The network for 'negative regulation of chromatin silencing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of chromatin silencing

Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing.

NameDescriptionProbabilityFunc Analog Organism
Chd1Chromodomain-helicase-DNA-binding protein 10.457
Su(var)3-3Suppressor of variegation 3-30.321
noinoisette0.298
CTCFCG8591 gene product from transcript CG8591-RA0.155
HcfHost cell factor0.133
msl-2male-specific lethal 20.127
mod(mdg4)modifier of mdg40.122
lidlittle imaginal discs0.116
msl-3male-specific lethal 30.113
Su(var)3-7Suppressor of variegation 3-70.099
Dp1Dodeca-satellite-binding protein 10.098
mofmales absent on the first0.096
eggeggless0.082
Sir2CG5216 gene product from transcript CG5216-RA0.080
ash1absent, small, or homeotic discs 10.079
ScmSex comb on midleg0.072
cgcombgap0.058
brmbrahma0.057
Su(z)2Suppressor of zeste 20.056
msl-1male-specific lethal 10.051
domedomeless0.049
PcPolycomb0.048
PcafCG4107 gene product from transcript CG4107-RA0.042
RgaRegena0.038
Pk61CProtein kinase 61C0.030
mlemaleless0.029
JIL-1CG6297 gene product from transcript CG6297-RA0.027
tnatonalli0.027
SxlSex lethal0.024
trxtrithorax0.024
Snr1Snf5-related 10.023
Vap-33-1CG5014 gene product from transcript CG5014-RB0.022
bin3bicoid-interacting protein 30.022
Rsf1Repressor splicing factor 10.019
MRG15CG6363 gene product from transcript CG6363-RA0.019
sinaseven in absentia0.019
lokloki0.017
mip130Myb-interacting protein 1300.017
CG4119CG4119 gene product from transcript CG4119-RA0.016
polybromoCG11375 gene product from transcript CG11375-RA0.016
pzgputzig0.016
D1D1 chromosomal protein0.015
bonbonus0.015
SlbpStem-loop binding protein0.015
snfsans fille0.015
dalaoCG7055 gene product from transcript CG7055-RA0.014
CG8436CG8436 gene product from transcript CG8436-RA0.014
E(var)3-9Enhancer of variegation 3-90.014
Hr39Hormone receptor-like in 390.014
CG5591CG5591 gene product from transcript CG5591-RA0.013
Hdac3Histone deacetylase 30.013
CG1622CG1622 gene product from transcript CG1622-RA0.012
rinrasputin0.012
sxcsuper sex combs0.012
zzeste0.012
astasteroid0.011
waplwings apart-like0.011
Mcm3Minichromosome maintenance 30.011
simjsimjang0.011
CG11504CG11504 gene product from transcript CG11504-RB0.010
wechCG42396 gene product from transcript CG42396-RC0.010
CG10153CG10153 gene product from transcript CG10153-RA0.010
escextra sexcombs0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 41.000
PBRM1polybromo 10.998
HDAC1histone deacetylase 10.997
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.993
ARID1AAT rich interactive domain 1A (SWI-like)0.991
ARID2AT rich interactive domain 2 (ARID, RFX-like)0.986
NCOR1nuclear receptor corepressor 10.981
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.977
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 10.972
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.959
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.945
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.872
SMURF1SMAD specific E3 ubiquitin protein ligase 10.861
SIN3ASIN3 homolog A, transcription regulator (yeast)0.859
EP300E1A binding protein p3000.828
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.750
BCORBCL6 corepressor0.746
CREBBPCREB binding protein0.692
NR2E3nuclear receptor subfamily 2, group E, member 30.621
SP1Sp1 transcription factor0.612
NCOR2nuclear receptor corepressor 20.600
RBBP4retinoblastoma binding protein 40.472
BCL6B-cell CLL/lymphoma 60.469
SAP30Sin3A-associated protein, 30kDa0.466
HCFC1host cell factor C1 (VP16-accessory protein)0.458
RBBP7retinoblastoma binding protein 70.451
SKIv-ski sarcoma viral oncogene homolog (avian)0.429
SMAD3SMAD family member 30.357
RB1retinoblastoma 10.303
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.273
CHD4chromodomain helicase DNA binding protein 40.240
MCM7minichromosome maintenance complex component 70.201
ARID1BAT rich interactive domain 1B (SWI1-like)0.172
MAPK14mitogen-activated protein kinase 140.153
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.133
MSL2male-specific lethal 2 homolog (Drosophila)0.118
HDAC2histone deacetylase 20.118
SETD2SET domain containing 20.113
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.098
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.092
BAZ1Bbromodomain adjacent to zinc finger domain, 1B0.091
RCOR1REST corepressor 10.087
LIG1ligase I, DNA, ATP-dependent0.085
NCOA3nuclear receptor coactivator 30.084
PHF12PHD finger protein 120.080
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.077
TRIM33tripartite motif containing 330.076
NONOnon-POU domain containing, octamer-binding0.074
CHD7chromodomain helicase DNA binding protein 70.073
SMAD1SMAD family member 10.071
BRD1bromodomain containing 10.069
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.069
SPENspen homolog, transcriptional regulator (Drosophila)0.069
MED13Lmediator complex subunit 13-like0.068
HDAC3histone deacetylase 30.068
ING2inhibitor of growth family, member 20.066
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.065
ESR1estrogen receptor 10.064
HDAC4histone deacetylase 40.059
MECP2methyl CpG binding protein 2 (Rett syndrome)0.053
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.052
CARM1coactivator-associated arginine methyltransferase 10.051
SAP30LSAP30-like0.050
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.049
ADRBK1adrenergic, beta, receptor kinase 10.048
BRWD1bromodomain and WD repeat domain containing 10.047
WHSC1Wolf-Hirschhorn syndrome candidate 10.046
ZNF512Bzinc finger protein 512B0.046
TRAF4TNF receptor-associated factor 40.042
CDK9cyclin-dependent kinase 90.040
RBL1retinoblastoma-like 1 (p107)0.039
PRC1protein regulator of cytokinesis 10.039
PPARAperoxisome proliferator-activated receptor alpha0.038
RNF19Aring finger protein 19A0.038
NQO1NAD(P)H dehydrogenase, quinone 10.038
MAPK3mitogen-activated protein kinase 30.038
NCOA1nuclear receptor coactivator 10.036
SFPQsplicing factor proline/glutamine-rich0.035
HIPK2homeodomain interacting protein kinase 20.033
SMAD7SMAD family member 70.033
THAP11THAP domain containing 110.031
SMARCD2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 20.031
SKILSKI-like oncogene0.031
MASTLmicrotubule associated serine/threonine kinase-like0.030
RSBN1round spermatid basic protein 10.030
HDAC6histone deacetylase 60.029
SIRT1sirtuin 10.029
KIAA1267KIAA12670.028
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.028
ZMYM2zinc finger, MYM-type 20.028
SETD7SET domain containing (lysine methyltransferase) 70.027
PABPN1poly(A) binding protein, nuclear 10.027
CEP350centrosomal protein 350kDa0.026
TRRAPtransformation/transcription domain-associated protein0.026
DNMT1DNA (cytosine-5-)-methyltransferase 10.025
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.024
YY1YY1 transcription factor0.024
MYST1MYST histone acetyltransferase 10.023
PRRC2Cproline-rich coiled-coil 2C0.023
PLEKHO1pleckstrin homology domain containing, family O member 10.023
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Arid1aAT rich interactive domain 1A (SWI-like)0.996
Hdac1histone deacetylase 10.870
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.816
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.798
Ncor1nuclear receptor co-repressor 10.721
Hdac2histone deacetylase 20.550
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.509
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.502
Pum2pumilio 2 (Drosophila)0.481
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.350
Arid2AT rich interactive domain 2 (ARID, RFX-like)0.235
Ep300E1A binding protein p3000.209
Sp1trans-acting transcription factor 10.209
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.189
Kdm5blysine (K)-specific demethylase 5B0.188
Ezh2enhancer of zeste homolog 2 (Drosophila)0.170
Hist1h2bchistone cluster 1, H2bc0.162
Dnmt1DNA methyltransferase (cytosine-5) 10.160
Mcm6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)0.155
CtcfCCCTC-binding factor0.151
Bod1lbiorientation of chromosomes in cell division 1-like0.135
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.128
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.126
Tcf3transcription factor 30.116
Cdt1chromatin licensing and DNA replication factor 10.115
NipblNipped-B homolog (Drosophila)0.110
Sap25sin3 associated polypeptide0.108
Trp53transformation related protein 530.103
Smad4MAD homolog 4 (Drosophila)0.099
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.095
Cdk2cyclin-dependent kinase 20.093
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.087
Timelesstimeless homolog (Drosophila)0.084
Rnf220ring finger protein 2200.081
Racgap1Rac GTPase-activating protein 10.080
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.071
Zfp292zinc finger protein 2920.068
CrebbpCREB binding protein0.067
Lig1ligase I, DNA, ATP-dependent0.066
Yy1YY1 transcription factor0.062
Asxl1additional sex combs like 1 (Drosophila)0.062
Foxp1forkhead box P10.061
Rrm2ribonucleotide reductase M20.061
Ccna2cyclin A20.061
Pbrm1polybromo 10.058
Cnot6CCR4-NOT transcription complex, subunit 60.054
Angel2angel homolog 2 (Drosophila)0.053
Rfc5replication factor C (activator 1) 50.051
Nononon-POU-domain-containing, octamer binding protein0.047
Rnf38ring finger protein 380.047
Ncapg2non-SMC condensin II complex, subunit G20.046
Prkd3protein kinase D30.045
NanogNanog homeobox0.043
Tk1thymidine kinase 10.043
Rad54lRAD54 like (S. cerevisiae)0.042
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.041
Rcor1REST corepressor 10.041
Rrm1ribonucleotide reductase M10.041
Rcc1regulator of chromosome condensation 10.041
8430410K20RikRIKEN cDNA 8430410K20 gene0.038
Tet1tet oncogene 10.038
Jarid2jumonji, AT rich interactive domain 20.038
Zmym5zinc finger, MYM-type 50.038
Pias1protein inhibitor of activated STAT 10.037
Tcfcp2l1transcription factor CP2-like 10.037
Hcfc1host cell factor C10.035
Zmym4zinc finger, MYM-type 40.035
Ncoa6nuclear receptor coactivator 60.034
Rararetinoic acid receptor, alpha0.034
Ccne1cyclin E10.034
Polepolymerase (DNA directed), epsilon0.034
Pou2f1POU domain, class 2, transcription factor 10.034
Rpa2replication protein A20.033
Fam76bfamily with sequence similarity 76, member B0.032
Pum1pumilio 1 (Drosophila)0.032
Pou5f1POU domain, class 5, transcription factor 10.031
Kdm1alysine (K)-specific demethylase 1A0.031
Smad1MAD homolog 1 (Drosophila)0.031
Gnb2guanine nucleotide binding protein (G protein), beta 20.030
Gtf3c2general transcription factor IIIC, polypeptide 2, beta0.030
Atmataxia telangiectasia mutated homolog (human)0.030
Ss18synovial sarcoma translocation, Chromosome 180.030
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.029
Sox2SRY-box containing gene 20.029
Rad50RAD50 homolog (S. cerevisiae)0.029
Mecp2methyl CpG binding protein 20.029
Chd4chromodomain helicase DNA binding protein 40.028
Pld3phospholipase D family, member 30.028
Msl1male-specific lethal 1 homolog (Drosophila)0.028
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.027
Numa1nuclear mitotic apparatus protein 10.027
Ylpm1YLP motif containing 10.027
Ncapd3non-SMC condensin II complex, subunit D30.027
Tmem115transmembrane protein 1150.027
Arid1bAT rich interactive domain 1B (SWI-like)0.026
Tex264testis expressed gene 2640.026
Tmem131transmembrane protein 1310.026
Etv6ets variant gene 6 (TEL oncogene)0.025
Brd4bromodomain containing 40.025
Mta2metastasis-associated gene family, member 20.025
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RXT2Rxt2p0.854
PHO23Pho23p0.736
CTI6Cti6p0.724
SIN3Sin3p0.706
UME1Ume1p0.704
HOS4Hos4p0.376
SAP30Sap30p0.360
NTO1Nto1p0.351
RNR2Rnr2p0.304
HHT1Hht1p0.265
HHO1Hho1p0.253
SNT1Snt1p0.245
SDS3Sds3p0.222
RAP1Rap1p0.158
NDD1Ndd1p0.146
EAF3Eaf3p0.143
RPD3Rpd3p0.143
HOS3Hos3p0.125
MIG2Mig2p0.123
SRP54Srp54p0.118
HDA2Hda2p0.118
SIR2Sir2p0.117
MCM3Mcm3p0.115
MOB1Mob1p0.111
IRC8Irc8p0.109
RCO1Rco1p0.108
SUM1Sum1p0.102
ASH1Ash1p0.100
FKH2Fkh2p0.091
CDC6Cdc6p0.088
SWI1Swi1p0.085
SET3Set3p0.083
OPI1Opi1p0.080
UME6Ume6p0.079
ROX1Rox1p0.078
CAF40Caf40p0.077
KIC1Kic1p0.077
RIM101Rim101p0.076
HXT3Hxt3p0.076
HOS2Hos2p0.069
YKR075Chypothetical protein0.068
IXR1Ixr1p0.067
HST3Hst3p0.066
GLN3Gln3p0.066
DEF1Def1p0.064
RXT3Rxt3p0.061
GBP2Gbp2p0.061
HST1Hst1p0.060
YLR455Whypothetical protein0.057
CYC8Cyc8p0.056
CSR2Csr2p0.055
MIG3Mig3p0.054
MRS6Mrs6p0.054
BUD4Bud4p0.053
VHS1Vhs1p0.052
CKA1Cka1p0.051
SGF73Sgf73p0.051
AFT1Aft1p0.050
AGP2Agp2p0.050
NRG1Nrg1p0.048
POP2Pop2p0.048
SPT8Spt8p0.047
CCT2Cct2p0.046
HHF2Hhf2p0.046
SNF5Snf5p0.045
ARP8Arp8p0.042
SWI6Swi6p0.042
HAL5Hal5p0.041
SIR4Sir4p0.041
STE4Ste4p0.039
TBS1Tbs1p0.039
SPT10Spt10p0.039
PRR2Prr2p0.038
PHM8Phm8p0.037
VAC17Vac17p0.037
TRA1Tra1p0.037
HOHop0.035
DED1Ded1p0.035
MTR10Mtr10p0.035
SWI5Swi5p0.034
CTK1Ctk1p0.034
AVT6Avt6p0.034
YPL014Whypothetical protein0.034
RSC4Rsc4p0.034
CHD1Chd1p0.033
HFI1Hfi1p0.033
GCR2Gcr2p0.033
SFL1Sfl1p0.033
PMD1Pmd1p0.032
YLR278Chypothetical protein0.032
HHT2Hht2p0.032
MSN4Msn4p0.032
YML082Whypothetical protein0.032
PSR1Psr1p0.032
DOT6Dot6p0.031
CAT8Cat8p0.031
YOR390Whypothetical protein0.030
GDH3Gdh3p0.029
UBP8Ubp8p0.029
CTK3Ctk3p0.029