The network for 'negative regulation of sister chromatid segregation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of sister chromatid segregation

Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.

NameDescriptionProbabilityFunc Analog Organism
IswiImitation SWI0.293
Bap55Brahma associated protein 55kD0.145
Nup153Nucleoporin 1530.126
spn-Dspindle D0.119
msb1lCG10364 gene product from transcript CG10364-RA0.113
cavcaravaggio0.090
CycBCyclin B0.081
flflfalafel0.068
ncdnon-claret disjunctional0.064
CycB3Cyclin B30.056
mus209mutagen-sensitive 2090.056
nbsCG6754 gene product from transcript CG6754-RC0.055
gekgenghis khan0.052
PPP4R2rProtein phosphatase 4 regulatory subunit 2-related protein0.049
alphaTub67Calpha-Tubulin at 67C0.047
ruxroughex0.045
prodproliferation disrupter0.042
Pp1-87BProtein phosphatase 1 at 87B0.042
BubR1Bub1-related kinase0.041
RanGapRan GTPase activating protein0.040
mus301mutagen-sensitive 3010.039
Sep2Septin-20.036
CycACyclin A0.035
pavpavarotti0.034
Mcm10Sensitized chromosome inheritance modifier 190.033
cnncentrosomin0.032
Bj1Bj1 protein0.032
Mcm7Minichromosome maintenance 70.032
mad2CG17498 gene product from transcript CG17498-RA0.025
Cap-GCG34438 gene product from transcript CG34438-RF0.023
Cks30ACyclin-dependent kinase subunit 30A0.022
CG14213CG14213 gene product from transcript CG14213-RB0.021
SMC2CG10212 gene product from transcript CG10212-RA0.021
Mi-2CG8103 gene product from transcript CG8103-RA0.021
hayhaywire0.020
bambag of marbles0.020
aslasterless0.020
crpcropped0.019
fzyfizzy0.019
Vap-33-1CG5014 gene product from transcript CG5014-RB0.019
CycJCyclin J0.019
enokenoki mushroom0.019
Cdc37CG12019 gene product from transcript CG12019-RA0.018
mus312mutagen-sensitive 3120.017
dupdouble parked0.017
atmsantimeros0.017
CG8223CG8223 gene product from transcript CG8223-RA0.017
NiPp1Nuclear inhibitor of Protein phosphatase 10.016
MEP-1CG1244 gene product from transcript CG1244-RG0.016
Pms2CG8169 gene product from transcript CG8169-RA0.016
CG2617CG2617 gene product from transcript CG2617-RA0.016
mus308mutagen-sensitive 3080.016
RecQ4CG7487 gene product from transcript CG7487-RA0.016
pimpimples0.015
CycECyclin E0.015
Axud1CG4272 gene product from transcript CG4272-RA0.015
CSN6COP9 complex homolog subunit 60.014
CG32685CG32685 gene product from transcript CG32685-RC0.014
CG6418CG6418 gene product from transcript CG6418-RB0.014
CSN4COP9 complex homolog subunit 40.013
Mcm5Minichromosome maintenance 50.013
CycCCyclin C0.013
gwlgreatwall0.013
DNApol-alpha60DNA polymerase alpha 60kD0.013
CG10694CG10694 gene product from transcript CG10694-RA0.013
dre4CG1828 gene product from transcript CG1828-RB0.013
CG4973CG4973 gene product from transcript CG4973-RA0.012
CTCFCG8591 gene product from transcript CG8591-RA0.012
gsbgooseberry0.011
HP1eCG8120 gene product from transcript CG8120-RA0.011
pontpontin0.011
Grip75CG6176 gene product from transcript CG6176-RA0.011
nodno distributive disjunction0.011
NELF-BCG32721 gene product from transcript CG32721-RA0.011
I-2Inhibitor-20.011
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.010
tldtolloid0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
bmk-1Protein BMK-10.018
ZK507.6Protein ZK507.60.014
bub-1Protein BUB-10.012
rnr-1Protein RNR-10.012
cdl-1Protein CDL-10.012
his-6Protein HIS-60.011
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDK2cyclin-dependent kinase 20.801
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.797
CDC27cell division cycle 27 homolog (S. cerevisiae)0.756
CCT4chaperonin containing TCP1, subunit 4 (delta)0.549
CCNA2cyclin A20.507
CDC20cell division cycle 20 homolog (S. cerevisiae)0.341
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.338
CCNB1cyclin B10.309
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.300
CCT8chaperonin containing TCP1, subunit 8 (theta)0.180
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.158
ANAPC4anaphase promoting complex subunit 40.121
CASC5cancer susceptibility candidate 50.116
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.109
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.098
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.095
BRCA2breast cancer 2, early onset0.092
ANAPC7anaphase promoting complex subunit 70.088
CBX5chromobox homolog 50.084
CCNE1cyclin E10.081
SKA1spindle and kinetochore associated complex subunit 10.072
MDC1mediator of DNA-damage checkpoint 10.064
SKP2S-phase kinase-associated protein 2 (p45)0.064
CCT5chaperonin containing TCP1, subunit 5 (epsilon)0.063
TP53BP1tumor protein p53 binding protein 10.053
ORC2origin recognition complex, subunit 20.049
SKA2spindle and kinetochore associated complex subunit 20.049
TINF2TERF1 (TRF1)-interacting nuclear factor 20.047
FANCD2Fanconi anemia, complementation group D20.046
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.045
ANAPC5anaphase promoting complex subunit 50.045
CKS1BCDC28 protein kinase regulatory subunit 1B0.043
CHAF1Achromatin assembly factor 1, subunit A (p150)0.042
CDC23cell division cycle 23 homolog (S. cerevisiae)0.042
ANAPC11anaphase promoting complex subunit 110.035
SKA3spindle and kinetochore associated complex subunit 30.035
AURKBaurora kinase B0.033
H2AFXH2A histone family, member X0.033
C13orf34chromosome 13 open reading frame 340.030
KIF11kinesin family member 110.030
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.028
CENPEcentromere protein E, 312kDa0.028
PRNPprion protein0.026
INCENPinner centromere protein antigens 135/155kDa0.026
FBXO5F-box protein 50.026
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.026
UBE2Cubiquitin-conjugating enzyme E2C0.026
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.026
ANAPC1anaphase promoting complex subunit 10.025
CDKN3cyclin-dependent kinase inhibitor 30.024
ANKRD52ankyrin repeat domain 520.024
HERC2hect domain and RLD 20.024
PTTG1pituitary tumor-transforming 10.023
KIF18Akinesin family member 18A0.023
PLK4polo-like kinase 40.023
CDC6cell division cycle 6 homolog (S. cerevisiae)0.022
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.021
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.021
CDT1chromatin licensing and DNA replication factor 10.020
MYST1MYST histone acetyltransferase 10.020
SMC3structural maintenance of chromosomes 30.020
NBNnibrin0.019
C19orf39chromosome 19 open reading frame 390.018
PPME1protein phosphatase methylesterase 10.018
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.018
ZNF828zinc finger protein 8280.018
OTUB1OTU domain, ubiquitin aldehyde binding 10.017
FXR2fragile X mental retardation, autosomal homolog 20.017
HIST1H4Fhistone cluster 1, H4f0.017
NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.016
SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.016
PPP4Cprotein phosphatase 4, catalytic subunit0.016
ZNF207zinc finger protein 2070.016
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.015
CDC16cell division cycle 16 homolog (S. cerevisiae)0.015
CHEK2CHK2 checkpoint homolog (S. pombe)0.015
CCNB2cyclin B20.015
HIST1H4Ahistone cluster 1, H4a0.015
ZWINTZW10 interactor0.015
SMC1Astructural maintenance of chromosomes 1A0.015
NASPnuclear autoantigenic sperm protein (histone-binding)0.014
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.014
CCNE2cyclin E20.014
PARP3poly (ADP-ribose) polymerase family, member 30.014
MAD1L1MAD1 mitotic arrest deficient-like 1 (yeast)0.014
HIST1H3Dhistone cluster 1, H3d0.014
NEK2NIMA (never in mitosis gene a)-related kinase 20.013
BRCA1breast cancer 1, early onset0.013
CKS2CDC28 protein kinase regulatory subunit 20.013
UHRF2ubiquitin-like with PHD and ring finger domains 20.012
NSL1NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)0.012
KAT5K(lysine) acetyltransferase 50.012
HUWE1HECT, UBA and WWE domain containing 10.012
PAXIP1PAX interacting (with transcription-activation domain) protein 10.012
CBX1chromobox homolog 10.012
CEP55centrosomal protein 55kDa0.011
CCDC99coiled-coil domain containing 990.011
MAPRE1microtubule-associated protein, RP/EB family, member 10.011
MKRN1makorin ring finger protein 10.011
SMC4structural maintenance of chromosomes 40.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.681
Ccnb1cyclin B10.649
Cdk1cyclin-dependent kinase 10.636
Ccnb2cyclin B20.395
Ccna2cyclin A20.373
Kif20akinesin family member 20A0.274
Birc5baculoviral IAP repeat-containing 50.267
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.258
Kif22kinesin family member 220.245
Prc1protein regulator of cytokinesis 10.212
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.152
Aurkbaurora kinase B0.109
Cenpecentromere protein E0.094
Kif11kinesin family member 110.081
Ccnfcyclin F0.080
Trp53transformation related protein 530.079
Brca1breast cancer 10.076
Hmmrhyaluronan mediated motility receptor (RHAMM)0.075
Spag5sperm associated antigen 50.074
C330027C09RikRIKEN cDNA C330027C09 gene0.072
Cdca8cell division cycle associated 80.069
Kif23kinesin family member 230.054
Kif2ckinesin family member 2C0.050
Kif4kinesin family member 40.049
Aurkaaurora kinase A0.048
Cdc25ccell division cycle 25 homolog C (S. pombe)0.048
Ube2cubiquitin-conjugating enzyme E2C0.043
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.042
Mki67antigen identified by monoclonal antibody Ki 670.042
Cdk2cyclin-dependent kinase 20.041
Ckap2cytoskeleton associated protein 20.039
Ect2ect2 oncogene0.035
Smc2structural maintenance of chromosomes 20.031
Ube2tubiquitin-conjugating enzyme E2T (putative)0.031
Gsg2germ cell-specific gene 20.031
Brca2breast cancer 20.031
Melkmaternal embryonic leucine zipper kinase0.029
Top2atopoisomerase (DNA) II alpha0.028
Sgol1shugoshin-like 1 (S. pombe)0.028
Dlgap5discs, large (Drosophila) homolog-associated protein 50.028
Hmgb2high mobility group box 20.025
Trim59tripartite motif-containing 590.024
H2afzH2A histone family, member Z0.024
TtkTtk protein kinase0.023
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.023
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.023
Ncapgnon-SMC condensin I complex, subunit G0.022
Ooepoocyte expressed protein homolog (dog)0.021
Dna2DNA replication helicase 2 homolog (yeast)0.021
Racgap1Rac GTPase-activating protein 10.021
Smc4structural maintenance of chromosomes 40.020
Plk4polo-like kinase 4 (Drosophila)0.020
Cdca5cell division cycle associated 50.020
StilScl/Tal1 interrupting locus0.020
Wdhd1WD repeat and HMG-box DNA binding protein 10.018
Cep55centrosomal protein 550.018
Ccdc99coiled-coil domain containing 990.018
Rad51ap1RAD51 associated protein 10.017
Chek1checkpoint kinase 1 homolog (S. pombe)0.017
Nuf2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.016
Mis18bp1MIS18 binding protein 10.016
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.015
Tacc3transforming, acidic coiled-coil containing protein 30.015
Cdkn3cyclin-dependent kinase inhibitor 30.015
Chaf1bchromatin assembly factor 1, subunit B (p60)0.014
Cenpkcentromere protein K0.013
Cks2CDC28 protein kinase regulatory subunit 20.013
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.013
2810417H13RikRIKEN cDNA 2810417H13 gene0.013
Cenpacentromere protein A0.012
Cenpfcentromere protein F0.012
Ncapd2non-SMC condensin I complex, subunit D20.012
Msh2mutS homolog 2 (E. coli)0.012
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.012
Ccne1cyclin E10.012
Anlnanillin, actin binding protein0.012
Trip13thyroid hormone receptor interactor 130.012
Suv39h2suppressor of variegation 3-9 homolog 2 (Drosophila)0.012
BlmBloom syndrome, RecQ helicase-like0.012
Cenpncentromere protein N0.011
Ncaphnon-SMC condensin I complex, subunit H0.011
Lin9lin-9 homolog (C. elegans)0.011
Gtse1G two S phase expressed protein 10.011
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.011
Plk1polo-like kinase 1 (Drosophila)0.010
Depdc1aDEP domain containing 1a0.010
Hellshelicase, lymphoid specific0.010
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MAD2Mad2p0.908
IML3Iml3p0.891
CDC20Cdc20p0.846
DSN1Dsn1p0.791
AME1Ame1p0.757
NSL1Nsl1p0.751
BUB3Bub3p0.731
MTW1Mtw1p0.704
BUB1Bub1p0.481
GLC7Glc7p0.478
CSE4Cse4p0.471
MCM21Mcm21p0.432
TID3Tid3p0.407
PPH22Pph22p0.396
RTS1Rts1p0.391
PPZ1Ppz1p0.351
MAD1Mad1p0.339
SPC24Spc24p0.324
SLK19Slk19p0.317
CHL4Chl4p0.282
HHF2Hhf2p0.268
GIP2Gip2p0.267
HHT1Hht1p0.265
MAD3Mad3p0.257
CDC55Cdc55p0.247
MCM22Mcm22p0.246
YBP2Ybp2p0.245
PPH21Pph21p0.228
HTA1Hta1p0.200
TIP41Tip41p0.176
KIP1Kip1p0.171
SLI15Sli15p0.158
SPC105Spc105p0.151
FMP48Fmp48p0.149
KIC1Kic1p0.146
YPI1Ypi1p0.145
SDS22Sds22p0.124
OKP1Okp1p0.123
CTF3Ctf3p0.120
MIF2Mif2p0.105
SPC25Spc25p0.103
RAD53Rad53p0.099
IPL1Ipl1p0.096
NUF2Nuf2p0.095
SMC4Smc4p0.081
GLG1Glg1p0.071
MPS1Mps1p0.067
HHT2Hht2p0.066
DAM1Dam1p0.062
ECO1Eco1p0.061
NNF1Nnf1p0.060
NBL1Nbl1p0.060
CTF13Ctf13p0.052
BFA1Bfa1p0.051
PSP1Psp1p0.050
YKL075Chypothetical protein0.049
SMC5Smc5p0.048
PTI1Pti1p0.046
NTO1Nto1p0.044
CIN1Cin1p0.042
SCC2Scc2p0.042
SPO14Spo14p0.039
PKC1Pkc1p0.039
CTF19Ctf19p0.038
EAF1Eaf1p0.038
SPC110Spc110p0.038
HYM1Hym1p0.037
SRD1Srd1p0.037
VIK1Vik1p0.037
PSY4Psy4p0.036
YGL010Whypothetical protein0.034
SPO12Spo12p0.034
PCL10Pcl10p0.033
KAR3Kar3p0.033
RAD61Rad61p0.033
YOL038C-Ahypothetical protein0.032
MER1Mer1p0.031
ZDS2Zds2p0.031
CBF1Cbf1p0.031
LEU2Leu2p0.031
PCT1Pct1p0.030
YLR162Whypothetical protein0.030
ASE1Ase1p0.030
HST3Hst3p0.029
HAL1Hal1p0.029
YLR264C-Ahypothetical protein0.029
PSK1Psk1p0.029
YIL151Chypothetical protein0.029
IML1Iml1p0.028
CRP1Crp1p0.028
IRC15Irc15p0.028
ARG8Arg8p0.026
YHR033Whypothetical protein0.026
PRP28Prp28p0.026
YML053Chypothetical protein0.025
URA3Ura3p0.025
ZPS1Zps1p0.025
RCO1Rco1p0.025
THP3Thp3p0.025
SGE1Sge1p0.024