The network for 'regulation of intracellular signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of intracellular signal transduction

Any process that modulates the frequency, rate or extent of intracellular signal transduction.

NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.995
tkvthickveins0.990
S6kRPS6-p70-protein kinase0.976
SmoxSmad on X0.970
kaykayak0.951
stcksteamer duck0.948
lin19lin-19-like0.941
putpunt0.902
nmonemo0.887
Akt1CG4006 gene product from transcript CG4006-RA0.886
aopanterior open0.885
RhebCG1081 gene product from transcript CG1081-RA0.882
Rho1CG8416 gene product from transcript CG8416-RB0.881
ykiyorkie0.857
rapretina aberrant in pattern0.857
keykenny0.839
p38bCG7393 gene product from transcript CG7393-RA0.837
NetBNetrin-B0.832
Atg1Autophagy-specific gene 10.826
wtswarts0.825
hephemipterous0.808
edechinoid0.801
mbcmyoblast city0.797
Vps35Vacuolar protein sorting 350.791
shishibire0.775
drkdownstream of receptor kinase0.773
Rab5Rab-protein 50.761
rutrutabaga0.750
dcodiscs overgrown0.748
phlpole hole0.747
Ras85DRas oncogene at 85D0.745
dmdiminutive0.744
hpohippo0.744
pucpuckered0.736
foxoforkhead box, sub-group O0.735
maskmultiple ankyrin repeats single KH domain0.727
Taf1TBP-associated factor 10.719
ShcSHC-adaptor protein0.711
rlrolled0.704
Mpk2CG5475 gene product from transcript CG5475-RB0.682
Rac1CG2248 gene product from transcript CG2248-RA0.679
armarmadillo0.670
MadMothers against dpp0.669
dosdaughter of sevenless0.667
CG5794CG5794 gene product from transcript CG5794-RB0.649
mib1mind bomb 10.646
mnbminibrain0.645
dncdunce0.630
Tao-1CG14217 gene product from transcript CG14217-RF0.622
EndoGIEndonuclease G inhibitor0.611
Lis-1Lissencephaly-10.592
kiskismet0.590
MerMerlin0.585
SdcSyndecan0.580
Rpd3CG7471 gene product from transcript CG7471-RA0.580
eIF-4EEukaryotic initiation factor 4E0.578
rokRho-kinase0.568
mtsmicrotubule star0.563
Cul-5Cullin-50.561
Plc21CPhospholipase C at 21C0.560
mopmyopic0.558
CycGCyclin G0.556
Caf1Chromatin assembly factor 1 subunit0.556
chicchickadee0.547
CG4030CG4030 gene product from transcript CG4030-RA0.543
hppyhappyhour0.542
DadDaughters against dpp0.540
babobaboon0.540
Fcp1CG12252 gene product from transcript CG12252-RA0.537
msnmisshapen0.528
agoarchipelago0.521
RelRelish0.520
staustaufen0.519
JraJun-related antigen0.516
hrghiiragi0.512
ird1immune response deficient 10.511
AlkCG8250 gene product from transcript CG8250-RA0.505
MoeMoesin0.498
locolocomotion defects0.497
Ptp69DProtein tyrosine phosphatase 69D0.492
dockdreadlocks0.477
rictorrapamycin-insensitive companion of Tor0.475
Su(H)Suppressor of Hairless0.475
XNPCG4548 gene product from transcript CG4548-RA0.474
Dsor1Downstream of raf10.473
Myo31DFMyosin 31DF0.473
pydpolychaetoid0.466
AGO2Argonaute 20.466
tutlturtle0.461
SpnSpinophilin0.460
Prp31CG6876 gene product from transcript CG6876-RA0.455
lidlittle imaginal discs0.453
p53CG33336 gene product from transcript CG33336-RB0.453
p120ctnAdherens junction protein p1200.450
ttktramtrack0.432
SosSon of sevenless0.429
ushu-shaped0.425
rheaCG6831 gene product from transcript CG6831-RA0.421
HLHm7E(spl) region transcript m70.417
egreiger0.416
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
imb-2Protein IMB-20.502
bar-1Protein BAR-10.424
sem-5Protein SEM-50.413
pkg-1Protein PKG-10.398
egl-18Protein EGL-180.358
unc-40Protein UNC-400.354
glp-1Protein GLP-10.349
sma-6Protein SMA-60.341
goa-1Protein GOA-10.319
lin-45Protein LIN-450.303
hgrs-1Protein HGRS-10.291
nhr-6Protein NHR-60.270
msp-55Protein MSP-550.269
msp-78Protein MSP-780.265
msp-59Protein MSP-590.262
skn-1Protein SKN-10.248
mpk-1Protein MPK-10.224
mpz-2Protein MPZ-20.206
sma-1Protein SMA-10.197
nhr-35Protein NHR-350.193
csn-4Protein CSN-40.192
vab-3Protein VAB-30.191
plc-1Protein PLC-10.188
F22D3.2Protein F22D3.20.187
msp-19Protein MSP-190.177
abl-1Protein ABL-10.173
cpn-1Protein CPN-10.172
klp-12Protein KLP-120.169
sad-1Protein SAD-10.166
mec-2Protein MEC-20.165
egg-6Protein EGG-60.163
msp-77Protein MSP-770.161
ida-1Protein IDA-10.161
CELE_Y59E9AR.7Protein Y59E9AR.70.157
par-5Protein PAR-50.155
tag-343Protein TAG-3430.152
spd-5Protein SPD-50.147
eor-1Protein EOR-10.145
alx-1Protein ALX-10.144
snr-2Protein SNR-20.144
msp-65Protein MSP-650.143
gld-1Protein GLD-10.141
msp-40Protein MSP-400.140
msp-53Protein MSP-530.140
msp-36Protein MSP-360.138
cdc-42Protein CDC-420.138
daf-12Protein DAF-120.136
msp-79Protein MSP-790.133
exc-5Protein EXC-50.132
smp-1Protein SMP-10.131
mig-2Protein MIG-20.130
aak-2Protein AAK-20.129
F35F11.1Protein F35F11.10.129
T19B10.6Protein T19B10.60.126
camt-1Protein CAMT-10.124
arf-3Protein ARF-30.123
lin-36Protein LIN-360.121
zfp-1Protein ZFP-10.120
sur-2Protein SUR-20.118
ced-10Protein CED-100.116
nhr-34Protein NHR-340.116
K08E3.5Protein K08E3.50.114
ceh-32Protein CEH-320.112
scd-1Protein SCD-10.109
pqn-44Protein PQN-440.109
gana-1Protein GANA-10.108
T23F11.1Protein T23F11.10.108
zak-1Protein ZAK-10.106
sas-5Protein SAS-50.106
msp-33Protein MSP-330.105
nipi-3Protein NIPI-30.104
smk-1Protein SMK-10.104
ubq-1Protein UBQ-10.103
lin-12Protein LIN-120.103
T27A3.1Protein T27A3.10.100
rhi-1Protein RHI-10.099
msp-45Protein MSP-450.099
klp-7Protein KLP-70.098
unc-32Protein UNC-320.098
msp-38Protein MSP-380.098
F21A10.2Protein F21A10.20.097
soc-2Protein SOC-20.096
Y55F3BR.8Protein Y55F3BR.80.096
msp-10Protein MSP-100.095
snf-1Protein SNF-10.095
CELE_F56D5.6Protein F56D5.60.095
unc-43Protein UNC-430.094
hum-5Protein HUM-50.094
arrd-25Protein ARRD-250.093
msp-64Protein MSP-640.091
etr-1Protein ETR-10.091
unc-52Protein UNC-520.091
scc-1Protein SCC-10.091
hpo-32Protein HPO-320.088
lin-25Protein LIN-250.088
CELE_Y41D4B.4Protein Y41D4B.40.088
afd-1Protein AFD-10.088
pat-6Protein PAT-60.085
lag-1Protein LAG-10.085
unc-16Protein UNC-160.084
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.375
cxcr4achemokine (C-X-C motif) receptor 4a0.318
tp53bp2tumor protein p53 binding protein, 20.295
efnb2aephrin B2a0.277
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.256
sox2SRY-box containing gene 20.243
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.224
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.218
phox2bpaired-like homeobox 2b0.197
myod1myogenic differentiation 10.194
hey1hairy/enhancer-of-split related with YRPW motif 10.193
foxc1aforkhead box C1a0.190
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.189
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.173
cnn2calponin 20.172
fn1fibronectin 10.167
gpr126G protein-coupled receptor 1260.166
dag1dystroglycan 10.163
ahr2aryl hydrocarbon receptor 20.162
aplnraapelin receptor a0.159
baxabcl2-associated X protein, a0.149
twist1atwist1a0.148
lrrn1leucine rich repeat neuronal 10.148
trpm7transient receptor potential cation channel, subfamily M, member 70.146
oxtloxytocin-like0.139
itgb1b.2integrin, beta 1b.20.139
mapk1mitogen-activated protein kinase 10.139
prkciprotein kinase C, iota0.139
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.138
wnt2bbwingless-type MMTV integration site family, member 2Bb0.134
bmperBMP binding endothelial regulator0.130
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.129
dlbdeltaB0.127
spry2sprouty homolog 20.124
fzd7afrizzled homolog 7a0.123
tbx1T-box 10.123
notch3notch homolog 30.123
ptenaphosphatase and tensin homolog A0.122
si:ch211-212m21.5si:ch211-212m21.50.121
LOC100537975thyroid receptor-interacting protein 11-like0.121
nf1aneurofibromin 1a0.121
frem3Fras1 related extracellular matrix 30.120
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.118
evx1even-skipped homeobox 10.118
bcl2l1bcl2-like 10.117
cdh5cadherin 50.115
lef1lymphocyte enhancer binding factor 10.115
jag2jagged 20.114
otpaorthopedia homolog a0.113
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.108
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.108
csnk1dacasein kinase 1, delta a0.107
mpxmyeloid-specific peroxidase0.102
ptprfprotein tyrosine phosphatase, receptor type, F0.099
shhasonic hedgehog a0.098
nrp2bneuropilin 2b0.097
irf9interferon regulatory factor 90.097
igf1rainsulin-like growth factor 1a receptor0.097
vegfcvascular endothelial growth factor c0.096
zbtb4zinc finger and BTB domain containing 40.095
prox1prospero-related homeobox gene 10.093
trpv6transient receptor potential cation channel, subfamily V, member 60.088
dkk1bdickkopf 1b0.088
il6stinterleukin 6 signal transducer0.088
tpm4tropomyosin 40.086
odc1ornithine decarboxylase 10.085
igf1insulin-like growth factor 10.085
igf1rbinsulin-like growth factor 1b receptor0.085
drd2bdopamine receptor D2b0.084
atf3activating transcription factor 30.084
celf1cugbp, Elav-like family member 10.083
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.083
gclcglutamate-cysteine ligase, catalytic subunit0.082
znf703zinc finger protein 7030.082
brd4bromodomain containing 40.082
phox2apaired-like homeobox 2a0.081
cx43connexin 430.081
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.081
traf4atnf receptor-associated factor 4a0.079
plaaphospholipase A2-activating protein0.079
fzd5frizzled homolog 50.078
junbjun B proto-oncogene0.078
nrg2aneuregulin 2a0.078
mmp9matrix metalloproteinase 90.078
zgc:64114zgc:641140.077
bocbrother of CDO0.077
kdm5clysine (K)-specific demethylase 5C0.077
rnd3aRho family GTPase 3a0.077
stau2staufen, RNA binding protein, homolog 2 (Drosophila)0.076
ppm1aaprotein phosphatase, Mg2+/Mn2+ dependent, 1Aa0.076
emx2empty spiracles homeobox 20.076
LOC100003330melanocortin-2 receptor accessory protein 2-like0.075
fgfr1afibroblast growth factor receptor 1a0.074
gbx2gastrulation brain homeo box 20.074
bmp2abone morphogenetic protein 2a0.074
alcambactivated leukocyte cell adhesion molecule b0.073
mcl1bmyeloid cell leukemia sequence 1b0.072
slit3slit (Drosophila) homolog 30.071
fzd3afrizzled homolog 3a0.070
sfrp1bsecreted frizzled-related protein 1b0.070
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Adora2aadenosine A2a receptor0.860
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.754
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.635
Jak1Janus kinase 10.624
Il1ainterleukin 1 alpha0.623
Socs3suppressor of cytokine signaling 30.617
Nedd4neural precursor cell expressed, developmentally down-regulated 40.580
Jak2Janus kinase 20.567
Bcl2B-cell CLL/lymphoma 20.553
Dlg4discs, large homolog 4 (Drosophila)0.551
Fgfr2fibroblast growth factor receptor 20.549
Ccl4chemokine (C-C motif) ligand 40.542
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.532
Il6interleukin 60.532
Map2microtubule-associated protein 20.529
Gdnfglial cell derived neurotrophic factor0.510
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.490
Itgamintegrin, alpha M0.485
Nr5a2nuclear receptor subfamily 5, group A, member 20.485
Gzmbgranzyme B0.479
Acracrosin0.474
Cd4Cd4 molecule0.472
Ncr1natural cytotoxicity triggering receptor 10.469
Tgfbr2transforming growth factor, beta receptor II0.468
Prkcgprotein kinase C, gamma0.466
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.456
Sdc3syndecan 30.435
Sirpasignal-regulatory protein alpha0.429
Usf2upstream transcription factor 2, c-fos interacting0.428
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.420
Gng7guanine nucleotide binding protein (G protein), gamma 70.410
Muskmuscle, skeletal, receptor tyrosine kinase0.406
Mapk3mitogen activated protein kinase 30.404
Hckhemopoietic cell kinase0.399
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.398
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.393
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.393
Tpc1808tropic 18080.371
Smad7SMAD family member 70.360
Rararetinoic acid receptor, alpha0.358
Lgals5lectin, galactose binding, soluble 50.347
Ralgdsral guanine nucleotide dissociation stimulator0.344
Trhrthyrotropin releasing hormone receptor0.343
Appamyloid beta (A4) precursor protein0.343
Prkcdprotein kinase C, delta0.341
S1pr2sphingosine-1-phosphate receptor 20.336
Grm7glutamate receptor, metabotropic 70.332
Adam17ADAM metallopeptidase domain 170.330
Slc6a7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.324
Adcy10adenylate cyclase 10 (soluble)0.318
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.317
Prdm2PR domain containing 2, with ZNF domain0.317
Nos3nitric oxide synthase 3, endothelial cell0.316
Hpcal4hippocalcin-like 40.315
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.314
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.313
Zfp36zinc finger protein 360.312
Itpr1inositol 1,4,5-triphosphate receptor, type 10.310
Ctsjcathepsin J0.309
Mcf2lMCF.2 cell line derived transforming sequence-like0.307
Cd14CD14 molecule0.305
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.304
Mapk1mitogen activated protein kinase 10.304
Jtbjumping translocation breakpoint0.303
Errfi1ERBB receptor feedback inhibitor 10.302
Cd8aCD8a molecule0.302
Cxcl2chemokine (C-X-C motif) ligand 20.298
Klf9Kruppel-like factor 90.297
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.296
Ccl2chemokine (C-C motif) ligand 20.296
Fgf7fibroblast growth factor 70.295
Map3k8mitogen-activated protein kinase kinase kinase 80.294
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.292
Nos2nitric oxide synthase 2, inducible0.292
Myd88myeloid differentiation primary response gene 880.292
Rps6ka1ribosomal protein S6 kinase polypeptide 10.289
RGD1564327similar to integrin alpha 80.287
Fgfr1Fibroblast growth factor receptor 10.287
Vegfavascular endothelial growth factor A0.286
Pde4bphosphodiesterase 4B, cAMP specific0.286
Vcsa2variable coding sequence A20.284
Hdac7histone deacetylase 70.279
Ptk2bPTK2B protein tyrosine kinase 2 beta0.278
Prrx1paired related homeobox 10.276
Cabin1calcineurin binding protein 10.276
Notch1Notch homolog 1, translocation-associated (Drosophila)0.275
Il1r1interleukin 1 receptor, type I0.275
Dlgap1discs, large (Drosophila) homolog-associated protein 10.274
Olr416olfactory receptor 4160.270
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.268
Icam1intercellular adhesion molecule 10.268
Cdk4cyclin-dependent kinase 40.267
Egfrepidermal growth factor receptor0.266
Abcb4ATP-binding cassette, subfamily B (MDR/TAP), member 40.265
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.263
Kcnv2potassium channel, subfamily V, member 20.263
Mpeg1macrophage expressed 10.261
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.261
Tgm1transglutaminase 1, K polypeptide0.260
Cfpcomplement factor properdin0.260
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
BCK1Bck1p0.962
SLT2Slt2p0.833
ROM2Rom2p0.792
STE20Ste20p0.707
PBS2Pbs2p0.568
SSK2Ssk2p0.550
RHO1Rho1p0.529
ERP4Erp4p0.483
TPS1Tps1p0.460
GYL1Gyl1p0.387
TOR1Tor1p0.351
BNI1Bni1p0.324
TRS65Trs65p0.319
FAR1Far1p0.318
MKK1Mkk1p0.312
MSG5Msg5p0.300
KOG1Kog1p0.300
STE4Ste4p0.297
KEM1Kem1p0.252
CDC24Cdc24p0.233
RIM101Rim101p0.230
AKL1Akl1p0.223
CHC1Chc1p0.220
SSK22Ssk22p0.217
SHO1Sho1p0.199
GPB2Gpb2p0.197
RIM15Rim15p0.191
MKS1Mks1p0.187
ICE2Ice2p0.185
FUS3Fus3p0.181
OLE1Ole1p0.180
CRG1Crg1p0.175
RGC1Rgc1p0.171
NBP2Nbp2p0.169
MKT1Mkt1p0.167
MON1Mon1p0.166
MEH1Meh1p0.165
STE11Ste11p0.162
STE5Ste5p0.162
TOM1Tom1p0.161
KSS1Kss1p0.158
VAC8Vac8p0.155
YAK1Yak1p0.153
SSK1Ssk1p0.153
HOS4Hos4p0.152
CDC55Cdc55p0.152
DIG1Dig1p0.151
CLA4Cla4p0.150
BOI1Boi1p0.145
STE7Ste7p0.143
PTC1Ptc1p0.141
TCA17Tca17p0.138
LCB4Lcb4p0.135
SOK1Sok1p0.134
TSC11Tsc11p0.133
ERP3Erp3p0.132
ETR1Etr1p0.126
IRA1Ira1p0.122
BRO1Bro1p0.119
MTC5Mtc5p0.118
GIP2Gip2p0.117
BEM2Bem2p0.117
GSC2Gsc2p0.115
ARF2Arf2p0.111
YME1Yme1p0.110
POL5Pol5p0.106
MDS3Mds3p0.103
LSG1Lsg1p0.102
SAC7Sac7p0.096
YEL1Yel1p0.095
PIL1Pil1p0.095
CDC25Cdc25p0.094
PIB2Pib2p0.091
GDI1Gdi1p0.090
BUD14Bud14p0.090
TCO89Tco89p0.088
ZDS1Zds1p0.087
BCK2Bck2p0.087
RDI1Rdi1p0.087
PKC1Pkc1p0.087
BEM3Bem3p0.086
MDR1Mdr1p0.086
CCR4Ccr4p0.084
ENA5Ena5p0.082
VPS30Vps30p0.082
RUP1Rup1p0.081
CYC8Cyc8p0.081
CRM1Crm1p0.080
ALO1Alo1p0.079
SRP54Srp54p0.078
SSN8Ssn8p0.078
HKR1Hkr1p0.078
NTH1Nth1p0.078
HSP60Hsp60p0.075
SWE1Swe1p0.075
YPD1Ypd1p0.074
FAR11Far11p0.074
FUS2Fus2p0.073
INP53Inp53p0.071
CMP2Cmp2p0.071