The network for 'positive regulation of cell substrate adhesion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cell substrate adhesion

Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.

NameDescriptionProbabilityFunc Analog Organism
stcksteamer duck0.030
Ras85DRas oncogene at 85D0.022
gfAgiant fibre A0.016
SosSon of sevenless0.015
pod1CG4532 gene product from transcript CG4532-RF0.015
G-oalpha47AG protein oalpha 47A0.014
Atg1Autophagy-specific gene 10.014
wbwing blister0.014
Cad96CaCG10244 gene product from transcript CG10244-RA0.014
Ptp69DProtein tyrosine phosphatase 69D0.014
Sc2CG10849 gene product from transcript CG10849-RA0.013
Fas3Fasciclin 30.013
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.013
eIF-4EEukaryotic initiation factor 4E0.013
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.013
pgant3polypeptide GalNAc transferase 30.013
Sec61alphaCG9539 gene product from transcript CG9539-RA0.012
CG17082CG17082 gene product from transcript CG17082-RD0.012
ebiCG4063 gene product from transcript CG4063-RA0.012
Cnx99ACalnexin 99A0.012
EphrinCG1862 gene product from transcript CG1862-RA0.012
Klp64DKinesin-like protein at 64D0.011
betaTub56Dbeta-Tubulin at 56D0.011
Rab5Rab-protein 50.011
CG5794CG5794 gene product from transcript CG5794-RB0.011
IlkIntegrin linked kinase0.011
Sra-1specifically Rac1-associated protein 10.011
par-1CG8201 gene product from transcript CG8201-RA0.011
cdicenter divider0.011
CG6912CG6912 gene product from transcript CG6912-RA0.010
Wnt5Wnt oncogene analog 50.010
Myo31DFMyosin 31DF0.010
CG10638CG10638 gene product from transcript CG10638-RA0.010
gammaCopgamma-coatomer protein0.010
tbcetubulin-specific chaperone E0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.260
robo1roundabout homolog 10.250
vegfaavascular endothelial growth factor Aa0.162
emilin1aelastin microfibril interfacer 1a0.156
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.148
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.134
dag1dystroglycan 10.122
bocbrother of CDO0.113
lhfplipoma HMGIC fusion partner0.112
itgb1aintegrin, beta 1a0.109
ptprbprotein tyrosine phosphatase, receptor type, b0.106
ilkintegrin linked kinase0.102
plekhh1pleckstrin homology domain containing, family H (with MyTH4 domain) member 10.099
flhfloating head0.092
irx1airoquois homeobox protein 1, a0.090
foxo3bforkhead box O3b0.086
itgb1b.1integrin, beta 1b.10.082
prkciprotein kinase C, iota0.081
esamaendothelial cell adhesion molecule a0.080
kdrlkinase insert domain receptor like0.080
slc4a2asolute carrier family 4, anion exchanger, member 2a0.079
fggfibrinogen, gamma polypeptide0.079
mycbp2MYC binding protein 20.072
wtipWilms tumor 1 interacting protein0.071
dab2disabled homolog 2 (Drosophila)0.071
c9complement component 90.071
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.069
axin1axin 10.069
bmp7bbone morphogenetic protein 7b0.068
ca10acarbonic anhydrase Xa0.068
cnn2calponin 20.063
neo1neogenin 10.062
crb2bcrumbs homolog 2b0.062
alas2aminolevulinate, delta-, synthetase 20.058
itga3bintegrin, alpha 3b0.057
crb2acrumbs homolog 2a0.057
aqp3aaquaporin 3a0.057
wnt3wingless-type MMTV integration site family, member 30.056
btg1B-cell translocation gene 10.056
notch3notch homolog 30.054
appbamyloid beta (A4) precursor protein b0.053
rbpms2RNA binding protein with multiple splicing 20.052
tcf12transcription factor 120.052
arhgap29bRho GTPase activating protein 29b0.051
aqp1a.1aquaporin 1a, tandem duplicate 10.050
cxadrcoxsackie virus and adenovirus receptor0.047
tpm4tropomyosin 40.047
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.046
dtngdystrobrevin, gamma and dystrobrevin, gamma-like0.046
sfrp5secreted frizzled-related protein 50.046
metmet proto-oncogene (hepatocyte growth factor receptor)0.046
apomapolipoprotein M0.045
etv2ets variant gene 20.045
ptprjaprotein tyrosine phosphatase, receptor type, J a0.045
fgbfibrinogen, B beta polypeptide0.043
wt1bwilms tumor 1b0.043
mrc1amannose receptor, C type 1a0.043
robo3roundabout homolog 30.043
csadcysteine sulfinic acid decarboxylase0.042
epha4beph receptor A4b0.042
smtnlsmoothelin, like0.042
ift88intraflagellar transport 88 homolog0.042
fgfr2fibroblast growth factor receptor 20.042
sulf2lsulfatase 2, like0.041
angptl6angiopoietin-like 60.041
matn4matrilin 40.040
igfbp6binsulin-like growth factor binding protein 6b0.040
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.040
col1a1acollagen, type I, alpha 1a0.039
prox1prospero-related homeobox gene 10.039
mef2amyocyte enhancer factor 2a0.039
gna12guanine nucleotide binding protein (G protein) alpha 120.038
wnt1wingless-type MMTV integration site family, member 10.038
anxa2aannexin A2a0.038
cdh2cadherin 2, neuronal0.038
flt4fms-related tyrosine kinase 40.037
hgdhomogentisate 1,2-dioxygenase0.037
itgb1bintegrin, beta 1b0.036
tie1endothelium-specific receptor tyrosine kinase 10.036
robo2roundabout homolog 20.036
col18a1collagen type XVIII, alpha 10.035
tie2endothelium-specific receptor tyrosine kinase 20.035
ambplalpha-1-microglobulin/bikunin precursor, like0.035
anxa1aannexin A1a0.035
zbtb4zinc finger and BTB domain containing 40.034
egfl7EGF-like-domain, multiple 70.034
irx3airoquois homeobox protein 3a0.033
glcci1glucocorticoid induced transcript 10.033
polr3glapolymerase (RNA) III (DNA directed) polypeptide G like a0.032
lrp2low density lipoprotein-related protein 20.032
avpr1barginine vasopressin receptor 1B0.032
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
FYNFYN oncogene related to SRC, FGR, YES0.997
EGFRepidermal growth factor receptor0.996
BCAR1breast cancer anti-estrogen resistance 10.989
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.985
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.978
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.975
PTK2PTK2 protein tyrosine kinase 20.954
FN1fibronectin 10.943
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.938
VEGFAvascular endothelial growth factor A0.902
S100A6S100 calcium binding protein A60.895
FHL2four and a half LIM domains 20.869
S100A4S100 calcium binding protein A40.812
MPDZmultiple PDZ domain protein0.790
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.749
S100A8S100 calcium binding protein A80.726
SH3GL3SH3-domain GRB2-like 30.724
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.682
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.570
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.546
S100A9S100 calcium binding protein A90.524
COTL1coactosin-like 1 (Dictyostelium)0.497
CTNND1catenin (cadherin-associated protein), delta 10.479
CTGFconnective tissue growth factor0.423
COL4A1collagen, type IV, alpha 10.420
SOCS3suppressor of cytokine signaling 30.348
PTPN1protein tyrosine phosphatase, non-receptor type 10.340
FLNAfilamin A, alpha0.331
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.316
SMAD2SMAD family member 20.309
FKBP4FK506 binding protein 4, 59kDa0.302
CDH5cadherin 5, type 2 (vascular endothelium)0.282
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.281
NRP1neuropilin 10.278
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.272
LIMS1LIM and senescent cell antigen-like domains 10.271
ANGPT2angiopoietin 20.269
WASLWiskott-Aldrich syndrome-like0.269
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.256
CCND1cyclin D10.238
PDIA3protein disulfide isomerase family A, member 30.233
TSC2tuberous sclerosis 20.228
SH3KBP1SH3-domain kinase binding protein 10.224
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.224
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.209
LATlinker for activation of T cells0.187
ANXA2annexin A20.183
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.177
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.169
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.166
LGALS1lectin, galactoside-binding, soluble, 10.164
GHRgrowth hormone receptor0.164
PSEN2presenilin 2 (Alzheimer disease 4)0.153
EMP3epithelial membrane protein 30.153
LMNAlamin A/C0.140
PARVAparvin, alpha0.139
METmet proto-oncogene (hepatocyte growth factor receptor)0.134
CD63CD63 molecule0.129
PRKCAprotein kinase C, alpha0.125
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.125
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.124
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.114
HOXA1homeobox A10.113
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.112
PGFplacental growth factor0.111
COL1A1collagen, type I, alpha 10.108
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.107
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.105
ANGPT1angiopoietin 10.103
ZNF746zinc finger protein 7460.098
GAB1GRB2-associated binding protein 10.098
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.096
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.093
MAPTmicrotubule-associated protein tau0.091
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.086
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.086
SNX9sorting nexin 90.086
DSG2desmoglein 20.084
S100BS100 calcium binding protein B0.083
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.082
APOC1apolipoprotein C-I0.081
RRASrelated RAS viral (r-ras) oncogene homolog0.081
NCK2NCK adaptor protein 20.079
MDM2Mdm2 p53 binding protein homolog (mouse)0.078
DTNAdystrobrevin, alpha0.077
JUPjunction plakoglobin0.073
COL1A2collagen, type I, alpha 20.070
ANXA1annexin A10.068
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.068
SH2D1ASH2 domain containing 1A0.067
SMURF2SMAD specific E3 ubiquitin protein ligase 20.066
FYBFYN binding protein0.066
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Col1a2collagen, type I, alpha 20.782
Col5a2collagen, type V, alpha 20.738
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.690
Ldb3LIM domain binding 30.562
Flt4FMS-like tyrosine kinase 40.550
Thbs1thrombospondin 10.545
Ctnnb1catenin (cadherin associated protein), beta 10.531
Ptprbprotein tyrosine phosphatase, receptor type, B0.484
Kdrkinase insert domain protein receptor0.421
Dag1dystroglycan 10.374
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.370
Cdh5cadherin 50.322
Loxlysyl oxidase0.316
Nid1nidogen 10.293
Wnt4wingless-related MMTV integration site 40.272
Thbs2thrombospondin 20.269
Col4a1collagen, type IV, alpha 10.262
Flt1FMS-like tyrosine kinase 10.262
Fbn1fibrillin 10.246
Apcadenomatosis polyposis coli0.239
Col6a2collagen, type VI, alpha 20.238
Anxa2annexin A20.217
Col6a1collagen, type VI, alpha 10.216
Fermt2fermitin family homolog 2 (Drosophila)0.197
Lrrk2leucine-rich repeat kinase 20.195
Mmp11matrix metallopeptidase 110.192
Col1a1collagen, type I, alpha 10.189
Tgfbr2transforming growth factor, beta receptor II0.185
Spnb2spectrin beta 20.183
Col14a1collagen, type XIV, alpha 10.181
Tgfb1transforming growth factor, beta 10.164
Lhx1LIM homeobox protein 10.152
Tsc2tuberous sclerosis 20.149
Col4a2collagen, type IV, alpha 20.142
Plxnd1plexin D10.141
Nos3nitric oxide synthase 3, endothelial cell0.138
Sod3superoxide dismutase 3, extracellular0.138
Apoeapolipoprotein E0.137
Lamc1laminin, gamma 10.136
Ptgs2prostaglandin-endoperoxide synthase 20.136
Prss23protease, serine, 230.132
Ccnd2cyclin D20.128
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.126
Psen1presenilin 10.123
Nid2nidogen 20.118
Parvaparvin, alpha0.117
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.116
Cxcl12chemokine (C-X-C motif) ligand 120.112
Col4a5collagen, type IV, alpha 50.109
Gpc3glypican 30.109
Arid1bAT rich interactive domain 1B (SWI-like)0.109
Lamb1laminin B10.107
Notch3Notch gene homolog 3 (Drosophila)0.104
Pecam1platelet/endothelial cell adhesion molecule 10.101
Mmp2matrix metallopeptidase 20.101
Col8a1collagen, type VIII, alpha 10.099
Fgf18fibroblast growth factor 180.095
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.094
Ilkintegrin linked kinase0.094
Fstl1follistatin-like 10.093
Matn4matrilin 40.092
Rock2Rho-associated coiled-coil containing protein kinase 20.092
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.091
Ptrfpolymerase I and transcript release factor0.091
Tbx2T-box 20.091
Ldlrlow density lipoprotein receptor0.090
Meox1mesenchyme homeobox 10.089
Aplnrapelin receptor0.087
Phldb1pleckstrin homology-like domain, family B, member 10.087
Col12a1collagen, type XII, alpha 10.085
H2-DMahistocompatibility 2, class II, locus DMa0.084
Wwtr1WW domain containing transcription regulator 10.082
Tekendothelial-specific receptor tyrosine kinase0.082
Fn1fibronectin 10.081
Hif1ahypoxia inducible factor 1, alpha subunit0.081
Leprel2leprecan-like 20.080
Col5a1collagen, type V, alpha 10.079
Postnperiostin, osteoblast specific factor0.078
Tmeff2transmembrane protein with EGF-like and two follistatin-like domains 20.076
Dkk1dickkopf homolog 1 (Xenopus laevis)0.075
Cd34CD34 antigen0.074
Angptl2angiopoietin-like 20.073
Ltbp1latent transforming growth factor beta binding protein 10.073
Wnt7awingless-related MMTV integration site 7A0.072
Srpxsushi-repeat-containing protein0.072
Rb1retinoblastoma 10.069
Svep1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 10.069
Acvrl1activin A receptor, type II-like 10.069
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.068
Ptk2PTK2 protein tyrosine kinase 20.067
Smoc2SPARC related modular calcium binding 20.066
Sema3bsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B0.066
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gna12guanine nucleotide binding protein (G protein) alpha 120.023
Anxa5annexin A50.012
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism