The network for 'kidney development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

kidney development

The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.

NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.979
EgfrEpidermal growth factor receptor0.978
eyaeyes absent0.931
E(spl)Enhancer of split0.921
bowlbrother of odd with entrails limited0.834
snssticks and stones0.791
DadDaughters against dpp0.748
HLHmdeltaE(spl) region transcript mdelta0.742
rheaCG6831 gene product from transcript CG6831-RA0.641
mbcmyoblast city0.614
Fas2Fasciclin 20.592
Cg25CCollagen type IV0.559
plexAplexin A0.556
HLHm7E(spl) region transcript m70.553
Stat92ESignal-transducer and activator of transcription protein at 92E0.480
m2E(spl) region transcript m20.466
gcmglial cells missing0.456
rolsrolling pebbles0.450
Irk2Inwardly rectifying potassium channel 20.434
HLHmgammaE(spl) region transcript mgamma0.433
HLHmbetaE(spl) region transcript mbeta0.403
Cyp316a1CG8540 gene product from transcript CG8540-RA0.390
HLHm3E(spl) region transcript m30.390
Wnt2Wnt oncogene analog 20.324
salmspalt major0.323
nocno ocelli0.301
nrv2nervana 20.288
TomTwin of m40.282
LanB2Laminin B20.274
opaodd paired0.265
wbwing blister0.264
gbbglass bottom boat0.257
18w18 wheeler0.253
shotshort stop0.249
Ptp69DProtein tyrosine phosphatase 69D0.249
Pink1PTEN-induced putative kinase 10.242
Syx1ASyntaxin 1A0.242
Akap200A kinase anchor protein 2000.241
Mlp84BMuscle LIM protein at 84B0.238
argosCG4531 gene product from transcript CG4531-RA0.227
stanstarry night0.225
sosine oculis0.215
cv-2crossveinless 20.214
TolloCG6890 gene product from transcript CG6890-RA0.205
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.987
notch1anotch homolog 1a0.986
shhasonic hedgehog a0.984
jag2jagged 20.978
pax2apaired box gene 2a0.977
ift88intraflagellar transport 88 homolog0.962
osr1odd-skipped related 1 (Drosophila)0.957
lmx1b.1LIM homeobox transcription factor 1, beta 10.935
hnf1baHNF1 homeobox Ba0.931
wnt2bbwingless-type MMTV integration site family, member 2Bb0.907
lef1lymphocyte enhancer binding factor 10.871
gli1GLI-Kruppel family member 10.869
rfx2regulatory factor X, 2 (influences HLA class II expression)0.844
osr2odd-skipped related 2 (Drosophila)0.821
eya1eyes absent homolog 10.803
hand2heart and neural crest derivatives expressed transcript 20.793
wt1bwilms tumor 1b0.791
flhfloating head0.786
fgfr1afibroblast growth factor receptor 1a0.779
bmp4bone morphogenetic protein 40.775
rarabretinoic acid receptor, alpha b0.768
cdh2cadherin 2, neuronal0.765
mecomMDS1 and EVI1 complex locus0.763
dusp6dual specificity phosphatase 60.756
tgfb3transforming growth factor, beta 30.736
pea3ETS-domain transcription factor pea30.722
jag1bjagged 1b0.715
tbx2aT-box gene 2a0.710
gdnfglial cell derived neurotrophic factor0.710
kif17kinesin family member 170.675
six4bsine oculis homeobox homolog 4b0.658
nkx2.3NK2 transcription factor related 30.657
fstafollistatin a0.637
ntlano tail a0.636
sim1asingle-minded homolog 1a (Drosophila)0.636
notch3notch homolog 30.620
sema3aasemaphorin 3aa0.613
lrrc6leucine rich repeat containing 60.611
slc4a4asolute carrier family 4, member 4a0.600
wt1awilms tumor 1a0.600
notch2notch homolog 20.595
emx3empty spiracles homeobox 30.585
hey2hairy/enhancer-of-split related with YRPW motif 20.584
kdrlkinase insert domain receptor like0.568
her12hairy-related 120.547
ndr1nodal-related 10.546
tal1T-cell acute lymphocytic leukemia 10.544
emx1empty spiracles homeobox 10.533
gdf6agrowth differentiation factor 6a0.526
wlswntless homolog (Drosophila)0.524
bmp2abone morphogenetic protein 2a0.522
ptgs1prostaglandin-endoperoxide synthase 10.515
ndr2nodal-related 20.508
fgf10afibroblast growth factor 10a0.491
lhx2bLIM homeobox 2b0.491
oepone-eyed pinhead0.490
lmo4aLIM domain only 4a0.486
gbx2gastrulation brain homeo box 20.480
lrrc50leucine rich repeat containing 500.467
hnf1bbHNF1 homeobox Bb0.466
cdh1cadherin 1, epithelial0.465
bmp2bbone morphogenetic protein 2b0.462
wtipWilms tumor 1 interacting protein0.447
epha4aeph receptor A4a0.443
wnt11wingless-type MMTV integration site family, member 110.434
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.420
sox10SRY-box containing gene 100.415
wnt3awingless-type MMTV integration site family, member 3A0.413
rasl11bRAS-like, family 11, member B0.410
runx3runt-related transcription factor 30.410
metmet proto-oncogene (hepatocyte growth factor receptor)0.403
tbx16T-box gene 160.403
gli2aGLI-Kruppel family member GLI2a0.397
lhx1aLIM homeobox 1a0.394
nf1aneurofibromin 1a0.356
pdgfaaplatelet-derived growth factor alpha a0.352
bocbrother of CDO0.351
nkx2.5NK2 transcription factor related 50.347
fzd7bfrizzled homolog 7b0.344
foxj1aforkhead box J1a0.343
gpr126G protein-coupled receptor 1260.342
aplnrbapelin receptor b0.340
nrp1aneuropilin 1a0.335
ccbe1collagen and calcium binding EGF domains 10.330
fgfr1bfibroblast growth factor receptor 1b0.327
fzd7afrizzled homolog 7a0.324
hoxc8ahomeo box C8a0.322
wnt2bawingless-type MMTV integration site family, member 2Ba0.310
wnt8bwingless-type MMTV integration site family, member 8b0.300
cdh5cadherin 50.297
cyp26a1cytochrome P450, subfamily XXVIA, polypeptide 10.294
fgf4fibroblast growth factor 40.294
ptch1patched 10.291
fgfr4fibroblast growth factor receptor 40.291
lrp2low density lipoprotein-related protein 20.285
irx4biroquois homeobox protein 4b0.283
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMAD2SMAD family member 21.000
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.999
SMAD3SMAD family member 30.999
FGFR2fibroblast growth factor receptor 20.999
NOTCH1notch 10.998
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.998
VEGFAvascular endothelial growth factor A0.997
FHL2four and a half LIM domains 20.996
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.993
FN1fibronectin 10.984
TAL1T-cell acute lymphocytic leukemia 10.983
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.974
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.974
SKILSKI-like oncogene0.972
JAG1jagged 10.970
COL4A2collagen, type IV, alpha 20.968
RB1retinoblastoma 10.932
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.926
CASP3caspase 3, apoptosis-related cysteine peptidase0.911
SMAD7SMAD family member 70.904
DVL3dishevelled, dsh homolog 3 (Drosophila)0.865
BCL9B-cell CLL/lymphoma 90.851
THBS1thrombospondin 10.786
ADRB1adrenergic, beta-1-, receptor0.786
PLCG1phospholipase C, gamma 10.781
NOTCH3notch 30.775
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.759
TP53tumor protein p530.756
LAPTM5lysosomal protein transmembrane 50.753
PTPRCprotein tyrosine phosphatase, receptor type, C0.746
CUL3cullin 30.726
NRP1neuropilin 10.683
SMAD4SMAD family member 40.670
METmet proto-oncogene (hepatocyte growth factor receptor)0.666
MEIS1Meis homeobox 10.659
PAX8paired box 80.653
ARandrogen receptor0.645
TEKTEK tyrosine kinase, endothelial0.643
SMAD1SMAD family member 10.628
DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A0.620
FGFR1fibroblast growth factor receptor 10.619
KLHL12kelch-like 12 (Drosophila)0.608
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.595
FGF1fibroblast growth factor 1 (acidic)0.595
CREBBPCREB binding protein0.592
TIMP3TIMP metallopeptidase inhibitor 30.591
RXRAretinoid X receptor, alpha0.590
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.570
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.568
ZNF512Bzinc finger protein 512B0.556
EGR2early growth response 20.548
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.529
TCF4transcription factor 40.509
COL4A4collagen, type IV, alpha 40.504
WNK4WNK lysine deficient protein kinase 40.490
EGR3early growth response 30.489
TLN1talin 10.458
COL2A1collagen, type II, alpha 10.453
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.450
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.425
COL4A5collagen, type IV, alpha 50.411
PKD2polycystic kidney disease 2 (autosomal dominant)0.410
GATA2GATA binding protein 20.399
WNT1wingless-type MMTV integration site family, member 10.397
DYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B0.394
COL1A1collagen, type I, alpha 10.393
FGF10fibroblast growth factor 100.380
COL4A1collagen, type IV, alpha 10.372
COL4A6collagen, type IV, alpha 60.367
GLIS2GLIS family zinc finger 20.363
UHRF2ubiquitin-like with PHD and ring finger domains 20.335
TSC2tuberous sclerosis 20.335
STC1stanniocalcin 10.332
BMPR1Abone morphogenetic protein receptor, type IA0.332
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.324
CALD1caldesmon 10.322
KLHL3kelch-like 3 (Drosophila)0.311
IGFBP5insulin-like growth factor binding protein 50.308
CTGFconnective tissue growth factor0.308
MEOX1mesenchyme homeobox 10.306
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.305
HEYLhairy/enhancer-of-split related with YRPW motif-like0.304
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.301
PRMT2protein arginine methyltransferase 20.301
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.295
FAF1Fas (TNFRSF6) associated factor 10.295
FOXF1forkhead box F10.294
SMURF2SMAD specific E3 ubiquitin protein ligase 20.294
NKX2-1NK2 homeobox 10.291
PTGISprostaglandin I2 (prostacyclin) synthase0.290
TGFB2transforming growth factor, beta 20.287
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.284
BMP2bone morphogenetic protein 20.275
MYOD1myogenic differentiation 10.273
DAPK1death-associated protein kinase 10.272
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.266
BMP4bone morphogenetic protein 40.265
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax2paired box gene 21.000
Fgfr2fibroblast growth factor receptor 21.000
Shhsonic hedgehog1.000
Wt1Wilms tumor 1 homolog1.000
Gli3GLI-Kruppel family member GLI31.000
Retret proto-oncogene1.000
Nos3nitric oxide synthase 3, endothelial cell1.000
Bmp4bone morphogenetic protein 41.000
Fgfr1fibroblast growth factor receptor 11.000
Bcl2B-cell leukemia/lymphoma 21.000
Pdgfraplatelet derived growth factor receptor, alpha polypeptide1.000
Lhx1LIM homeobox protein 11.000
Pax8paired box gene 81.000
Ptenphosphatase and tensin homolog1.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Hoxd11homeobox D110.999
Foxc1forkhead box C10.999
Gdnfglial cell line derived neurotrophic factor0.999
Rargretinoic acid receptor, gamma0.999
Foxc2forkhead box C20.999
Pbx1pre B-cell leukemia transcription factor 10.998
Jag1jagged 10.998
Pkd1polycystic kidney disease 1 homolog0.998
Pax6paired box gene 60.998
Hoxa11homeobox A110.998
Itgb1integrin beta 1 (fibronectin receptor beta)0.997
Gata4GATA binding protein 40.997
Fgf8fibroblast growth factor 80.997
Efnb2ephrin B20.997
Sox9SRY-box containing gene 90.995
Ptgs2prostaglandin-endoperoxide synthase 20.994
Vegfavascular endothelial growth factor A0.994
Ctnnb1catenin (cadherin associated protein), beta 10.994
Tcf21transcription factor 210.993
Smad6MAD homolog 6 (Drosophila)0.993
Emx2empty spiracles homolog 2 (Drosophila)0.992
Slc12a1solute carrier family 12, member 10.992
Pitx2paired-like homeodomain transcription factor 20.990
Notch1Notch gene homolog 1 (Drosophila)0.988
Arandrogen receptor0.987
Bicc1bicaudal C homolog 1 (Drosophila)0.986
Ror2receptor tyrosine kinase-like orphan receptor 20.986
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.985
Tbx3T-box 30.985
Isl1ISL1 transcription factor, LIM/homeodomain0.985
Mks1Meckel syndrome, type 10.984
Hoxd13homeobox D130.983
Gas1growth arrest specific 10.981
Fgfr3fibroblast growth factor receptor 30.980
Sox2SRY-box containing gene 20.980
Pcsk5proprotein convertase subtilisin/kexin type 50.980
Wnt5awingless-related MMTV integration site 5A0.977
Hes1hairy and enhancer of split 1 (Drosophila)0.976
Hoxa13homeobox A130.976
Tbx2T-box 20.975
Otx2orthodenticle homolog 2 (Drosophila)0.975
Col4a3collagen, type IV, alpha 30.975
Agtr2angiotensin II receptor, type 20.970
Kif3akinesin family member 3A0.970
Tgfbr2transforming growth factor, beta receptor II0.969
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.968
Hand2heart and neural crest derivatives expressed transcript 20.967
Rarbretinoic acid receptor, beta0.964
Rxraretinoid X receptor alpha0.963
Hes5hairy and enhancer of split 5 (Drosophila)0.962
Ptk7PTK7 protein tyrosine kinase 70.961
Hoxa10homeobox A100.961
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.953
Nkx2-1NK2 homeobox 10.950
Lama5laminin, alpha 50.950
Psen1presenilin 10.947
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.945
Gata6GATA binding protein 60.944
Prrx1paired related homeobox 10.942
Notch3Notch gene homolog 3 (Drosophila)0.939
Onecut1one cut domain, family member 10.938
Pax3paired box gene 30.937
Ren1renin 1 structural0.936
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.935
Trp63transformation related protein 630.934
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.934
Otx1orthodenticle homolog 1 (Drosophila)0.933
Dkk1dickkopf homolog 1 (Xenopus laevis)0.931
Flt4FMS-like tyrosine kinase 40.929
Meox2mesenchyme homeobox 20.928
Foxh1forkhead box H10.927
Lamc1laminin, gamma 10.925
Foxf1aforkhead box F1a0.924
Hoxa1homeobox A10.923
Dll1delta-like 1 (Drosophila)0.920
Kdrkinase insert domain protein receptor0.911
Fgf15fibroblast growth factor 150.907
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.906
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.904
Ascl1achaete-scute complex homolog 1 (Drosophila)0.898
Fgf9fibroblast growth factor 90.896
Gpc3glypican 30.893
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col12a1collagen, type XII, alpha 10.516
Col1a2collagen, type I, alpha 20.496
Aebp1AE binding protein 10.476
Bcl2B-cell CLL/lymphoma 20.420
Itpr2inositol 1,4,5-triphosphate receptor, type 20.416
Col3a1collagen, type III, alpha 10.392
Ednraendothelin receptor type A0.344
Flt1FMS-related tyrosine kinase 10.341
Col1a1collagen, type I, alpha 10.330
C1scomplement component 1, s subcomponent0.310
Smad7SMAD family member 70.269
Fgfr2fibroblast growth factor receptor 20.263
Cpzcarboxypeptidase Z0.249
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.247
Adrb1adrenergic, beta-1-, receptor0.245
DbpD site of albumin promoter (albumin D-box) binding protein0.235
Myh13myosin, heavy chain 13, skeletal muscle0.227
Htra3HtrA serine peptidase 30.210
Cmklr1chemokine-like receptor 10.209
Nek9NIMA (never in mitosis gene a)- related kinase 90.199
FcgrtFc fragment of IgG, receptor, transporter, alpha0.191
Tcf4transcription factor 40.184
Lim2lens intrinsic membrane protein 20.179
Ppap2bphosphatidic acid phosphatase type 2B0.179
Nfibnuclear factor I/B0.169
Tgfbr3transforming growth factor, beta receptor III0.168
Rararetinoic acid receptor, alpha0.168
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.160
Cpxm1carboxypeptidase X (M14 family), member 10.158
Has2hyaluronan synthase 20.157
Nfianuclear factor I/A0.156
Olfml3olfactomedin-like 30.147
Krt5keratin 50.147
Gja5gap junction protein, alpha 50.145
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.144
Gata3GATA binding protein 30.141
Baiap2BAI1-associated protein 20.140
Nr1d2nuclear receptor subfamily 1, group D, member 20.137
Ghrgrowth hormone receptor0.137
Npy5rneuropeptide Y receptor Y50.135
Tgfbr2transforming growth factor, beta receptor II0.133
Pou2f3POU class 2 homeobox 30.131
Trhr2thyrotropin releasing hormone receptor 20.129
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.129
Egr2early growth response 20.127
Irs1insulin receptor substrate 10.124
FosFBJ osteosarcoma oncogene0.119
Ctskcathepsin K0.118
Sod3superoxide dismutase 3, extracellular0.115
Il13ra1interleukin 13 receptor, alpha 10.115
Aqp4aquaporin 40.113
Degs2degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)0.112
Ccdc80coiled-coil domain containing 800.108
Lamc1laminin, gamma 10.106
Plauplasminogen activator, urokinase0.106
Agtr1aangiotensin II receptor, type 1a0.105
Angptl2angiopoietin-like 20.104
Igfbp5insulin-like growth factor binding protein 50.104
Ephx1epoxide hydrolase 1, microsomal0.104
Slc34a1solute carrier family 34 (sodium phosphate), member 10.104
Akap4A kinase (PRKA) anchor protein 40.102
RGD1308165similar to hypothetical protein MGC173370.101
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.099
Ahraryl hydrocarbon receptor0.099
Slit3slit homolog 3 (Drosophila)0.096
C7complement component 70.096
Pnliprp2pancreatic lipase-related protein 20.096
Psbpc1prostatic steroid binding protein C10.096
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.095
Muc5acmucin 5AC, oligomeric mucus/gel-forming0.094
Aqp2aquaporin 2 (collecting duct)0.094
Phexphosphate regulating endopeptidase homolog, X-linked0.094
Agtr2angiotensin II receptor, type 20.094
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.092
Fgf16fibroblast growth factor 160.092
C1qbcomplement component 1, q subcomponent, B chain0.090
Nos3nitric oxide synthase 3, endothelial cell0.090
Arandrogen receptor0.090
Mpeg1macrophage expressed 10.090
Gpr182G protein-coupled receptor 1820.090
Dchs1dachsous 1 (Drosophila)0.089
Cd46CD46 molecule, complement regulatory protein0.089
Crxcone-rod homeobox0.088
Ctla4cytotoxic T-lymphocyte-associated protein 40.086
P22k15cystatin related protein 20.086
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.085
Jak2Janus kinase 20.085
Col9a1collagen, type IX, alpha 10.085
Lgals7lectin, galactoside-binding, soluble, 70.083
Col14a1collagen, type XIV, alpha 10.083
Cyp51cytochrome P450, family 510.081
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism