1dual specificity phosphatase 10.049
egr1early growth response 10.048
sox9bSRY-box containing gene 9b0.039
mapk14amitogen-activated protein kinase 14a0.037
LOC567131calcitonin gene-related peptide type 1 receptor-like0.036
tp53tumor protein p530.036
smc2structural maintenance of chromosomes 20.035
acadmacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain0.034
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.033
vps24vacuolar protein sorting 24 homolog (S. cerevisiae)0.032
bcl2B-cell leukemia/lymphoma 20.032
slc9a8solute carrier family 9 (sodium/hydrogen exchanger), member 80.031
lin28alin-28 homolog A (C. elegans)0.029
sod1superoxide dismutase 1, soluble0.028
fn1fibronectin 10.027
sox10SRY-box containing gene 100.027
hsp47heat shock protein 470.026
acsl4aacyl-CoA synthetase long-chain family member 4a0.025
fbln4fibulin 40.024
znf207azinc finger protein 207, a0.024
cdkn1acyclin-dependent kinase inhibitor 1A0.024
bidaBH3 interacting domain death agonist0.022
gadd45aagrowth arrest and DNA-damage-inducible, alpha, a0.021
pax6bpaired box gene 6b0.021
slc25a25asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a0.021
sema3aasemaphorin 3aa0.021
trpv6transient receptor potential cation channel, subfamily V, member 60.020
bbc3BCL2 binding component 30.020
warstryptophanyl-tRNA synthetase0.020
chukconserved helix-loop-helix ubiquitous kinase0.020
mmp9matrix metalloproteinase 90.020
tbx16T-box gene 160.020
myf5myogenic factor 50.019
cx45.6connexin 45.60.019
park7parkinson disease (autosomal recessive, early onset) 70.019
znf536zinc finger protein 5360.019
prom1aprominin 1a0.019
myod1myogenic differentiation 10.018
tgif1TGFB-induced factor homeobox 10.018
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.018
pdgfrlplatelet-derived growth factor receptor-like0.017
chatcholine acetyltransferase0.017
her1hairy-related 10.017
maxmyc-associated factor X0.017
hspa5heat shock protein 50.017
rbm4.3RNA binding motif protein 4.30.016
smad5MAD homolog 5 (Drosophila)0.016
thraathyroid hormone receptor alpha a0.016
zfand2azinc finger, AN1-type domain 2A0.015
sat1aspermidine/spermine N1-acetyltransferase 1a0.015
bnip3lbBCL2/adenovirus E1B interacting protein 3-like b0.014
cx52.9connexin 52.90.014
mespbmesoderm posterior b0.014
tbpTATA box binding protein0.014
ptmaaprothymosin, alpha a0.014
gpt2glutamic pyruvate transaminase (alanine aminotransferase) 20.014
hyou1hypoxia up-regulated 10.013
ntn2netrin 20.013
stc1lstanniocalcin 1, like0.013
igfbp1ainsulin-like growth factor binding protein 1a0.012
trpv4transient receptor potential cation channel, subfamily V, member 40.012
LOC568935ARF GTPase-activating protein GIT1-like0.012
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.012
lmx1b.1LIM homeobox transcription factor 1, beta 10.012
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.012
ilf2interleukin enhancer binding factor 20.012
cacnb2acalcium channel, voltage-dependent, beta 2a0.012
cebpgCCAAT/enhancer binding protein (C/EBP), gamma0.012
dtldenticleless homolog (Drosophila)0.012
mapk6mitogen-activated protein kinase 60.011
rspo1R-spondin homolog (Xenopus laevis)0.011
mt2metallothionein 20.011
atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.011
scn1basodium channel, voltage-gated, type I, beta a0.011
hsp90a.2heat shock protein 90-alpha 20.011
bcl2l10BCL2-like 10 (apoptosis facilitator)0.011
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BCL2L1BCL2-like 10.996
BCL2B-cell CLL/lymphoma 20.964
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.910
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.791
HDAC1histone deacetylase 10.591
SIN3ASIN3 homolog A, transcription regulator (yeast)0.552
PMLpromyelocytic leukemia0.512
BAXBCL2-associated X protein0.495
BCL2L11BCL2-like 11 (apoptosis facilitator)0.378
TP53tumor protein p530.333
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.317
SFPQsplicing factor proline/glutamine-rich0.310
LASS2LAG1 homolog, ceramide synthase 20.245
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.235
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.213
DAXXdeath-domain associated protein0.183
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.181
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.180
WBP4WW domain binding protein 4 (formin binding protein 21)0.178
RB1retinoblastoma 10.178
TP53BP2tumor protein p53 binding protein, 20.175
SPRR2Asmall proline-rich protein 2A0.158
BAK1BCL2-antagonist/killer 10.152
BADBCL2-associated agonist of cell death0.148
LCKlymphocyte-specific protein tyrosine kinase0.144
MDM2Mdm2 p53 binding protein homolog (mouse)0.144
MAPK8mitogen-activated protein kinase 80.143
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.135
BIDBH3 interacting domain death agonist0.131
BMI1BMI1 polycomb ring finger oncogene0.127
MDM4Mdm4 p53 binding protein homolog (mouse)0.121
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.120
DERL1Der1-like domain family, member 10.117
SQSTM1sequestosome 10.115
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.110
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.108
GSK3Bglycogen synthase kinase 3 beta0.088
EFTUD2elongation factor Tu GTP binding domain containing 20.088
KEAP1kelch-like ECH-associated protein 10.075
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.075
MAP2K5mitogen-activated protein kinase kinase 50.073
UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.073
SYKspleen tyrosine kinase0.073
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.067
UHRF1ubiquitin-like with PHD and ring finger domains 10.065
HCKhemopoietic cell kinase0.062
EEDembryonic ectoderm development0.062
RBBP4retinoblastoma binding protein 40.060
HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 10.060
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.060
CREBBPCREB binding protein0.060
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.057
YY1YY1 transcription factor0.056
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.056
MAP2K7mitogen-activated protein kinase kinase 70.056
ZNF746zinc finger protein 7460.055
SYVN1synovial apoptosis inhibitor 1, synoviolin0.055
CXCR4chemokine (C-X-C motif) receptor 40.051
EIF4A1eukaryotic translation initiation factor 4A10.051
E2F3E2F transcription factor 30.051
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.050
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.049
WBP2WW domain binding protein 20.047
WIPF1WAS/WASL interacting protein family, member 10.047
FAM162Afamily with sequence similarity 162, member A0.046
BIRC3baculoviral IAP repeat containing 30.046
UBASH3Bubiquitin associated and SH3 domain containing B0.045
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.044
EGLN1egl nine homolog 1 (C. elegans)0.043
UBE3Aubiquitin protein ligase E3A0.042
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.042
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.042
ATMataxia telangiectasia mutated0.042
ICAM1intercellular adhesion molecule 10.041
HUWE1HECT, UBA and WWE domain containing 10.041
NAMPTnicotinamide phosphoribosyltransferase0.040
CBX8chromobox homolog 80.039
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.038
VDAC1voltage-dependent anion channel 10.038
RPL41ribosomal protein L410.037
BLNKB-cell linker0.037
FBXO7F-box protein 70.036
PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 10.036
ETF1eukaryotic translation termination factor 10.036
SOD1superoxide dismutase 1, soluble0.035
IL1Binterleukin 1, beta0.035
OTUB1OTU domain, ubiquitin aldehyde binding 10.035
PDCD6IPprogrammed cell death 6 interacting protein0.035
FBXO33F-box protein 330.035
IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase0.035
RYBPRING1 and YY1 binding protein0.035
DAD1defender against cell death 10.034
LIN28Blin-28 homolog B (C. elegans)0.034
EGFRepidermal growth factor receptor0.034
GAS7growth arrest-specific 70.033
RFWD2ring finger and WD repeat domain 20.033
RBBP7retinoblastoma binding protein 70.032
PCDH9protocadherin 90.032
NR4A1nuclear receptor subfamily 4, group A, member 10.032
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.942
Itgb1integrin beta 1 (fibronectin receptor beta)0.763
Trp53transformation related protein 530.752
Kdm2blysine (K)-specific demethylase 2B0.751
Wt1Wilms tumor 1 homolog0.728
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.579
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.572
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.480
Leprleptin receptor0.458
Vhlvon Hippel-Lindau tumor suppressor0.439
Ikbkbinhibitor of kappaB kinase beta0.421
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.386
Map3k7mitogen-activated protein kinase kinase kinase 70.368
Ptgs2prostaglandin-endoperoxide synthase 20.306
Ren1renin 1 structural0.286
Hdac2histone deacetylase 20.272
Bcl2B-cell leukemia/lymphoma 20.269
Hdac1histone deacetylase 10.266
Nos3nitric oxide synthase 3, endothelial cell0.266
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.254
Retret proto-oncogene0.219
Vegfavascular endothelial growth factor A0.204
H2-Eb1histocompatibility 2, class II antigen E beta0.193
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.192
Cd151CD151 antigen0.190
Tgfb1transforming growth factor, beta 10.156
Lyz2lysozyme 20.154
Ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.154
Cdkn1bcyclin-dependent kinase inhibitor 1B0.148
FasFas (TNF receptor superfamily member 6)0.147
Ppargperoxisome proliferator activated receptor gamma0.146
Rb1retinoblastoma 10.121
Cav1caveolin 1, caveolae protein0.118
Pax2paired box gene 20.117
Stat3signal transducer and activator of transcription 30.115
Ighimmunoglobulin heavy chain complex0.114
Sqstm1sequestosome 10.113
Timm23translocase of inner mitochondrial membrane 23 homolog (yeast)0.113
RybpRING1 and YY1 binding protein0.110
Eif2c1eukaryotic translation initiation factor 2C, 10.106
Gja1gap junction protein, alpha 10.103
Psen1presenilin 10.102
Lrp2low density lipoprotein receptor-related protein 20.100
Ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.100
Gdnfglial cell line derived neurotrophic factor0.099
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.095
Kif27kinesin family member 270.093
Bag3BCL2-associated athanogene 30.093
H2-Aahistocompatibility 2, class II antigen A, alpha0.091
Csf1colony stimulating factor 1 (macrophage)0.089
Sin3atranscriptional regulator, SIN3A (yeast)0.083
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.079
Bmi1Bmi1 polycomb ring finger oncogene0.079
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.078
Ctnnb1catenin (cadherin associated protein), beta 10.073
Ezh2enhancer of zeste homolog 2 (Drosophila)0.072
Ptk2PTK2 protein tyrosine kinase 20.072
Nfe2l2nuclear factor, erythroid derived 2, like 20.069
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.069
Pcgf2polycomb group ring finger 20.068
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.066
Timm17atranslocase of inner mitochondrial membrane 17a0.065
Hprthypoxanthine guanine phosphoribosyl transferase0.063
Tlr4toll-like receptor 40.062
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.058
Rxraretinoid X receptor alpha0.057
Agtr1aangiotensin II receptor, type 1a0.057
Ndufs2NADH dehydrogenase (ubiquinone) Fe-S protein 20.057
Mta2metastasis-associated gene family, member 20.057
Coq7demethyl-Q 70.056
Chukconserved helix-loop-helix ubiquitous kinase0.056
Agtrapangiotensin II, type I receptor-associated protein0.054
Wbp2WW domain binding protein 20.054
Suclg1succinate-CoA ligase, GDP-forming, alpha subunit0.054
En1engrailed 10.053
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.053
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.052
Prkciprotein kinase C, iota0.052
Kitlkit ligand0.052
Ncoa3nuclear receptor coactivator 30.049
Adam17a disintegrin and metallopeptidase domain 170.048
Col4a3collagen, type IV, alpha 30.048
Notch2Notch gene homolog 2 (Drosophila)0.046
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.046
Cxcr4chemokine (C-X-C motif) receptor 40.046
Ptf1apancreas specific transcription factor, 1a0.045
Tlr2toll-like receptor 20.044
Stim2stromal interaction molecule 20.044
Dnmt3bDNA methyltransferase 3B0.043
Ets1E26 avian leukemia oncogene 1, 5' domain0.043
Cryabcrystallin, alpha B0.043
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.043
Cftrcystic fibrosis transmembrane conductance regulator homolog0.042
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.042
H2-DMahistocompatibility 2, class II, locus DMa0.042
Ldlrlow density lipoprotein receptor0.040
Mrpl16mitochondrial ribosomal protein L160.040
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-DaRT1 class II, locus Da0.012
RT1-Db1RT1 class II, locus Db10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism