The network for 'negative regulation of bmp signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of bmp signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.409
witwishful thinking0.331
Ras85DRas oncogene at 85D0.154
EcREcdysone receptor0.054
EgfrEpidermal growth factor receptor0.048
Pi3K92ECG4141 gene product from transcript CG4141-RB0.045
InRInsulin-like receptor0.042
gbbglass bottom boat0.040
endoAendophilin A0.035
cv-ccrossveinless c0.033
Pk61CProtein kinase 61C0.030
Akt1CG4006 gene product from transcript CG4006-RA0.027
CaMKIICalcium/calmodulin-dependent protein kinase II0.027
Gprk2G protein-coupled receptor kinase 20.025
Irk2Inwardly rectifying potassium channel 20.025
DadDaughters against dpp0.024
Dap160Dynamin associated protein 1600.024
dallydivision abnormally delayed0.023
LaspCG3849 gene product from transcript CG3849-RB0.022
Letm1CG4589 gene product from transcript CG4589-RB0.021
AcslAcyl-CoA synthetase long-chain0.021
SmoxSmad on X0.020
msl-3male-specific lethal 30.020
htshu li tai shao0.020
l(2)gllethal (2) giant larvae0.019
HcfHost cell factor0.017
coroCG9446 gene product from transcript CG9446-RC0.015
SnooSno oncogene0.015
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.015
cicubitus interruptus0.015
GluRIIAGlutamate receptor IIA0.015
SaraSmad anchor for receptor activation0.014
trioCG18214 gene product from transcript CG18214-RA0.014
salmspalt major0.014
tsgtwisted gastrulation0.014
Pak3CG14895 gene product from transcript CG14895-RA0.013
Gef26CG9491 gene product from transcript CG9491-RB0.013
NFATNFAT homolog0.012
msl-1male-specific lethal 10.012
BaldspotCG3971 gene product from transcript CG3971-RA0.011
crolcrooked legs0.011
CG12753CG12753 gene product from transcript CG12753-RB0.011
argosCG4531 gene product from transcript CG4531-RA0.011
MarfMitochondrial assembly regulatory factor0.010
neuroliginCG13772 gene product from transcript CG13772-RA0.010
mofmales absent on the first0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
daf-4Protein DAF-40.301
dpy-22Protein DPY-220.228
hlh-30Protein HLH-300.226
lag-2Protein LAG-20.202
plc-1Protein PLC-10.189
sma-9Protein SMA-90.180
elt-6Protein ELT-60.175
egl-8Protein EGL-80.158
ncam-1Protein NCAM-10.155
F10G8.8Protein F10G8.80.128
pqn-62Protein PQN-620.110
sdc-2Protein SDC-20.107
pha-4Protein PHA-40.106
sel-8Protein SEL-80.098
tps-1Protein TPS-10.089
R05G6.10Protein R05G6.100.086
daf-14Protein DAF-140.083
egl-18Protein EGL-180.077
chd-7Protein CHD-70.069
crm-1Protein CRM-10.067
frm-7Protein FRM-70.064
pqn-44Protein PQN-440.062
tag-241Protein TAG-2410.062
egl-44Protein EGL-440.062
let-19Protein LET-190.057
dlg-1Protein DLG-10.056
nhr-67Protein NHR-670.054
daf-3Protein DAF-30.053
chd-3Protein CHD-30.052
F54D1.6Protein F54D1.60.049
bar-1Protein BAR-10.048
nhr-2Protein NHR-20.046
CELE_F15A8.6Protein F15A8.60.042
ten-1Protein TEN-10.040
max-1Protein MAX-10.040
magu-4Protein MAGU-40.038
pqn-71Protein PQN-710.038
lmn-1Protein LMN-10.035
cwn-1Protein CWN-10.035
mml-1Protein MML-10.033
daf-1Protein DAF-10.032
R09A8.5Protein R09A8.50.032
T28B11.1Protein T28B11.10.032
peb-1Protein PEB-10.032
pry-1Protein PRY-10.031
F10D7.5Protein F10D7.50.031
F39G3.5Protein F39G3.50.031
F21A10.2Protein F21A10.20.030
CELE_C08F11.13Protein C08F11.130.030
lit-1Protein LIT-10.029
scrm-1Protein SCRM-10.029
spc-1Protein SPC-10.029
afd-1Protein AFD-10.029
ech-8Protein ECH-80.028
ist-1Protein IST-10.028
daf-8Protein DAF-80.028
zak-1Protein ZAK-10.028
C11E4.6Protein C11E4.60.028
nhr-25Protein NHR-250.027
pas-6Protein PAS-60.027
pqn-89Protein PQN-890.026
ikke-1Protein IKKE-10.026
exc-5Protein EXC-50.025
rig-3Protein RIG-30.025
CELE_F12A10.8Protein F12A10.80.024
uso-1Protein USO-10.024
hlh-1Protein HLH-10.024
mff-2Protein MFF-20.023
egl-15Protein EGL-150.023
CELE_F59C6.11Protein F59C6.110.022
cec-1Protein CEC-10.022
lir-1Protein LIR-10.022
scd-1Protein SCD-10.022
igdb-2Protein IGDB-20.022
flt-1Protein FLT-10.021
K09E3.7Protein K09E3.70.021
lin-12Protein LIN-120.020
F07A11.2Protein F07A11.20.020
pme-5Protein PME-50.020
sqv-1Protein SQV-10.020
CELE_F56D5.6Protein F56D5.60.020
ZC247.1Protein ZC247.10.020
let-60Protein LET-600.020
F22D3.6Protein F22D3.60.020
Y76A2B.4Protein Y76A2B.40.020
ilys-4Protein ILYS-40.019
cyd-1Protein CYD-10.019
cnd-1Protein CND-10.019
unc-10Protein UNC-100.019
F32B5.6Protein F32B5.60.019
pxd-1Protein PXD-10.018
dpy-27Protein DPY-270.018
K10B3.6Protein K10B3.60.018
gei-8Protein GEI-80.018
pkn-1Protein PKN-10.018
fmi-1Protein FMI-10.018
sma-6Protein SMA-60.018
dlk-1Protein DLK-10.018
W04B5.5Protein W04B5.50.018
lin-28Protein LIN-280.017
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.950
bmp4bone morphogenetic protein 40.690
bocbrother of CDO0.592
rargaretinoic acid receptor gamma a0.487
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.226
flhfloating head0.212
ntlano tail a0.199
wnt8awingless-type MMTV integration site family, member 8a0.197
hoxb1bhomeo box B1b0.192
rxraaretinoid X receptor, alpha a0.159
ctsl1bcathepsin L, 1 b0.152
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.151
spry4sprouty (Drosophila) homolog 40.138
egr2bearly growth response 2b0.135
raraaretinoic acid receptor, alpha a0.134
nog2noggin 20.134
nr1d2bnuclear receptor subfamily 1, group D, member 2b0.119
rxrgaretinoid x receptor, gamma a0.118
ntn2netrin 20.113
rasl11bRAS-like, family 11, member B0.110
bmpr1aabone morphogenetic protein receptor, type 1aa0.108
tll1tolloid-like 10.105
hdac4histone deacetylase 40.105
mbnl2muscleblind-like 2 (Drosophila)0.104
per2period homolog 2 (Drosophila)0.099
fgfr4fibroblast growth factor receptor 40.099
tcf7transcription factor 7 (T-cell specific, HMG-box)0.098
col27a1acollagen, type XXVII, alpha 1a0.097
wnt5bwingless-type MMTV integration site family, member 5b0.096
dusp6dual specificity phosphatase 60.095
foxo3bforkhead box O3b0.089
wnt9awingless-type MMTV integration site family, member 9A0.088
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.087
klf4aKruppel-like transcription factor 4a0.081
rereaarginine-glutamic acid dipeptide (RE) repeats a0.079
rbp4retinol binding protein 4, plasma0.078
kctd15apotassium channel tetramerisation domain containing 15a0.076
cdx4caudal type homeo box transcription factor 40.069
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.067
cdoncell adhesion molecule-related/down-regulated by oncogenes0.064
efnb3bephrin B3b0.064
nr1d2anuclear receptor subfamily 1, group D, member 2a0.060
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.058
tgfb1atransforming growth factor, beta 1a0.058
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.057
atoh8atonal homolog 80.057
nog1noggin 10.055
gbx2gastrulation brain homeo box 20.054
mapk4mitogen-activated protein kinase 40.052
ctgfconnective tissue growth factor0.052
kif5bbkinesin family member 5B, b0.052
myod1myogenic differentiation 10.050
bmp2abone morphogenetic protein 2a0.049
foxd5forkhead box D50.048
ephb4beph receptor B4b0.048
gng2guanine nucleotide binding protein (G protein), gamma 20.048
frzbfrizzled-related protein0.047
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.046
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.046
e2f5E2F transcription factor 50.044
mef2amyocyte enhancer factor 2a0.040
zbtb4zinc finger and BTB domain containing 40.039
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.038
brd2bbromodomain containing 2b0.037
cry3cryptochrome 30.037
tob1atransducer of ERBB2, 1a0.036
voxventral homeobox0.036
mcoln1mucolipin 10.036
tp53inp1tumor protein p53 inducible nuclear protein 10.035
wnt11rwingless-type MMTV integration site family, member 11, related0.035
dab2ipDAB2 interacting protein0.034
sema3dsemaphorin 3d0.034
pbx1apre-B-cell leukemia transcription factor 1a0.033
prrx1apaired related homeobox 1a0.033
bmp3bone morphogenetic protein 30.032
pcdh18bprotocadherin 18b0.032
epha7eph receptor A70.031
egr1early growth response 10.031
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.031
mgpmatrix Gla protein0.031
epha4aeph receptor A4a0.031
fn1fibronectin 10.030
smoc1SPARC related modular calcium binding 10.029
slit3slit (Drosophila) homolog 30.029
arg2arginase, type II0.029
nkd1naked cuticle homolog 1 (Drosophila)0.029
mef2dmyocyte enhancer factor 2d0.028
fbn2bfibrillin 2b0.028
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.028
nfianuclear factor I/A0.028
znf395bzinc finger protein 395b0.027
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMURF2SMAD specific E3 ubiquitin protein ligase 21.000
SMAD4SMAD family member 41.000
SMAD3SMAD family member 31.000
SMAD2SMAD family member 20.996
SKILSKI-like oncogene0.995
SMAD7SMAD family member 70.987
TRIM33tripartite motif containing 330.979
BMPR1Abone morphogenetic protein receptor, type IA0.968
SMAD1SMAD family member 10.961
SMAD5SMAD family member 50.853
FBLN1fibulin 10.674
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.640
LRP6low density lipoprotein receptor-related protein 60.622
JAG1jagged 10.600
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.596
EP300E1A binding protein p3000.542
CREBBPCREB binding protein0.486
SMURF1SMAD specific E3 ubiquitin protein ligase 10.459
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.441
BMP1bone morphogenetic protein 10.295
NCOR1nuclear receptor corepressor 10.271
TGFBR1transforming growth factor, beta receptor 10.251
ARandrogen receptor0.249
NOTCH3notch 30.226
ADAM12ADAM metallopeptidase domain 120.207
SP1Sp1 transcription factor0.188
SKIv-ski sarcoma viral oncogene homolog (avian)0.174
ZFYVE9zinc finger, FYVE domain containing 90.169
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.167
BMP2bone morphogenetic protein 20.160
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.151
LIMD1LIM domains containing 10.145
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.137
PIAS1protein inhibitor of activated STAT, 10.126
WNT5Awingless-type MMTV integration site family, member 5A0.105
TGFB1transforming growth factor, beta 10.097
COL1A1collagen, type I, alpha 10.095
CTGFconnective tissue growth factor0.086
CAV1caveolin 1, caveolae protein, 22kDa0.079
PDGFCplatelet derived growth factor C0.078
FSTL1follistatin-like 10.077
CXXC5CXXC finger protein 50.077
SOCS5suppressor of cytokine signaling 50.075
FN1fibronectin 10.074
SMAD6SMAD family member 60.074
RASSF5Ras association (RalGDS/AF-6) domain family member 50.074
WWP2WW domain containing E3 ubiquitin protein ligase 20.066
BMP7bone morphogenetic protein 70.066
SFRP1secreted frizzled-related protein 10.059
MECP2methyl CpG binding protein 2 (Rett syndrome)0.057
MFAP4microfibrillar-associated protein 40.056
PRKCDBPprotein kinase C, delta binding protein0.055
MTMR4myotubularin related protein 40.053
TCF12transcription factor 120.053
FGF18fibroblast growth factor 180.052
NOTCH2notch 20.051
RNF111ring finger protein 1110.051
FZD8frizzled homolog 8 (Drosophila)0.050
PKD2polycystic kidney disease 2 (autosomal dominant)0.049
SIN3ASIN3 homolog A, transcription regulator (yeast)0.047
HIC1hypermethylated in cancer 10.045
FZD1frizzled homolog 1 (Drosophila)0.045
RUNX1runt-related transcription factor 10.043
GSK3Bglycogen synthase kinase 3 beta0.042
SPRY2sprouty homolog 2 (Drosophila)0.042
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.041
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.040
YY1YY1 transcription factor0.040
PAPPApregnancy-associated plasma protein A, pappalysin 10.040
DCAF7DDB1 and CUL4 associated factor 70.039
ATN1atrophin 10.039
INHBAinhibin, beta A0.038
TRAF4TNF receptor-associated factor 40.038
PTGISprostaglandin I2 (prostacyclin) synthase0.037
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.036
MAML1mastermind-like 1 (Drosophila)0.034
SORBS3sorbin and SH3 domain containing 30.033
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.033
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.032
ZEB2zinc finger E-box binding homeobox 20.031
GAS6growth arrest-specific 60.031
LOXlysyl oxidase0.030
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.029
SIRT1sirtuin 10.028
FBXL15F-box and leucine-rich repeat protein 150.028
EFEMP1EGF containing fibulin-like extracellular matrix protein 10.027
HDAC3histone deacetylase 30.027
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.027
FZD7frizzled homolog 7 (Drosophila)0.027
ING2inhibitor of growth family, member 20.027
FOXF2forkhead box F20.026
RSBN1round spermatid basic protein 10.026
SOX7SRY (sex determining region Y)-box 70.025
MESTmesoderm specific transcript homolog (mouse)0.025
TGFB2transforming growth factor, beta 20.024
NR2F2nuclear receptor subfamily 2, group F, member 20.024
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.024
PPARAperoxisome proliferator-activated receptor alpha0.023
FBN2fibrillin 20.023
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr1fibroblast growth factor receptor 11.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr2fibroblast growth factor receptor 21.000
Gli2GLI-Kruppel family member GLI20.999
Ctnnb1catenin (cadherin associated protein), beta 10.999
Bmp4bone morphogenetic protein 40.998
Smad6MAD homolog 6 (Drosophila)0.991
Shhsonic hedgehog0.988
Smad3MAD homolog 3 (Drosophila)0.981
Pax2paired box gene 20.977
Bmp7bone morphogenetic protein 70.976
Smosmoothened homolog (Drosophila)0.973
Sox9SRY-box containing gene 90.972
Ptenphosphatase and tensin homolog0.967
Lef1lymphoid enhancer binding factor 10.964
Rargretinoic acid receptor, gamma0.960
Msx1homeobox, msh-like 10.949
Smad4MAD homolog 4 (Drosophila)0.941
Tgfb2transforming growth factor, beta 20.941
Fgf8fibroblast growth factor 80.935
Otx2orthodenticle homolog 2 (Drosophila)0.931
Fzd1frizzled homolog 1 (Drosophila)0.924
En1engrailed 10.923
Rarbretinoic acid receptor, beta0.905
Apcadenomatosis polyposis coli0.904
Wnt4wingless-related MMTV integration site 40.896
Bmpr1abone morphogenetic protein receptor, type 1A0.891
Lhx1LIM homeobox protein 10.889
Gdnfglial cell line derived neurotrophic factor0.885
Wnt3awingless-related MMTV integration site 3A0.869
Foxc1forkhead box C10.856
Smad7MAD homolog 7 (Drosophila)0.853
Itgb1integrin beta 1 (fibronectin receptor beta)0.821
Amhr2anti-Mullerian hormone type 2 receptor0.812
Pax3paired box gene 30.810
Pthlhparathyroid hormone-like peptide0.807
Trp53transformation related protein 530.806
Bcl2B-cell leukemia/lymphoma 20.802
Hes1hairy and enhancer of split 1 (Drosophila)0.792
Ptch1patched homolog 10.788
Wnt5awingless-related MMTV integration site 5A0.780
Prrx2paired related homeobox 20.774
Twist2twist homolog 2 (Drosophila)0.764
Gas1growth arrest specific 10.759
Wnt6wingless-related MMTV integration site 60.757
Sfrp1secreted frizzled-related protein 10.741
Pbx1pre B-cell leukemia transcription factor 10.741
Gpc3glypican 30.719
Ror2receptor tyrosine kinase-like orphan receptor 20.718
Msx2homeobox, msh-like 20.717
Gopcgolgi associated PDZ and coiled-coil motif containing0.703
Acvr1activin A receptor, type 10.687
Vangl2vang-like 2 (van gogh, Drosophila)0.686
Pax8paired box gene 80.686
Psen1presenilin 10.659
Hoxd11homeobox D110.650
Dkk1dickkopf homolog 1 (Xenopus laevis)0.639
Rararetinoic acid receptor, alpha0.619
Sfrp2secreted frizzled-related protein 20.616
Hif1ahypoxia inducible factor 1, alpha subunit0.614
Smad1MAD homolog 1 (Drosophila)0.605
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.599
Hoxd9homeobox D90.596
Ptk7PTK7 protein tyrosine kinase 70.584
Nos3nitric oxide synthase 3, endothelial cell0.582
Efna4ephrin A40.565
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.556
Gli1GLI-Kruppel family member GLI10.542
Retret proto-oncogene0.537
Hspg2perlecan (heparan sulfate proteoglycan 2)0.533
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.522
Axin1axin 10.509
Wnt3wingless-related MMTV integration site 30.506
Dll1delta-like 1 (Drosophila)0.496
Foxa2forkhead box A20.495
Hoxa11homeobox A110.482
Ptgs2prostaglandin-endoperoxide synthase 20.476
Wt1Wilms tumor 1 homolog0.471
Lbx1ladybird homeobox homolog 1 (Drosophila)0.441
Meox2mesenchyme homeobox 20.425
Ptpn14protein tyrosine phosphatase, non-receptor type 140.425
Hoxa5homeobox A50.421
Dlg1discs, large homolog 1 (Drosophila)0.409
Notch1Notch gene homolog 1 (Drosophila)0.409
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.387
Fgfr3fibroblast growth factor receptor 30.376
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.360
Hic1hypermethylated in cancer 10.359
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.359
Lama5laminin, alpha 50.357
Fzd8frizzled homolog 8 (Drosophila)0.349
Prrx1paired related homeobox 10.343
Col11a1collagen, type XI, alpha 10.336
Wnt11wingless-related MMTV integration site 110.331
Fzd2frizzled homolog 2 (Drosophila)0.320
Gata4GATA binding protein 40.314
Inhbainhibin beta-A0.306
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism