The network for 'positive regulation of proteolysis involved in cellular protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of proteolysis involved in cellular protein catabolic process

Any process that activates or increases the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.

NameDescriptionProbabilityFunc Analog Organism
Rpn6Proteasome p44.5 subunit0.568
Pi3K92ECG4141 gene product from transcript CG4141-RB0.360
CG4673CG4673 gene product from transcript CG4673-RB0.339
Uch-L3Ubiquitin C-terminal hydrolase0.316
CG13349CG13349 gene product from transcript CG13349-RA0.255
Pros25Proteasome 25kD subunit0.217
CG12321CG12321 gene product from transcript CG12321-RA0.216
Pros35Proteasome 35kD subunit0.203
Mov34CG3416 gene product from transcript CG3416-RA0.200
tefutelomere fusion0.199
Prosbeta7Proteasome beta7 subunit0.197
CG5384CG5384 gene product from transcript CG5384-RA0.147
Tbp-1Tat-binding protein-10.139
Rpt1CG1341 gene product from transcript CG1341-RA0.131
idaimaginal discs arrested0.128
dosdaughter of sevenless0.122
dltdiscs lost0.114
CycBCyclin B0.108
stanstarry night0.108
mspsmini spindles0.107
Rpn9CG10230 gene product from transcript CG10230-RB0.104
Rpt3CG16916 gene product from transcript CG16916-RA0.098
RYBPRing and YY1 Binding Protein0.096
Rpn3Regulatory particle non-ATPase 30.092
Vap-33-1CG5014 gene product from transcript CG5014-RB0.088
Rpn1CG7762 gene product from transcript CG7762-RA0.081
cdc23CG2508 gene product from transcript CG2508-RA0.081
CG2046CG2046 gene product from transcript CG2046-RA0.077
PcafCG4107 gene product from transcript CG4107-RA0.068
slmbsupernumerary limbs0.065
G9aCG2995 gene product from transcript CG2995-RA0.062
Act5CActin 5C0.061
CSN4COP9 complex homolog subunit 40.060
CycACyclin A0.060
Trim9CG31721 gene product from transcript CG31721-RB0.058
drkdownstream of receptor kinase0.057
CG30382CG30382 gene product from transcript CG30382-RB0.057
Pros54Proteasome 54kD subunit0.055
Prosbeta3Proteasome beta3 subunit0.054
Fcp1CG12252 gene product from transcript CG12252-RA0.054
Pros45CG1489 gene product from transcript CG1489-RA0.052
Rpt4CG3455 gene product from transcript CG3455-RA0.050
Orc2Origin recognition complex subunit 20.047
Klp10ACG1453 gene product from transcript CG1453-RA0.046
UbcD2Ubiquitin conjugating enzyme 20.043
Akt1CG4006 gene product from transcript CG4006-RA0.043
Rpn7CG5378 gene product from transcript CG5378-RA0.041
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.041
Prosbeta1Proteasome beta1 subunit0.040
kermitCG11546 gene product from transcript CG11546-RB0.040
PlapPhospholipase A2 activator protein0.040
MlfMyelodysplasia/myeloid leukemia factor0.040
Mob4CG3403 gene product from transcript CG3403-RA0.039
Ras85DRas oncogene at 85D0.039
chbchromosome bows0.038
DJ-1alphaCG6646 gene product from transcript CG6646-RA0.038
Rpn11CG18174 gene product from transcript CG18174-RA0.038
CSN3COP9 complex homolog subunit 30.036
Cenp-CCG31258 gene product from transcript CG31258-RA0.036
HoHeme oxygenase0.035
fz2frizzled 20.034
skpACG16983 gene product from transcript CG16983-RD0.033
bratbrain tumor0.033
CSN1bCOP9 complex homolog subunit 1 b0.032
TER94CG2331 gene product from transcript CG2331-RA0.030
gbbglass bottom boat0.030
poloCG12306 gene product from transcript CG12306-RA0.030
Rca1Regulator of cyclin A10.029
polyCG9829 gene product from transcript CG9829-RB0.029
CG33129CG33129 gene product from transcript CG33129-RE0.028
SF2CG6987 gene product from transcript CG6987-RA0.028
cal1chromosome alignment defect 10.027
CG5510CG5510 gene product from transcript CG5510-RA0.026
CSN8COP9 complex homolog subunit 80.026
matsmob as tumor suppressor0.026
Sir2CG5216 gene product from transcript CG5216-RA0.025
cdc16CG6759 gene product from transcript CG6759-RA0.025
droshaCG8730 gene product from transcript CG8730-RA0.025
l(1)dd4lethal (1) discs degenerate 40.025
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
lin-36Protein LIN-360.053
ima-3Protein IMA-30.052
mex-3Protein MEX-30.046
klp-16Protein KLP-160.044
pme-3Protein PME-30.037
npl-4.2Protein NPL-4.20.035
ZK686.4Protein ZK686.40.033
air-1Protein AIR-10.033
hcp-2Protein HCP-20.031
imb-2Protein IMB-20.031
spn-4Protein SPN-40.030
tpxl-1Protein TPXL-10.029
pry-1Protein PRY-10.029
usp-14Protein USP-140.028
hda-1Protein HDA-10.027
cks-1Protein CKS-10.027
rnr-1Protein RNR-10.026
mcm-7Protein MCM-70.026
rpn-2Protein RPN-20.026
ran-2Protein RAN-20.025
F32D1.7Protein F32D1.70.025
car-1Protein CAR-10.025
axl-1Protein AXL-10.024
zen-4Protein ZEN-40.024
lst-1Protein LST-10.024
zif-1Protein ZIF-10.023
nipi-3Protein NIPI-30.023
wago-1Protein WAGO-10.023
tps-1Protein TPS-10.023
rfc-2Protein RFC-20.022
rpt-1Protein RPT-10.022
mbk-2Protein MBK-20.022
mog-4Protein MOG-40.022
rpn-3Protein RPN-30.022
pal-1Protein PAL-10.021
tag-296Protein TAG-2960.021
gla-3Protein GLA-30.021
pcn-1Protein PCN-10.021
C56G2.7Protein C56G2.70.021
R11A8.7Protein R11A8.70.020
rpn-1Protein RPN-10.020
csr-1Protein CSR-10.020
mex-6Protein MEX-60.020
C28C12.12Protein C28C12.120.019
cyk-7Protein CYK-70.019
klp-19Protein KLP-190.019
R04F11.3Protein R04F11.30.019
bar-1Protein BAR-10.019
uaf-1Protein UAF-10.019
R11A8.2Protein R11A8.20.019
clec-87Protein CLEC-870.019
C02F5.7Protein C02F5.70.019
ptp-3Protein PTP-30.019
pbs-3Protein PBS-30.018
ect-2Protein ECT-20.018
vang-1Protein VANG-10.018
M106.8Protein M106.80.018
air-2Protein AIR-20.018
K08E3.5Protein K08E3.50.017
rpt-6Protein RPT-60.017
CELE_Y47G6A.25Protein Y47G6A.250.017
nhr-10Protein NHR-100.017
E04D5.1Protein E04D5.10.017
ppk-2Protein PPK-20.017
ptr-2Protein PTR-20.017
egl-30Protein EGL-300.017
spk-1Protein SPK-10.017
csnk-1Protein CSNK-10.017
nkcc-1Protein NKCC-10.017
R05D3.2Protein R05D3.20.017
pgl-1Protein PGL-10.017
CELE_T10C6.6Protein T10C6.60.017
ZK863.4Protein ZK863.40.016
pisy-1Protein PISY-10.016
C46C11.1Protein C46C11.10.016
CELE_T05H4.11Protein T05H4.110.016
ZC410.3Protein ZC410.30.016
F49C12.9Protein F49C12.90.016
mec-15Protein MEC-150.016
cdc-25.1Protein CDC-25.10.016
bath-42Protein BATH-420.016
zwl-1Protein ZWL-10.016
F10B5.8Protein F10B5.80.016
skr-1Protein SKR-10.016
CELE_T03F6.3Protein T03F6.30.016
taf-5Protein TAF-50.016
retr-1Protein RETR-10.015
hsr-9Protein HSR-90.015
F21A10.2Protein F21A10.20.015
bub-1Protein BUB-10.015
R05G6.10Protein R05G6.100.015
tim-1Protein TIM-10.015
madf-5Protein MADF-50.015
gsk-3Protein GSK-30.015
ubc-18Protein UBC-180.015
pup-2Protein PUP-20.015
mab-5Protein MAB-50.015
CELE_Y54E10BR.3Protein Y54E10BR.30.015
mat-3Protein MAT-30.015
crn-1Protein CRN-10.015
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SMURF2SMAD specific E3 ubiquitin protein ligase 20.998
CDC27cell division cycle 27 homolog (S. cerevisiae)0.982
SMAD4SMAD family member 40.946
CDC20cell division cycle 20 homolog (S. cerevisiae)0.915
SMAD3SMAD family member 30.876
SMAD2SMAD family member 20.823
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.790
DVL3dishevelled, dsh homolog 3 (Drosophila)0.740
TP53tumor protein p530.718
ADRM1adhesion regulating molecule 10.702
UBCubiquitin C0.690
MDM4Mdm4 p53 binding protein homolog (mouse)0.658
SMAD1SMAD family member 10.643
SMAD5SMAD family member 50.636
CSNK1Ecasein kinase 1, epsilon0.607
MAP3K5mitogen-activated protein kinase kinase kinase 50.598
GSK3Bglycogen synthase kinase 3 beta0.573
CUL2cullin 20.481
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.466
SMAD7SMAD family member 70.459
UBQLN1ubiquilin 10.432
ANAPC4anaphase promoting complex subunit 40.426
RNF11ring finger protein 110.423
DVL1dishevelled, dsh homolog 1 (Drosophila)0.399
PIAS4protein inhibitor of activated STAT, 40.320
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.267
EPORerythropoietin receptor0.266
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.245
DVL2dishevelled, dsh homolog 2 (Drosophila)0.231
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.215
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.210
SKILSKI-like oncogene0.206
UBE2D2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.203
PSMA4proteasome (prosome, macropain) subunit, alpha type, 40.195
PTK2PTK2 protein tyrosine kinase 20.194
MDM2Mdm2 p53 binding protein homolog (mouse)0.194
TADA3transcriptional adaptor 30.184
SMC6structural maintenance of chromosomes 60.183
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.183
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.180
ANAPC11anaphase promoting complex subunit 110.178
PSEN1presenilin 10.176
PLK1polo-like kinase 10.156
BBS10Bardet-Biedl syndrome 100.156
PSEN2presenilin 2 (Alzheimer disease 4)0.154
OTUB1OTU domain, ubiquitin aldehyde binding 10.146
CUL5cullin 50.145
SMURF1SMAD specific E3 ubiquitin protein ligase 10.143
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.137
AURKBaurora kinase B0.136
JUNjun proto-oncogene0.126
PTPN1protein tyrosine phosphatase, non-receptor type 10.126
ATXN3ataxin 30.125
UHRF2ubiquitin-like with PHD and ring finger domains 20.122
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.117
WWP2WW domain containing E3 ubiquitin protein ligase 20.116
HDAC6histone deacetylase 60.108
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.107
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.106
PRNPprion protein0.097
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.091
DAXXdeath-domain associated protein0.089
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.089
CSNK1Dcasein kinase 1, delta0.087
SOCS2suppressor of cytokine signaling 20.086
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.085
CDC26cell division cycle 26 homolog (S. cerevisiae)0.084
AIPL1aryl hydrocarbon receptor interacting protein-like 10.084
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.083
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.079
ANAPC7anaphase promoting complex subunit 70.079
BRCA1breast cancer 1, early onset0.077
CUL1cullin 10.077
XIAPX-linked inhibitor of apoptosis0.076
WWP1WW domain containing E3 ubiquitin protein ligase 10.073
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.073
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.072
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.072
RBBP8retinoblastoma binding protein 80.070
ADRBK1adrenergic, beta, receptor kinase 10.069
PSMA2proteasome (prosome, macropain) subunit, alpha type, 20.067
PDCD10programmed cell death 100.065
PDCD6IPprogrammed cell death 6 interacting protein0.065
AXIN1axin 10.065
CDK2cyclin-dependent kinase 20.064
PTTG1pituitary tumor-transforming 10.063
HSPB1heat shock 27kDa protein 10.063
GCLMglutamate-cysteine ligase, modifier subunit0.062
CDC16cell division cycle 16 homolog (S. cerevisiae)0.062
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.061
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.061
PSMA6proteasome (prosome, macropain) subunit, alpha type, 60.060
SKIv-ski sarcoma viral oncogene homolog (avian)0.060
ATF5activating transcription factor 50.058
SOCS1suppressor of cytokine signaling 10.057
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.056
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.056
ZNF746zinc finger protein 7460.056
RAD23BRAD23 homolog B (S. cerevisiae)0.055
BAG2BCL2-associated athanogene 20.054
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
Ptenphosphatase and tensin homolog0.995
Axin1axin 10.995
Gsk3bglycogen synthase kinase 3 beta0.995
Trp53transformation related protein 530.986
Psen1presenilin 10.979
Apcadenomatosis polyposis coli0.958
Per2period homolog 2 (Drosophila)0.955
Per1period homolog 1 (Drosophila)0.890
Notch1Notch gene homolog 1 (Drosophila)0.871
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.828
Itgb1integrin beta 1 (fibronectin receptor beta)0.732
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.697
Notch2Notch gene homolog 2 (Drosophila)0.685
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.668
Cry2cryptochrome 2 (photolyase-like)0.544
Hif1ahypoxia inducible factor 1, alpha subunit0.508
Ccnb2cyclin B20.489
Clockcircadian locomotor output cycles kaput0.481
Sufusuppressor of fused homolog (Drosophila)0.473
Prkceprotein kinase C, epsilon0.463
Hprthypoxanthine guanine phosphoribosyl transferase0.446
Arntlaryl hydrocarbon receptor nuclear translocator-like0.418
Ccnb1cyclin B10.412
Cdk1cyclin-dependent kinase 10.384
Psma4proteasome (prosome, macropain) subunit, alpha type 40.356
Smad7MAD homolog 7 (Drosophila)0.346
Atf4activating transcription factor 40.339
Csnk1ecasein kinase 1, epsilon0.316
Psma2proteasome (prosome, macropain) subunit, alpha type 20.297
Rnf111ring finger 1110.251
Ptch1patched homolog 10.241
Smad3MAD homolog 3 (Drosophila)0.240
Gclmglutamate-cysteine ligase, modifier subunit0.220
Ccna2cyclin A20.220
Dvl2dishevelled 2, dsh homolog (Drosophila)0.199
Ube2d3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.197
Fgfr1fibroblast growth factor receptor 10.194
Fzr1fizzy/cell division cycle 20 related 1 (Drosophila)0.171
Cops2COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)0.170
Kif22kinesin family member 220.162
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.161
Psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.157
Kif20akinesin family member 20A0.156
Cdkn3cyclin-dependent kinase inhibitor 30.149
Smurf2SMAD specific E3 ubiquitin protein ligase 20.146
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.142
Lef1lymphoid enhancer binding factor 10.142
BrafBraf transforming gene0.141
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.140
Usp9xubiquitin specific peptidase 9, X chromosome0.137
Smad4MAD homolog 4 (Drosophila)0.132
Psmb7proteasome (prosome, macropain) subunit, beta type 70.127
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.126
Cyldcylindromatosis (turban tumor syndrome)0.126
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.120
Plk1polo-like kinase 1 (Drosophila)0.120
Lrp6low density lipoprotein receptor-related protein 60.118
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.115
Rb1retinoblastoma 10.113
Pick1protein interacting with C kinase 10.111
Dctn1dynactin 10.111
Rnf11ring finger protein 110.109
Ccnfcyclin F0.107
Aurkaaurora kinase A0.103
Ilkintegrin linked kinase0.096
Vhlvon Hippel-Lindau tumor suppressor0.095
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.093
1110004F10RikRIKEN cDNA 1110004F10 gene0.092
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.092
Pdpk13-phosphoinositide dependent protein kinase 10.092
Csnk1g2casein kinase 1, gamma 20.092
Ncoa3nuclear receptor coactivator 30.091
Nfe2l2nuclear factor, erythroid derived 2, like 20.091
Wdr26WD repeat domain 260.090
Prc1protein regulator of cytokinesis 10.089
Ube2cubiquitin-conjugating enzyme E2C0.087
Rrm2ribonucleotide reductase M20.087
Birc5baculoviral IAP repeat-containing 50.086
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.085
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.085
Cry1cryptochrome 1 (photolyase-like)0.085
Ckap2cytoskeleton associated protein 20.084
Sertad2SERTA domain containing 20.079
Apoeapolipoprotein E0.077
Mki67antigen identified by monoclonal antibody Ki 670.074
Smad2MAD homolog 2 (Drosophila)0.072
Gtse1G two S phase expressed protein 10.071
Hmmrhyaluronan mediated motility receptor (RHAMM)0.071
Chukconserved helix-loop-helix ubiquitous kinase0.067
Rab10RAB10, member RAS oncogene family0.066
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.065
Psma6proteasome (prosome, macropain) subunit, alpha type 60.065
Bcar1breast cancer anti-estrogen resistance 10.065
Mdm4transformed mouse 3T3 cell double minute 40.064
Igf1rinsulin-like growth factor I receptor0.063
Efnb2ephrin B20.062
Ppargperoxisome proliferator activated receptor gamma0.062
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Eef2eukaryotic translation elongation factor 20.016
Rpl6ribosomal protein L60.012
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.012
Mdm2Mdm2 p53 binding protein homolog (mouse)0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism