The network for 'negative regulation of erk1 and erk2 cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of erk1 and erk2 cascade

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

NameDescriptionProbabilityFunc Analog Organism
Dsor1Downstream of raf10.243
prodproliferation disrupter0.163
Pp2B-14DProtein phosphatase 2B at 14D0.163
Ras64BRas oncogene at 64B0.114
dosdaughter of sevenless0.111
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.104
ksrkinase suppressor of ras0.095
pigeonCG10739 gene product from transcript CG10739-RB0.091
X11LCG5675 gene product from transcript CG5675-RB0.086
Socs36ESuppressor of cytokine signaling at 36E0.079
Sry-deltaSerendipity delta0.077
drkdownstream of receptor kinase0.073
dwgdeformed wings0.068
cnkconnector enhancer of ksr0.067
gekgenghis khan0.066
SosSon of sevenless0.061
CG10267CG10267 gene product from transcript CG10267-RB0.059
CycJCyclin J0.058
CG2662CG2662 gene product from transcript CG2662-RA0.056
CdsACDP diglyceride synthetase0.056
C3GCG42328 gene product from transcript CG42328-RC0.053
CG6792CG6792 gene product from transcript CG6792-RA0.051
mbtmushroom bodies tiny0.042
CG5794CG5794 gene product from transcript CG5794-RB0.040
Hs6stHeparan sulfate 6-O-sulfotransferase0.040
enokenoki mushroom0.039
MAN1CG3167 gene product from transcript CG3167-RA0.039
CG12299CG12299 gene product from transcript CG12299-RA0.039
Gap1GTPase-activating protein 10.038
CG7928CG7928 gene product from transcript CG7928-RA0.037
tremtrade embargo0.036
CG5180CG5180 gene product from transcript CG5180-RB0.036
cdc2cCG10498 gene product from transcript CG10498-RC0.035
rdgCretinal degeneration C0.033
Mkp3Mitogen-activated protein kinase phosphatase 30.032
CG11560CG11560 gene product from transcript CG11560-RA0.032
CG14667CG14667 gene product from transcript CG14667-RA0.031
RglRal guanine nucleotide exchange factor0.031
trptransient receptor potential0.030
S6kIIRPS6-protein kinase-II0.030
CG15436CG15436 gene product from transcript CG15436-RA0.029
Dip3Dorsal interacting protein 30.029
rdgBretinal degeneration B0.028
CG15601CG15601 gene product from transcript CG15601-RA0.028
CG4424CG4424 gene product from transcript CG4424-RA0.027
mip120Myb-interacting protein 1200.026
CG11403CG11403 gene product from transcript CG11403-RA0.026
YL-1CG4621 gene product from transcript CG4621-RA0.026
bossbride of sevenless0.026
CG4853CG4853 gene product from transcript CG4853-RA0.026
Zyx102EFCG32018 gene product from transcript CG32018-RA0.026
Arr2Arrestin 20.026
Arr1Arrestin 10.026
CG6985CG6985 gene product from transcript CG6985-RA0.025
GluClalphaCG7535 gene product from transcript CG7535-RG0.025
CG4294CG4294 gene product from transcript CG4294-RB0.025
fs(2)ltoPP43female sterile (2) ltoPP430.025
A2bp1Ataxin-2 binding protein 10.025
CG31365CG31365 gene product from transcript CG31365-RA0.024
ninaBneither inactivation nor afterpotential B0.024
CG11866CG11866 gene product from transcript CG11866-RA0.023
ShcSHC-adaptor protein0.023
GckIIIGerminal centre kinase III0.023
Rh6Rhodopsin 60.023
spn-Bspindle B0.022
CG1792CG1792 gene product from transcript CG1792-RA0.022
CrebB-17ACyclic-AMP response element binding protein B at 17A0.022
NFATNFAT homolog0.022
CG2712CG2712 gene product from transcript CG2712-RA0.021
cutletCG33122 gene product from transcript CG33122-RA0.021
SaraSmad anchor for receptor activation0.021
CG12713CG12713 gene product from transcript CG12713-RA0.020
spensplit ends0.020
CG5199CG5199 gene product from transcript CG5199-RA0.020
CG7239CG7239 gene product from transcript CG7239-RA0.020
Sra-1specifically Rac1-associated protein 10.020
CG2129CG2129 gene product from transcript CG2129-RA0.019
Src42ASrc oncogene at 42A0.019
CG13830CG13830 gene product from transcript CG13830-RD0.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nf1bneurofibromin 1b0.013
nf1aneurofibromin 1a0.012
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAPK1mitogen-activated protein kinase 11.000
MAPK14mitogen-activated protein kinase 141.000
DUSP1dual specificity phosphatase 10.999
C1QAcomplement component 1, q subcomponent, A chain0.997
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.988
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.947
MAPK3mitogen-activated protein kinase 30.921
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.920
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.912
DUSP5dual specificity phosphatase 50.824
MAP2K1mitogen-activated protein kinase kinase 10.782
DUSP3dual specificity phosphatase 30.761
GHRgrowth hormone receptor0.743
DUSP7dual specificity phosphatase 70.610
FYNFYN oncogene related to SRC, FGR, YES0.546
KLF6Kruppel-like factor 60.479
PTPRRprotein tyrosine phosphatase, receptor type, R0.455
TICAM2toll-like receptor adaptor molecule 20.303
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.257
DUSP6dual specificity phosphatase 60.242
IGF1Rinsulin-like growth factor 1 receptor0.236
PEA15phosphoprotein enriched in astrocytes 150.221
PTPRJprotein tyrosine phosphatase, receptor type, J0.220
KLHL3kelch-like 3 (Drosophila)0.218
BCRbreakpoint cluster region0.213
C1QCcomplement component 1, q subcomponent, C chain0.198
MAP2K4mitogen-activated protein kinase kinase 40.171
C1QBcomplement component 1, q subcomponent, B chain0.168
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.150
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.135
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.126
ZFP36L1zinc finger protein 36, C3H type-like 10.126
ARHGAP9Rho GTPase activating protein 90.118
PTPN7protein tyrosine phosphatase, non-receptor type 70.099
GRB10growth factor receptor-bound protein 100.098
MAPK8mitogen-activated protein kinase 80.095
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.083
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.081
RANBP3RAN binding protein 30.077
IER2immediate early response 20.076
ATF2activating transcription factor 20.073
BCAR1breast cancer anti-estrogen resistance 10.060
NR4A2nuclear receptor subfamily 4, group A, member 20.058
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.057
MBPmyelin basic protein0.056
MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)0.050
INSRinsulin receptor0.049
PTPN11protein tyrosine phosphatase, non-receptor type 110.045
ATF3activating transcription factor 30.044
MAP2K3mitogen-activated protein kinase kinase 30.043
FAF1Fas (TNFRSF6) associated factor 10.040
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.039
JUNjun proto-oncogene0.039
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.039
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.039
OXSR1oxidative-stress responsive 10.038
LY96lymphocyte antigen 960.038
IRS2insulin receptor substrate 20.037
STAT5Asignal transducer and activator of transcription 5A0.036
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.036
FOSFBJ murine osteosarcoma viral oncogene homolog0.036
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.035
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.035
PTPRBprotein tyrosine phosphatase, receptor type, B0.035
CSNK2Bcasein kinase 2, beta polypeptide0.034
IER3immediate early response 30.034
C19orf46chromosome 19 open reading frame 460.032
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.032
MKNK1MAP kinase interacting serine/threonine kinase 10.031
MAP2K6mitogen-activated protein kinase kinase 60.030
JUNDjun D proto-oncogene0.029
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.028
SEC24DSEC24 family, member D (S. cerevisiae)0.027
SHC1SHC (Src homology 2 domain containing) transforming protein 10.027
MKNK2MAP kinase interacting serine/threonine kinase 20.025
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.024
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.023
RPS6KA4ribosomal protein S6 kinase, 90kDa, polypeptide 40.022
GSK3Bglycogen synthase kinase 3 beta0.022
IRS1insulin receptor substrate 10.022
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.021
LCKlymphocyte-specific protein tyrosine kinase0.020
GLIS2GLIS family zinc finger 20.020
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.020
FZD5frizzled homolog 5 (Drosophila)0.019
EGR1early growth response 10.018
MYO6myosin VI0.018
DUSP9dual specificity phosphatase 90.017
MARCOmacrophage receptor with collagenous structure0.017
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.017
ZNF746zinc finger protein 7460.017
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.016
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.016
LDB2LIM domain binding 20.016
SLC26A3solute carrier family 26, member 30.016
TRIB1tribbles homolog 1 (Drosophila)0.015
PTPN3protein tyrosine phosphatase, non-receptor type 30.015
CSDAcold shock domain protein A0.015
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grb2growth factor receptor bound protein 20.979
Cd44CD44 antigen0.920
Inpp5dinositol polyphosphate-5-phosphatase D0.845
Il10interleukin 100.711
Ptprcprotein tyrosine phosphatase, receptor type, C0.628
Ptpn11protein tyrosine phosphatase, non-receptor type 110.607
Dok1docking protein 10.535
CblCasitas B-lineage lymphoma0.515
Ccr2chemokine (C-C motif) receptor 20.480
Ptk2PTK2 protein tyrosine kinase 20.459
Leprleptin receptor0.429
Cd80CD80 antigen0.416
Myd88myeloid differentiation primary response gene 880.397
Il1r1interleukin 1 receptor, type I0.385
Lyz2lysozyme 20.334
Fcgr2bFc receptor, IgG, low affinity IIb0.317
Adam17a disintegrin and metallopeptidase domain 170.305
Csf1rcolony stimulating factor 1 receptor0.288
Mapk1mitogen-activated protein kinase 10.240
Nos2nitric oxide synthase 2, inducible0.237
WasWiskott-Aldrich syndrome homolog (human)0.201
Casp4caspase 4, apoptosis-related cysteine peptidase0.199
Casp1caspase 10.192
Fcgr1Fc receptor, IgG, high affinity I0.178
Tgfb1transforming growth factor, beta 10.149
Dok2docking protein 20.144
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.135
Tlr4toll-like receptor 40.133
Csf1colony stimulating factor 1 (macrophage)0.128
Egfrepidermal growth factor receptor0.120
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.115
BlnkB-cell linker0.115
PycardPYD and CARD domain containing0.112
Tnftumor necrosis factor0.112
Ccl4chemokine (C-C motif) ligand 40.102
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.098
Nr3c1nuclear receptor subfamily 3, group C, member 10.096
Mrc1mannose receptor, C type 10.090
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.089
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.086
Ooepoocyte expressed protein homolog (dog)0.074
Lcklymphocyte protein tyrosine kinase0.073
Ccl2chemokine (C-C motif) ligand 20.072
Hif1ahypoxia inducible factor 1, alpha subunit0.068
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.067
C1qacomplement component 1, q subcomponent, alpha polypeptide0.066
Fliiflightless I homolog (Drosophila)0.063
Il22interleukin 220.063
Ticam1toll-like receptor adaptor molecule 10.061
Atf2activating transcription factor 20.061
Itgb1integrin beta 1 (fibronectin receptor beta)0.061
Spry1sprouty homolog 1 (Drosophila)0.058
Itgalintegrin alpha L0.057
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.055
Plcg2phospholipase C, gamma 20.055
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.054
FasFas (TNF receptor superfamily member 6)0.054
Dab1disabled homolog 1 (Drosophila)0.051
Spp1secreted phosphoprotein 10.051
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.051
Cenpjcentromere protein J0.050
NsfN-ethylmaleimide sensitive fusion protein0.050
Cd86CD86 antigen0.049
Ppargperoxisome proliferator activated receptor gamma0.048
Sykbspleen tyrosine kinase0.047
Mmp9matrix metallopeptidase 90.047
C3ar1complement component 3a receptor 10.047
Gnb2guanine nucleotide binding protein (G protein), beta 20.046
Cd5CD5 antigen0.046
Sh3kbp1SH3-domain kinase binding protein 10.045
BtkBruton agammaglobulinemia tyrosine kinase0.044
Bcar1breast cancer anti-estrogen resistance 10.043
Ccr6chemokine (C-C motif) receptor 60.042
Nos1nitric oxide synthase 1, neuronal0.042
Tbx21T-box 210.041
Itsn1intersectin 1 (SH3 domain protein 1A)0.040
MefvMediterranean fever0.040
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.040
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.039
C1qbcomplement component 1, q subcomponent, beta polypeptide0.038
Nlrp3NLR family, pyrin domain containing 30.037
Grm1glutamate receptor, metabotropic 10.037
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.036
Spry2sprouty homolog 2 (Drosophila)0.036
Fnip1folliculin interacting protein 10.036
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.035
Cftrcystic fibrosis transmembrane conductance regulator homolog0.035
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.035
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.034
Aim2absent in melanoma 20.034
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.034
Stat3signal transducer and activator of transcription 30.034
Ptk2bPTK2 protein tyrosine kinase 2 beta0.034
Ikzf1IKAROS family zinc finger 10.033
Retret proto-oncogene0.033
Ncr1natural cytotoxicity triggering receptor 10.033
Crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.033
Lrp10low-density lipoprotein receptor-related protein 100.032
Cd22CD22 antigen0.031
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100362824caveolin 2-like0.615
Cav1caveolin 1, caveolae protein0.558
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.356
FosFBJ osteosarcoma oncogene0.310
Junbjun B proto-oncogene0.087
Egr1early growth response 10.082
Wipf1WAS/WASL interacting protein family, member 10.077
Rabac1Rab acceptor 1 (prenylated)0.048
Gstm1glutathione S-transferase mu 10.044
Jdp2Jun dimerization protein 20.044
Dusp1dual specificity phosphatase 10.043
Grinaglutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)0.043
Tsc22d3TSC22 domain family, member 30.042
JunJun oncogene0.035
Cav2caveolin 20.032
Pdk2pyruvate dehydrogenase kinase, isozyme 20.029
Fmnl1formin-like 10.029
Pink1PTEN induced putative kinase 10.028
Ptafrplatelet-activating factor receptor0.023
Pcdhga11protocadherin gamma subfamily A, 110.023
Prkcdprotein kinase C, delta0.022
Cyb5r3cytochrome b5 reductase 30.022
Id3inhibitor of DNA binding 30.020
Rab7aRAB7A, member RAS oncogene family0.020
Hoxc4homeo box C40.019
Emp1epithelial membrane protein 10.019
Errfi1ERBB receptor feedback inhibitor 10.017
Klf9Kruppel-like factor 90.017
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.017
Cxcr7chemokine (C-X-C motif) receptor 70.016
Lin7blin-7 homolog b (C. elegans)0.016
Hspa1aheat shock 70kD protein 1A0.015
Rhobras homolog gene family, member B0.014
Ptproprotein tyrosine phosphatase, receptor type, O0.014
Myh7myosin, heavy chain 7, cardiac muscle, beta0.014
Gprc5aG protein-coupled receptor, family C, group 5, member A0.014
Klf4Kruppel-like factor 4 (gut)0.013
Il18interleukin 180.013
Dock8dedicator of cytokinesis 80.013
Crygccrystallin, gamma C0.013
Vegfavascular endothelial growth factor A0.013
Lamc1laminin, gamma 10.012
Cald1caldesmon 10.012
Kcnn3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 30.012
Csrnp1cysteine-serine-rich nuclear protein 10.012
Klf3Kruppel-like factor 3 (basic)0.012
Smad1SMAD family member 10.012
Inpp5dinositol polyphosphate-5-phosphatase D0.011
Cx3cl1chemokine (C-X3-C motif) ligand 10.011
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.011
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.011
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.011
Nr4a2nuclear receptor subfamily 4, group A, member 20.010
Cdkn1acyclin-dependent kinase inhibitor 1A0.010
Zfp36zinc finger protein 360.010
Scarb1scavenger receptor class B, member 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism