The network for 'negative regulation of cell communication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell communication

Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

NameDescriptionProbabilityFunc Analog Organism
rlrolled0.999
hephemipterous0.998
Pi3K92ECG4141 gene product from transcript CG4141-RB0.998
pucpuckered0.997
dshdishevelled0.989
InRInsulin-like receptor0.988
EcREcdysone receptor0.985
smosmoothened0.978
shnschnurri0.975
Akt1CG4006 gene product from transcript CG4006-RA0.972
Fmr1CG6203 gene product from transcript CG6203-RC0.965
slmbsupernumerary limbs0.957
tkvthickveins0.949
nosnanos0.942
wtswarts0.940
dmdiminutive0.940
cicubitus interruptus0.938
ykiyorkie0.935
chicoCG5686 gene product from transcript CG5686-RB0.934
putpunt0.930
numbCG3779 gene product from transcript CG3779-RB0.929
saxsaxophone0.928
Sir2CG5216 gene product from transcript CG5216-RA0.927
Atg1Autophagy-specific gene 10.921
Sulf1Sulfated0.921
Ras85DRas oncogene at 85D0.907
UbxUltrabithorax0.906
foxoforkhead box, sub-group O0.877
C3GCG42328 gene product from transcript CG42328-RC0.875
panpangolin0.866
mysmyospheroid0.857
SoxNSoxNeuro0.843
kaykayak0.841
MrtfMyocardin-related transcription factor0.834
dncdunce0.830
MoeMoesin0.827
Rho1CG8416 gene product from transcript CG8416-RB0.827
sdscalloped0.826
p38bCG7393 gene product from transcript CG7393-RA0.825
Sema-1aCG18405 gene product from transcript CG18405-RD0.809
Pk61CProtein kinase 61C0.807
apapterous0.800
chercheerio0.790
rutrutabaga0.787
drkdownstream of receptor kinase0.759
dcodiscs overgrown0.758
giggigas0.751
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.748
CycGCyclin G0.743
AblAbl tyrosine kinase0.730
nctnicastrin0.726
roboroundabout0.725
SmoxSmad on X0.722
Dcr-2Dicer-20.719
EndoGIEndonuclease G inhibitor0.716
rstroughest0.713
ash2absent, small, or homeotic discs 20.712
Stat92ESignal-transducer and activator of transcription protein at 92E0.709
stepsteppke0.707
cindrCIN85 and CD2AP orthologue0.700
Snap25Synapse protein 250.694
ChroChromator0.694
nejnejire0.692
Mkp3Mitogen-activated protein kinase phosphatase 30.688
krzkurtz0.685
bskbasket0.678
wgwingless0.676
RelRelish0.675
NFATNFAT homolog0.675
POSHPlenty of SH3s0.672
DDichaete0.663
rictorrapamycin-insensitive companion of Tor0.662
inscinscuteable0.659
Sin3ACG8815 gene product from transcript CG8815-RC0.655
NNotch0.650
l(2)gd1lethal (2) giant discs 10.648
grogroucho0.646
eghegghead0.637
notnon-stop0.615
bab2CG9102 gene product from transcript CG9102-RA0.607
PknProtein kinase related to protein kinase N0.606
jarjaguar0.605
boibrother of iHog0.601
Tsc1CG6147 gene product from transcript CG6147-RA0.596
Src42ASrc oncogene at 42A0.588
shishibire0.584
Tab2TAK1-associated binding protein 20.583
Mpk2CG5475 gene product from transcript CG5475-RB0.583
Nop60BNucleolar protein at 60B0.580
cazcabeza0.579
CspCysteine string protein0.577
RalaRas-related protein0.570
Klp64DKinesin-like protein at 64D0.567
Pka-C1cAMP-dependent protein kinase 10.562
pygopygopus0.557
Trim9CG31721 gene product from transcript CG31721-RB0.556
fl(2)dfemale lethal d0.546
kiskismet0.545
slislit0.539
wunwunen0.537
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.643
vab-3Protein VAB-30.570
pry-1Protein PRY-10.367
unc-9Protein UNC-90.346
unc-62Protein UNC-620.255
bar-1Protein BAR-10.191
pha-4Protein PHA-40.152
mec-2Protein MEC-20.145
unc-7Protein UNC-70.139
glp-1Protein GLP-10.134
goa-1Protein GOA-10.120
egl-8Protein EGL-80.118
zyg-8Protein ZYG-80.118
eat-4Protein EAT-40.099
sax-7Protein SAX-70.099
akt-1Protein AKT-10.097
pkg-1Protein PKG-10.096
pat-12Protein PAT-120.094
eps-8Protein EPS-80.090
mig-5Protein MIG-50.089
daf-21Protein DAF-210.084
egl-13Protein EGL-130.082
inx-4Protein INX-40.079
sur-2Protein SUR-20.076
ida-1Protein IDA-10.076
nhr-67Protein NHR-670.074
lin-25Protein LIN-250.072
K10D6.4Protein K10D6.40.071
pat-6Protein PAT-60.069
fshr-1Protein FSHR-10.069
efn-2Protein EFN-20.068
ceh-44Protein CEH-440.067
inx-13Protein INX-130.065
lin-17Protein LIN-170.065
hcp-3Protein HCP-30.064
eef-1A.1Protein EEF-1A.10.064
plc-1Protein PLC-10.063
peb-1Protein PEB-10.063
mes-3Protein MES-30.062
inx-1Protein INX-10.061
cst-2Protein CST-20.061
gpb-1Protein GPB-10.061
dlk-1Protein DLK-10.060
elt-6Protein ELT-60.060
let-23Protein LET-230.059
aak-2Protein AAK-20.059
madf-5Protein MADF-50.058
unc-42Protein UNC-420.057
egl-30Protein EGL-300.056
par-5Protein PAR-50.055
hmr-1Protein HMR-10.055
fdps-1Protein FDPS-10.055
ttyh-1Protein TTYH-10.055
sup-12Protein SUP-120.054
nlg-1Protein NLG-10.054
F52C12.4Protein F52C12.40.054
soc-2Protein SOC-20.053
nhr-34Protein NHR-340.053
cbp-1Protein CBP-10.052
odr-3Protein ODR-30.051
unc-112Protein UNC-1120.050
pdfr-1Protein PDFR-10.050
set-2Protein SET-20.050
mrck-1Protein MRCK-10.050
atn-1Protein ATN-10.050
che-3Protein CHE-30.049
CELE_T05E11.3Protein T05E11.30.049
daf-19Protein DAF-190.049
sea-2Protein SEA-20.047
gsk-3Protein GSK-30.047
hlh-1Protein HLH-10.046
ncam-1Protein NCAM-10.045
apl-1Protein APL-10.044
T03G6.3Protein T03G6.30.044
skn-1Protein SKN-10.044
eya-1Protein EYA-10.044
imp-2Protein IMP-20.044
K03E6.7Protein K03E6.70.044
hsp-4Protein HSP-40.043
ten-1Protein TEN-10.043
zfp-3Protein ZFP-30.043
gld-1Protein GLD-10.043
egl-27Protein EGL-270.043
lit-1Protein LIT-10.043
inx-3Protein INX-30.042
sax-3Protein SAX-30.042
pkn-1Protein PKN-10.042
sma-6Protein SMA-60.042
unc-51Protein UNC-510.041
magi-1Protein MAGI-10.041
daf-6Protein DAF-60.040
F52A8.1Protein F52A8.10.040
dpy-31Protein DPY-310.040
C24G6.2Protein C24G6.20.040
grk-2Protein GRK-20.040
trim-9Protein TRIM-90.039
mrg-1Protein MRG-10.039
lsy-2Protein LSY-20.039
C53B4.4Protein C53B4.40.039
tag-241Protein TAG-2410.039
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gli1GLI-Kruppel family member 10.827
flhfloating head0.817
bmp2bbone morphogenetic protein 2b0.785
chdchordin0.775
pea3ETS-domain transcription factor pea30.760
tbx1T-box 10.756
fn1fibronectin 10.733
wnt11rwingless-type MMTV integration site family, member 11, related0.715
per3period homolog 3 (Drosophila)0.697
lef1lymphocyte enhancer binding factor 10.672
sema3aasemaphorin 3aa0.664
sox9aSRY-box containing gene 9a0.604
ntn1bnetrin 1b0.598
bmp2abone morphogenetic protein 2a0.584
fgf3fibroblast growth factor 30.570
igf1rainsulin-like growth factor 1a receptor0.543
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.541
acvr1bactivin A receptor, type IB0.530
fgf8afibroblast growth factor 8 a0.518
bmp4bone morphogenetic protein 40.517
tp53bp2tumor protein p53 binding protein, 20.517
znf703zinc finger protein 7030.514
wnt10awingless-type MMTV integration site family, member 10a0.502
ndr2nodal-related 20.501
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.495
appaamyloid beta (A4) precursor protein a0.479
wlswntless homolog (Drosophila)0.475
lft1lefty10.460
aldh1a2aldehyde dehydrogenase 1 family, member A20.446
cry1acryptochrome 1a0.443
tbx16T-box gene 160.432
zeb2azinc finger E-box binding homeobox 2a0.418
baxabcl2-associated X protein, a0.416
itgb1b.2integrin, beta 1b.20.415
tnfrsfatumor necrosis factor receptor superfamily, member a0.413
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.400
wnt3wingless-type MMTV integration site family, member 30.378
dharmadharma0.377
tll1tolloid-like 10.376
cyp1acytochrome P450, family 1, subfamily A0.375
fibinfin bud initiation factor0.369
wnt5bwingless-type MMTV integration site family, member 5b0.357
wnt4awingless-type MMTV integration site family, member 4a0.354
cdh1cadherin 1, epithelial0.353
edn1endothelin 10.348
tbx20T-box 200.347
sh3gl1bSH3-domain GRB2-like 1b0.343
egr1early growth response 10.340
dusp6dual specificity phosphatase 60.340
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.339
spry4sprouty (Drosophila) homolog 40.334
robo3roundabout homolog 30.329
pax8paired box gene 80.316
mt2metallothionein 20.306
twist1atwist1a0.298
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.296
nog1noggin 10.290
zgc:111944zgc:1119440.287
notch2notch homolog 20.284
hoxb1bhomeo box B1b0.282
rag1recombination activating gene 10.279
yap1Yes-associated protein 10.277
wnt9bwingless-type MMTV integration site family, member 9B0.274
otpaorthopedia homolog a0.270
twist3twist30.268
gdf6agrowth differentiation factor 6a0.264
col10a1collagen, type X, alpha 10.259
hey1hairy/enhancer-of-split related with YRPW motif 10.255
lama5laminin, alpha 50.254
mmp9matrix metalloproteinase 90.249
tcf12transcription factor 120.242
mxi1max interacting protein0.240
twist2twist20.240
inspreproinsulin0.239
wnt11wingless-type MMTV integration site family, member 110.236
fgf20afibroblast growth factor 20a0.236
dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.236
dlx6adistal-less homeobox gene 6a0.236
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.232
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.231
sox9bSRY-box containing gene 9b0.231
amotl2aangiomotin like 2a0.227
sulf2lsulfatase 2, like0.227
hoxa13ahomeo box A13a0.226
brd4bromodomain containing 40.225
camk2g1calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 10.225
ahi1Abelson helper integration site 10.224
pcnaproliferating cell nuclear antigen0.222
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.222
col27a1acollagen, type XXVII, alpha 1a0.221
alcambactivated leukocyte cell adhesion molecule b0.221
dlddeltaD0.219
notch1anotch homolog 1a0.218
snai1asnail homolog 1a (Drosophila)0.218
egr2bearly growth response 2b0.216
igf1insulin-like growth factor 10.216
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.213
btg1B-cell translocation gene 10.212
fabp11afatty acid binding protein 11a0.211
pcdh18bprotocadherin 18b0.209
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gria2glutamate receptor, ionotropic, AMPA 20.498
Ddr1discoidin domain receptor tyrosine kinase 10.438
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.351
Gria1glutamate receptor, ionotropic, AMPA 10.342
Pctk1PCTAIRE protein kinase 10.317
Cyp51cytochrome P450, family 510.314
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.299
Grm7glutamate receptor, metabotropic 70.267
Sirpasignal-regulatory protein alpha0.235
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.234
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.231
Prkcgprotein kinase C, gamma0.227
Tmod2tropomodulin 20.210
Adam10ADAM metallopeptidase domain 100.205
Calcrlcalcitonin receptor-like0.203
Usf2upstream transcription factor 2, c-fos interacting0.198
Pfn1profilin 10.198
Fgfr2fibroblast growth factor receptor 20.197
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.196
Pipprolactin induced protein0.191
Prkcdprotein kinase C, delta0.185
Ctnnd2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.183
Homer1homer homolog 1 (Drosophila)0.181
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.180
Ins2insulin 20.179
Adrbk1adrenergic, beta, receptor kinase 10.177
Jak2Janus kinase 20.176
SeboxSEBOX homeobox0.176
Itgamintegrin, alpha M0.167
Myo9amyosin IXA0.167
Akt1v-akt murine thymoma viral oncogene homolog 10.164
Sdc3syndecan 30.163
Smad7SMAD family member 70.160
Vegfavascular endothelial growth factor A0.159
Galr3galanin receptor 30.159
Dmddystrophin0.156
Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha0.153
Jdp2Jun dimerization protein 20.152
Syt8synaptotagmin VIII0.152
Unc5aunc-5 homolog A (C. elegans)0.150
Csnk1g2casein kinase 1, gamma 20.146
DbpD site of albumin promoter (albumin D-box) binding protein0.145
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.145
Cmklr1chemokine-like receptor 10.142
Stk10serine/threonine kinase 100.137
Foxe3forkhead box E30.136
Sox17SRY (sex determining region Y)-box 170.136
Ptgfrprostaglandin F receptor0.136
Fgfr1Fibroblast growth factor receptor 10.135
Metmet proto-oncogene0.134
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.134
KitlgKIT ligand0.134
Galnt1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)0.133
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.133
Klf2Kruppel-like factor 2 (lung)0.133
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.133
Nr4a2nuclear receptor subfamily 4, group A, member 20.131
Vipvasoactive intestinal peptide0.131
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.130
Nos3nitric oxide synthase 3, endothelial cell0.130
LOC100362824caveolin 2-like0.129
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.129
Sgk1serum/glucocorticoid regulated kinase 10.128
Gfi1growth factor independent 1 transcription repressor0.127
Olr226olfactory receptor 2260.127
Dlgap3discs, large (Drosophila) homolog-associated protein 30.125
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.124
Tnp2transition protein 20.124
Dmrta1DMRT-like family A10.123
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.123
Il11interleukin 110.122
Ptpn6protein tyrosine phosphatase, non-receptor type 60.122
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.122
Cishcytokine inducible SH2-containing protein0.122
Crip2cysteine-rich protein 20.120
Map2microtubule-associated protein 20.120
Grm5glutamate receptor, metabotropic 50.117
Ifitm3interferon induced transmembrane protein 30.117
Dock8dedicator of cytokinesis 80.115
Notch3Notch homolog 3 (Drosophila)0.114
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.114
Plagl1pleiomorphic adenoma gene-like 10.114
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.113
Ptger3prostaglandin E receptor 3 (subtype EP3)0.112
Slc25a3solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 30.112
Vcanversican0.111
Tgfb1transforming growth factor, beta 10.110
Ptpreprotein tyrosine phosphatase, receptor type, E0.109
Sf1splicing factor 10.109
Jak1Janus kinase 10.109
Scn8asodium channel, voltage gated, type VIII, alpha subunit0.108
Dusp6dual specificity phosphatase 60.107
Vav1vav 1 guanine nucleotide exchange factor0.107
Adora2aadenosine A2a receptor0.107
Hpcal4hippocalcin-like 40.106
Tcfe2atranscription factor E2a0.106
Nr1d2nuclear receptor subfamily 1, group D, member 20.106
Utrnutrophin0.106
Ube2hubiquitin-conjugating enzyme E2H0.105
Bcanbrevican0.105
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
TPK2Tpk2p0.454
BBC1Bbc1p0.436
YOL087Chypothetical protein0.403
PPH21Pph21p0.383
TPK1Tpk1p0.367
BEM1Bem1p0.344
BCK1Bck1p0.291
SCH9Sch9p0.269
KSS1Kss1p0.250
KSP1Ksp1p0.244
MKK1Mkk1p0.223
REG1Reg1p0.190
FUS3Fus3p0.189
STE4Ste4p0.178
FAR1Far1p0.168
PKH2Pkh2p0.166
IRA1Ira1p0.150
CLA4Cla4p0.149
DID4Did4p0.149
SSN8Ssn8p0.144
CAK1Cak1p0.125
SSA3Ssa3p0.123
MEH1Meh1p0.122
LHS1Lhs1p0.120
VPS8Vps8p0.113
BMH1Bmh1p0.108
DID2Did2p0.106
ICE2Ice2p0.106
MSN2Msn2p0.102
ROM2Rom2p0.101
FTH1Fth1p0.101
STE7Ste7p0.098
PHO85Pho85p0.095
SOK1Sok1p0.092
BEM2Bem2p0.089
VPS15Vps15p0.085
RIM101Rim101p0.085
TOR1Tor1p0.083
RHO1Rho1p0.081
CCR4Ccr4p0.080
CKS1Cks1p0.079
VAM6Vam6p0.071
BOI1Boi1p0.068
CDC34Cdc34p0.067
RTT101Rtt101p0.065
SLG1Slg1p0.064
PMR1Pmr1p0.063
HOG1Hog1p0.063
GSC2Gsc2p0.063
MEC1Mec1p0.062
HKR1Hkr1p0.060
RAS2Ras2p0.060
SCP1Scp1p0.060
KOG1Kog1p0.058
CMK1Cmk1p0.058
PLC1Plc1p0.058
VPS45Vps45p0.057
RTS1Rts1p0.057
PBS2Pbs2p0.056
SIZ1Siz1p0.055
CDC55Cdc55p0.055
SNF4Snf4p0.054
SPT16Spt16p0.054
GCN2Gcn2p0.054
PSY4Psy4p0.053
SKN7Skn7p0.053
NHA1Nha1p0.052
WHI2Whi2p0.052
STE12Ste12p0.052
PPE1Ppe1p0.052
SLM2Slm2p0.052
RSC1Rsc1p0.051
BOP3Bop3p0.051
CHC1Chc1p0.050
SSE1Sse1p0.050
LSP1Lsp1p0.050
YCL042Whypothetical protein0.049
SHO1Sho1p0.048
RUP1Rup1p0.048
ULP2Ulp2p0.046
POG1Pog1p0.046
MSS11Mss11p0.045
PEP1Pep1p0.045
CCZ1Ccz1p0.045
MDS3Mds3p0.044
PKC1Pkc1p0.044
YKR017Chypothetical protein0.044
ZDS1Zds1p0.044
MPT5Mpt5p0.043
SPT8Spt8p0.043
CKA2Cka2p0.043
BOI2Boi2p0.043
HSP60Hsp60p0.042
SKT5Skt5p0.042
CNA1Cna1p0.042
RSC6Rsc6p0.042
SAC7Sac7p0.042
BDH1Bdh1p0.041
SWI1Swi1p0.040
TPK3Tpk3p0.040