The network for 'response to muscle stretch' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to muscle stretch

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.

Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TTNtitin0.995
MYOZ1myozenin 10.284
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.166
ACTN2actinin, alpha 20.163
MYOZ2myozenin 20.160
MYOD1myogenic differentiation 10.098
NEBnebulin0.091
TNNI1troponin I type 1 (skeletal, slow)0.066
TCAPtitin-cap (telethonin)0.043
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.036
ANKRD1ankyrin repeat domain 1 (cardiac muscle)0.034
TAGLNtransgelin0.032
ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptide0.030
DMPKdystrophia myotonica-protein kinase0.026
TRIM63tripartite motif containing 630.026
CAPN3calpain 3, (p94)0.024
MYL1myosin, light chain 1, alkali; skeletal, fast0.024
ACTA1actin, alpha 1, skeletal muscle0.020
MYH6myosin, heavy chain 6, cardiac muscle, alpha0.020
ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)0.019
MYL2myosin, light chain 2, regulatory, cardiac, slow0.019
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.019
MYOGmyogenin (myogenic factor 4)0.018
ILKintegrin-linked kinase0.017
MYH7myosin, heavy chain 7, cardiac muscle, beta0.016
PDPK13-phosphoinositide dependent protein kinase-10.013
OBSL1obscurin-like 10.013
SPRY2sprouty homolog 2 (Drosophila)0.013
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif, 100.013
ENO3enolase 3 (beta, muscle)0.013
CD151CD151 molecule (Raph blood group)0.013
TPPP3tubulin polymerization-promoting protein family member 30.013
CAV3caveolin 30.012
SMPXsmall muscle protein, X-linked0.012
MYH1myosin, heavy chain 1, skeletal muscle, adult0.011
S100A4S100 calcium binding protein A40.010
TNNC1troponin C type 1 (slow)0.010
CYR61cysteine-rich, angiogenic inducer, 610.010
MYF5myogenic factor 50.010
COL4A2collagen, type IV, alpha 20.010
CSRP1cysteine and glycine-rich protein 10.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Actn2actinin alpha 20.564
Myl3myosin, light polypeptide 30.172
Vegfavascular endothelial growth factor A0.168
Ednraendothelin receptor type A0.155
Ldb3LIM domain binding 30.093
Acvr1activin A receptor, type 10.089
Tnnc1troponin C, cardiac/slow skeletal0.067
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.066
Mkl2MKL/myocardin-like 20.062
Rararetinoic acid receptor, alpha0.061
Pgam2phosphoglycerate mutase 20.059
Ilkintegrin linked kinase0.058
Rargretinoic acid receptor, gamma0.056
Ckmt2creatine kinase, mitochondrial 20.054
Cox8bcytochrome c oxidase, subunit VIIIb0.051
Fitm1fat storage-inducing transmembrane protein 10.051
Ckmcreatine kinase, muscle0.051
Tnnt3troponin T3, skeletal, fast0.049
Kctd10potassium channel tetramerisation domain containing 100.048
Rxraretinoid X receptor alpha0.047
Xirp1xin actin-binding repeat containing 10.046
S100a6S100 calcium binding protein A6 (calcyclin)0.045
Myom2myomesin 20.042
Cnn2calponin 20.041
Hrchistidine rich calcium binding protein0.041
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.041
Lgals1lectin, galactose binding, soluble 10.034
S100a10S100 calcium binding protein A10 (calpactin)0.033
Cd99CD99 antigen0.032
Csrp3cysteine and glycine-rich protein 30.030
Kbtbd10kelch repeat and BTB (POZ) domain containing 100.030
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.029
Trim54tripartite motif-containing 540.028
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.027
Myl1myosin, light polypeptide 10.027
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.027
Ttntitin0.026
Lmod2leiomodin 2 (cardiac)0.026
Myo1cmyosin IC0.026
Tnnt2troponin T2, cardiac0.026
Cav3caveolin 30.025
Actn3actinin alpha 30.025
Ankrd2ankyrin repeat domain 2 (stretch responsive muscle)0.025
Tpm1tropomyosin 1, alpha0.024
Hoxa3homeobox A30.024
Tcaptitin-cap0.024
Actc1actin, alpha, cardiac muscle 10.024
Taglntransgelin0.024
Flncfilamin C, gamma0.022
Tnni2troponin I, skeletal, fast 20.022
Capn3calpain 30.021
Sh3bgrl3SH3 domain binding glutamic acid-rich protein-like 30.021
Acta1actin, alpha 1, skeletal muscle0.020
Eef1a2eukaryotic translation elongation factor 1 alpha 20.020
Crip1cysteine-rich protein 1 (intestinal)0.020
Myoz2myozenin 20.019
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.019
Plin4perilipin 40.019
Icam2intercellular adhesion molecule 20.019
Capzbcapping protein (actin filament) muscle Z-line, beta0.018
Id3inhibitor of DNA binding 30.018
Tmsb4xthymosin, beta 4, X chromosome0.018
Smosmoothened homolog (Drosophila)0.018
Nrapnebulin-related anchoring protein0.018
Kcna7potassium voltage-gated channel, shaker-related subfamily, member 70.017
Serpinb6aserine (or cysteine) peptidase inhibitor, clade B, member 6a0.017
Clic1chloride intracellular channel 10.017
S100a13S100 calcium binding protein A130.017
Hspb7heat shock protein family, member 7 (cardiovascular)0.016
Popdc3popeye domain containing 30.016
S100a11S100 calcium binding protein A11 (calgizzarin)0.016
Maged1melanoma antigen, family D, 10.016
Tax1bp3Tax1 (human T-cell leukemia virus type I) binding protein 30.016
Rbp1retinol binding protein 1, cellular0.016
Hhatlhedgehog acyltransferase-like0.016
Tnnc2troponin C2, fast0.016
S100a4S100 calcium binding protein A40.016
Art1ADP-ribosyltransferase 10.015
Tagln2transgelin 20.015
Kbtbd5kelch repeat and BTB (POZ) domain containing 50.015
Tnnt1troponin T1, skeletal, slow0.015
Lmod3leiomodin 3 (fetal)0.015
Lsp1lymphocyte specific 10.015
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.014
Myom1myomesin 10.014
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.014
Pgls6-phosphogluconolactonase0.014
Pdlim3PDZ and LIM domain 30.014
Gm8894predicted gene 88940.014
Mtch1mitochondrial carrier homolog 1 (C. elegans)0.013
Cacng1calcium channel, voltage-dependent, gamma subunit 10.013
Tcea3transcription elongation factor A (SII), 30.013
Casq2calsequestrin 20.013
Synpo2lsynaptopodin 2-like0.013
Tcof1Treacher Collins Franceschetti syndrome 1, homolog0.013
Cybacytochrome b-245, alpha polypeptide0.013
Wdr1WD repeat domain 10.013
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.013
Art5ADP-ribosyltransferase 50.013
Myl9myosin, light polypeptide 9, regulatory0.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Casq2calsequestrin 2 (cardiac muscle)0.152
Actc1actin, alpha, cardiac muscle 10.143
Mbmyoglobin0.117
Desdesmin0.097
Smpxsmall muscle protein, X-linked0.077
Lamc1laminin, gamma 10.074
Myh7myosin, heavy chain 7, cardiac muscle, beta0.058
Tnnt2troponin T type 2 (cardiac)0.056
Myoz2myozenin 20.045
Ldb3LIM domain binding 30.039
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.039
RhdRh blood group, D antigen0.036
Il6interleukin 60.031
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.030
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.029
Hspb7heat shock protein family, member 7 (cardiovascular)0.026
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.021
Sctsecretin0.020
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.019
Tnnc1troponin C type 1 (slow)0.017
Pdlim3PDZ and LIM domain 30.017
Flt1FMS-related tyrosine kinase 10.016
Grk4G protein-coupled receptor kinase 40.014
Nexnnexilin (F actin binding protein)0.013
Csrp3cysteine and glycine-rich protein 30.013
Ccl20chemokine (C-C motif) ligand 200.013
Notch4Notch homolog 4 (Drosophila)0.013
Ptpn14protein tyrosine phosphatase, non-receptor type 140.012
Mybpc1myosin binding protein C, slow type0.012
Bdkrb2bradykinin receptor B20.012
Nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.012
Hemgnhemogen0.012
RGD1309414similar to KIAA0913 protein0.011
RatNP-3bdefensin RatNP-3 precursor0.011
Csf3colony stimulating factor 3 (granulocyte)0.011
Ifna1interferon-alpha 10.011
Nxph1neurexophilin 10.011
Scn9asodium channel, voltage-gated, type IX, alpha0.011
Myom2myomesin 20.010
Spta1spectrin, alpha, erythrocytic 1 (elliptocytosis 2)0.010
Xirp1xin actin-binding repeat containing 10.010
Fcer1aFc fragment of IgE, high affinity I, receptor for; alpha polypeptide0.010
Ccr3chemokine (C-C motif) receptor 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism