The network for 'serotonin receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

serotonin receptor signaling pathway

The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.

NameDescriptionProbabilityFunc Analog Organism
fasfaint sausage0.084
rdgCretinal degeneration C0.053
caccacophony0.042
norpAno receptor potential A0.041
klgklingon0.041
CG42629CG42629 gene product from transcript CG42629-RB0.028
gsb-ngooseberry-neuro0.023
Glut1Glucose transporter 10.020
hughugin0.018
PhmPeptidylglycine-alpha-hydroxylating monooxygenase0.017
RdlResistant to dieldrin0.017
dpr10CG32057 gene product from transcript CG32057-RB0.016
Hs3st-AHeparan sulfate 3-O sulfotransferase-A0.015
GABA-B-R3metabotropic GABA-B receptor subtype 30.015
NmnatNicotinamide mononucleotide adenylyltransferase0.013
onecutCG1922 gene product from transcript CG1922-RA0.012
rtvretroactive0.012
HeyHairy/E(spl)-related with YRPW motif0.012
Gef64CGuanine nucleotide exchange factor GEF64C0.012
CG16778CG16778 gene product from transcript CG16778-RA0.011
sklsickle0.011
dpr15CG10095 gene product from transcript CG10095-RA0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
gpb-1Protein GPB-10.022
CELE_H12D21.9Protein H12D21.90.015
cmd-1Protein CMD-10.015
egl-5Protein EGL-50.014
F55A4.7Protein F55A4.70.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MPDZmultiple PDZ domain protein1.000
ARRB1arrestin, beta 10.999
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.992
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.971
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.816
ARRDC3arrestin domain containing 30.426
CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)0.378
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.273
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.231
PTENphosphatase and tensin homolog0.193
SSTR3somatostatin receptor 30.162
CHRNDcholinergic receptor, nicotinic, delta0.141
OR2AG1olfactory receptor, family 2, subfamily AG, member 10.129
HTR45-hydroxytryptamine (serotonin) receptor 40.114
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.105
MADCAM1mucosal vascular addressin cell adhesion molecule 10.104
ADRA2Badrenergic, alpha-2B-, receptor0.099
BAI1brain-specific angiogenesis inhibitor 10.072
TBC1D10ATBC1 domain family, member 10A0.067
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.063
DRD2dopamine receptor D20.059
CHRNGcholinergic receptor, nicotinic, gamma0.059
SLC30A3solute carrier family 30 (zinc transporter), member 30.052
CNTFRciliary neurotrophic factor receptor0.052
AFF2AF4/FMR2 family, member 20.047
PPT1palmitoyl-protein thioesterase 10.046
HTR1B5-hydroxytryptamine (serotonin) receptor 1B0.042
TSHRthyroid stimulating hormone receptor0.040
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.038
GPR6G protein-coupled receptor 60.036
SLC5A5solute carrier family 5 (sodium iodide symporter), member 50.034
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.033
AQP2aquaporin 2 (collecting duct)0.031
DRD1dopamine receptor D10.030
ADRB3adrenergic, beta-3-, receptor0.030
COPG2coatomer protein complex, subunit gamma 20.029
HRH3histamine receptor H30.029
P2RX3purinergic receptor P2X, ligand-gated ion channel, 30.029
HTR5A5-hydroxytryptamine (serotonin) receptor 5A0.027
DLGAP2discs, large (Drosophila) homolog-associated protein 20.027
AVPR1Barginine vasopressin receptor 1B0.027
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.025
NFICnuclear factor I/C (CCAAT-binding transcription factor)0.025
DSCAML1Down syndrome cell adhesion molecule like 10.024
KRT9keratin 90.024
CHRNEcholinergic receptor, nicotinic, epsilon0.024
GRM5glutamate receptor, metabotropic 50.022
MAPK10mitogen-activated protein kinase 100.021
ABOABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)0.020
HTR1A5-hydroxytryptamine (serotonin) receptor 1A0.020
OPRK1opioid receptor, kappa 10.019
EZRezrin0.019
NTSR1neurotensin receptor 1 (high affinity)0.019
CHRNB4cholinergic receptor, nicotinic, beta 40.019
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.019
GHRHRgrowth hormone releasing hormone receptor0.018
CHRM5cholinergic receptor, muscarinic 50.018
GABRA1gamma-aminobutyric acid (GABA) A receptor, alpha 10.018
MLNmotilin0.018
CALCAcalcitonin-related polypeptide alpha0.018
AQP7aquaporin 70.017
CCKBRcholecystokinin B receptor0.017
OR2H1olfactory receptor, family 2, subfamily H, member 10.017
PSG7pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)0.017
GRPRgastrin-releasing peptide receptor0.017
PAX8paired box 80.017
HTR1D5-hydroxytryptamine (serotonin) receptor 1D0.017
TACR3tachykinin receptor 30.017
LBX1ladybird homeobox 10.016
KRT33Bkeratin 33B0.016
CALCRcalcitonin receptor0.016
SLC16A8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.016
PRODH2proline dehydrogenase (oxidase) 20.016
YAP1Yes-associated protein 10.016
PADI4peptidyl arginine deiminase, type IV0.016
PLEKHA2pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 20.015
SCRT1scratch homolog 1, zinc finger protein (Drosophila)0.015
SCTRsecretin receptor0.015
SMR3Asubmaxillary gland androgen regulated protein 3A0.014
KCNJ1potassium inwardly-rectifying channel, subfamily J, member 10.014
TFF2trefoil factor 20.014
FGF4fibroblast growth factor 40.014
HNF1AHNF1 homeobox A0.014
GRIK1glutamate receptor, ionotropic, kainate 10.014
ODF1outer dense fiber of sperm tails 10.014
CHRNB2cholinergic receptor, nicotinic, beta 2 (neuronal)0.014
TBX5T-box 50.014
NELL1NEL-like 1 (chicken)0.013
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.013
PYYpeptide YY0.013
CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.013
ATP4BATPase, H+/K+ exchanging, beta polypeptide0.013
TRPM3transient receptor potential cation channel, subfamily M, member 30.013
PNLIPRP1pancreatic lipase-related protein 10.013
TBXA2Rthromboxane A2 receptor0.013
ALPPL2alkaline phosphatase, placental-like 20.013
HTR75-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)0.013
NPY2Rneuropeptide Y receptor Y20.013
ATP2B3ATPase, Ca++ transporting, plasma membrane 30.013
ZP2zona pellucida glycoprotein 2 (sperm receptor)0.013
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pnpla2patatin-like phospholipase domain containing 20.883
Drd2dopamine receptor D20.818
Adrb1adrenergic receptor, beta 10.806
Cckbrcholecystokinin B receptor0.791
Sstr4somatostatin receptor 40.641
Klklotho0.620
Chrm1cholinergic receptor, muscarinic 1, CNS0.582
Ppargperoxisome proliferator activated receptor gamma0.521
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.479
Grid1glutamate receptor, ionotropic, delta 10.421
Gabrg3gamma-aminobutyric acid (GABA) A receptor, subunit gamma 30.343
ND6NADH dehydrogenase subunit 60.336
Htr45 hydroxytryptamine (serotonin) receptor 40.332
Crhr1corticotropin releasing hormone receptor 10.304
Adra2cadrenergic receptor, alpha 2c0.289
Cav1caveolin 1, caveolae protein0.278
Oprm1opioid receptor, mu 10.268
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.263
Kcns2K+ voltage-gated channel, subfamily S, 20.241
Sstr1somatostatin receptor 10.205
Hrkharakiri, BCL2 interacting protein (contains only BH3 domain)0.203
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.190
Shc3src homology 2 domain-containing transforming protein C30.185
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.178
Otogotogelin0.152
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.150
Sstr3somatostatin receptor 30.150
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.132
Epha6Eph receptor A60.117
Pgrprogesterone receptor0.113
F2rl2coagulation factor II (thrombin) receptor-like 20.112
Gsx1GS homeobox 10.109
Gabrb2gamma-aminobutyric acid (GABA) A receptor, subunit beta 20.104
Lhx6LIM homeobox protein 60.100
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.088
Adrb2adrenergic receptor, beta 20.085
Krt2keratin 20.083
Foxd2forkhead box D20.082
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.079
Thrathyroid hormone receptor alpha0.078
Hrh1histamine receptor H10.078
Syn2synapsin II0.074
Gpr12G-protein coupled receptor 120.074
Oprd1opioid receptor, delta 10.069
Npy2rneuropeptide Y receptor Y20.069
Col4a3collagen, type IV, alpha 30.068
Wnt7awingless-related MMTV integration site 7A0.067
Adrb3adrenergic receptor, beta 30.065
Fgf5fibroblast growth factor 50.064
CblCasitas B-lineage lymphoma0.062
Npy5rneuropeptide Y receptor Y50.061
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.060
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.060
Glycam1glycosylation dependent cell adhesion molecule 10.060
Lepleptin0.058
Enamenamelin0.058
Htr1f5-hydroxytryptamine (serotonin) receptor 1F0.058
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.057
Htr75-hydroxytryptamine (serotonin) receptor 70.056
Krt86keratin 860.054
Leprleptin receptor0.053
Chrna7cholinergic receptor, nicotinic, alpha polypeptide 70.052
Kcnd3potassium voltage-gated channel, Shal-related family, member 30.050
Adra2badrenergic receptor, alpha 2b0.049
Tgfbr3transforming growth factor, beta receptor III0.048
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.048
Gastgastrin0.047
SeboxSEBOX homeobox0.047
Slc6a18solute carrier family 6 (neurotransmitter transporter), member 180.047
Cnr1cannabinoid receptor 1 (brain)0.047
Glra1glycine receptor, alpha 1 subunit0.046
Zfr2zinc finger RNA binding protein 20.045
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.045
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.045
Fndc7fibronectin type III domain containing 70.045
Kcnk4potassium channel, subfamily K, member 40.044
Nrg3neuregulin 30.044
Nxph1neurexophilin 10.044
Trpc5transient receptor potential cation channel, subfamily C, member 50.040
Sox1SRY-box containing gene 10.040
Mc3rmelanocortin 3 receptor0.040
Il12binterleukin 12b0.039
Chiachitinase, acidic0.039
Tacr1tachykinin receptor 10.039
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.037
Oprk1opioid receptor, kappa 10.037
Runx2runt related transcription factor 20.037
Gucy2eguanylate cyclase 2e0.036
Pspnpersephin0.035
Idsiduronate 2-sulfatase0.034
Thrbthyroid hormone receptor beta0.034
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.034
Cntn3contactin 30.034
Fgf4fibroblast growth factor 40.034
Cntn4contactin 40.033
Fam164cfamily with sequence similarity 164, member C0.033
Btn1a1butyrophilin, subfamily 1, member A10.033
Gjd2gap junction protein, delta 20.032
Lmx1bLIM homeobox transcription factor 1 beta0.032
Gabrdgamma-aminobutyric acid (GABA) A receptor, subunit delta0.031
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Chrnecholinergic receptor, nicotinic, epsilon0.436
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.380
Slc6a7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.202
Aif1lallograft inflammatory factor 1-like0.185
Chrna6cholinergic receptor, nicotinic, alpha 60.145
Fgf14fibroblast growth factor 140.136
Gcm1glial cells missing homolog 1 (Drosophila)0.136
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.134
Chrna7cholinergic receptor, nicotinic, alpha 70.125
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.121
Grik3glutamate receptor, ionotropic, kainate 30.114
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.106
Mc5rmelanocortin 5 receptor0.105
Olr416olfactory receptor 4160.105
Svs3aseminal vesicle secretory protein 3A0.098
Lim2lens intrinsic membrane protein 20.095
Grik1glutamate receptor, ionotropic, kainate 10.092
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.091
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.084
Cntn2contactin 2 (axonal)0.083
Rin1Ras and Rab interactor 10.081
Syt8synaptotagmin VIII0.079
Sstr5somatostatin receptor 50.078
Slc7a3solute carrier family 7 (cationic amino acid transporter, y+ system), member 30.078
Arandrogen receptor0.077
Ccbp2chemokine binding protein 20.073
Cacng1calcium channel, voltage-dependent, gamma subunit 10.070
Avpr1barginine vasopressin receptor 1B0.067
Vom2r27vomeronasal 2 receptor, 270.067
Vom2r53vomeronasal 2 receptor, 530.066
Zp1zona pellucida glycoprotein 1 (sperm receptor)0.065
Olr1500olfactory receptor 15000.063
Trpc4transient receptor potential cation channel, subfamily C, member 40.062
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.062
Gja3gap junction protein, alpha 30.061
Myh3myosin, heavy chain 3, skeletal muscle, embryonic0.059
Pmfbp1polyamine modulated factor 1 binding protein 10.057
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.057
Htr75-hydroxytryptamine (serotonin) receptor 70.055
Chrnb2cholinergic receptor, nicotinic, beta 2 (neuronal)0.055
Plcd4phospholipase C, delta 40.055
Oprl1opiate receptor-like 10.051
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.050
Phkg1phosphorylase kinase, gamma 10.047
Npy5rneuropeptide Y receptor Y50.046
Tacr2tachykinin receptor 20.046
Mmp13matrix metallopeptidase 130.046
Cckarcholecystokinin A receptor0.045
Spt1salivary protein 10.045
Ddndendrin0.044
RGD1559748similar to Palate lung and nasal carcinoma-like protein precursor (Tongue plunc-like protein)0.042
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.041
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.041
Toretrispanning orphan0.039
UncxUNC homeobox0.039
Smad3SMAD family member 30.037
Atxn1ataxin 10.036
Oprk1opioid receptor, kappa 10.036
KlKlotho0.036
Svs1seminal vesicle secretory protein 10.036
Chrnb1cholinergic receptor, nicotinic, beta 1 (muscle)0.035
Il13interleukin 130.035
Crisp1cysteine-rich secretory protein 10.035
Krt4keratin 40.035
Odf4outer dense fiber of sperm tails 40.034
Cpne9copine family member IX0.034
Crxcone-rod homeobox0.034
Grm6glutamate receptor, metabotropic 60.034
Ompolfactory marker protein0.034
Prp15proline-rich protein 150.034
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.033
Vom1r93vomeronasal 1 receptor 930.033
Ifnb1interferon beta 1, fibroblast0.032
Chrngcholinergic receptor, nicotinic, gamma0.032
Pthparathyroid hormone0.032
Il2rainterleukin 2 receptor, alpha0.031
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.031
Fgf7fibroblast growth factor 70.031
Scn5asodium channel, voltage-gated, type V, alpha subunit0.031
Pomcproopiomelanocortin0.030
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.030
Rgs8regulator of G-protein signaling 80.030
Grid2glutamate receptor, ionotropic, delta 20.029
Ncanneurocan0.028
Gfra2GDNF family receptor alpha 20.028
Grm2glutamate receptor, metabotropic 20.028
Cysscystatin S0.027
Atp7bATPase, Cu++ transporting, beta polypeptide0.027
Mr1major histocompatibility complex, class I-related0.027
Cnga2cyclic nucleotide gated channel alpha 20.027
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.027
Gabrpgamma-aminobutyric acid (GABA-A) receptor, pi0.026
Isl2ISL LIM homeobox 20.026
Npy1rneuropeptide Y receptor Y10.026
Olr1082olfactory receptor 10820.026
Drd2dopamine receptor D20.026
Prlprolactin0.026
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.026
Syt4synaptotagmin IV0.026
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.026
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism