The network for 'negative regulation of peptidyl tyrosine phosphorylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of peptidyl tyrosine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

NameDescriptionProbabilityFunc Analog Organism
ash2absent, small, or homeotic discs 20.706
cv-2crossveinless 20.206
CG32372CG32372 gene product from transcript CG32372-RA0.150
Pp2B-14DProtein phosphatase 2B at 14D0.094
Exp6Exportin 60.091
ShcSHC-adaptor protein0.078
CSN4COP9 complex homolog subunit 40.071
drkdownstream of receptor kinase0.057
SaraSmad anchor for receptor activation0.056
Zyx102EFCG32018 gene product from transcript CG32018-RA0.051
sogshort gastrulation0.048
Bsg25DBlastoderm-specific gene 25D0.043
Arr2Arrestin 20.035
Hip14Huntingtin-interacting protein 140.035
Tm1Tropomyosin 10.031
CG12734CG12734 gene product from transcript CG12734-RA0.027
SnooSno oncogene0.027
Mkp3Mitogen-activated protein kinase phosphatase 30.026
CG5794CG5794 gene product from transcript CG5794-RB0.026
Socs36ESuppressor of cytokine signaling at 36E0.026
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.025
trioCG18214 gene product from transcript CG18214-RA0.024
GgaCG3002 gene product from transcript CG3002-RB0.023
Mnn1Menin 10.021
C3GCG42328 gene product from transcript CG42328-RC0.020
A2bp1Ataxin-2 binding protein 10.020
Upf2CG2253 gene product from transcript CG2253-RA0.019
bossbride of sevenless0.019
nudECG8104 gene product from transcript CG8104-RB0.018
CG3194CG3194 gene product from transcript CG3194-RB0.018
RpL3Ribosomal protein L30.018
ninaBneither inactivation nor afterpotential B0.017
trpmltransient receptor potential mucolipin0.016
Ras64BRas oncogene at 64B0.016
CG17568CG17568 gene product from transcript CG17568-RA0.016
Top3alphaTopoisomerase 3alpha0.016
Tao-1CG14217 gene product from transcript CG14217-RF0.015
l(2)35Bdlethal (2) 35Bd0.015
ninaEneither inactivation nor afterpotential E0.015
Tip60CG6121 gene product from transcript CG6121-RA0.014
cln3CG5582 gene product from transcript CG5582-RA0.014
EDTPEgg-derived tyrosine phosphatase0.014
CG1021CG1021 gene product from transcript CG1021-RE0.014
Rh6Rhodopsin 60.013
rdgBretinal degeneration B0.013
sopstring of pearls0.013
cdicenter divider0.012
l(3)L1231lethal (3) L12310.012
CG13830CG13830 gene product from transcript CG13830-RD0.012
CG14614CG14614 gene product from transcript CG14614-RA0.012
tsgtwisted gastrulation0.011
Pat1Protein interacting with APP tail-10.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
PTPN1protein tyrosine phosphatase, non-receptor type 11.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.999
GRB2growth factor receptor-bound protein 20.999
LCKlymphocyte-specific protein tyrosine kinase0.998
EGFRepidermal growth factor receptor0.986
BTKBruton agammaglobulinemia tyrosine kinase0.983
GHRgrowth hormone receptor0.933
PTPN6protein tyrosine phosphatase, non-receptor type 60.922
FYNFYN oncogene related to SRC, FGR, YES0.900
SHC1SHC (Src homology 2 domain containing) transforming protein 10.889
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.860
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.819
PLCG1phospholipase C, gamma 10.730
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.708
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.582
SYKspleen tyrosine kinase0.557
BCAR1breast cancer anti-estrogen resistance 10.541
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.499
NCK1NCK adaptor protein 10.421
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.387
VAV1vav 1 guanine nucleotide exchange factor0.350
PRKCZprotein kinase C, zeta0.308
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.300
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.277
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.267
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.257
SH2D1ASH2 domain containing 1A0.236
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.217
SPRR2Asmall proline-rich protein 2A0.215
MUC1mucin 1, cell surface associated0.209
NCF1neutrophil cytosolic factor 10.208
PSEN1presenilin 10.202
ZNF496zinc finger protein 4960.192
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.188
SOCS1suppressor of cytokine signaling 10.173
SLAMF1signaling lymphocytic activation molecule family member 10.162
BLNKB-cell linker0.160
PRKCBprotein kinase C, beta0.154
CD44CD44 molecule (Indian blood group)0.152
NOXA1NADPH oxidase activator 10.151
ITKIL2-inducible T-cell kinase0.147
IRS1insulin receptor substrate 10.144
EPORerythropoietin receptor0.141
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.140
LATlinker for activation of T cells0.137
PDCD6IPprogrammed cell death 6 interacting protein0.137
GRB7growth factor receptor-bound protein 70.130
TFF1trefoil factor 10.128
SH2D3ASH2 domain containing 3A0.117
JAK2Janus kinase 20.115
NTRK1neurotrophic tyrosine kinase, receptor, type 10.115
METmet proto-oncogene (hepatocyte growth factor receptor)0.096
SOCS2suppressor of cytokine signaling 20.092
SHC2SHC (Src homology 2 domain containing) transforming protein 20.086
PROX1prospero homeobox 10.080
SCHIP1schwannomin interacting protein 10.078
MED28mediator complex subunit 280.078
PTPN11protein tyrosine phosphatase, non-receptor type 110.078
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.074
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.070
PTPRBprotein tyrosine phosphatase, receptor type, B0.069
PTENphosphatase and tensin homolog0.066
GAB1GRB2-associated binding protein 10.064
PTK2BPTK2B protein tyrosine kinase 2 beta0.063
PSEN2presenilin 2 (Alzheimer disease 4)0.062
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.060
UBASH3Bubiquitin associated and SH3 domain containing B0.059
CUL2cullin 20.059
PTK2PTK2 protein tyrosine kinase 20.058
ADAM15ADAM metallopeptidase domain 150.057
NTRK2neurotrophic tyrosine kinase, receptor, type 20.055
SH3KBP1SH3-domain kinase binding protein 10.053
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.053
FLNAfilamin A, alpha0.051
CD84CD84 molecule0.046
NCF4neutrophil cytosolic factor 4, 40kDa0.045
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.042
TBC1D10ATBC1 domain family, member 10A0.042
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.041
RASA1RAS p21 protein activator (GTPase activating protein) 10.039
TNS4tensin 40.037
PTPN3protein tyrosine phosphatase, non-receptor type 30.037
SHC3SHC (Src homology 2 domain containing) transforming protein 30.037
VHLvon Hippel-Lindau tumor suppressor0.037
NRG1neuregulin 10.036
SORBS3sorbin and SH3 domain containing 30.036
PRKCAprotein kinase C, alpha0.035
SH3BP2SH3-domain binding protein 20.035
CD2APCD2-associated protein0.035
VAV2vav 2 guanine nucleotide exchange factor0.033
CDCP1CUB domain containing protein 10.033
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.032
FLNBfilamin B, beta0.032
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.031
CAV2caveolin 20.030
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grb2growth factor receptor bound protein 20.999
Leprleptin receptor0.997
FynFyn proto-oncogene0.996
Egfrepidermal growth factor receptor0.994
Ptpn11protein tyrosine phosphatase, non-receptor type 110.982
Slamf1signaling lymphocytic activation molecule family member 10.978
Cd28CD28 antigen0.957
Jak2Janus kinase 20.953
CblCasitas B-lineage lymphoma0.936
Arrb2arrestin, beta 20.924
Psen1presenilin 10.923
Notch1Notch gene homolog 1 (Drosophila)0.906
Shc1src homology 2 domain-containing transforming protein C10.892
Gab2growth factor receptor bound protein 2-associated protein 20.761
Vhlvon Hippel-Lindau tumor suppressor0.759
Ctnnb1catenin (cadherin associated protein), beta 10.739
Sfrp2secreted frizzled-related protein 20.738
Stat3signal transducer and activator of transcription 30.719
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.711
Arrb1arrestin, beta 10.707
Sfrp1secreted frizzled-related protein 10.608
SrcRous sarcoma oncogene0.597
Cishcytokine inducible SH2-containing protein0.590
Vav1vav 1 oncogene0.579
Notch2Notch gene homolog 2 (Drosophila)0.554
Ppargperoxisome proliferator activated receptor gamma0.433
Gsk3bglycogen synthase kinase 3 beta0.417
Frs2fibroblast growth factor receptor substrate 20.393
Itgb1integrin beta 1 (fibronectin receptor beta)0.385
Dlg4discs, large homolog 4 (Drosophila)0.364
Bcl2B-cell leukemia/lymphoma 20.363
Ncoa3nuclear receptor coactivator 30.362
Plcg1phospholipase C, gamma 10.360
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.349
Socs3suppressor of cytokine signaling 30.349
Nf1neurofibromatosis 10.340
Hif1ahypoxia inducible factor 1, alpha subunit0.339
Ldb3LIM domain binding 30.323
Sos1son of sevenless homolog 1 (Drosophila)0.280
Ptk2PTK2 protein tyrosine kinase 20.246
Vangl2vang-like 2 (van gogh, Drosophila)0.238
BlnkB-cell linker0.227
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.189
NsfN-ethylmaleimide sensitive fusion protein0.188
FybFYN binding protein0.184
Vegfavascular endothelial growth factor A0.182
Vav2vav 2 oncogene0.182
Socs2suppressor of cytokine signaling 20.171
Apcadenomatosis polyposis coli0.162
Lcklymphocyte protein tyrosine kinase0.153
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.152
Lmnalamin A0.148
Cav1caveolin 1, caveolae protein0.139
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.135
Inpp5dinositol polyphosphate-5-phosphatase D0.127
Insrinsulin receptor0.125
Foxo1forkhead box O10.124
Cdkn1bcyclin-dependent kinase inhibitor 1B0.123
Ptrfpolymerase I and transcript release factor0.122
Ptpraprotein tyrosine phosphatase, receptor type, A0.120
Kitkit oncogene0.117
Foxa2forkhead box A20.115
Map4k1mitogen-activated protein kinase kinase kinase kinase 10.111
Il1r1interleukin 1 receptor, type I0.110
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.102
ItkIL2-inducible T-cell kinase0.098
Sh3kbp1SH3-domain kinase binding protein 10.096
Myd88myeloid differentiation primary response gene 880.094
Cd84CD84 antigen0.094
Prkceprotein kinase C, epsilon0.091
Plxna4plexin A40.089
Adam17a disintegrin and metallopeptidase domain 170.088
Dnm1ldynamin 1-like0.086
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.084
Dll1delta-like 1 (Drosophila)0.082
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.080
Prkcdprotein kinase C, delta0.078
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.078
Fliiflightless I homolog (Drosophila)0.078
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.076
Mgat3mannoside acetylglucosaminyltransferase 30.073
Jak1Janus kinase 10.069
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.069
Ptpreprotein tyrosine phosphatase, receptor type, E0.068
Ptenphosphatase and tensin homolog0.067
Prkcbprotein kinase C, beta0.062
Ptpn1protein tyrosine phosphatase, non-receptor type 10.062
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.061
Stat5asignal transducer and activator of transcription 5A0.059
Tnip1TNFAIP3 interacting protein 10.058
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.058
Rps3ribosomal protein S30.057
Ptk2bPTK2 protein tyrosine kinase 2 beta0.057
Cul5cullin 50.057
Gab1growth factor receptor bound protein 2-associated protein 10.056
Vav3vav 3 oncogene0.056
Gna11guanine nucleotide binding protein, alpha 110.054
4732456N10RikRIKEN cDNA 4732456N10 gene0.054
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism