The network for 'positive regulation of phagocytosis engulfment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of phagocytosis engulfment

Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.

Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mbcmyoblast city0.658
dockdreadlocks0.526
PvrPDGF- and VEGF-receptor related0.219
inscinscuteable0.150
CG10083CG10083 gene product from transcript CG10083-RA0.142
HemHEM-protein0.114
plexAplexin A0.109
DadDaughters against dpp0.109
htlheartless0.107
numbCG3779 gene product from transcript CG3779-RB0.080
ik2IkappaB kinase-like 20.073
Vrp1Verprolin 10.061
toktolkin0.061
kstkarst0.055
bibbig brain0.053
StimStromal interaction molecule0.045
WnkCG7177 gene product from transcript CG7177-RA0.044
PknProtein kinase related to protein kinase N0.042
retnretained0.034
stumpsCG31317 gene product from transcript CG31317-RC0.032
fngfringe0.032
crqcroquemort0.028
Rab7Rab-protein 70.027
dvedefective proventriculus0.027
Sra-1specifically Rac1-associated protein 10.025
AbiAbelson interacting protein0.024
PakPAK-kinase0.023
LanB2Laminin B20.023
Nrx-IVNeurexin IV0.023
mewmultiple edematous wings0.021
RelRelish0.021
CG3764CG3764 gene product from transcript CG3764-RA0.021
SbfSET domain binding factor0.020
RhoLrho-like0.019
RalaRas-related protein0.019
SaraSmad anchor for receptor activation0.018
scbscab0.018
Letm1CG4589 gene product from transcript CG4589-RB0.018
cicubitus interruptus0.018
svrsilver0.017
Akap200A kinase anchor protein 2000.017
mib1mind bomb 10.016
myoglianinCG1838 gene product from transcript CG1838-RD0.015
CortactinCG3637 gene product from transcript CG3637-RA0.015
Eb1CG3265 gene product from transcript CG3265-RF0.015
FhosCG42610 gene product from transcript CG42610-RC0.014
tbcetubulin-specific chaperone E0.014
AckCG14992 gene product from transcript CG14992-RA0.013
RYBPRing and YY1 Binding Protein0.013
rostrolling stone0.012
kelkelch0.012
cpbcapping protein beta0.012
pnrpannier0.012
srpserpent0.012
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.012
p130CASCG1212 gene product from transcript CG1212-RA0.011
LamCLamin C0.011
Vps4Vacuolar protein sorting 40.011
CG5270CG5270 gene product from transcript CG5270-RB0.011
Myd88CG2078 gene product from transcript CG2078-RA0.010
CG12207CG12207 gene product from transcript CG12207-RB0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
FN1fibronectin 10.982
NCKAP1NCK-associated protein 10.978
ENGendoglin0.960
SOS1son of sevenless homolog 1 (Drosophila)0.745
ADAM19ADAM metallopeptidase domain 190.701
FLNAfilamin A, alpha0.553
NCK1NCK adaptor protein 10.544
EPS8epidermal growth factor receptor pathway substrate 80.487
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.264
CTGFconnective tissue growth factor0.200
S100BS100 calcium binding protein B0.186
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.137
WASF1WAS protein family, member 10.135
THBS1thrombospondin 10.106
ITGA6integrin, alpha 60.101
ITGB5integrin, beta 50.092
TLN1talin 10.085
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.085
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.079
FHL2four and a half LIM domains 20.074
ITSN1intersectin 1 (SH3 domain protein)0.064
PDIA3protein disulfide isomerase family A, member 30.064
ADAM9ADAM metallopeptidase domain 90.058
RASA1RAS p21 protein activator (GTPase activating protein) 10.055
TGFB1transforming growth factor, beta 10.054
CD63CD63 molecule0.048
MSH5mutS homolog 5 (E. coli)0.047
TTRtransthyretin0.046
FYNFYN oncogene related to SRC, FGR, YES0.044
PDLIM5PDZ and LIM domain 50.043
HSPG2heparan sulfate proteoglycan 20.042
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.039
SHARPINSHANK-associated RH domain interactor0.038
MAP4K3mitogen-activated protein kinase kinase kinase kinase 30.036
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.034
CD2APCD2-associated protein0.033
CAV1caveolin 1, caveolae protein, 22kDa0.030
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.030
SPRR2Asmall proline-rich protein 2A0.029
VCLvinculin0.028
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.027
STXBP3syntaxin binding protein 30.026
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.026
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.026
CYFIP1cytoplasmic FMR1 interacting protein 10.025
SWAP70SWAP switching B-cell complex 70kDa subunit0.024
CD9CD9 molecule0.024
YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.023
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.023
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.022
TMEM30Atransmembrane protein 30A0.019
PXNpaxillin0.019
MAVSmitochondrial antiviral signaling protein0.018
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.017
PIKFYVEphosphoinositide kinase, FYVE finger containing0.017
ATP2C1ATPase, Ca++ transporting, type 2C, member 10.017
MORC3MORC family CW-type zinc finger 30.017
INADLInaD-like (Drosophila)0.017
CD46CD46 molecule, complement regulatory protein0.016
FNDC3Bfibronectin type III domain containing 3B0.016
CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like)0.016
S100A1S100 calcium binding protein A10.016
STK38Lserine/threonine kinase 38 like0.016
PLOD2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 20.016
TMEM123transmembrane protein 1230.015
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.015
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.015
ARFGAP3ADP-ribosylation factor GTPase activating protein 30.015
MSNmoesin0.015
SSFA2sperm specific antigen 20.015
SHOC2soc-2 suppressor of clear homolog (C. elegans)0.015
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.014
IGFBP3insulin-like growth factor binding protein 30.014
WASF2WAS protein family, member 20.014
NCK2NCK adaptor protein 20.014
TNCtenascin C0.014
EGFRepidermal growth factor receptor0.014
ITSN2intersectin 20.014
TGFBR1transforming growth factor, beta receptor 10.014
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 30.014
EFR3AEFR3 homolog A (S. cerevisiae)0.014
ROCK1Rho-associated, coiled-coil containing protein kinase 10.013
PLAUplasminogen activator, urokinase0.013
DYNLT3dynein, light chain, Tctex-type 30.013
WDR11WD repeat domain 110.013
SEC23ASec23 homolog A (S. cerevisiae)0.013
CAV2caveolin 20.013
PROCRprotein C receptor, endothelial0.013
C3orf64chromosome 3 open reading frame 640.013
TUBB6tubulin, beta 60.013
NEBnebulin0.012
NEK7NIMA (never in mitosis gene a)-related kinase 70.012
SDC2syndecan 20.012
ACVRL1activin A receptor type II-like 10.012
PICALMphosphatidylinositol binding clathrin assembly protein0.012
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.012
GAS7growth arrest-specific 70.012
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.012
NPTNneuroplastin0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apoeapolipoprotein E0.955
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.682
Cav1caveolin 1, caveolae protein0.453
Tgfbr1transforming growth factor, beta receptor I0.437
Stat5bsignal transducer and activator of transcription 5B0.425
Nos3nitric oxide synthase 3, endothelial cell0.256
Stim1stromal interaction molecule 10.219
Npc1Niemann Pick type C10.183
Itgb3integrin beta 30.158
Stim2stromal interaction molecule 20.155
Ptenphosphatase and tensin homolog0.132
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.131
Rdh8retinol dehydrogenase 80.130
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.128
Slc12a6solute carrier family 12, member 60.125
Agpat21-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)0.119
Ttc7tetratricopeptide repeat domain 70.119
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.107
Tgfbr2transforming growth factor, beta receptor II0.106
9430031J16RikRIKEN cDNA 9430031J16 gene0.092
Becn1beclin 1, autophagy related0.089
Spp1secreted phosphoprotein 10.088
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.086
Clockcircadian locomotor output cycles kaput0.081
Leprleptin receptor0.080
Notch2Notch gene homolog 2 (Drosophila)0.076
Ppifpeptidylprolyl isomerase F (cyclophilin F)0.071
Lipalysosomal acid lipase A0.069
Tlr4toll-like receptor 40.067
Wasf2WAS protein family, member 20.063
Scd1stearoyl-Coenzyme A desaturase 10.062
Nfibnuclear factor I/B0.061
Engendoglin0.060
Pacsin2protein kinase C and casein kinase substrate in neurons 20.057
Ldlrlow density lipoprotein receptor0.057
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.056
Foxf1aforkhead box F1a0.054
Ghrgrowth hormone receptor0.053
Adrb3adrenergic receptor, beta 30.052
Spna1spectrin alpha 10.051
Nfe2l2nuclear factor, erythroid derived 2, like 20.051
Ank1ankyrin 1, erythroid0.048
Prkciprotein kinase C, iota0.048
Plin1perilipin 10.047
Lystlysosomal trafficking regulator0.045
Fnbp1formin binding protein 10.042
Lpin1lipin 10.041
Ate1arginyltransferase 10.040
Lrp1low density lipoprotein receptor-related protein 10.040
Gata1GATA binding protein 10.040
Lepleptin0.039
Rbl2retinoblastoma-like 20.039
Cd44CD44 antigen0.039
Fabp4fatty acid binding protein 4, adipocyte0.037
Treml1triggering receptor expressed on myeloid cells-like 10.037
Lyz2lysozyme 20.037
Dync1i2dynein cytoplasmic 1 intermediate chain 20.037
Ifngr1interferon gamma receptor 10.037
Tgfbr3transforming growth factor, beta receptor III0.036
Arntlaryl hydrocarbon receptor nuclear translocator-like0.036
Gbaglucosidase, beta, acid0.035
Cyfip2cytoplasmic FMR1 interacting protein 20.035
Nr3c1nuclear receptor subfamily 3, group C, member 10.035
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.035
Ncf1neutrophil cytosolic factor 10.034
Adcy4adenylate cyclase 40.033
Stat5asignal transducer and activator of transcription 5A0.033
Gpd2glycerol phosphate dehydrogenase 2, mitochondrial0.032
Grik5glutamate receptor, ionotropic, kainate 5 (gamma 2)0.032
Cpdcarboxypeptidase D0.031
Abl2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)0.031
Hspg2perlecan (heparan sulfate proteoglycan 2)0.029
Bmp4bone morphogenetic protein 40.029
Tmem38btransmembrane protein 38B0.029
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.028
Cpeb4cytoplasmic polyadenylation element binding protein 40.027
XiapX-linked inhibitor of apoptosis0.027
Abi1abl-interactor 10.027
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.026
Prpf40aPRP40 pre-mRNA processing factor 40 homolog A (yeast)0.026
Foxa2forkhead box A20.026
Lmod1leiomodin 1 (smooth muscle)0.026
Cd36CD36 antigen0.026
Cyfip1cytoplasmic FMR1 interacting protein 10.026
Gp5glycoprotein 5 (platelet)0.026
Gata6GATA binding protein 60.025
Ccl2chemokine (C-C motif) ligand 20.025
Lrp2low density lipoprotein receptor-related protein 20.025
Acvrl1activin A receptor, type II-like 10.025
C3complement component 30.025
Slc4a1solute carrier family 4 (anion exchanger), member 10.024
Foxn4forkhead box N40.024
Cry1cryptochrome 1 (photolyase-like)0.024
Sorl1sortilin-related receptor, LDLR class A repeats-containing0.024
Thrbthyroid hormone receptor beta0.024
Itsn1intersectin 1 (SH3 domain protein 1A)0.024
Klf5Kruppel-like factor 50.024
Mtmr6myotubularin related protein 60.024
Aff1AF4/FMR2 family, member 10.024
Tal1T-cell acute lymphocytic leukemia 10.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.350
Fgf1fibroblast growth factor 10.309
Slc22a1solute carrier family 22 (organic cation transporter), member 10.262
Slco2a1solute carrier organic anion transporter family, member 2a10.209
Gja5gap junction protein, alpha 50.197
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.189
Ptafrplatelet-activating factor receptor0.146
Ceacam1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.136
Acot12acyl-CoA thioesterase 120.115
Gata6GATA binding protein 60.113
Mef2dmyocyte enhancer factor 2D0.103
Icam2intercellular adhesion molecule 20.086
Ptprhprotein tyrosine phosphatase, receptor type, H0.084
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.073
Dhdpsldihydrodipicolinate synthase-like, mitochondrial0.072
Nr1i2nuclear receptor subfamily 1, group I, member 20.066
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.065
Prdm2PR domain containing 2, with ZNF domain0.064
Rdh2retinol dehydrogenase 20.059
Gzmbgranzyme B0.055
RT1-M5RT1 class Ib, locus M50.050
MrgprfMAS-related GPR, member F0.048
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.047
Ush1cUsher syndrome 1C homolog (human)0.047
Hnf4ahepatocyte nuclear factor 4, alpha0.047
Efnb1ephrin B10.045
Ednraendothelin receptor type A0.045
Il1r1interleukin 1 receptor, type I0.045
Cpt1bcarnitine palmitoyltransferase 1b, muscle0.044
Trib1tribbles homolog 1 (Drosophila)0.042
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.042
Galnt10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)0.042
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.041
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.040
DaoD-amino-acid oxidase0.040
Gpr116G protein-coupled receptor 1160.040
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.040
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.040
Mettl7bmethyltransferase like 7B0.039
Akr1c14aldo-keto reductase family 1, member C140.039
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.039
Ncf1neutrophil cytosolic factor 10.039
Lpllipoprotein lipase0.038
Il1ainterleukin 1 alpha0.038
Pdk4pyruvate dehydrogenase kinase, isozyme 40.037
Slc4a1solute carrier family 4 (anion exchanger), member 10.037
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.037
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.037
Utrnutrophin0.036
Abcd1ATP-binding cassette, subfamily D (ALD), member 10.036
Zbp1Z-DNA binding protein 10.035
Foxe3forkhead box E30.034
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.033
Smad6SMAD family member 60.033
TriobpTRIO and F-actin binding protein0.032
Tshrthyroid stimulating hormone receptor0.032
Epha2Eph receptor A20.032
Hk2hexokinase 20.032
Podxlpodocalyxin-like0.032
Prg2proteoglycan 2, bone marrow0.030
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.029
Gckrglucokinase (hexokinase 4) regulator0.029
Asb2ankyrin repeat and SOCS box-containing 20.028
LOC679368similar to carboxylesterase 50.028
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.027
Defadefensin, alpha 5, Paneth cell-specific0.027
Defb1defensin beta 10.026
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.026
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.026
Ly6g6elymphocyte antigen 6 complex, locus G6E0.026
Cd8bCD8b molecule0.026
Clockclock homolog (mouse)0.026
Fli1Friend leukemia virus integration 10.025
KitlgKIT ligand0.025
Ddcdopa decarboxylase (aromatic L-amino acid decarboxylase)0.025
Prap1proline-rich acidic protein 10.025
Xpnpep2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound0.025
RGD1304644similar to RIKEN cDNA 2310046K010.024
Clic4chloride intracellular channel 40.024
Cd4Cd4 molecule0.023
Muc13mucin 13, cell surface associated0.023
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.022
Hmha1histocompatibility (minor) HA-10.022
Elf1E74-like factor 10.022
Sptbn1spectrin, beta, non-erythrocytic 10.022
Aqp7aquaporin 70.021
Cdh17cadherin 170.021
Sgk2serum/glucocorticoid regulated kinase 20.021
Hand2heart and neural crest derivatives expressed 20.020
Adra2badrenergic, alpha-2B-, receptor0.020
Slco2b1solute carrier organic anion transporter family, member 2b10.020
Lypd3Ly6/Plaur domain containing 30.020
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.020
Cideacell death-inducing DFFA-like effector a0.020
Ralgdsral guanine nucleotide dissociation stimulator0.020
Hnf1bHNF1 homeobox B0.019
Tff3trefoil factor 3, intestinal0.019
Gpr4G protein-coupled receptor 40.019
Aldobaldolase B, fructose-bisphosphate0.019
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.019
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism