The network for 'notch signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

notch signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
Su(H)Suppressor of Hairless0.994
E(spl)Enhancer of split0.993
HLHm7E(spl) region transcript m70.974
HLHmgammaE(spl) region transcript mgamma0.974
HLHmdeltaE(spl) region transcript mdelta0.940
gbbglass bottom boat0.939
O-fut1O-fucosyltransferase 10.923
TomTwin of m40.914
Gp150CG5820 gene product from transcript CG5820-RA0.908
m4E(spl) region transcript m40.851
lqfRliquid facets-Related0.766
m2E(spl) region transcript m20.765
HLHm5E(spl) region transcript m50.761
NotumCG13076 gene product from transcript CG13076-RB0.688
malphaE(spl) region transcript malpha0.671
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.636
cicubitus interruptus0.612
par-6CG5884 gene product from transcript CG5884-RA0.606
VangVan Gogh0.602
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.495
cdicenter divider0.474
CtBPC-terminal Binding Protein0.470
stcksteamer duck0.415
CG9986CG9986 gene product from transcript CG9986-RA0.400
ebiCG4063 gene product from transcript CG4063-RA0.374
Vps35Vacuolar protein sorting 350.370
Rab5Rab-protein 50.364
CG9772CG9772 gene product from transcript CG9772-RB0.350
amosabsent MD neurons and olfactory sensilla0.327
sinaseven in absentia0.321
HLHm3E(spl) region transcript m30.313
Mi-2CG8103 gene product from transcript CG8103-RA0.312
snssticks and stones0.299
EgfrEpidermal growth factor receptor0.280
Eps-15Epidermal growth factor receptor pathway substrate clone 150.278
Vps25Vacuolar protein sorting 250.278
Ten-mTenascin major0.268
cindrCIN85 and CD2AP orthologue0.259
Arp14DActin-related protein 14D0.256
boibrother of iHog0.256
Traf4TNF-receptor-associated factor 40.254
vps2CG14542 gene product from transcript CG14542-RA0.246
M6CG7540 gene product from transcript CG7540-RA0.241
Akt1CG4006 gene product from transcript CG4006-RA0.240
mib1mind bomb 10.225
Tsp3ATetraspanin 3A0.225
numbCG3779 gene product from transcript CG3779-RB0.223
CG6116CG6116 gene product from transcript CG6116-RA0.208
Su(z)12CG8013 gene product from transcript CG8013-RA0.202
HLHmbetaE(spl) region transcript mbeta0.193
aopanterior open0.191
Caf1-180CG12109 gene product from transcript CG12109-RB0.190
kibrakibra ortholog0.181
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.181
RhebCG1081 gene product from transcript CG1081-RA0.179
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.151
ehs-1Protein EHS-10.082
sel-12Protein SEL-120.073
pal-1Protein PAL-10.071
lag-1Protein LAG-10.064
igcm-3Protein IGCM-30.051
eor-2Protein EOR-20.044
CELE_M01B12.4Protein M01B12.40.039
ten-1Protein TEN-10.039
sel-8Protein SEL-80.037
F10D7.5Protein F10D7.50.031
vps-11Protein VPS-110.027
bus-18Protein BUS-180.026
che-13Protein CHE-130.025
lag-2Protein LAG-20.024
pha-4Protein PHA-40.024
cki-2Protein CKI-20.023
hnd-1Protein HND-10.021
CELE_Y60A3A.9Protein Y60A3A.90.021
dnj-25Protein DNJ-250.021
tlf-1Protein TLF-10.020
crml-1Protein CRML-10.020
CELE_Y47G6A.18Protein Y47G6A.180.020
nab-1Protein NAB-10.019
C27C12.1Protein C27C12.10.019
sur-2Protein SUR-20.019
dab-1Protein DAB-10.019
F52A8.1Protein F52A8.10.019
dpy-26Protein DPY-260.019
F23H11.4Protein F23H11.40.018
eif-1.AProtein EIF-1.A0.018
let-502Protein LET-5020.018
ubr-1Protein UBR-10.018
C14A4.11Protein C14A4.110.018
exoc-7Protein EXOC-70.017
apb-1Protein APB-10.017
lin-40Protein LIN-400.017
figl-1Protein FIGL-10.017
che-3Protein CHE-30.017
pmp-3Protein PMP-30.016
osm-3Protein OSM-30.016
hlh-2Protein HLH-20.016
lin-12Protein LIN-120.016
mls-2Protein MLS-20.016
zyg-1Protein ZYG-10.015
let-60Protein LET-600.015
tbx-33Protein TBX-330.015
C31E10.6Protein C31E10.60.015
imb-2Protein IMB-20.015
rer-1Protein RER-10.015
wdr-5.3Protein WDR-5.30.015
helq-1Protein HELQ-10.014
clh-6Protein CLH-60.014
rab-35Protein RAB-350.014
nath-10Protein NATH-100.014
alx-1Protein ALX-10.014
ndx-4Protein NDX-40.014
ref-1Protein REF-10.014
acl-14Protein ACL-140.014
Y87G2A.7Protein Y87G2A.70.014
nhr-67Protein NHR-670.014
nra-3Protein NRA-30.013
tag-353Protein TAG-3530.013
gfi-3Protein GFI-30.013
npp-23Protein NPP-230.013
ZK632.11Protein ZK632.110.013
drap-1Protein DRAP-10.013
tag-231Protein TAG-2310.013
inx-3Protein INX-30.012
osm-6Protein OSM-60.012
dre-1Protein DRE-10.012
egl-30Protein EGL-300.012
aps-2Protein APS-20.012
htz-1Protein HTZ-10.012
F43D9.1Protein F43D9.10.012
C52E12.4Protein C52E12.40.012
btbd-10Protein BTBD-100.012
rps-1Protein RPS-10.012
C02F5.13Protein C02F5.130.012
cnd-1Protein CND-10.012
kin-4Protein KIN-40.012
sel-11Protein SEL-110.012
unc-108Protein UNC-1080.012
erfa-3Protein ERFA-30.012
cpt-1Protein CPT-10.012
tag-77Protein TAG-770.011
pho-5Protein PHO-50.011
K10C9.3Protein K10C9.30.011
ntl-2Protein NTL-20.011
ocam-1Protein OCAM-10.011
tbc-2Protein TBC-20.011
C13B4.1Protein C13B4.10.011
cit-1.1Protein CIT-1.10.011
unc-53Protein UNC-530.011
toca-1Protein TOCA-10.011
D2030.4Protein D2030.40.011
unc-32Protein UNC-320.011
D2013.6Protein D2013.60.011
Y44E3A.6Protein Y44E3A.60.011
vang-1Protein VANG-10.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mespbmesoderm posterior b0.817
foxc1aforkhead box C1a0.802
epb41l5erythrocyte membrane protein band 4.1 like 50.666
wnt5bwingless-type MMTV integration site family, member 5b0.630
notch1anotch homolog 1a0.617
wnt11wingless-type MMTV integration site family, member 110.365
axin2axin 2 (conductin, axil)0.334
her9hairy-related 90.285
tbx16T-box gene 160.251
wt1bwilms tumor 1b0.246
wlswntless homolog (Drosophila)0.237
mespamesoderm posterior a0.234
tfap2atranscription factor AP-2 alpha0.234
crb2acrumbs homolog 2a0.224
pea3ETS-domain transcription factor pea30.204
gro2groucho 20.197
il6rinterleukin 6 receptor0.186
ift88intraflagellar transport 88 homolog0.185
myf5myogenic factor 50.180
cc2d2acoiled-coil and C2 domain containing 2A0.175
her15.1hairy and enhancer of split-related 15.10.174
her6hairy-related 60.174
her1hairy-related 10.173
tbx6T-box gene 60.166
eya1eyes absent homolog 10.162
kif17kinesin family member 170.161
fzd10frizzled homolog 100.153
pou5f1POU domain, class 5, transcription factor 10.152
mibmind bomb0.148
lfnglunatic fringe homolog0.147
mmp2matrix metalloproteinase 20.145
dlx5adistal-less homeobox gene 5a0.139
actn1actinin, alpha 10.137
sesn1sestrin 10.134
ascl1bachaete-scute complex-like 1b (Drosophila)0.127
nod1nucleotide-binding oligomerization domain containing 10.127
flt4fms-related tyrosine kinase 40.126
neurog1neurogenin 10.125
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.124
msxcmuscle segment homeobox C0.123
ephb4beph receptor B4b0.121
prkciprotein kinase C, iota0.119
sox3SRY-box containing gene 30.116
meis1myeloid ecotropic viral integration 10.115
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.111
six3bsine oculis homeobox homolog 3b0.110
pak1p21/Cdc42/Rac1-activated kinase 10.101
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.100
lamb1alaminin, beta 1a0.099
notch3notch homolog 30.097
pitx3paired-like homeodomain transcription factor 30.095
hlx1H2.0-like homeo box 1 (Drosophila)0.094
tcf7transcription factor 7 (T-cell specific, HMG-box)0.090
plekhg4pleckstrin homology domain containing, family G (with RhoGef domain) member 40.083
pppde1PPPDE peptidase domain containing 10.081
spint1aserine peptidase inhibitor, Kunitz type 1 a0.081
nrarpanotch-regulated ankyrin repeat protein a0.078
lmx1b.1LIM homeobox transcription factor 1, beta 10.078
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.078
bmp2bbone morphogenetic protein 2b0.074
sarsseryl-tRNA synthetase0.074
ephb4aeph receptor B4a0.073
her3hairy-related 30.071
otx2orthodenticle homolog 20.070
rx2retinal homeobox gene 20.070
lamc1laminin, gamma 10.069
hlxb9lahomeo box HB9 like a0.068
zmynd11zinc finger, MYND domain containing 110.067
tm9sf2transmembrane 9 superfamily member 20.067
gja3gap junction protein, alpha 30.067
klf2aKruppel-like factor 2a0.066
ascl1aachaete-scute complex-like 1a (Drosophila)0.065
vegfabvascular endothelial growth factor Ab0.065
hey2hairy/enhancer-of-split related with YRPW motif 20.064
gyltl1bglycosyltransferase-like 1b0.063
supt6hsuppressor of Ty 6 homolog0.063
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.063
jag1bjagged 1b0.063
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.062
msi1musashi homolog 1 (Drosophila)0.062
fgf13bfibroblast growth factor 13b0.062
rfx2regulatory factor X, 2 (influences HLA class II expression)0.062
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.062
vsx2visual system homeobox 20.062
supt5hsuppressor of Ty 5 homolog (S. cerevisiae)0.061
srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.060
olig4oligodendrocyte transcription factor 40.059
cdh2cadherin 2, neuronal0.058
hoxc6ahomeo box C6a0.057
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
NOTCH1notch 10.990
GRB2growth factor receptor-bound protein 20.959
JAG1jagged 10.895
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.833
EPS15epidermal growth factor receptor pathway substrate 150.770
SIN3ASIN3 homolog A, transcription regulator (yeast)0.662
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.651
SH3KBP1SH3-domain kinase binding protein 10.625
MDM2Mdm2 p53 binding protein homolog (mouse)0.573
DVL2dishevelled, dsh homolog 2 (Drosophila)0.566
TAL1T-cell acute lymphocytic leukemia 10.531
POU5F1POU class 5 homeobox 10.511
HDAC1histone deacetylase 10.510
NOTCH3notch 30.491
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.477
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.458
ATP13A2ATPase type 13A20.436
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.434
CP110CP110 protein0.366
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.355
CALM1calmodulin 1 (phosphorylase kinase, delta)0.328
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.309
SOS1son of sevenless homolog 1 (Drosophila)0.300
SHC1SHC (Src homology 2 domain containing) transforming protein 10.272
LATlinker for activation of T cells0.269
RASSF5Ras association (RalGDS/AF-6) domain family member 50.256
CREBBPCREB binding protein0.251
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.249
SMAD4SMAD family member 40.231
MAGEA3melanoma antigen family A, 30.219
ADAM10ADAM metallopeptidase domain 100.212
CSNK1Ecasein kinase 1, epsilon0.199
LCKlymphocyte-specific protein tyrosine kinase0.197
CDK6cyclin-dependent kinase 60.190
SKILSKI-like oncogene0.189
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.182
SMURF2SMAD specific E3 ubiquitin protein ligase 20.182
CSNK1Dcasein kinase 1, delta0.182
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.176
BMPR1Abone morphogenetic protein receptor, type IA0.161
GRB7growth factor receptor-bound protein 70.158
MAGEA6melanoma antigen family A, 60.155
GDAguanine deaminase0.151
AP2B1adaptor-related protein complex 2, beta 1 subunit0.146
NCOR1nuclear receptor corepressor 10.145
SPG20spastic paraplegia 20 (Troyer syndrome)0.144
DNM1dynamin 10.140
FYNFYN oncogene related to SRC, FGR, YES0.135
EGFRepidermal growth factor receptor0.135
HNRNPKheterogeneous nuclear ribonucleoprotein K0.133
SPENspen homolog, transcriptional regulator (Drosophila)0.129
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.128
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.127
SMAD2SMAD family member 20.125
DVL1dishevelled, dsh homolog 1 (Drosophila)0.124
TNIP1TNFAIP3 interacting protein 10.124
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.124
NAP1L5nucleosome assembly protein 1-like 50.123
CTAG1Bcancer/testis antigen 1B0.123
MAGEA12melanoma antigen family A, 120.121
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.116
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.116
RUNX1runt-related transcription factor 10.115
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.115
CDAN1congenital dyserythropoietic anemia, type I0.109
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.103
ZNF496zinc finger protein 4960.102
XIAPX-linked inhibitor of apoptosis0.100
SYKspleen tyrosine kinase0.099
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.099
NCOR2nuclear receptor corepressor 20.099
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.099
SNX9sorting nexin 90.096
AXIN1axin 10.094
EXOC7exocyst complex component 70.090
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.087
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.086
PRKCZprotein kinase C, zeta0.086
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.085
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.082
ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.080
TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.079
SH3BP2SH3-domain binding protein 20.077
PICALMphosphatidylinositol binding clathrin assembly protein0.076
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.076
RBPMSRNA binding protein with multiple splicing0.075
YY1YY1 transcription factor0.073
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.072
TEKT4tektin 40.072
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.070
DLL1delta-like 1 (Drosophila)0.068
PTCH1patched 10.067
AP2A1adaptor-related protein complex 2, alpha 1 subunit0.066
PMLpromyelocytic leukemia0.065
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.065
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.064
TCF4transcription factor 40.064
DVL3dishevelled, dsh homolog 3 (Drosophila)0.062
CBX5chromobox homolog 50.062
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Psen1presenilin 11.000
Notch1Notch gene homolog 1 (Drosophila)0.999
Shhsonic hedgehog0.998
Vangl2vang-like 2 (van gogh, Drosophila)0.994
Hes1hairy and enhancer of split 1 (Drosophila)0.983
Eya1eyes absent 1 homolog (Drosophila)0.960
Sox2SRY-box containing gene 20.960
Gli3GLI-Kruppel family member GLI30.951
Tbx1T-box 10.933
Dll1delta-like 1 (Drosophila)0.932
Ctnnb1catenin (cadherin associated protein), beta 10.916
Rb1retinoblastoma 10.898
Trp53transformation related protein 530.897
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.890
Hoxb6homeobox B60.886
Hand2heart and neural crest derivatives expressed transcript 20.877
Efnb2ephrin B20.872
Fgfr2fibroblast growth factor receptor 20.861
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.841
Pax3paired box gene 30.804
Ascl1achaete-scute complex homolog 1 (Drosophila)0.792
Foxc2forkhead box C20.778
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.732
Neurod1neurogenic differentiation 10.729
Gscgoosecoid homeobox0.724
Otx2orthodenticle homolog 2 (Drosophila)0.718
Ccnd1cyclin D10.695
Msx1homeobox, msh-like 10.683
Gata4GATA binding protein 40.681
Cdkn1bcyclin-dependent kinase inhibitor 1B0.664
Dlx2distal-less homeobox 20.661
Dll3delta-like 3 (Drosophila)0.643
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.631
Prrx1paired related homeobox 10.628
Foxc1forkhead box C10.620
Meox2mesenchyme homeobox 20.616
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.588
Foxd3forkhead box D30.575
Shesrc homology 2 domain-containing transforming protein E0.543
Hoxa13homeobox A130.525
Foxa2forkhead box A20.525
Hes5hairy and enhancer of split 5 (Drosophila)0.523
Nkx2-1NK2 homeobox 10.512
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.483
Sox4SRY-box containing gene 40.478
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.470
Ptk7PTK7 protein tyrosine kinase 70.469
Appamyloid beta (A4) precursor protein0.456
Sox18SRY-box containing gene 180.435
Ptenphosphatase and tensin homolog0.424
Dlx5distal-less homeobox 50.423
Hey1hairy/enhancer-of-split related with YRPW motif 10.421
Edarectodysplasin-A receptor0.405
Isl1ISL1 transcription factor, LIM/homeodomain0.403
Notch3Notch gene homolog 3 (Drosophila)0.400
Hoxa11homeobox A110.387
Pax6paired box gene 60.367
Bmp7bone morphogenetic protein 70.363
Pitx3paired-like homeodomain transcription factor 30.352
Hoxa3homeobox A30.351
Tcf21transcription factor 210.350
Wnt3awingless-related MMTV integration site 3A0.345
Pax9paired box gene 90.341
Ptch1patched homolog 10.335
Chd7chromodomain helicase DNA binding protein 70.335
Efna2ephrin A20.334
Cyldcylindromatosis (turban tumor syndrome)0.325
Snai1snail homolog 1 (Drosophila)0.322
Fgfr1fibroblast growth factor receptor 10.318
Smad3MAD homolog 3 (Drosophila)0.317
Fgf15fibroblast growth factor 150.314
Ptf1apancreas specific transcription factor, 1a0.306
Tbx15T-box 150.303
Ebf3early B-cell factor 30.300
UncxUNC homeobox0.300
Pitx2paired-like homeodomain transcription factor 20.293
Dll4delta-like 4 (Drosophila)0.291
Pou3f3POU domain, class 3, transcription factor 30.285
Foxg1forkhead box G10.285
Pbx1pre B-cell leukemia transcription factor 10.284
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.281
Hoxa2homeobox A20.279
Mdm2transformed mouse 3T3 cell double minute 20.277
Emx1empty spiracles homolog 1 (Drosophila)0.273
Padi3peptidyl arginine deiminase, type III0.271
Dlg1discs, large homolog 1 (Drosophila)0.265
Dvl3dishevelled 3, dsh homolog (Drosophila)0.263
Bbs2Bardet-Biedl syndrome 2 (human)0.261
Tbx2T-box 20.257
Fzd7frizzled homolog 7 (Drosophila)0.249
Tcfap2atranscription factor AP-2, alpha0.248
Hdac1histone deacetylase 10.247
Kitlkit ligand0.247
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.246
Alx4aristaless-like homeobox 40.243
Tbx3T-box 30.242
Tlx3T-cell leukemia, homeobox 30.235
Smad6MAD homolog 6 (Drosophila)0.233
Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)0.229
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism