The network for 'establishment of blood brain barrier' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of blood brain barrier

Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.

Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
McrMacroglobulin complement-related0.995
pckpickel0.987
Tsf2Transferrin 20.905
CG17218CG17218 gene product from transcript CG17218-RA0.758
CG2813CG2813 gene product from transcript CG2813-RA0.693
sinusinuous0.598
CG8121CG8121 gene product from transcript CG8121-RA0.572
wunwunen0.471
CG1298CG1298 gene product from transcript CG1298-RA0.264
Ggamma1G protein gamma 10.221
nrv2nervana 20.204
ContContactin0.189
ghoghost0.160
varivaricose0.123
CG6038CG6038 gene product from transcript CG6038-RA0.102
btlbreathless0.094
Nrx-IVNeurexin IV0.089
form3formin 30.084
bouboudin0.076
kniknirps0.066
rhorhomboid0.062
par-6CG5884 gene product from transcript CG5884-RA0.057
beta-Specbeta Spectrin0.053
coracoracle0.051
LacLachesin0.051
rawCG12437 gene product from transcript CG12437-RB0.049
Tre1trapped in endoderm-10.048
Wnt2Wnt oncogene analog 20.046
convconvoluted0.042
elavembryonic lethal abnormal vision0.041
miramiranda0.035
NrgNeuroglian0.032
sec23CG1250 gene product from transcript CG1250-RA0.031
AtpalphaNa pump alpha subunit0.031
CG6398CG6398 gene product from transcript CG6398-RA0.031
runrunt0.031
fogfolded gastrulation0.030
kugkugelei0.030
M6CG7540 gene product from transcript CG7540-RA0.030
rtvretroactive0.030
acj6abnormal chemosensory jump 60.030
Xe7CG2179 gene product from transcript CG2179-RA0.030
VhaPPA1-1CG7007 gene product from transcript CG7007-RA0.027
stumpsCG31317 gene product from transcript CG31317-RC0.027
RopRas opposite0.026
blotbloated tubules0.026
MrtfMyocardin-related transcription factor0.024
koknockout0.024
CG9628CG9628 gene product from transcript CG9628-RA0.024
virvirilizer0.023
painpainless0.023
Blimp-1CG5249 gene product from transcript CG5249-RA0.021
ogreoptic ganglion reduced0.021
CG8600CG8600 gene product from transcript CG8600-RB0.021
cascastor0.021
CG9867CG9867 gene product from transcript CG9867-RA0.021
Vhlvon Hippel-Lindau0.020
lblladybird late0.020
commcommissureless0.020
CG10960CG10960 gene product from transcript CG10960-RC0.019
CG15784CG15784 gene product from transcript CG15784-RA0.019
Eaat2Excitatory amino acid transporter 20.019
nerfin-1nervous fingers 10.018
Mpk2CG5475 gene product from transcript CG5475-RB0.018
porporcupine0.017
HsfHeat shock factor0.017
vvlventral veins lacking0.017
dsxdoublesex0.017
reporeversed polarity0.017
CG12020CG12020 gene product from transcript CG12020-RA0.017
Fer2LCHFerritin 2 light chain homologue0.017
rdgCretinal degeneration C0.017
Gprk1G protein-coupled receptor kinase 10.016
CG6231CG6231 gene product from transcript CG6231-RC0.016
PknProtein kinase related to protein kinase N0.015
G-oalpha47AG protein oalpha 47A0.014
wbwing blister0.014
GckIIIGerminal centre kinase III0.014
CG11009CG11009 gene product from transcript CG11009-RB0.013
Gyc76CGuanylyl cyclase at 76C0.013
slislit0.013
bgcnbenign gonial cell neoplasm0.013
roboroundabout0.013
CG17838CG17838 gene product from transcript CG17838-RA0.013
cp309CG33957 gene product from transcript CG33957-RB0.012
gfAgiant fibre A0.012
wtrwCG31284 gene product from transcript CG31284-RB0.012
srpk79Dserine-arginine protein kinase at 79D0.012
lazalazaro0.012
ribribbon0.012
CG13889CG13889 gene product from transcript CG13889-RA0.012
Obp49aOdorant-binding protein 49a0.012
ninaGCG6728 gene product from transcript CG6728-RA0.012
Zasp66Z band alternatively spliced PDZ-motif protein 660.012
Vha68-1CG12403 gene product from transcript CG12403-RA0.011
KrnKeren0.011
Arc-p34CG10954 gene product from transcript CG10954-RA0.011
CatsupCatecholamines up0.011
inaCinactivation no afterpotential C0.011
Spn5Serine protease inhibitor 50.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sncgbsynuclein, gamma b (breast cancer-specific protein 1)0.499
calb2bcalbindin 2b, (calretinin)0.372
scn8aasodium channel, voltage-gated, type VIII, alpha a0.333
wnt3awingless-type MMTV integration site family, member 3A0.246
cdh6cadherin 60.167
gnao1aguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a0.092
sepp1aselenoprotein P, plasma, 1a0.081
rcv1recoverin0.076
chgachromogranin A0.069
wnt7bbwingless-type MMTV integration site family, member 7Bb0.066
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.065
dlg1discs, large (Drosophila) homolog 10.064
slc4a1asolute carrier family 4, anion exchanger, member 1a0.064
gngt1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 10.063
gnav1guanine nucleotide binding protein (G protein) alpha v10.061
crxcone-rod homeobox0.060
calb2acalbindin 2a0.058
pax9paired box gene 90.058
irx4airoquois homeobox protein 4a0.057
gna11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)0.057
pde6hphosphodiesterase 6H, cGMP-specific, cone, gamma0.057
mmp13amatrix metalloproteinase 13a0.056
gnb3bguanine nucleotide binding protein (G protein), beta polypeptide 3b0.055
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.052
kctd12.1potassium channel tetramerisation domain containing 12.10.052
wu:fb08e07wu:fb08e070.052
stmn2bstathmin-like 2b0.049
gnaqguanine nucleotide binding protein (G protein), q polypeptide0.048
zgc:73359zgc:733590.048
phox2apaired-like homeobox 2a0.047
rnf17ring finger protein 170.046
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.046
tcf21transcription factor 210.046
phox2bpaired-like homeobox 2b0.045
sfrp1bsecreted frizzled-related protein 1b0.045
ngbneuroglobin0.044
gnat1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 10.043
gna12guanine nucleotide binding protein (G protein) alpha 120.043
gnalguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type0.043
slc1a2bsolute carrier family 1 (glial high affinity glutamate transporter), member 2b0.043
guk1guanylate kinase 10.042
hoxa13ahomeo box A13a0.042
dnddead end0.042
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.041
sncbsynuclein, beta0.040
cadm3cell adhesion molecule 30.040
flot1flotillin 10.039
gnazguanine nucleotide binding protein (G protein), alpha z polypeptide0.038
alas2aminolevulinate, delta-, synthetase 20.038
nrarpanotch-regulated ankyrin repeat protein a0.038
islr2immunoglobulin superfamily containing leucine-rich repeat 20.038
LOC100000094hypothetical protein LOC1000000940.038
zgc:103663zgc:1036630.038
LOC563527brain-specific angiogenesis inhibitor 1-like0.038
cadm2acell adhesion molecule 2a0.038
si:dkey-174m14.3si:dkey-174m14.30.038
angptl2angiopoietin-like 20.036
wnt3wingless-type MMTV integration site family, member 30.036
rtcd1RNA terminal phosphate cyclase domain 10.036
ntd5ntl-dependent gene 50.036
olfm2olfactomedin 20.035
si:dkey-72l14.3si:dkey-72l14.30.035
s100tS100 calcium binding protein T0.034
s100zS100 calcium binding protein Z0.034
irbpinterphotoreceptor retinoid-binding protein0.034
prrx1bpaired related homeobox 1b0.034
efna2ephrin A20.034
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.033
fahfumarylacetoacetate hydrolase (fumarylacetoacetase)0.032
rhorhodopsin0.032
chrna6cholinergic receptor, nicotinic, alpha 60.032
kcnip1bKv channel interacting protein 1 b0.032
maptbmicrotubule-associated protein tau b0.032
sptbspectrin, beta, erythrocytic0.030
gnai2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.030
nrn1neuritin 10.030
cdr2lcerebellar degeneration-related protein 2-like0.030
olfm1aolfactomedin 1a0.030
hmx3homeo box (H6 family) 30.029
ncs1bneuronal calcium sensor 1b0.029
slc20a1asolute carrier family 20, member 1a0.028
lpar1lysophosphatidic acid receptor 10.028
mafv-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog0.028
opn1mw2opsin 1 (cone pigments), medium-wave-sensitive, 20.028
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.028
ndel1anudE nuclear distribution gene E homolog like 1 (A. nidulans) A0.028
cntn2contactin 20.027
rlbp1aretinaldehyde binding protein 1a0.027
zgc:92090zgc:920900.027
meis2.2myeloid ecotropic viral integration site 2.20.027
rp2retinitis pigmentosa 2 (X-linked recessive)0.027
snap25bsynaptosome-associated protein 25b0.027
atp1a3aATPase, Na+/K+ transporting, alpha 3a polypeptide0.027
arr3aarrestin 3a, retinal (X-arrestin)0.027
plxna4plexin A40.026
her9hairy-related 90.026
wu:fc85c01wu:fc85c010.026
zgc:194678zgc:1946780.026
scrt2scratch homolog 2, zinc finger protein (Drosophila)0.026
hapln3hyaluronan and proteoglycan link protein 30.026
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.454
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.439
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.427
TGFB1transforming growth factor, beta 10.144
DTNAdystrobrevin, alpha0.128
TCF4transcription factor 40.104
BTRCbeta-transducin repeat containing0.071
SYNMsynemin, intermediate filament protein0.069
BZW1basic leucine zipper and W2 domains 10.063
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.061
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.057
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.051
GLIS2GLIS family zinc finger 20.048
DTNBdystrobrevin, beta0.041
APCadenomatous polyposis coli0.038
CXCR5chemokine (C-X-C motif) receptor 50.033
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.031
PSEN1presenilin 10.026
ROD1ROD1 regulator of differentiation 1 (S. pombe)0.026
UTRNutrophin0.025
JUPjunction plakoglobin0.023
MAST1microtubule associated serine/threonine kinase 10.023
CADM1cell adhesion molecule 10.022
SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)0.022
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.021
YAP1Yes-associated protein 10.021
NONOnon-POU domain containing, octamer-binding0.019
NRASneuroblastoma RAS viral (v-ras) oncogene homolog0.019
DCTN2dynactin 2 (p50)0.018
GPSM2G-protein signaling modulator 20.018
GMFBglia maturation factor, beta0.017
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.016
PTK7PTK7 protein tyrosine kinase 70.016
ACTN4actinin, alpha 40.016
TGFB3transforming growth factor, beta 30.015
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.015
TGFBR1transforming growth factor, beta receptor 10.015
SKP1S-phase kinase-associated protein 10.015
HNRNPABheterogeneous nuclear ribonucleoprotein A/B0.015
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.015
AXIN1axin 10.015
PLD3phospholipase D family, member 30.015
RAB8ARAB8A, member RAS oncogene family0.014
RNF32ring finger protein 320.014
RGS19regulator of G-protein signaling 190.014
NCOA2nuclear receptor coactivator 20.014
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.014
PKP4plakophilin 40.014
EMDemerin0.014
ABCB4ATP-binding cassette, sub-family B (MDR/TAP), member 40.013
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.013
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.013
DR1down-regulator of transcription 1, TBP-binding (negative cofactor 2)0.013
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.013
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.013
ILKintegrin-linked kinase0.013
FAM82A2family with sequence similarity 82, member A20.013
ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 10.013
CTNNBIP1catenin, beta interacting protein 10.013
FSTL1follistatin-like 10.012
ARL6IP1ADP-ribosylation factor-like 6 interacting protein 10.012
GNB4guanine nucleotide binding protein (G protein), beta polypeptide 40.012
NCANneurocan0.012
NUMA1nuclear mitotic apparatus protein 10.012
HIC1hypermethylated in cancer 10.012
SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1-like0.012
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.012
ACVRL1activin A receptor type II-like 10.011
GNG2guanine nucleotide binding protein (G protein), gamma 20.011
PRKCAprotein kinase C, alpha0.011
FLNAfilamin A, alpha0.011
FLOT2flotillin 20.011
SYT9synaptotagmin IX0.011
CACNA1Bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.011
CAPZA1capping protein (actin filament) muscle Z-line, alpha 10.011
LARP1La ribonucleoprotein domain family, member 10.011
CBFBcore-binding factor, beta subunit0.011
ARRB2arrestin, beta 20.011
LEF1lymphoid enhancer-binding factor 10.011
STARD13StAR-related lipid transfer (START) domain containing 130.010
MPRIPmyosin phosphatase Rho interacting protein0.010
MYST2MYST histone acetyltransferase 20.010
OXSR1oxidative-stress responsive 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.594
Shhsonic hedgehog0.522
Dkk1dickkopf homolog 1 (Xenopus laevis)0.512
Lhx1LIM homeobox protein 10.399
Fgfr1fibroblast growth factor receptor 10.367
Wnt1wingless-related MMTV integration site 10.284
Gli3GLI-Kruppel family member GLI30.253
Trp53transformation related protein 530.244
Pax8paired box gene 80.243
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.225
Dab1disabled homolog 1 (Drosophila)0.214
Wnt4wingless-related MMTV integration site 40.172
Wnt3awingless-related MMTV integration site 3A0.161
Tgfb1transforming growth factor, beta 10.159
Rargretinoic acid receptor, gamma0.153
Fgf8fibroblast growth factor 80.147
Otx2orthodenticle homolog 2 (Drosophila)0.145
Apcadenomatosis polyposis coli0.144
Appamyloid beta (A4) precursor protein0.138
Pou3f3POU domain, class 3, transcription factor 30.121
Ptenphosphatase and tensin homolog0.120
Lrp6low density lipoprotein receptor-related protein 60.120
Sox9SRY-box containing gene 90.113
Celf4CUGBP, Elav-like family member 40.091
Bmp7bone morphogenetic protein 70.090
Gsk3bglycogen synthase kinase 3 beta0.085
Wnt10bwingless related MMTV integration site 10b0.073
D930020E02RikRIKEN cDNA D930020E02 gene0.067
Bmp4bone morphogenetic protein 40.065
Rarbretinoic acid receptor, beta0.063
Acvrl1activin A receptor, type II-like 10.063
Slc32a1solute carrier family 32 (GABA vesicular transporter), member 10.061
Dlx2distal-less homeobox 20.058
Fzd10frizzled homolog 10 (Drosophila)0.057
Dag1dystroglycan 10.054
Ece1endothelin converting enzyme 10.052
Hspg2perlecan (heparan sulfate proteoglycan 2)0.052
Dlx5distal-less homeobox 50.051
Ror2receptor tyrosine kinase-like orphan receptor 20.051
Gdnfglial cell line derived neurotrophic factor0.049
Mbmyoglobin0.049
Chl1cell adhesion molecule with homology to L1CAM0.048
Cdh10cadherin 100.048
Tbrachyury0.047
Fgf12fibroblast growth factor 120.044
Il6stinterleukin 6 signal transducer0.044
Abcb1aATP-binding cassette, sub-family B (MDR/TAP), member 1A0.043
Emx2empty spiracles homolog 2 (Drosophila)0.043
Ptpn11protein tyrosine phosphatase, non-receptor type 110.042
Adora3adenosine A3 receptor0.041
Onecut1one cut domain, family member 10.040
Epha5Eph receptor A50.040
Vstm2bV-set and transmembrane domain containing 2B0.040
Rspo2R-spondin 2 homolog (Xenopus laevis)0.040
Myt1myelin transcription factor 10.039
Porcnporcupine homolog (Drosophila)0.039
UncxUNC homeobox0.038
Cdh8cadherin 80.038
Foxc1forkhead box C10.038
Col22a1collagen, type XXII, alpha 10.037
Dync1i1dynein cytoplasmic 1 intermediate chain 10.037
Dll4delta-like 4 (Drosophila)0.036
Mogmyelin oligodendrocyte glycoprotein0.036
Pax7paired box gene 70.035
3110079O15RikRIKEN cDNA 3110079O15 gene0.034
Socs1suppressor of cytokine signaling 10.034
Ctnna2catenin (cadherin associated protein), alpha 20.033
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.033
Rac1RAS-related C3 botulinum substrate 10.033
Tgfbr2transforming growth factor, beta receptor II0.032
Ank1ankyrin 1, erythroid0.032
Insm1insulinoma-associated 10.031
Col13a1collagen, type XIII, alpha 10.031
Foxf2forkhead box F20.031
Vax1ventral anterior homeobox containing gene 10.030
Dlx1distal-less homeobox 10.030
Hoxb7homeobox B70.029
Cdx1caudal type homeobox 10.028
L1camL1 cell adhesion molecule0.028
Scn8asodium channel, voltage-gated, type VIII, alpha0.027
Alx4aristaless-like homeobox 40.027
Foxb1forkhead box B10.027
Ptprz1protein tyrosine phosphatase, receptor type Z, polypeptide 10.026
Rit2Ras-like without CAAX 20.026
Pax3paired box gene 30.026
Col1a1collagen, type I, alpha 10.026
Zfp651zinc finger protein 6510.025
Trp73transformation related protein 730.025
Stat3signal transducer and activator of transcription 30.024
Sstr1somatostatin receptor 10.024
Igfbpl1insulin-like growth factor binding protein-like 10.024
Lhx5LIM homeobox protein 50.024
Mmp24matrix metallopeptidase 240.024
Cnr1cannabinoid receptor 1 (brain)0.024
Ednraendothelin receptor type A0.023
Ctnnd2catenin (cadherin associated protein), delta 20.023
Accn1amiloride-sensitive cation channel 1, neuronal (degenerin)0.023
Nrg3neuregulin 30.022
Khdrbs2KH domain containing, RNA binding, signal transduction associated 20.022
Acanaggrecan0.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism