The network for 'notochord development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

notochord development

The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
flhfloating head0.999
lamc1laminin, gamma 10.998
shhasonic hedgehog a0.992
ntlano tail a0.988
chdchordin0.983
col8a1acollagen, type VIII, alpha 1a0.973
tbx2bT-box 2b0.970
fgf17fibroblast growth factor 170.968
hnf1baHNF1 homeobox Ba0.951
tbx1T-box 10.947
dharmadharma0.939
lamb1alaminin, beta 1a0.931
col27a1acollagen, type XXVII, alpha 1a0.925
col1a1acollagen, type I, alpha 1a0.921
lft1lefty10.921
col11a2collagen type XI alpha-20.921
gli2aGLI-Kruppel family member GLI2a0.908
bmp2abone morphogenetic protein 2a0.878
ndr2nodal-related 20.864
bmp2bbone morphogenetic protein 2b0.851
lft2lefty20.846
col5a2lcollagen, type V, alpha 2-like0.829
col5a1procollagen, type V, alpha 10.813
sox10SRY-box containing gene 100.770
ptch2patched 20.766
pou5f1POU domain, class 5, transcription factor 10.760
wnt5bwingless-type MMTV integration site family, member 5b0.729
gli1GLI-Kruppel family member 10.695
admpanti-dorsalizing morphogenic protein0.682
wnt9awingless-type MMTV integration site family, member 9A0.678
col1a2collagen, type I, alpha 20.677
unc45bunc-45 homolog B (C. elegans)0.662
foxh1forkhead box H10.647
col2a1acollagen type II, alpha-1a0.623
eve1even-skipped-like10.616
notch2notch homolog 20.614
foxa2forkhead box A20.605
sparcsecreted acidic cysteine rich glycoprotein0.577
fbn2bfibrillin 2b0.577
wnt11wingless-type MMTV integration site family, member 110.571
cdh2cadherin 2, neuronal0.549
myod1myogenic differentiation 10.543
frzbfrizzled-related protein0.542
wnt2wingless-type MMTV integration site family member 20.509
foxa3forkhead box A30.494
ccm2cerebral cavernous malformation 20.494
neo1neogenin 10.486
rbp4retinol binding protein 4, plasma0.474
cdx4caudal type homeo box transcription factor 40.472
zgc:85866zgc:858660.459
nanos3nanos homolog 30.452
runx2brunt-related transcription factor 2b0.446
bmp4bone morphogenetic protein 40.438
copb1coatomer protein complex, subunit beta 10.423
ventventral expressed homeobox0.423
bmp1abone morphogenetic protein 1a0.418
dlx5adistal-less homeobox gene 5a0.407
osr2odd-skipped related 2 (Drosophila)0.407
foxd5forkhead box D50.406
col9a2procollagen, type IX, alpha 20.403
mibmind bomb0.393
wnt8bwingless-type MMTV integration site family, member 8b0.381
wnt2bbwingless-type MMTV integration site family, member 2Bb0.358
sox9bSRY-box containing gene 9b0.356
kitakit receptor a0.346
twist2twist20.337
nog3noggin 30.336
zgc:111821zgc:1118210.332
ndr1nodal-related 10.332
tbx16T-box gene 160.325
fgf3fibroblast growth factor 30.320
tll1tolloid-like 10.319
smyd1bSET and MYND domain containing 1b0.317
wnt9bwingless-type MMTV integration site family, member 9B0.316
dkk1bdickkopf 1b0.313
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.304
tbx24T-box 240.286
plod3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 30.278
fzd7afrizzled homolog 7a0.278
ltbp3latent transforming growth factor beta binding protein 30.276
cdh6cadherin 60.273
wnt4awingless-type MMTV integration site family, member 4a0.273
sox32SRY-box containing gene 320.271
fn1fibronectin 10.267
copacoatomer protein complex, subunit alpha0.266
ier2immediate early response 20.259
wnt10bwingless-type MMTV integration site family, member 10b0.255
dcndecorin0.254
hand2heart and neural crest derivatives expressed transcript 20.254
hhiphedgehog interacting protein0.253
dlddeltaD0.247
plod2procollagen-lysine, 2-oxoglutarate 5-dioxygenase 20.241
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.239
slc45a2solute carrier family 45, member 20.238
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.235
tgfb3transforming growth factor, beta 30.232
pax7apaired box gene 7a0.230
si:xx-bac7cse.2si:xx-bac7cse.20.223
lhx5LIM homeobox 50.213
dlx2adistal-less homeobox gene 2a0.207
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Efnb2ephrin B20.993
Gli3GLI-Kruppel family member GLI30.988
Nodalnodal0.940
Tbx3T-box 30.913
Ephb2Eph receptor B20.896
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.895
Col1a1collagen, type I, alpha 10.882
Jag1jagged 10.875
Zic3zinc finger protein of the cerebellum 30.874
Shhsonic hedgehog0.844
Fgfr2fibroblast growth factor receptor 20.818
Bmp4bone morphogenetic protein 40.817
Pax3paired box gene 30.778
Col2a1collagen, type II, alpha 10.744
Gli2GLI-Kruppel family member GLI20.707
Id3inhibitor of DNA binding 30.705
Wt1Wilms tumor 1 homolog0.685
Smad6MAD homolog 6 (Drosophila)0.663
Gata4GATA binding protein 40.641
Pitx2paired-like homeodomain transcription factor 20.634
Yap1yes-associated protein 10.590
Epha4Eph receptor A40.523
Foxh1forkhead box H10.514
Sall4sal-like 4 (Drosophila)0.474
Crb2crumbs homolog 2 (Drosophila)0.471
Vangl2vang-like 2 (van gogh, Drosophila)0.398
Pax2paired box gene 20.395
Col5a2collagen, type V, alpha 20.389
Foxc2forkhead box C20.385
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.376
Prrx1paired related homeobox 10.342
Ptrfpolymerase I and transcript release factor0.336
Wwtr1WW domain containing transcription regulator 10.332
Hand1heart and neural crest derivatives expressed transcript 10.328
Fstl1follistatin-like 10.327
Fgfr3fibroblast growth factor receptor 30.323
Vegfavascular endothelial growth factor A0.321
Pitx1paired-like homeodomain transcription factor 10.318
Fgfr1fibroblast growth factor receptor 10.318
Efnb1ephrin B10.313
Sox2SRY-box containing gene 20.308
Nos3nitric oxide synthase 3, endothelial cell0.308
Hey2hairy/enhancer-of-split related with YRPW motif 20.299
Col3a1collagen, type III, alpha 10.295
Foxg1forkhead box G10.273
Tbrachyury0.269
Tgfb2transforming growth factor, beta 20.268
Id1inhibitor of DNA binding 10.263
Notch1Notch gene homolog 1 (Drosophila)0.253
Col1a2collagen, type I, alpha 20.235
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.234
Ephb3Eph receptor B30.225
Tead1TEA domain family member 10.219
Alx4aristaless-like homeobox 40.205
Foxc1forkhead box C10.202
Pthlhparathyroid hormone-like peptide0.200
Hes1hairy and enhancer of split 1 (Drosophila)0.191
Ntf3neurotrophin 30.190
Grb10growth factor receptor bound protein 100.185
Fgf10fibroblast growth factor 100.175
Nognoggin0.171
Lamb1laminin B10.170
Ror2receptor tyrosine kinase-like orphan receptor 20.168
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.161
Col6a1collagen, type VI, alpha 10.153
Six2sine oculis-related homeobox 2 homolog (Drosophila)0.136
Gdf1growth differentiation factor 10.133
Chd7chromodomain helicase DNA binding protein 70.128
Ren1renin 1 structural0.125
Copb1coatomer protein complex, subunit beta 10.120
Hspg2perlecan (heparan sulfate proteoglycan 2)0.120
Fgf8fibroblast growth factor 80.119
Col4a1collagen, type IV, alpha 10.117
Efsembryonal Fyn-associated substrate0.116
Sox9SRY-box containing gene 90.115
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.115
Capn6calpain 60.114
Loxlysyl oxidase0.113
Pou5f1POU domain, class 5, transcription factor 10.110
Gata5GATA binding protein 50.106
Tead2TEA domain family member 20.106
Nid1nidogen 10.105
Ptk7PTK7 protein tyrosine kinase 70.105
Dll4delta-like 4 (Drosophila)0.104
Hoxa1homeobox A10.096
Fbn2fibrillin 20.094
Rnf2ring finger protein 20.094
Atoh7atonal homolog 7 (Drosophila)0.093
Col11a1collagen, type XI, alpha 10.089
Efna4ephrin A40.088
Meox2mesenchyme homeobox 20.088
Col5a1collagen, type V, alpha 10.088
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.086
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.085
Elnelastin0.082
Col13a1collagen, type XIII, alpha 10.081
Hey1hairy/enhancer-of-split related with YRPW motif 10.081
Gdnfglial cell line derived neurotrophic factor0.080
Tcf3transcription factor 30.079
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.076
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism