The network for 'actin filament capping' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

actin filament capping

The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.

NameDescriptionProbabilityFunc Analog Organism
wupAwings up A0.588
Arp66BActin-related protein 66B0.438
cpacapping protein alpha0.337
Sop2Suppressor of profilin 20.183
CortactinCG3637 gene product from transcript CG3637-RA0.138
sec6CG5341 gene product from transcript CG5341-RA0.137
sqhspaghetti squash0.136
flrflare0.109
CG11299CG11299 gene product from transcript CG11299-RA0.106
cpbcapping protein beta0.105
upupheld0.073
sds22CG5851 gene product from transcript CG5851-RA0.057
TER94CG2331 gene product from transcript CG2331-RA0.050
ifcinfertile crescent0.048
Mlc2Myosin light chain 20.048
Act5CActin 5C0.046
Zasp66Z band alternatively spliced PDZ-motif protein 660.038
Arc-p34CG10954 gene product from transcript CG10954-RA0.038
PrmParamyosin0.037
slssallimus0.031
flwflapwing0.031
Tom34Translocase of outer membrane 340.028
laceCG4162 gene product from transcript CG4162-RA0.027
Arp14DActin-related protein 14D0.022
SH3PX1CG6757 gene product from transcript CG6757-RA0.022
Rab11Rab-protein 110.021
GstS1Glutathione S transferase S10.018
Mlc1Myosin alkali light chain 10.016
RalaRas-related protein0.015
Gef26CG9491 gene product from transcript CG9491-RB0.015
Act57BActin 57B0.015
sec5CG8843 gene product from transcript CG8843-RA0.015
par-6CG5884 gene product from transcript CG5884-RA0.015
Rpn6Proteasome p44.5 subunit0.015
cindrCIN85 and CD2AP orthologue0.014
Vrp1Verprolin 10.014
M6CG7540 gene product from transcript CG7540-RA0.014
IlkIntegrin linked kinase0.014
captcapulet0.013
Rab6Rab-protein 60.012
Syx13Syntaxin 130.012
Act88FActin 88F0.012
lqfRliquid facets-Related0.012
CG12007CG12007 gene product from transcript CG12007-RA0.012
LaspCG3849 gene product from transcript CG3849-RB0.012
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.011
CanB2Calcineurin B20.011
par-1CG8201 gene product from transcript CG8201-RA0.011
EndoGIEndonuclease G inhibitor0.010
Mlc-cMyosin light chain cytoplasmic0.010
RhoGAP92BCG4755 gene product from transcript CG4755-RA0.010
VhaM9.7-1CG11589 gene product from transcript CG11589-RA0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.967
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.950
TRIM63tripartite motif containing 630.833
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.706
TTNtitin0.634
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.569
MOBKL1BMOB1, Mps One Binder kinase activator-like 1B (yeast)0.547
MYPNmyopalladin0.488
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.385
SOS1son of sevenless homolog 1 (Drosophila)0.290
CORO1Ccoronin, actin binding protein, 1C0.280
IQGAP1IQ motif containing GTPase activating protein 10.237
MYH9myosin, heavy chain 9, non-muscle0.215
SVILsupervillin0.187
MAPK1mitogen-activated protein kinase 10.150
FLNAfilamin A, alpha0.150
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.148
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa0.135
TPM4tropomyosin 40.126
ROD1ROD1 regulator of differentiation 1 (S. pombe)0.126
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.124
ITSN1intersectin 1 (SH3 domain protein)0.114
NRASneuroblastoma RAS viral (v-ras) oncogene homolog0.099
ACTN1actinin, alpha 10.096
RIPK3receptor-interacting serine-threonine kinase 30.084
BZW1basic leucine zipper and W2 domains 10.083
ABI1abl-interactor 10.076
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.067
GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 30.066
BAIAP2BAI1-associated protein 20.060
SCYL2SCY1-like 2 (S. cerevisiae)0.058
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.055
KBTBD10kelch repeat and BTB (POZ) domain containing 100.054
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.052
TEX11testis expressed 110.051
ACTA1actin, alpha 1, skeletal muscle0.050
ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDa0.049
RAB11ARAB11A, member RAS oncogene family0.046
DR1down-regulator of transcription 1, TBP-binding (negative cofactor 2)0.045
CSNK2A2casein kinase 2, alpha prime polypeptide0.042
MRPL20mitochondrial ribosomal protein L200.042
RHOAras homolog gene family, member A0.041
EXOC5exocyst complex component 50.040
WASF2WAS protein family, member 20.038
MYL12Bmyosin, light chain 12B, regulatory0.036
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.035
SCP2sterol carrier protein 20.035
GULP1GULP, engulfment adaptor PTB domain containing 10.034
UEVLDUEV and lactate/malate dehyrogenase domains0.034
PEA15phosphoprotein enriched in astrocytes 150.032
TOM1L1target of myb1 (chicken)-like 10.032
LASP1LIM and SH3 protein 10.032
CAPZA1capping protein (actin filament) muscle Z-line, alpha 10.029
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.029
PICALMphosphatidylinositol binding clathrin assembly protein0.028
PINK1PTEN induced putative kinase 10.027
PTPN12protein tyrosine phosphatase, non-receptor type 120.026
RAB10RAB10, member RAS oncogene family0.024
RASSF7Ras association (RalGDS/AF-6) domain family (N-terminal) member 70.023
NCKIPSDNCK interacting protein with SH3 domain0.023
VCLvinculin0.023
ZYXzyxin0.022
ALDH7A1aldehyde dehydrogenase 7 family, member A10.022
ADD1adducin 1 (alpha)0.022
SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)0.022
GNG10guanine nucleotide binding protein (G protein), gamma 100.022
ARRB1arrestin, beta 10.021
PPP1CBprotein phosphatase 1, catalytic subunit, beta isozyme0.021
GRB2growth factor receptor-bound protein 20.021
TMEM123transmembrane protein 1230.020
MSNmoesin0.020
CD164CD164 molecule, sialomucin0.020
CD2APCD2-associated protein0.019
ATG4BATG4 autophagy related 4 homolog B (S. cerevisiae)0.019
MYL12Amyosin, light chain 12A, regulatory, non-sarcomeric0.019
MAP3K3mitogen-activated protein kinase kinase kinase 30.019
CNN2calponin 20.018
ITGB5integrin, beta 50.018
ACTBactin, beta0.018
RAP1BRAP1B, member of RAS oncogene family0.018
XIRP2xin actin-binding repeat containing 20.017
PRSS8protease, serine, 80.017
TAGLN2transgelin 20.017
CFL1cofilin 1 (non-muscle)0.017
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.017
ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific )0.017
NCKAP1NCK-associated protein 10.017
NPTNneuroplastin0.017
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.017
ALS2CLALS2 C-terminal like0.016
MAP2K1mitogen-activated protein kinase kinase 10.016
ACTG1actin, gamma 10.016
CAPN3calpain 3, (p94)0.016
AP1M2adaptor-related protein complex 1, mu 2 subunit0.015
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.015
DUSP3dual specificity phosphatase 30.015
PRMT2protein arginine methyltransferase 20.015
MYH14myosin, heavy chain 14, non-muscle0.015
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.014
MRFAP1Morf4 family associated protein 10.014
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.962
Actr3ARP3 actin-related protein 3 homolog (yeast)0.817
Rac1RAS-related C3 botulinum substrate 10.712
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.703
Ywhahtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.549
Arpc4actin related protein 2/3 complex, subunit 40.462
Capzbcapping protein (actin filament) muscle Z-line, beta0.292
Cltcclathrin, heavy polypeptide (Hc)0.225
Wdr1WD repeat domain 10.212
Msnmoesin0.172
Arhgap1Rho GTPase activating protein 10.166
Rap1bRAS related protein 1b0.114
Rhoaras homolog gene family, member A0.111
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.106
Rod1ROD1 regulator of differentiation 1 (S. pombe)0.104
Arf1ADP-ribosylation factor 10.076
Akt1thymoma viral proto-oncogene 10.072
Capza2capping protein (actin filament) muscle Z-line, alpha 20.066
Sept7septin 70.064
Gnb2guanine nucleotide binding protein (G protein), beta 20.059
Dbnldrebrin-like0.058
Gnb1guanine nucleotide binding protein (G protein), beta 10.052
Tmod3tropomodulin 30.046
Cfl1cofilin 1, non-muscle0.038
Lrrk2leucine-rich repeat kinase 20.036
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.036
Actr2ARP2 actin-related protein 2 homolog (yeast)0.035
Pfn1profilin 10.033
Lims1LIM and senescent cell antigen-like domains 10.029
Csrp1cysteine and glycine-rich protein 10.027
Calm1calmodulin 10.025
Bcl10B-cell leukemia/lymphoma 100.023
Tpm4tropomyosin 40.023
Actg1actin, gamma, cytoplasmic 10.022
Stx7syntaxin 70.022
Vaspvasodilator-stimulated phosphoprotein0.021
Ilkintegrin linked kinase0.021
Wsb2WD repeat and SOCS box-containing 20.019
Srisorcin0.018
Cyfip1cytoplasmic FMR1 interacting protein 10.018
Mtpnmyotrophin0.017
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.017
Actbactin, beta0.017
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.016
Psapprosaposin0.016
Sdcbpsyndecan binding protein0.014
Rap2cRAP2C, member of RAS oncogene family0.014
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.013
Cttncortactin0.013
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.013
Abi1abl-interactor 10.013
Arl6ip5ADP-ribosylation factor-like 6 interacting protein 50.012
Arpc2actin related protein 2/3 complex, subunit 20.012
Gng10guanine nucleotide binding protein (G protein), gamma 100.012
Ccng1cyclin G10.011
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.011
Hn1hematological and neurological expressed sequence 10.011
Fam49bfamily with sequence similarity 49, member B0.011
Snx2sorting nexin 20.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tpm4tropomyosin 40.816
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.632
Tpm3tropomyosin 3, gamma0.530
Taglntransgelin0.485
Actr3ARP3 actin-related protein 3 homolog (yeast)0.368
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.298
Emp1epithelial membrane protein 10.279
Mapre1microtubule-associated protein, RP/EB family, member 10.259
Efhd2EF-hand domain family, member D20.246
Acta2smooth muscle alpha-actin0.192
Myl9myosin, light chain 9, regulatory0.162
Actg2actin, gamma 2, smooth muscle, enteric0.106
Actbactin, beta0.105
Clic4chloride intracellular channel 40.098
Stk17bserine/threonine kinase 17b0.098
Anxa2annexin A20.085
Tubb5tubulin, beta 50.068
Rhoaras homolog gene family, member A0.068
Arpc2actin related protein 2/3 complex, subunit 20.061
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.059
Rac1ras-related C3 botulinum toxin substrate 10.049
Sept2septin 20.048
Sec62SEC62 homolog (S. cerevisiae)0.047
Cfl1cofilin 1, non-muscle0.045
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.039
Actg1actin, gamma 10.037
Cttncortactin0.036
Cd44Cd44 molecule0.032
Sept11septin 110.028
Lbrlamin B receptor0.028
Bnip2BCL2/adenovirus E1B interacting protein 20.027
Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.027
Arf6ADP-ribosylation factor 60.026
Csrp1cysteine and glycine-rich protein 10.024
Castcalpastatin0.024
Tagln2transgelin 20.023
Wdr1WD repeat domain 10.023
Laptm4alysosomal protein transmembrane 4 alpha0.022
Cav1caveolin 1, caveolae protein0.022
Kpnb1karyopherin (importin) beta 10.021
Acta1actin, alpha 1, skeletal muscle0.021
Rnf4ring finger protein 40.020
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.019
Msnmoesin0.017
Soat1sterol O-acyltransferase 10.017
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.017
Itgb1integrin, beta 10.017
Caprin1cell cycle associated protein 10.015
BidBH3 interacting domain death agonist0.015
Cnn1calponin 1, basic, smooth muscle0.014
Capza1capping protein (actin filament) muscle Z-line, alpha 10.013
LOC100151767hypothetical LOC1001517670.013
Myh9myosin, heavy chain 9, non-muscle0.013
Iqgap1IQ motif containing GTPase activating protein 10.012
Ralbv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.012
Myo1cmyosin IC0.012
Srisorcin0.012
Cryabcrystallin, alpha B0.012
Slc35e3solute carrier family 35, member E30.012
Syncripsynaptotagmin binding, cytoplasmic RNA interacting protein0.011
Casp3caspase 30.011
Galnt1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)0.010
LOC100360165rCG29588-like0.010
Picalmphosphatidylinositol binding clathrin assembly protein0.010
Cttnbp2nlCTTNBP2 N-terminal like0.010
Copacoatomer protein complex subunit alpha0.010
Pitpnaphosphatidylinositol transfer protein, alpha0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MYO5Myo5p0.218
CAP2Cap2p0.100
ABP1Abp1p0.052
SRV2Srv2p0.041
LAS17Las17p0.037
GYL1Gyl1p0.036
ARC15Arc15p0.030
ARC40Arc40p0.026
PAN1Pan1p0.017
SLA2Sla2p0.017
ARP2Arp2p0.016
STE5Ste5p0.015
ARC35Arc35p0.014
ARP3Arp3p0.013
AIP1Aip1p0.013
SAC6Sac6p0.013
BBC1Bbc1p0.013
LSB1Lsb1p0.011
CAP1Cap1p0.011
SRD1Srd1p0.011
YFR016Chypothetical protein0.010
LEU2Leu2p0.010
ARP10Arp10p0.010