The network for 'negative regulation of homeostatic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of homeostatic process

Any process that stops, prevents, or reduces the frequency, rate, or extent of a homeostatic process.

NameDescriptionProbabilityFunc Analog Organism
Rh5Rhodopsin 50.660
inaDinactivation no afterpotential D0.525
inaCinactivation no afterpotential C0.400
trptransient receptor potential0.308
Rh3Rhodopsin 30.253
Arr2Arrestin 20.238
ninaEneither inactivation nor afterpotential E0.197
Rh6Rhodopsin 60.194
norpAno receptor potential A0.115
Arr1Arrestin 10.106
ninaCneither inactivation nor afterpotential C0.098
CG7979CG7979 gene product from transcript CG7979-RA0.097
Wnt5Wnt oncogene analog 50.091
RdlResistant to dieldrin0.083
myoglianinCG1838 gene product from transcript CG1838-RD0.082
CG4686CG4686 gene product from transcript CG4686-RA0.069
Nrx-1Neurexin 10.067
ninaAneither inactivation nor afterpotential A0.065
Gbeta76CG protein beta-subunit 76C0.064
CG33960CG33960 gene product from transcript CG33960-RB0.058
Gyc76CGuanylyl cyclase at 76C0.057
CdsACDP diglyceride synthetase0.053
EphEph receptor tyrosine kinase0.049
cal1chromosome alignment defect 10.048
bossbride of sevenless0.045
CG8086CG8086 gene product from transcript CG8086-RF0.044
Bj1Bj1 protein0.042
CG8889CG8889 gene product from transcript CG8889-RA0.040
Rh4Rhodopsin 40.039
EphrinCG1862 gene product from transcript CG1862-RA0.037
CG4880CG4880 gene product from transcript CG4880-RA0.037
tadrtorn and diminished rhabdomeres0.035
Pp2B-14DProtein phosphatase 2B at 14D0.034
CG4468CG4468 gene product from transcript CG4468-RA0.033
CG13585CG13585 gene product from transcript CG13585-RA0.033
CG13636CG13636 gene product from transcript CG13636-RB0.033
Ras64BRas oncogene at 64B0.033
inaF-DCG42563 gene product from transcript CG42563-RB0.031
Dhc93ABDynein heavy chain at 93AB0.031
Gr43aGustatory receptor 43a0.031
santa-mariascavenger receptor acting in neural tissue and majority of rhodopsin is absent0.030
NPFR1neuropeptide F receptor0.030
Gr28bGustatory receptor 28b0.030
CG42629CG42629 gene product from transcript CG42629-RB0.029
VGlutVesicular glutamate transporter0.029
wtrwCG31284 gene product from transcript CG31284-RB0.027
stopsslow termination of phototransduction0.027
Zasp66Z band alternatively spliced PDZ-motif protein 660.027
Mlp84BMuscle LIM protein at 84B0.027
plexBplexin B0.025
drkdownstream of receptor kinase0.025
PP2A-B'CG7913 gene product from transcript CG7913-RK0.025
CG10638CG10638 gene product from transcript CG10638-RA0.024
Rh2Rhodopsin 20.023
CG7156CG7156 gene product from transcript CG7156-RA0.023
CG14646CG14646 gene product from transcript CG14646-RA0.023
CG8090CG8090 gene product from transcript CG8090-RB0.022
plexAplexin A0.022
CG11317CG11317 gene product from transcript CG11317-RA0.022
unc-104CG8566 gene product from transcript CG8566-RB0.021
npfneuropeptide F0.021
CG5807CG5807 gene product from transcript CG5807-RA0.021
Patr-1Protein associated with topo II related - 10.021
CG4452CG4452 gene product from transcript CG4452-RB0.021
SuURSuppressor of Under-Replication0.021
Applbeta amyloid protein precursor-like0.021
nonAno on or off transient A0.021
CG32810CG32810 gene product from transcript CG32810-RB0.021
boibrother of iHog0.020
PHGPxCG12013 gene product from transcript CG12013-RC0.020
GaspCG10287 gene product from transcript CG10287-RB0.020
elavembryonic lethal abnormal vision0.020
G-oalpha47AG protein oalpha 47A0.020
cpocouch potato0.019
rtGEFrho-type guanine exchange factor0.019
GstS1Glutathione S transferase S10.019
CG31075CG31075 gene product from transcript CG31075-RA0.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
hoxd4ahomeo box D4a0.302
wnt10awingless-type MMTV integration site family, member 10a0.123
opn4lopsin 4, like0.114
tgfb3transforming growth factor, beta 30.098
chatcholine acetyltransferase0.057
spry4sprouty (Drosophila) homolog 40.048
mpxmyeloid-specific peroxidase0.048
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.046
tmem2transmembrane protein 20.041
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.040
wnt7aawingless-type MMTV integration site family, member 7Aa0.034
opn4aopsin 4a (melanopsin)0.033
opn4x1opsin 4x10.026
exorhextra-ocular rhodopsin0.025
lzts2aleucine zipper, putative tumor suppressor 2a0.024
wnt9awingless-type MMTV integration site family, member 9A0.024
pth2parathyroid hormone 20.023
tbx1T-box 10.022
rad21RAD21 homolog (S. pombe)0.022
stac3SH3 and cysteine rich domain 30.021
glra1glycine receptor, alpha 10.021
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.020
pcsk5bproprotein convertase subtilisin/kexin type 5b0.019
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.018
th2tyrosine hydroxylase 20.018
wnt4awingless-type MMTV integration site family, member 4a0.018
nbl1neuroblastoma, suppression of tumorigenicity 10.016
hbae1hemoglobin alpha embryonic-10.016
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.016
paqr7bprogestin and adipoQ receptor family member VII, b0.015
paqr8progestin and adipoQ receptor family member VIII0.015
opn1mw1opsin 1 (cone pigments), medium-wave-sensitive, 10.014
rag2recombination activating gene 20.014
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.012
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.011
wnt1wingless-type MMTV integration site family, member 10.011
wnt16wingless-type MMTV integration site family, member 160.011
otx5orthodenticle homolog 50.011
tbx18T-box 180.011
lama2laminin, alpha 20.010
tfpi2tissue factor pathway inhibitor 20.010
gngt2bguanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b0.010
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SYKspleen tyrosine kinase0.993
IL8interleukin 80.988
FGFR2fibroblast growth factor receptor 20.987
GSTM1glutathione S-transferase mu 10.968
TERF2telomeric repeat binding factor 20.963
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.957
PTPN1protein tyrosine phosphatase, non-receptor type 10.951
CCR5chemokine (C-C motif) receptor 50.945
BCL2B-cell CLL/lymphoma 20.915
CCL5chemokine (C-C motif) ligand 50.851
CXCL9chemokine (C-X-C motif) ligand 90.827
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.766
CXCL2chemokine (C-X-C motif) ligand 20.710
TINF2TERF1 (TRF1)-interacting nuclear factor 20.706
CXCL3chemokine (C-X-C motif) ligand 30.688
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.675
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.624
BCL2L1BCL2-like 10.622
GSTM2glutathione S-transferase mu 2 (muscle)0.602
CD22CD22 molecule0.599
TRPC4transient receptor potential cation channel, subfamily C, member 40.553
TERF2IPtelomeric repeat binding factor 2, interacting protein0.537
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.522
CXCL10chemokine (C-X-C motif) ligand 100.512
BLNKB-cell linker0.482
CXCL11chemokine (C-X-C motif) ligand 110.471
ADORA2Aadenosine A2a receptor0.466
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.451
SH3BP2SH3-domain binding protein 20.440
CCL4chemokine (C-C motif) ligand 40.431
CXCL5chemokine (C-X-C motif) ligand 50.417
CCL22chemokine (C-C motif) ligand 220.408
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.406
FASFas (TNF receptor superfamily, member 6)0.399
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.384
EPORerythropoietin receptor0.381
CCL20chemokine (C-C motif) ligand 200.378
IL6interleukin 6 (interferon, beta 2)0.378
CCR7chemokine (C-C motif) receptor 70.372
IFNGinterferon, gamma0.369
TGFBR1transforming growth factor, beta receptor 10.360
IL2RBinterleukin 2 receptor, beta0.360
NRP1neuropilin 10.354
ARRB2arrestin, beta 20.350
BTKBruton agammaglobulinemia tyrosine kinase0.349
SLX1BSLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)0.347
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.340
HOXB5homeobox B50.332
MPDZmultiple PDZ domain protein0.331
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.323
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.306
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.299
ACDadrenocortical dysplasia homolog (mouse)0.296
CD2CD2 molecule0.290
CCR2chemokine (C-C motif) receptor 20.251
ITPR2inositol 1,4,5-trisphosphate receptor, type 20.251
CCL8chemokine (C-C motif) ligand 80.236
BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 10.227
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.222
IL1Binterleukin 1, beta0.218
DPP4dipeptidyl-peptidase 40.216
CCL7chemokine (C-C motif) ligand 70.214
PKD2polycystic kidney disease 2 (autosomal dominant)0.209
NAMPTnicotinamide phosphoribosyltransferase0.202
CCR4chemokine (C-C motif) receptor 40.201
HOXA5homeobox A50.196
HOXB7homeobox B70.191
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.179
CASP8caspase 8, apoptosis-related cysteine peptidase0.179
CCR1chemokine (C-C motif) receptor 10.174
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.173
ACVR1Bactivin A receptor, type IB0.172
CCL3chemokine (C-C motif) ligand 30.172
CARD11caspase recruitment domain family, member 110.172
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.167
TRPC1transient receptor potential cation channel, subfamily C, member 10.162
HOXA10homeobox A100.160
CCL19chemokine (C-C motif) ligand 190.157
HOXA7homeobox A70.148
CXCL13chemokine (C-X-C motif) ligand 130.147
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.146
NFE2L2nuclear factor (erythroid-derived 2)-like 20.146
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.145
CXCR4chemokine (C-X-C motif) receptor 40.141
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.141
IRF4interferon regulatory factor 40.140
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.139
CCL2chemokine (C-C motif) ligand 20.137
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.137
IL10interleukin 100.136
VEGFAvascular endothelial growth factor A0.134
GSTM4glutathione S-transferase mu 40.132
PSEN2presenilin 2 (Alzheimer disease 4)0.131
HOXB3homeobox B30.128
CREBBPCREB binding protein0.125
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.125
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.124
S100A8S100 calcium binding protein A80.121
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lyz2lysozyme 20.976
Ccr1chemokine (C-C motif) receptor 10.964
Trp53transformation related protein 530.958
Inpp5dinositol polyphosphate-5-phosphatase D0.922
FynFyn proto-oncogene0.912
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.901
Ikzf1IKAROS family zinc finger 10.890
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.872
Ifnginterferon gamma0.856
Ptprcprotein tyrosine phosphatase, receptor type, C0.854
BaxBCL2-associated X protein0.849
Prkccprotein kinase C, gamma0.829
Ccl2chemokine (C-C motif) ligand 20.827
H2-Ab1histocompatibility 2, class II antigen A, beta 10.782
Ldb3LIM domain binding 30.743
Ccl8chemokine (C-C motif) ligand 80.717
Klrk1killer cell lectin-like receptor subfamily K, member 10.676
Ncr1natural cytotoxicity triggering receptor 10.659
LOC100048884novel member of the major urinary protein (Mup) gene family0.654
Clockcircadian locomotor output cycles kaput0.635
Il2interleukin 20.615
H2-Eb1histocompatibility 2, class II antigen E beta0.610
Cd44CD44 antigen0.583
Foxp3forkhead box P30.571
Dok1docking protein 10.556
Ptenphosphatase and tensin homolog0.536
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.523
Dok2docking protein 20.513
Il2rginterleukin 2 receptor, gamma chain0.512
Esr1estrogen receptor 1 (alpha)0.503
Nckap1lNCK associated protein 1 like0.501
Itgaxintegrin alpha X0.496
FasFas (TNF receptor superfamily member 6)0.492
Lcklymphocyte protein tyrosine kinase0.489
Sfpi1SFFV proviral integration 10.485
WasWiskott-Aldrich syndrome homolog (human)0.484
Bcl2B-cell leukemia/lymphoma 20.480
Prkcdprotein kinase C, delta0.476
H2-Aahistocompatibility 2, class II antigen A, alpha0.470
Cd7CD7 antigen0.467
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.453
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.448
Hrchistidine rich calcium binding protein0.447
Bdnfbrain derived neurotrophic factor0.429
Ptk2bPTK2 protein tyrosine kinase 2 beta0.425
SrcRous sarcoma oncogene0.402
Il27rainterleukin 27 receptor, alpha0.400
Ntrk3neurotrophic tyrosine kinase, receptor, type 30.393
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.384
Ciitaclass II transactivator0.375
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.370
FaslFas ligand (TNF superfamily, member 6)0.366
Ctswcathepsin W0.365
Adam17a disintegrin and metallopeptidase domain 170.365
Ccr6chemokine (C-C motif) receptor 60.364
Meox2mesenchyme homeobox 20.358
Trpc4transient receptor potential cation channel, subfamily C, member 40.344
Prdm1PR domain containing 1, with ZNF domain0.342
Smyd1SET and MYND domain containing 10.340
Ntf3neurotrophin 30.332
Grb2growth factor receptor bound protein 20.331
CblCasitas B-lineage lymphoma0.329
Il4interleukin 40.329
Fcgr1Fc receptor, IgG, high affinity I0.322
Opn1swopsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)0.320
Mcpt4mast cell protease 40.317
Itgb1integrin beta 1 (fibronectin receptor beta)0.309
Ccl3chemokine (C-C motif) ligand 30.301
Kitkit oncogene0.297
Tgfb1transforming growth factor, beta 10.290
Fcgr2bFc receptor, IgG, low affinity IIb0.287
Runx1runt related transcription factor 10.280
Actn2actinin alpha 20.276
Necap2NECAP endocytosis associated 20.275
Klrg1killer cell lectin-like receptor subfamily G, member 10.269
Mup9major urinary protein 90.264
Mup10major urinary protein 100.262
Arandrogen receptor0.261
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.256
Mup19major urinary protein 190.254
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.249
Mmp12matrix metallopeptidase 120.249
Pik3cgphosphoinositide-3-kinase, catalytic, gamma polypeptide0.247
Srpk3serine/arginine-rich protein specific kinase 30.247
Il2rbinterleukin 2 receptor, beta chain0.239
Ccl22chemokine (C-C motif) ligand 220.229
Acdadrenocortical dysplasia0.228
Pim2proviral integration site 20.215
ND6NADH dehydrogenase subunit 60.211
Ttc7tetratricopeptide repeat domain 70.211
Il9rinterleukin 9 receptor0.210
Il10interleukin 100.208
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.207
TcraT-cell receptor alpha chain0.203
Mup5major urinary protein 50.203
Il6stinterleukin 6 signal transducer0.202
Socs1suppressor of cytokine signaling 10.202
Stat6signal transducer and activator of transcription 60.198
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-BaRT1 class II, locus Ba0.295
RT1-BbRT1 class II, locus Bb0.175
Lim2lens intrinsic membrane protein 20.161
Hckhemopoietic cell kinase0.117
Casp1caspase 10.116
Cd53Cd53 molecule0.113
Ccr5chemokine (C-C motif) receptor 50.095
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.094
Gzmkgranzyme K0.092
Aif1allograft inflammatory factor 10.089
Csf1colony stimulating factor 1 (macrophage)0.087
Ptpn6protein tyrosine phosphatase, non-receptor type 60.075
Dock8dedicator of cytokinesis 80.072
Phkg1phosphorylase kinase, gamma 10.068
Fgf16fibroblast growth factor 160.065
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.060
Il2rginterleukin 2 receptor, gamma0.059
Cd38CD38 molecule0.058
Cd37CD37 molecule0.057
Lcp2lymphocyte cytosolic protein 20.056
Myl7myosin, light chain 7, regulatory0.054
Inpp5dinositol polyphosphate-5-phosphatase D0.054
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.053
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.052
Adora2aadenosine A2a receptor0.051
Cd247Cd247 molecule0.051
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.050
Ly86lymphocyte antigen 860.049
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.044
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.043
Calcrlcalcitonin receptor-like0.043
Igsf6immunoglobulin superfamily, member 60.043
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.043
Spt1salivary protein 10.042
Atp2a3ATPase, Ca++ transporting, ubiquitous0.042
Gabra6gamma-aminobutyric acid (GABA) A receptor, alpha 60.042
Sellselectin L0.042
Sirpasignal-regulatory protein alpha0.041
Olr1278olfactory receptor 12780.041
P2ry14purinergic receptor P2Y, G-protein coupled, 140.040
Cd4Cd4 molecule0.040
Hcrtr2hypocretin (orexin) receptor 20.040
Cxcl13chemokine (C-X-C motif) ligand 130.040
LOC100361706lambda-chain C1-region-like0.039
Cd3gCD3 molecule, gamma0.039
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.039
Arhgap23Rho GTPase activating protein 230.039
C3ar1complement component 3a receptor 10.038
Hpgdshematopoietic prostaglandin D synthase0.038
Sqlesqualene epoxidase0.038
Il2rbinterleukin 2 receptor, beta0.038
Mgat5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase0.037
Cacng1calcium channel, voltage-dependent, gamma subunit 10.036
Tlr4toll-like receptor 40.036
Il1binterleukin 1 beta0.035
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.035
Flt1FMS-related tyrosine kinase 10.035
Olr287olfactory receptor 2870.035
Igh-6immunoglobulin heavy chain 60.034
Cgaglycoprotein hormones, alpha polypeptide0.034
Cxcr5chemokine (C-X-C motif) receptor 50.033
Grm7glutamate receptor, metabotropic 70.033
Cybbcytochrome b-245, beta polypeptide0.033
Ptprcprotein tyrosine phosphatase, receptor type, C0.032
Ccr3chemokine (C-C motif) receptor 30.032
Cd8aCD8a molecule0.032
Grm6glutamate receptor, metabotropic 60.032
Mca32mast cell antigen 320.031
Cysscystatin S0.031
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.031
Slc14a2solute carrier family 14 (urea transporter), member 20.030
Cotl1coactosin-like 1 (Dictyostelium)0.030
Cd2Cd2 molecule0.030
Ccr1chemokine (C-C motif) receptor 10.030
Arl11ADP-ribosylation factor-like 110.030
Ctsscathepsin S0.030
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.029
Ciitaclass II, major histocompatibility complex, transactivator0.029
Tbxas1thromboxane A synthase 1, platelet0.029
Prkcgprotein kinase C, gamma0.029
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.028
Rassf5Ras association (RalGDS/AF-6) domain family member 50.028
RT1-DMbRT1 class II, locus DMb0.028
Cacng5calcium channel, voltage-dependent, gamma subunit 50.028
Ptpn18protein tyrosine phosphatase, non-receptor type 180.027
Syt7synaptotagmin VII0.027
Smad9SMAD family member 90.027
RT1-A3RT1 class I, locus A30.027
MrgprfMAS-related GPR, member F0.027
Igf2insulin-like growth factor 20.027
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.027
Smad3SMAD family member 30.027
Fam70bfamily with sequence similarity 70, member B0.026
Gja6gap junction protein, alpha 60.026
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.026
Vav1vav 1 guanine nucleotide exchange factor0.026
Cfpcomplement factor properdin0.025
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YMR086Whypothetical protein0.010