The network for 'telomere capping' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

telomere capping

A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.

NameDescriptionProbabilityFunc Analog Organism
rad50CG6339 gene product from transcript CG6339-RD1.000
tefutelomere fusion0.990
nbsCG6754 gene product from transcript CG6754-RC0.929
cavcaravaggio0.912
mre11meiotic recombination 110.911
RfC4Replication factor C subunit 40.733
l(3)S147910lethal (3) S1479100.722
moimodigliani0.499
dpadisc proliferation abnormal0.226
p53CG33336 gene product from transcript CG33336-RB0.223
pds5CG17509 gene product from transcript CG17509-RA0.211
SseSeparase0.186
pr-set7CG3307 gene product from transcript CG3307-RC0.179
shtdshattered0.106
snamasomething that sticks like glue0.104
Nuf2CG8902 gene product from transcript CG8902-RA0.094
vtdverthandi0.094
His2AvHistone H2A variant0.080
Cap-GCG34438 gene product from transcript CG34438-RF0.079
CG5524CG5524 gene product from transcript CG5524-RA0.079
tatltat-like0.069
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.061
fzyfizzy0.053
mus101mutagen-sensitive 1010.053
SMC2CG10212 gene product from transcript CG10212-RA0.050
ash2absent, small, or homeotic discs 20.044
RecQ5homolog of RecQ0.041
Orc2Origin recognition complex subunit 20.037
barrbarren0.036
Mcm10Sensitized chromosome inheritance modifier 190.036
Nipped-ACG33554 gene product from transcript CG33554-RE0.034
Orc6Origin recognition complex subunit 60.031
cmetCENP-meta0.031
HP6Heterochromatin protein 60.024
NiPp1Nuclear inhibitor of Protein phosphatase 10.024
skpACG16983 gene product from transcript CG16983-RD0.021
Ndc80CG9938 gene product from transcript CG9938-RA0.019
Smc5CG32438 gene product from transcript CG32438-RE0.019
DNApol-etaCG7143 gene product from transcript CG7143-RA0.019
raspCG11495 gene product from transcript CG11495-RA0.018
Orc5Origin recognition complex subunit 50.017
ytryantar0.017
Fen1Flap endonuclease 10.016
Su(var)205Suppressor of variegation 2050.016
pzgputzig0.015
Cenp-CCG31258 gene product from transcript CG31258-RA0.013
Pp1-87BProtein phosphatase 1 at 87B0.013
BubR1Bub1-related kinase0.012
cdc16CG6759 gene product from transcript CG6759-RA0.011
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
TERF2telomeric repeat binding factor 21.000
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)1.000
NBNnibrin0.994
H2AFXH2A histone family, member X0.994
FANCD2Fanconi anemia, complementation group D20.966
MDC1mediator of DNA-damage checkpoint 10.947
TINF2TERF1 (TRF1)-interacting nuclear factor 20.935
ATMataxia telangiectasia mutated0.880
BRCA1breast cancer 1, early onset0.855
WRNWerner syndrome, RecQ helicase-like0.385
BLMBloom syndrome, RecQ helicase-like0.330
RAD50RAD50 homolog (S. cerevisiae)0.303
ACDadrenocortical dysplasia homolog (mouse)0.194
TP53BP1tumor protein p53 binding protein 10.144
TERF2IPtelomeric repeat binding factor 2, interacting protein0.124
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.124
RBBP8retinoblastoma binding protein 80.093
TOP3Atopoisomerase (DNA) III alpha0.077
ATRXalpha thalassemia/mental retardation syndrome X-linked0.076
TERF1telomeric repeat binding factor (NIMA-interacting) 10.064
SMC1Astructural maintenance of chromosomes 1A0.034
TNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase0.022
ORC2origin recognition complex, subunit 20.020
PINX1PIN2/TERF1 interacting, telomerase inhibitor 10.020
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.999
Trp53transformation related protein 530.999
Lig4ligase IV, DNA, ATP-dependent0.961
Ighimmunoglobulin heavy chain complex0.953
Nbnnibrin0.919
Acdadrenocortical dysplasia0.903
Terf1telomeric repeat binding factor 10.736
Pola1polymerase (DNA directed), alpha 10.564
Brca1breast cancer 10.524
Dna2DNA replication helicase 2 homolog (yeast)0.428
Prim2DNA primase, p58 subunit0.418
Brca2breast cancer 20.402
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.372
Mre11ameiotic recombination 11 homolog A (S. cerevisiae)0.359
Mdm4transformed mouse 3T3 cell double minute 40.326
Atmataxia telangiectasia mutated homolog (human)0.317
Mdm2transformed mouse 3T3 cell double minute 20.307
Rad50RAD50 homolog (S. cerevisiae)0.266
Msh2mutS homolog 2 (E. coli)0.197
Trp53bp1transformation related protein 53 binding protein 10.174
Mphosph9M-phase phosphoprotein 90.142
WrnWerner syndrome homolog (human)0.091
Mlh1mutL homolog 1 (E. coli)0.089
TcraT-cell receptor alpha chain0.079
Ints9integrator complex subunit 90.072
Rfc1replication factor C (activator 1) 10.070
Rnf8ring finger protein 80.054
Smn1survival motor neuron 10.049
Rag1recombination activating gene 10.046
Parp2poly (ADP-ribose) polymerase family, member 20.046
Ckap5cytoskeleton associated protein 50.043
Ikzf1IKAROS family zinc finger 10.042
Pot1aprotection of telomeres 1A0.041
Sin3atranscriptional regulator, SIN3A (yeast)0.040
Xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.039
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.037
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.036
FancmFanconi anemia, complementation group M0.032
Zmym4zinc finger, MYM-type 40.032
Xrcc6X-ray repair complementing defective repair in Chinese hamster cells 60.032
Obfc1oligonucleotide/oligosaccharide-binding fold containing 10.031
Atrataxia telangiectasia and Rad3 related0.029
Card11caspase recruitment domain family, member 110.029
Mtf2metal response element binding transcription factor 20.028
Pou2f1POU domain, class 2, transcription factor 10.027
Zfp101zinc finger protein 1010.027
Huwe1HECT, UBA and WWE domain containing 10.027
5830418K08RikRIKEN cDNA 5830418K08 gene0.026
RecqlRecQ protein-like0.026
Tpp1tripeptidyl peptidase I0.025
Rttnrotatin0.025
TcrbT-cell receptor beta chain0.022
Gps2G protein pathway suppressor 20.021
Rbl1retinoblastoma-like 1 (p107)0.021
TcrdT-cell receptor delta chain0.020
Parp1poly (ADP-ribose) polymerase family, member 10.020
Etaa1Ewing's tumor-associated antigen 10.020
Smc6structural maintenance of chromosomes 60.018
Aqraquarius0.018
Lcp2lymphocyte cytosolic protein 20.017
Hmbox1homeobox containing 10.017
Hmgxb4HMG box domain containing 40.017
Saal1serum amyloid A-like 10.016
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.016
Zw10ZW10 homolog (Drosophila), centromere/kinetochore protein0.016
HjurpHolliday junction recognition protein0.016
Nup188nucleoporin 1880.016
Tcf3transcription factor 30.015
Usp48ubiquitin specific peptidase 480.015
Odf2outer dense fiber of sperm tails 20.015
Snhg5small nucleolar RNA host gene 50.015
Cdk5rap2CDK5 regulatory subunit associated protein 20.015
Terf2telomeric repeat binding factor 20.015
AW146020expressed sequence AW1460200.014
Asxl1additional sex combs like 1 (Drosophila)0.014
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.014
Ankrd26ankyrin repeat domain 260.014
Hltfhelicase-like transcription factor0.014
Rnf219ring finger protein 2190.014
Sp1trans-acting transcription factor 10.014
Suz12suppressor of zeste 12 homolog (Drosophila)0.014
Brd8bromodomain containing 80.014
Clk2CDC-like kinase 20.013
Men1multiple endocrine neoplasia 10.013
1500010J02RikRIKEN cDNA 1500010J02 gene0.013
Rps6kb1ribosomal protein S6 kinase, polypeptide 10.013
Pinx1PIN2/TERF1 interacting, telomerase inhibitor 10.013
Setdb1SET domain, bifurcated 10.013
Pot1bprotection of telomeres 1B0.013
Dclre1aDNA cross-link repair 1A, PSO2 homolog (S. cerevisiae)0.013
Med1mediator complex subunit 10.013
Rtel1regulator of telomere elongation helicase 10.013
Arid4aAT rich interactive domain 4A (RBP1-like)0.012
Spice1spindle and centriole associated protein 10.012
Narg2NMDA receptor-regulated gene 20.012
C2cd3C2 calcium-dependent domain containing 30.012
Ncapd3non-SMC condensin II complex, subunit D30.012
Chek2CHK2 checkpoint homolog (S. pombe)0.012
Tubgcp4tubulin, gamma complex associated protein 40.012
Alms1Alstrom syndrome 1 homolog (human)0.012
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RIF1Rif1p0.107
EST2Est2p0.098
PRI1Pri1p0.095
CDC13Cdc13p0.089
TEL1Tel1p0.081
TEN1Ten1p0.064
RAD53Rad53p0.058
STN1Stn1p0.050
YLR162Whypothetical protein0.042
SAE2Sae2p0.037
RIF2Rif2p0.036
SRD1Srd1p0.033
LEU2Leu2p0.031
XRS2Xrs2p0.029
YLR264C-Ahypothetical protein0.027
EST1Est1p0.026
ARP10Arp10p0.026
YOL038C-Ahypothetical protein0.026
YBL044Whypothetical protein0.026
HOHop0.025
MER1Mer1p0.024
RAD55Rad55p0.024
DNA2Dna2p0.023
MEC1Mec1p0.023
YAR068Whypothetical protein0.022
SPL2Spl2p0.022
ATP6Atp6p0.022
CUP1-1Cup1-1p0.021
BYE1Bye1p0.021
CHA1Cha1p0.020
GCR1Gcr1p0.020
YPR157Whypothetical protein0.020
HXT3Hxt3p0.020
RMI1Rmi1p0.020
PTI1Pti1p0.020
ARG8Arg8p0.020
YLR042Chypothetical protein0.020
FMT1Fmt1p0.019
YNR066Chypothetical protein0.019
MGS1Mgs1p0.019
HPF1Hpf1p0.019
GCN4Gcn4p0.018
AUA1Aua1p0.018
YNR071Chypothetical protein0.018
YIR035Chypothetical protein0.018
YBR013Chypothetical protein0.018
YOL013W-Ahypothetical protein0.018
SPR6Spr6p0.018
YLR278Chypothetical protein0.018
BSC1Bsc1p0.018
ZPS1Zps1p0.018
SWI1Swi1p0.018
AQY2Aqy2p0.017
OPT2Opt2p0.017
SCM4Scm4p0.017
RAD5Rad5p0.017
IZH4Izh4p0.017
DIC1Dic1p0.016
YPR096Chypothetical protein0.016
YIL151Chypothetical protein0.016
YAL064Whypothetical protein0.016
CPD1Cpd1p0.016
IXR1Ixr1p0.016
RRN5Rrn5p0.016
ALT2Alt2p0.016
WSS1Wss1p0.016
RNP1Rnp1p0.015
MF(ALPHA)2Mf(alpha)2p0.015
HST3Hst3p0.015
YAL037C-Ahypothetical protein0.015
YAR066Whypothetical protein0.015
SEN54Sen54p0.015
MMS21Mms21p0.014
YKR075Chypothetical protein0.014
YBL029Whypothetical protein0.014
SWM2Swm2p0.014
YNL033Whypothetical protein0.014
URA3Ura3p0.014
YLR040Chypothetical protein0.014
YGL006W-Ahypothetical protein0.014
UPS3Ups3p0.014
COS12Cos12p0.014
YLL053Chypothetical protein0.014
GYL1Gyl1p0.014
RTT105Rtt105p0.014
POL2Pol2p0.014
BAT2Bat2p0.014
YCR102Chypothetical protein0.014
PHO11Pho11p0.014
MSH3Msh3p0.013
REE1Ree1p0.013
SPS4Sps4p0.013
TYE7Tye7p0.013
TIR3Tir3p0.013
DUR1,2Dur1,2p0.013
YPL067Chypothetical protein0.013
YMR317Whypothetical protein0.013
YNR063Whypothetical protein0.013
NRG2Nrg2p0.013
YJL181Whypothetical protein0.013