The network for 'regulation of pathway restricted smad protein phosphorylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of pathway restricted smad protein phosphorylation

Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp1.000
gbbglass bottom boat1.000
Ras85DRas oncogene at 85D0.946
EgfrEpidermal growth factor receptor0.755
ash2absent, small, or homeotic discs 20.645
Pi3K92ECG4141 gene product from transcript CG4141-RB0.630
SaraSmad anchor for receptor activation0.586
dallydivision abnormally delayed0.537
myoglianinCG1838 gene product from transcript CG1838-RD0.483
sogshort gastrulation0.294
dcodiscs overgrown0.269
Akt1CG4006 gene product from transcript CG4006-RA0.247
DadDaughters against dpp0.245
cicubitus interruptus0.227
EcREcdysone receptor0.218
Stat92ESignal-transducer and activator of transcription protein at 92E0.155
Atg1Autophagy-specific gene 10.143
InRInsulin-like receptor0.111
slmbsupernumerary limbs0.107
Nrx-1Neurexin 10.103
rapretina aberrant in pattern0.087
mxcmulti sex combs0.068
Fak56DFocal Adhesion Kinase0.065
Plc21CPhospholipase C at 21C0.064
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.056
sydsunday driver0.053
Atg6Autophagy-specific gene 60.050
WASpCG1520 gene product from transcript CG1520-RA0.048
RhebCG1081 gene product from transcript CG1081-RA0.048
unc-104CG8566 gene product from transcript CG8566-RB0.044
Snap25Synapse protein 250.039
PP2A-B'CG7913 gene product from transcript CG7913-RK0.037
PtenCG5671 gene product from transcript CG5671-RB0.037
Pk61CProtein kinase 61C0.035
Irk2Inwardly rectifying potassium channel 20.034
Smg1CG32743 gene product from transcript CG32743-RA0.034
dvedefective proventriculus0.033
fbl6CG13213 gene product from transcript CG13213-RB0.033
Su(H)Suppressor of Hairless0.032
SmoxSmad on X0.032
StimStromal interaction molecule0.030
Dap160Dynamin associated protein 1600.029
Nsf2NEM-sensitive fusion protein 20.029
CG8709CG8709 gene product from transcript CG8709-RK0.029
witwishful thinking0.028
coroCG9446 gene product from transcript CG9446-RC0.027
AcslAcyl-CoA synthetase long-chain0.027
CG9139CG9139 gene product from transcript CG9139-RA0.027
prodproliferation disrupter0.027
eyaeyes absent0.026
SnooSno oncogene0.026
beta-Specbeta Spectrin0.026
hydhyperplastic discs0.025
Bre1CG10542 gene product from transcript CG10542-RA0.025
G-oalpha47AG protein oalpha 47A0.024
cv-2crossveinless 20.022
TER94CG2331 gene product from transcript CG2331-RA0.022
CaMKIICalcium/calmodulin-dependent protein kinase II0.022
LaspCG3849 gene product from transcript CG3849-RB0.022
Pde8Phosphodiesterase 80.021
ATPCLATP citrate lyase0.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TGFBR2transforming growth factor, beta receptor II (70/80kDa)1.000
SMURF2SMAD specific E3 ubiquitin protein ligase 21.000
BMP2bone morphogenetic protein 21.000
BMPR1Abone morphogenetic protein receptor, type IA1.000
SMAD7SMAD family member 71.000
TGFB1transforming growth factor, beta 10.999
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.999
TGFB3transforming growth factor, beta 30.998
SMAD4SMAD family member 40.997
FSTL1follistatin-like 10.992
TGFBR1transforming growth factor, beta receptor 10.988
BMPR1Bbone morphogenetic protein receptor, type IB0.987
SMAD1SMAD family member 10.986
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.979
SMAD5SMAD family member 50.973
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.958
ACVR1activin A receptor, type I0.922
GDF5growth differentiation factor 50.888
NRP1neuropilin 10.873
SMAD2SMAD family member 20.822
LRP6low density lipoprotein receptor-related protein 60.787
ZFYVE9zinc finger, FYVE domain containing 90.721
SMAD3SMAD family member 30.707
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.701
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.492
SKILSKI-like oncogene0.484
SMAD6SMAD family member 60.464
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.449
ACVR1Bactivin A receptor, type IB0.298
FKBP1AFK506 binding protein 1A, 12kDa0.278
SKIv-ski sarcoma viral oncogene homolog (avian)0.251
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.246
CXXC5CXXC finger protein 50.236
TGFB2transforming growth factor, beta 20.235
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.222
ACVR2Bactivin A receptor, type IIB0.220
PRKG1protein kinase, cGMP-dependent, type I0.213
BMP4bone morphogenetic protein 40.191
ZMYND11zinc finger, MYND-type containing 110.164
NEDD4neural precursor cell expressed, developmentally down-regulated 40.104
SOX7SRY (sex determining region Y)-box 70.100
MAPK8mitogen-activated protein kinase 80.100
ADARB1adenosine deaminase, RNA-specific, B10.098
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.097
THBS1thrombospondin 10.097
FN1fibronectin 10.094
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.084
HEYLhairy/enhancer-of-split related with YRPW motif-like0.082
MYO6myosin VI0.082
WDYHV1WDYHV motif containing 10.079
ZEB2zinc finger E-box binding homeobox 20.076
RXRAretinoid X receptor, alpha0.075
DAZAP2DAZ associated protein 20.067
SMURF1SMAD specific E3 ubiquitin protein ligase 10.066
GRB7growth factor receptor-bound protein 70.058
HOXC8homeobox C80.057
NLKnemo-like kinase0.053
MKL2MKL/myocardin-like 20.053
PITX1paired-like homeodomain 10.053
QKIquaking homolog, KH domain RNA binding (mouse)0.052
NRP2neuropilin 20.049
PDLIM4PDZ and LIM domain 40.049
VPS24vacuolar protein sorting 24 homolog (S. cerevisiae)0.047
COL2A1collagen, type II, alpha 10.047
SMN1survival of motor neuron 1, telomeric0.045
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.045
SPG20spastic paraplegia 20 (Troyer syndrome)0.044
CSNK2A2casein kinase 2, alpha prime polypeptide0.044
RNF11ring finger protein 110.044
TFPI2tissue factor pathway inhibitor 20.043
NEDD9neural precursor cell expressed, developmentally down-regulated 90.042
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.041
TRAF4TNF receptor-associated factor 40.041
CCDC126coiled-coil domain containing 1260.039
ANTXR2anthrax toxin receptor 20.036
FBLN1fibulin 10.035
PHF1PHD finger protein 10.035
ACVR2Aactivin A receptor, type IIA0.034
TGFBR3transforming growth factor, beta receptor III0.033
ARHGAP5Rho GTPase activating protein 50.031
SMAD9SMAD family member 90.030
RBMS3RNA binding motif, single stranded interacting protein 30.030
LRP2low density lipoprotein receptor-related protein 20.029
PMEPA1prostate transmembrane protein, androgen induced 10.029
RHOXF2Rhox homeobox family, member 20.029
DOCK8dedicator of cytokinesis 80.028
POLKpolymerase (DNA directed) kappa0.028
INHBBinhibin, beta B0.026
CTGFconnective tissue growth factor0.026
FHL2four and a half LIM domains 20.026
PDGFCplatelet derived growth factor C0.026
WWP2WW domain containing E3 ubiquitin protein ligase 20.025
MED25mediator complex subunit 250.025
PAPPApregnancy-associated plasma protein A, pappalysin 10.025
FILIP1Lfilamin A interacting protein 1-like0.025
VEGFCvascular endothelial growth factor C0.025
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Smad4MAD homolog 4 (Drosophila)0.967
Tgfbr2transforming growth factor, beta receptor II0.905
Bmp4bone morphogenetic protein 40.900
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.827
Apcadenomatosis polyposis coli0.793
Smad3MAD homolog 3 (Drosophila)0.748
Bmp7bone morphogenetic protein 70.407
Ctnnb1catenin (cadherin associated protein), beta 10.400
Acvr1activin A receptor, type 10.308
Smad2MAD homolog 2 (Drosophila)0.221
Tgfb2transforming growth factor, beta 20.208
Fgfr3fibroblast growth factor receptor 30.172
Fgfr2fibroblast growth factor receptor 20.163
Axin1axin 10.155
Ptch1patched homolog 10.137
Acvrl1activin A receptor, type II-like 10.115
Fgfr1fibroblast growth factor receptor 10.107
Hand1heart and neural crest derivatives expressed transcript 10.095
Erbb2ipErbb2 interacting protein0.084
Smad1MAD homolog 1 (Drosophila)0.068
Bmpr1abone morphogenetic protein receptor, type 1A0.067
Map3k7mitogen-activated protein kinase kinase kinase 70.052
Prrx1paired related homeobox 10.051
Shhsonic hedgehog0.051
Smurf1SMAD specific E3 ubiquitin protein ligase 10.048
Foxc1forkhead box C10.047
Smad7MAD homolog 7 (Drosophila)0.047
Gli3GLI-Kruppel family member GLI30.046
Tgfbr1transforming growth factor, beta receptor I0.046
Csf1colony stimulating factor 1 (macrophage)0.037
Sox9SRY-box containing gene 90.037
Ptenphosphatase and tensin homolog0.037
Smosmoothened homolog (Drosophila)0.031
Tgfbr3transforming growth factor, beta receptor III0.031
Gdf5growth differentiation factor 50.031
Msx2homeobox, msh-like 20.030
Ror2receptor tyrosine kinase-like orphan receptor 20.026
Amhr2anti-Mullerian hormone type 2 receptor0.026
Smad6MAD homolog 6 (Drosophila)0.025
Prkg1protein kinase, cGMP-dependent, type I0.025
Gli2GLI-Kruppel family member GLI20.023
Runx2runt related transcription factor 20.022
Meox2mesenchyme homeobox 20.022
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.022
Fgf8fibroblast growth factor 80.022
Otx2orthodenticle homolog 2 (Drosophila)0.022
Yap1yes-associated protein 10.022
Il6stinterleukin 6 signal transducer0.021
Tcte3t-complex-associated testis expressed 30.021
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.021
Prrx2paired related homeobox 20.020
Gata4GATA binding protein 40.019
Ednraendothelin receptor type A0.018
Hand2heart and neural crest derivatives expressed transcript 20.016
Bmp2bone morphogenetic protein 20.015
Tbx3T-box 30.014
Stat3signal transducer and activator of transcription 30.013
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.013
Gdf6growth differentiation factor 60.013
Col1a1collagen, type I, alpha 10.013
Itgb1integrin beta 1 (fibronectin receptor beta)0.013
Lrp2low density lipoprotein receptor-related protein 20.013
Nos3nitric oxide synthase 3, endothelial cell0.013
Hspg2perlecan (heparan sulfate proteoglycan 2)0.013
Lrp6low density lipoprotein receptor-related protein 60.013
Gsk3bglycogen synthase kinase 3 beta0.013
Fzd7frizzled homolog 7 (Drosophila)0.013
Rnf111ring finger 1110.012
Twsg1twisted gastrulation homolog 1 (Drosophila)0.012
Foxc2forkhead box C20.012
Foxf1aforkhead box F1a0.012
Gpc3glypican 30.012
Tdgf1teratocarcinoma-derived growth factor 10.011
Psmb5proteasome (prosome, macropain) subunit, beta type 50.011
Ece1endothelin converting enzyme 10.010
Hhexhematopoietically expressed homeobox0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism