The network for 'positive regulation of protein import into nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of protein import into nucleus

Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.

Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
wgwingless0.634
EndoGIEndonuclease G inhibitor0.307
spispitz0.217
enengrailed0.198
CG16885CG16885 gene product from transcript CG16885-RA0.190
tkvthickveins0.166
AxnAxin0.154
Cul-3Cullin-30.153
hhhedgehog0.150
panpangolin0.134
Act87EActin 87E0.132
hthhomothorax0.132
coroCG9446 gene product from transcript CG9446-RC0.130
Toll-7CG8595 gene product from transcript CG8595-RA0.124
ftfat0.124
EgfrEpidermal growth factor receptor0.123
Toll-6CG7250 gene product from transcript CG7250-RA0.092
exexpanded0.090
hydhyperplastic discs0.086
Cul-2Cullin-20.080
Stat92ESignal-transducer and activator of transcription protein at 92E0.079
Cp190Centrosomal protein 190kD0.078
hpohippo0.076
scrascraps0.073
Taf1TBP-associated factor 10.071
MadMothers against dpp0.071
tumtumbleweed0.070
Fs(2)KetFemale sterile (2) Ketel0.069
HcfHost cell factor0.068
poloCG12306 gene product from transcript CG12306-RA0.067
Ras85DRas oncogene at 85D0.063
Ca-P60ACalcium ATPase at 60A0.063
traltrailer hitch0.057
PrmParamyosin0.054
Mlc1Myosin alkali light chain 10.054
cpacapping protein alpha0.053
CG4962CG4962 gene product from transcript CG4962-RA0.053
TlToll0.052
kibrakibra ortholog0.050
CanA1Calcineurin A10.048
ptcpatched0.048
RelRelish0.047
Vap-33-1CG5014 gene product from transcript CG5014-RB0.045
RanBPMRan-binding protein M0.043
DatDopamine N acetyltransferase0.043
pr-set7CG3307 gene product from transcript CG3307-RC0.043
comtcomatose0.040
sosine oculis0.039
TolloCG6890 gene product from transcript CG6890-RA0.035
Tm2Tropomyosin 20.034
sdscalloped0.034
cpbcapping protein beta0.034
gbbglass bottom boat0.033
arrarrow0.032
tbcetubulin-specific chaperone E0.032
Tak1TGF-beta activated kinase 10.032
upupheld0.032
rho-5rhomboid-50.032
ThorCG8846 gene product from transcript CG8846-RA0.031
MerMerlin0.031
PGRP-LEPeptidoglycan recognition protein LE0.031
coscosta0.031
CG16884CG16884 gene product from transcript CG16884-RA0.031
CG16718CG16718 gene product from transcript CG16718-RA0.030
cicubitus interruptus0.029
Caf1Chromatin assembly factor 1 subunit0.029
RanGapRan GTPase activating protein0.028
highikaru genki0.028
perperiod0.028
ird5immune response deficient 50.028
keykenny0.028
Traf6TNF-receptor-associated factor 60.028
vgvestigial0.027
Grip163CG5688 gene product from transcript CG5688-RA0.027
Droj2DnaJ-like-20.027
argosCG4531 gene product from transcript CG4531-RA0.027
GM130CG11061 gene product from transcript CG11061-RB0.026
scnyscrawny0.026
dhddeadhead0.026
NNotch0.025
myoglianinCG1838 gene product from transcript CG1838-RD0.025
vkgviking0.025
GitCG16728 gene product from transcript CG16728-RA0.023
CadNCadherin-N0.023
dnr1defense repressor 10.023
18w18 wheeler0.023
eyaeyes absent0.022
hoe1hoepel10.022
DadDaughters against dpp0.022
mib1mind bomb 10.022
ArgkArginine kinase0.021
Act79BActin 79B0.021
PGRP-LCPeptidoglycan recognition protein LC0.021
toytwin of eyeless0.021
CG31904CG31904 gene product from transcript CG31904-RD0.021
srasarah0.020
Mekk1CG7717 gene product from transcript CG7717-RB0.020
edechinoid0.020
dsdachsous0.020
CG10508CG10508 gene product from transcript CG10508-RH0.020
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMAD2SMAD family member 20.999
SMAD3SMAD family member 30.995
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.990
EGFRepidermal growth factor receptor0.958
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.944
BMPR1Abone morphogenetic protein receptor, type IA0.933
SMAD1SMAD family member 10.914
IL8interleukin 80.912
IL1R1interleukin 1 receptor, type I0.865
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.811
SMAD7SMAD family member 70.799
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.797
KPNB1karyopherin (importin) beta 10.792
ESR1estrogen receptor 10.791
PSEN1presenilin 10.747
CCL4chemokine (C-C motif) ligand 40.715
CXCL2chemokine (C-X-C motif) ligand 20.714
CCR5chemokine (C-C motif) receptor 50.695
TNFtumor necrosis factor0.675
BTRCbeta-transducin repeat containing0.667
MYD88myeloid differentiation primary response gene (88)0.665
CUL1cullin 10.655
BMP2bone morphogenetic protein 20.654
SHC1SHC (Src homology 2 domain containing) transforming protein 10.630
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.615
KPNA2karyopherin alpha 2 (RAG cohort 1, importin alpha 1)0.610
FLNAfilamin A, alpha0.588
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.571
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.569
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.550
CXCL3chemokine (C-X-C motif) ligand 30.549
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.545
IL1Binterleukin 1, beta0.523
FKBP1AFK506 binding protein 1A, 12kDa0.483
SMURF2SMAD specific E3 ubiquitin protein ligase 20.464
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.459
YAP1Yes-associated protein 10.441
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.439
FLNBfilamin B, beta0.430
TGFBR1transforming growth factor, beta receptor 10.423
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.422
NCOA1nuclear receptor coactivator 10.403
BMPR1Bbone morphogenetic protein receptor, type IB0.388
WASLWiskott-Aldrich syndrome-like0.384
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.381
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.375
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.370
RNF31ring finger protein 310.365
MAVSmitochondrial antiviral signaling protein0.362
IQGAP1IQ motif containing GTPase activating protein 10.356
APPamyloid beta (A4) precursor protein0.308
SRPK2SRSF protein kinase 20.307
TGFB1transforming growth factor, beta 10.306
CCL20chemokine (C-C motif) ligand 200.295
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.284
RACGAP1Rac GTPase activating protein 10.278
APCadenomatous polyposis coli0.273
ANGPT2angiopoietin 20.271
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.242
MYH9myosin, heavy chain 9, non-muscle0.235
CBX5chromobox homolog 50.234
LATlinker for activation of T cells0.223
GSK3Bglycogen synthase kinase 3 beta0.222
RXRAretinoid X receptor, alpha0.219
SKILSKI-like oncogene0.216
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.213
IRF2interferon regulatory factor 20.211
LRRK2leucine-rich repeat kinase 20.204
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.204
SP1Sp1 transcription factor0.203
DSG2desmoglein 20.202
TLR2toll-like receptor 20.198
DSPdesmoplakin0.194
HIPK3homeodomain interacting protein kinase 30.194
CCL2chemokine (C-C motif) ligand 20.191
SF3A1splicing factor 3a, subunit 1, 120kDa0.179
IL6interleukin 6 (interferon, beta 2)0.176
CREBBPCREB binding protein0.173
TRAF1TNF receptor-associated factor 10.172
FOXD3forkhead box D30.171
SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)0.170
SH2D4ASH2 domain containing 4A0.162
ENGendoglin0.158
RARAretinoic acid receptor, alpha0.157
SNAI1snail homolog 1 (Drosophila)0.157
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.157
CCR1chemokine (C-C motif) receptor 10.155
TRIM25tripartite motif containing 250.152
CTNND1catenin (cadherin-associated protein), delta 10.147
TGFB3transforming growth factor, beta 30.146
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.139
WWP2WW domain containing E3 ubiquitin protein ligase 20.138
ZFYVE9zinc finger, FYVE domain containing 90.136
IDEinsulin-degrading enzyme0.134
ICAM1intercellular adhesion molecule 10.133
FSTL1follistatin-like 10.133
NCOR1nuclear receptor corepressor 10.132
GDF5growth differentiation factor 50.129
CCL8chemokine (C-C motif) ligand 80.126
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.124
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.904
Ctnnb1catenin (cadherin associated protein), beta 10.892
Tnftumor necrosis factor0.842
Casp4caspase 4, apoptosis-related cysteine peptidase0.683
Fgfr2fibroblast growth factor receptor 20.672
Gli3GLI-Kruppel family member GLI30.662
Smad4MAD homolog 4 (Drosophila)0.640
Smad3MAD homolog 3 (Drosophila)0.621
Mapk14mitogen-activated protein kinase 140.588
Apcadenomatosis polyposis coli0.535
Gli2GLI-Kruppel family member GLI20.520
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.514
Map3k7mitogen-activated protein kinase kinase kinase 70.498
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.474
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.455
Ptpn11protein tyrosine phosphatase, non-receptor type 110.447
Leprleptin receptor0.398
Map3k14mitogen-activated protein kinase kinase kinase 140.389
Axin1axin 10.375
Sall4sal-like 4 (Drosophila)0.365
Sfrp2secreted frizzled-related protein 20.361
Tlr4toll-like receptor 40.360
Ikbkginhibitor of kappaB kinase gamma0.313
Smosmoothened homolog (Drosophila)0.276
Smad1MAD homolog 1 (Drosophila)0.255
EdaraddEDAR (ectodysplasin-A receptor)-associated death domain0.221
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.213
Il10interleukin 100.202
Ren1renin 1 structural0.201
Ikbkbinhibitor of kappaB kinase beta0.201
Tgfatransforming growth factor alpha0.200
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.199
Htthuntingtin0.186
Nr3c1nuclear receptor subfamily 3, group C, member 10.183
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.174
Il1r1interleukin 1 receptor, type I0.171
Cd44CD44 antigen0.167
Smad2MAD homolog 2 (Drosophila)0.157
Trp53transformation related protein 530.156
Sfrp1secreted frizzled-related protein 10.154
Stat3signal transducer and activator of transcription 30.122
Cux1cut-like homeobox 10.122
Tcf7l1transcription factor 7-like 1 (T-cell specific, HMG box)0.111
Rnf111ring finger 1110.111
Sox18SRY-box containing gene 180.110
Fgfr1fibroblast growth factor receptor 10.104
Stim2stromal interaction molecule 20.100
Esr2estrogen receptor 2 (beta)0.099
Gsk3bglycogen synthase kinase 3 beta0.099
Pitx2paired-like homeodomain transcription factor 20.098
Shhsonic hedgehog0.097
Ppp3cbprotein phosphatase 3, catalytic subunit, beta isoform0.097
Traf6TNF receptor-associated factor 60.096
Il7interleukin 70.096
Myd88myeloid differentiation primary response gene 880.091
Rac1RAS-related C3 botulinum substrate 10.090
Egfrepidermal growth factor receptor0.090
Bmpr1abone morphogenetic protein receptor, type 1A0.087
Ltalymphotoxin A0.087
Bmp4bone morphogenetic protein 40.085
Nodalnodal0.083
Tgfbr2transforming growth factor, beta receptor II0.082
Smad6MAD homolog 6 (Drosophila)0.081
Cxcl13chemokine (C-X-C motif) ligand 130.078
Ltblymphotoxin B0.077
Ccnb1cyclin B10.077
Shc1src homology 2 domain-containing transforming protein C10.075
Usp9xubiquitin specific peptidase 9, X chromosome0.075
Mapk1mitogen-activated protein kinase 10.073
Smtnsmoothelin0.072
Thbs1thrombospondin 10.072
Cxcr5chemokine (C-X-C motif) receptor 50.071
Smurf1SMAD specific E3 ubiquitin protein ligase 10.067
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.066
Pdlim4PDZ and LIM domain 40.065
Eya2eyes absent 2 homolog (Drosophila)0.065
Kpna3karyopherin (importin) alpha 30.064
Ror2receptor tyrosine kinase-like orphan receptor 20.063
Zic2zinc finger protein of the cerebellum 20.063
Vdrvitamin D receptor0.061
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.061
Erbb2ipErbb2 interacting protein0.058
Mapk8mitogen-activated protein kinase 80.058
Kpna1karyopherin (importin) alpha 10.058
Neurog3neurogenin 30.057
Hs1bp3HCLS1 binding protein 30.054
Gpc3glypican 30.053
CblCasitas B-lineage lymphoma0.052
Toxthymocyte selection-associated high mobility group box0.051
Efsembryonal Fyn-associated substrate0.051
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.050
Rnf31ring finger protein 310.050
Foxc1forkhead box C10.049
Yap1yes-associated protein 10.049
Zeb1zinc finger E-box binding homeobox 10.048
Map3k5mitogen-activated protein kinase kinase kinase 50.048
Pthlhparathyroid hormone-like peptide0.047
Mapkapk2MAP kinase-activated protein kinase 20.047
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.046
Ptch1patched homolog 10.045
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hsph1heat shock 105/110 protein 10.768
Mpripmyosin phosphatase Rho interacting protein0.108
Hspa8heat shock protein 80.107
Hist1h1ahistone cluster 1, H1a0.075
Eef2eukaryotic translation elongation factor 20.069
Mapk1mitogen activated protein kinase 10.062
Gja1gap junction protein, alpha 10.046
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.045
Stip1stress-induced phosphoprotein 10.042
Icam1intercellular adhesion molecule 10.031
Nek9NIMA (never in mitosis gene a)- related kinase 90.029
Jak1Janus kinase 10.028
Il6interleukin 60.027
Ece1endothelin converting enzyme 10.027
Mtpnmyotrophin0.023
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.020
Ccnd3cyclin D30.020
Gna12guanine nucleotide binding protein (G protein) alpha 120.020
Ptbp1polypyrimidine tract binding protein 10.020
Fgfr1Fibroblast growth factor receptor 10.019
Hspd1heat shock protein 1 (chaperonin)0.018
Top2atopoisomerase (DNA) II alpha0.017
BokBCL2-related ovarian killer0.017
Casp2caspase 20.016
Ptpn12protein tyrosine phosphatase, non-receptor type 120.016
Bgnbiglycan0.016
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.015
Falzfetal Alzheimer antigen0.015
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.015
Cyfip2cytoplasmic FMR1 interacting protein 20.015
Mapre1microtubule-associated protein, RP/EB family, member 10.015
Ipo5importin 50.014
Ptk2bPTK2B protein tyrosine kinase 2 beta0.014
Dlgap1discs, large (Drosophila) homolog-associated protein 10.014
Gria2glutamate receptor, ionotropic, AMPA 20.014
Hsp90b1heat shock protein 90, beta, member 10.013
Galnt1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)0.013
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.013
Hif1ahypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.013
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.013
Ddr2discoidin domain receptor tyrosine kinase 20.013
Acyp2acylphosphatase 2, muscle type0.012
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.012
Apex1APEX nuclease (multifunctional DNA repair enzyme) 10.012
Map2microtubule-associated protein 20.012
Nr4a3nuclear receptor subfamily 4, group A, member 30.012
Cdk4cyclin-dependent kinase 40.012
Grm7glutamate receptor, metabotropic 70.012
Tnks2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.012
Canxcalnexin0.011
Mib1mindbomb homolog 1 (Drosophila)0.011
Ctbp1C-terminal binding protein 10.011
Synj1synaptojanin 10.011
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.011
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.011
BtkBruton agammaglobulinemia tyrosine kinase0.011
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.011
Prkcbprotein kinase C, beta0.011
Aqp4aquaporin 40.011
Tlr2toll-like receptor 20.011
Exoc5exocyst complex component 50.011
Cd86CD86 molecule0.011
Sf3b3splicing factor 3b, subunit 30.010
Syngr2synaptogyrin 20.010
Csnk1dcasein kinase 1, delta0.010
Grip1glutamate receptor interacting protein 10.010
Hspb1heat shock protein 10.010
Hivep2human immunodeficiency virus type I enhancer binding protein 20.010
Slit3slit homolog 3 (Drosophila)0.010
Ccl3chemokine (C-C motif) ligand 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism