The network for 'appendage development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

appendage development

The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.

NameDescriptionProbabilityFunc Analog Organism
Rho1CG8416 gene product from transcript CG8416-RB1.000
mysmyospheroid1.000
fzfrizzled0.999
araaraucan0.998
gbbglass bottom boat0.998
emcextra macrochaetae0.997
Rac1CG2248 gene product from transcript CG2248-RA0.994
lolalongitudinals lacking0.992
fjfour-jointed0.991
argosCG4531 gene product from transcript CG4531-RA0.990
hhhedgehog0.990
howheld out wings0.988
mammastermind0.987
fngfringe0.987
dallydivision abnormally delayed0.985
ash2absent, small, or homeotic discs 20.978
twstwins0.976
hipkhomeodomain interacting protein kinase0.976
dshdishevelled0.973
fz2frizzled 20.973
rlrolled0.972
SerSerrate0.972
Ras85DRas oncogene at 85D0.972
TolloCG6890 gene product from transcript CG6890-RA0.967
rhorhomboid0.966
shgshotgun0.964
Gap1GTPase-activating protein 10.962
EgfrEpidermal growth factor receptor0.959
ttvtout-velu0.954
armarmadillo0.953
mewmultiple edematous wings0.950
sbbscribbler0.949
Src64BSrc oncogene at 64B0.948
LanB1CG7123 gene product from transcript CG7123-RA0.947
EcREcdysone receptor0.943
CG32372CG32372 gene product from transcript CG32372-RA0.942
MoeMoesin0.939
edechinoid0.938
Lim3CG10699 gene product from transcript CG10699-RB0.938
chicchickadee0.936
spispitz0.935
eyaeyes absent0.935
Mkp3Mitogen-activated protein kinase phosphatase 30.933
dacdachshund0.932
dvedefective proventriculus0.932
SnooSno oncogene0.927
shashavenoid0.926
DadDaughters against dpp0.925
mirrmirror0.923
Akt1CG4006 gene product from transcript CG4006-RA0.922
dcodiscs overgrown0.922
Bre1CG10542 gene product from transcript CG10542-RA0.918
eygeyegone0.918
ifinflated0.915
apapterous0.914
SsdpSequence-specific single-stranded DNA-binding protein0.910
alaristaless0.908
ababrupt0.905
sglsugarless0.902
Su(H)Suppressor of Hairless0.899
BxBeadex0.896
hephhephaestus0.891
bibifid0.889
mxcmulti sex combs0.889
vvlventral veins lacking0.883
rokRho-kinase0.877
neurneuralized0.875
PknProtein kinase related to protein kinase N0.874
wgwingless0.872
dsdachsous0.869
drkdownstream of receptor kinase0.867
nctnicastrin0.866
ctcut0.863
G-oalpha47AG protein oalpha 47A0.859
cswcorkscrew0.857
sdscalloped0.857
crbcrumbs0.849
rgrugose0.846
knknot0.845
hthhomothorax0.843
DllDistal-less0.836
sogshort gastrulation0.835
ftfat0.833
eyeyeless0.830
osoutstretched0.825
PakPAK-kinase0.825
JIL-1CG6297 gene product from transcript CG6297-RA0.818
Mob2CG11711 gene product from transcript CG11711-RC0.814
O-fut1O-fucosyltransferase 10.806
kuzkuzbanian0.804
tkvthickveins0.802
CkIalphaCasein kinase Ialpha0.794
Sema-1aCG18405 gene product from transcript CG18405-RD0.793
Sp1CG1343 gene product from transcript CG1343-RB0.793
MYPT-75DCG6896 gene product from transcript CG6896-RA0.789
foxoforkhead box, sub-group O0.783
smt3CG4494 gene product from transcript CG4494-RA0.781
Doc2Dorsocross20.779
MadMothers against dpp0.777
Cul-3Cullin-30.774
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fgf8afibroblast growth factor 8 a0.999
chdchordin0.998
bmp2bbone morphogenetic protein 2b0.994
bmp2abone morphogenetic protein 2a0.991
hoxc8ahomeo box C8a0.989
prdm1aPR domain containing 1a, with ZNF domain0.989
bmp4bone morphogenetic protein 40.984
tfap2atranscription factor AP-2 alpha0.983
hoxa9ahomeo box A9a0.983
shhasonic hedgehog a0.981
hoxc4ahomeo box C4a0.980
fgf3fibroblast growth factor 30.976
pax2apaired box gene 2a0.975
twist3twist30.961
bmp1abone morphogenetic protein 1a0.957
cdh2cadherin 2, neuronal0.955
msxcmuscle segment homeobox C0.955
hoxc6ahomeo box C6a0.953
wnt5bwingless-type MMTV integration site family, member 5b0.952
col1a1acollagen, type I, alpha 1a0.946
frem2aFras1 related extracellular matrix protein 2a0.945
hoxb1bhomeo box B1b0.943
eve1even-skipped-like10.940
hoxb5bhomeo box B5b0.938
eya1eyes absent homolog 10.936
tbx2bT-box 2b0.923
hoxa13bhomeo box A13b0.910
gbx2gastrulation brain homeo box 20.910
fgf24fibroblast growth factor 240.905
tbx18T-box 180.886
dlx4bdistal-less homeobox gene 4b0.886
hnf1baHNF1 homeobox Ba0.883
hoxa9bhomeo box A9b0.883
gscgoosecoid0.881
rarabretinoic acid receptor, alpha b0.878
fgf10afibroblast growth factor 10a0.875
hoxa5ahomeo box A5a0.875
hoxa11bhomeo box A11b0.851
fn1fibronectin 10.847
hoxd10ahomeo box D10a0.845
bocbrother of CDO0.843
hoxd4ahomeo box D4a0.843
crabp2acellular retinoic acid binding protein 2, a0.828
cdx4caudal type homeo box transcription factor 40.811
tbx1T-box 10.808
lef1lymphocyte enhancer binding factor 10.804
ptch1patched 10.786
fras1Fraser syndrome 10.775
six4asine oculis homeobox homolog 4a0.761
msxbmuscle segment homeobox B0.751
mibmind bomb0.747
atoh1aatonal homolog 1a0.733
frem1aFras1 related extracellular matrix 1a0.719
robo3roundabout homolog 30.719
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.708
hoxc9ahomeo box C9a0.701
dlx4adistal-less homeobox gene 4a0.694
szlsizzled0.688
hoxb3ahomeo box B3a0.684
msxdmuscle segment homeobox D0.682
hoxb5ahomeo box B5a0.675
vcanaversican a0.672
sox9aSRY-box containing gene 9a0.671
hoxb6ahomeo box B6a0.670
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.653
tcf7transcription factor 7 (T-cell specific, HMG-box)0.645
myf5myogenic factor 50.645
flhfloating head0.640
pou5f1POU domain, class 5, transcription factor 10.636
twist1btwist1b0.633
hoxb6bhomeo box B6b0.631
lama5laminin, alpha 50.630
neo1neogenin 10.615
evx1even-skipped homeobox 10.613
hmx4H6 family homeobox 40.612
col5a1procollagen, type V, alpha 10.608
dlx5adistal-less homeobox gene 5a0.602
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.601
itga3bintegrin, alpha 3b0.600
pcsk5bproprotein convertase subtilisin/kexin type 5b0.586
aldh1a2aldehyde dehydrogenase 1 family, member A20.586
rx2retinal homeobox gene 20.586
isl2aislet2a0.579
vsx2visual system homeobox 20.568
pax6bpaired box gene 6b0.544
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.540
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.530
msxemuscle segment homeobox E0.525
meis2.1myeloid ecotropic viral integration site 2.10.522
pcdh8protocadherin 80.516
vcanbversican b0.516
hoxd11ahomeo box D11a0.516
fstafollistatin a0.505
ccm2cerebral cavernous malformation 20.503
pax9paired box gene 90.502
myod1myogenic differentiation 10.493
wnt3awingless-type MMTV integration site family, member 3A0.491
irx3airoquois homeobox protein 3a0.485
edn1endothelin 10.484
six4bsine oculis homeobox homolog 4b0.478
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
FHL2four and a half LIM domains 20.976
ZNF43zinc finger protein 430.867
SMAD3SMAD family member 30.827
JAG1jagged 10.621
TGFB1transforming growth factor, beta 10.550
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.548
SUFUsuppressor of fused homolog (Drosophila)0.526
ZNF253zinc finger protein 2530.436
FN1fibronectin 10.420
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.401
ENGendoglin0.398
ZNF273zinc finger protein 2730.380
ZNF675zinc finger protein 6750.299
COL1A1collagen, type I, alpha 10.288
MEIS1Meis homeobox 10.272
BMP2bone morphogenetic protein 20.271
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.260
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.241
SKILSKI-like oncogene0.231
LAMC1laminin, gamma 1 (formerly LAMB2)0.180
PAX3paired box 30.155
ZNF91zinc finger protein 910.151
BMP1bone morphogenetic protein 10.129
COL7A1collagen, type VII, alpha 10.127
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.126
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.124
HDAC1histone deacetylase 10.117
COL6A1collagen, type VI, alpha 10.114
BMPR1Abone morphogenetic protein receptor, type IA0.112
ZNF708zinc finger protein 7080.111
HOXA10homeobox A100.109
FBLN1fibulin 10.105
TGFBR1transforming growth factor, beta receptor 10.101
CHRDchordin0.099
ZNF430zinc finger protein 4300.091
PDZD11PDZ domain containing 110.087
MMP14matrix metallopeptidase 14 (membrane-inserted)0.086
ATN1atrophin 10.085
PSEN1presenilin 10.084
ZNF85zinc finger protein 850.080
FLNAfilamin A, alpha0.080
ZNF93zinc finger protein 930.080
SMAD4SMAD family member 40.073
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.071
GDF5growth differentiation factor 50.071
PPARAperoxisome proliferator-activated receptor alpha0.070
ACVR1activin A receptor, type I0.069
CHD7chromodomain helicase DNA binding protein 70.069
HOXC8homeobox C80.066
BMPR1Bbone morphogenetic protein receptor, type IB0.064
MEIS2Meis homeobox 20.061
GATA4GATA binding protein 40.057
ARRB1arrestin, beta 10.057
BMP4bone morphogenetic protein 40.056
HOXD13homeobox D130.056
BMP7bone morphogenetic protein 70.056
HOXC11homeobox C110.055
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.054
THBS1thrombospondin 10.054
FGF10fibroblast growth factor 100.054
FSTL1follistatin-like 10.053
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.052
ZNF117zinc finger protein 1170.050
TLN1talin 10.049
HOXD9homeobox D90.049
RXRAretinoid X receptor, alpha0.048
CHD4chromodomain helicase DNA binding protein 40.048
RARGretinoic acid receptor, gamma0.047
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.047
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.047
NCOR2nuclear receptor corepressor 20.046
TJP1tight junction protein 1 (zona occludens 1)0.044
COL2A1collagen, type II, alpha 10.044
RBBP4retinoblastoma binding protein 40.044
EPS8epidermal growth factor receptor pathway substrate 80.044
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.043
SOX2SRY (sex determining region Y)-box 20.040
FKBP1AFK506 binding protein 1A, 12kDa0.040
SIN3ASIN3 homolog A, transcription regulator (yeast)0.039
SETD8SET domain containing (lysine methyltransferase) 80.038
DLX4distal-less homeobox 40.038
RAB14RAB14, member RAS oncogene family0.038
ATP6V1G1ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G10.038
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.037
DLX5distal-less homeobox 50.036
BAK1BCL2-antagonist/killer 10.036
LBX1ladybird homeobox 10.036
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.036
ZNF254zinc finger protein 2540.036
APPamyloid beta (A4) precursor protein0.035
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.033
WNT1wingless-type MMTV integration site family, member 10.033
PIAS1protein inhibitor of activated STAT, 10.033
FOXF2forkhead box F20.032
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D0.031
NGFRnerve growth factor receptor0.031
LRP6low density lipoprotein receptor-related protein 60.031
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.031
COL1A2collagen, type I, alpha 20.029
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Shhsonic hedgehog1.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Rargretinoic acid receptor, gamma1.000
Foxc1forkhead box C11.000
Pitx2paired-like homeodomain transcription factor 21.000
Sox2SRY-box containing gene 21.000
Pax6paired box gene 61.000
Pax2paired box gene 21.000
Fgfr2fibroblast growth factor receptor 21.000
Gli2GLI-Kruppel family member GLI21.000
Bmp7bone morphogenetic protein 71.000
Fgf10fibroblast growth factor 101.000
Msx2homeobox, msh-like 21.000
Pax3paired box gene 30.999
Hand1heart and neural crest derivatives expressed transcript 10.999
Hoxa10homeobox A100.999
Wnt5awingless-related MMTV integration site 5A0.999
Hoxa13homeobox A130.999
Ptenphosphatase and tensin homolog0.999
Hoxd11homeobox D110.998
Nognoggin0.998
Pbx1pre B-cell leukemia transcription factor 10.998
Fgfr1fibroblast growth factor receptor 10.998
Prrx1paired related homeobox 10.998
Ror2receptor tyrosine kinase-like orphan receptor 20.998
Msx1homeobox, msh-like 10.997
Emx2empty spiracles homolog 2 (Drosophila)0.997
Hoxa11homeobox A110.996
Tbx3T-box 30.995
Wnt3awingless-related MMTV integration site 3A0.995
Fgf8fibroblast growth factor 80.995
Emx1empty spiracles homolog 1 (Drosophila)0.994
Fgfr3fibroblast growth factor receptor 30.994
Tcfap2atranscription factor AP-2, alpha0.993
Rararetinoic acid receptor, alpha0.992
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.992
Col1a1collagen, type I, alpha 10.991
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.990
Rarbretinoic acid receptor, beta0.990
Hoxd13homeobox D130.989
Lef1lymphoid enhancer binding factor 10.987
Isl1ISL1 transcription factor, LIM/homeodomain0.987
Chrdchordin0.987
Smosmoothened homolog (Drosophila)0.986
Dlx5distal-less homeobox 50.985
Trp53transformation related protein 530.984
Alx4aristaless-like homeobox 40.984
Sox9SRY-box containing gene 90.983
Sox11SRY-box containing gene 110.982
Gscgoosecoid homeobox0.980
Hoxa5homeobox A50.978
Dkk1dickkopf homolog 1 (Xenopus laevis)0.977
Pcsk5proprotein convertase subtilisin/kexin type 50.974
Gbx2gastrulation brain homeobox 20.972
Sall4sal-like 4 (Drosophila)0.972
Ptch1patched homolog 10.969
Otx1orthodenticle homolog 1 (Drosophila)0.969
Twist2twist homolog 2 (Drosophila)0.964
Eya1eyes absent 1 homolog (Drosophila)0.961
Gas1growth arrest specific 10.961
Hoxd3homeobox D30.959
Rxraretinoid X receptor alpha0.959
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.958
Nodalnodal0.956
Lhx3LIM homeobox protein 30.956
Foxc2forkhead box C20.953
Psen1presenilin 10.951
Hand2heart and neural crest derivatives expressed transcript 20.949
Tbx15T-box 150.948
Acvr1activin A receptor, type 10.947
Hoxd10homeobox D100.939
Col2a1collagen, type II, alpha 10.939
Gdf5growth differentiation factor 50.938
Foxh1forkhead box H10.932
Tcfap2ctranscription factor AP-2, gamma0.928
Ctnnb1catenin (cadherin associated protein), beta 10.928
Smad3MAD homolog 3 (Drosophila)0.924
Wt1Wilms tumor 1 homolog0.924
Thrathyroid hormone receptor alpha0.924
Neurog3neurogenin 30.920
Wnt6wingless-related MMTV integration site 60.914
Hoxa9homeobox A90.912
Bmp4bone morphogenetic protein 40.911
Prrx2paired related homeobox 20.909
Pax8paired box gene 80.906
Ascl1achaete-scute complex homolog 1 (Drosophila)0.903
Hes1hairy and enhancer of split 1 (Drosophila)0.901
Lmx1aLIM homeobox transcription factor 1 alpha0.901
Efna2ephrin A20.893
Pou3f3POU domain, class 3, transcription factor 30.890
Hoxb3homeobox B30.885
Kitkit oncogene0.884
Ptf1apancreas specific transcription factor, 1a0.883
En1engrailed 10.880
Fgf9fibroblast growth factor 90.873
Trp63transformation related protein 630.868
Gdf11growth differentiation factor 110.854
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.852
Fgf15fibroblast growth factor 150.851
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nfianuclear factor I/A0.017
Nedd4neural precursor cell expressed, developmentally down-regulated 40.017
Col12a1collagen, type XII, alpha 10.013
Lef1lymphoid enhancer binding factor 10.013
Col3a1collagen, type III, alpha 10.011
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism