The network for 'negative regulation of proteolysis involved in cellular protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of proteolysis involved in cellular protein catabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.

NameDescriptionProbabilityFunc Analog Organism
Pp1-87BProtein phosphatase 1 at 87B0.153
CSN5COP9 complex homolog subunit 50.101
EgfrEpidermal growth factor receptor0.083
aslasterless0.057
ncdnon-claret disjunctional0.051
B52CG10851 gene product from transcript CG10851-RB0.046
fzyfizzy0.034
hhhedgehog0.028
IswiImitation SWI0.028
CycACyclin A0.027
gsbgooseberry0.026
brmbrahma0.025
DoaDarkener of apricot0.025
CSN4COP9 complex homolog subunit 40.024
Sep2Septin-20.023
CycBCyclin B0.023
Ras85DRas oncogene at 85D0.022
Nup153Nucleoporin 1530.022
Cks30ACyclin-dependent kinase subunit 30A0.022
CycB3Cyclin B30.021
Bap55Brahma associated protein 55kD0.020
ruxroughex0.018
CSN6COP9 complex homolog subunit 60.018
RanGapRan GTPase activating protein0.018
CG6540CG6540 gene product from transcript CG6540-RA0.018
hydhyperplastic discs0.017
bambag of marbles0.017
Cul-3Cullin-30.016
CG4030CG4030 gene product from transcript CG4030-RA0.016
MED6Mediator complex subunit 60.015
Cap-GCG34438 gene product from transcript CG34438-RF0.015
flflfalafel0.014
lgslegless0.014
borrborealin-related0.014
pngpan gu0.014
DrefDNA replication-related element factor0.013
dppdecapentaplegic0.013
Syx13Syntaxin 130.013
CG8223CG8223 gene product from transcript CG8223-RA0.013
tldtolloid0.013
cicubitus interruptus0.013
gammaTub23Cgamma-Tubulin at 23C0.012
jarjaguar0.012
sleslender lobes0.012
cdc2CG5363 gene product from transcript CG5363-RA0.011
CSN7COP9 complex homolog subunit 70.011
IncenpInner centromere protein0.011
wgwingless0.011
cutletCG33122 gene product from transcript CG33122-RA0.011
noinoisette0.011
snostrawberry notch0.011
spn-Dspindle D0.011
KP78bCG17216 gene product from transcript CG17216-RB0.011
edlETS-domain lacking0.010
PsaPuromycin sensitive aminopeptidase0.010
armarmadillo0.010
smosmoothened0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
spdl-1Protein SPDL-10.025
imb-2Protein IMB-20.023
asd-1Protein ASD-10.022
rga-1Protein RGA-10.021
let-502Protein LET-5020.020
ani-1Protein ANI-10.018
his-6Protein HIS-60.017
tba-2Protein TBA-20.017
spk-1Protein SPK-10.017
his-32Protein HIS-320.016
ZK507.6Protein ZK507.60.016
his-45Protein HIS-450.016
uaf-1Protein UAF-10.015
T22C1.1Protein T22C1.10.015
his-42Protein HIS-420.015
rnr-1Protein RNR-10.014
rsd-6Protein RSD-60.014
tba-1Protein TBA-10.014
icp-1Protein ICP-10.014
ubq-1Protein UBQ-10.014
math-33Protein MATH-330.014
wrb-1Protein WRB-10.014
F44E2.8Protein F44E2.80.013
E01A2.2Protein E01A2.20.013
lmn-1Protein LMN-10.013
exos-1Protein EXOS-10.013
npp-11Protein NPP-110.013
goa-1Protein GOA-10.013
pac-1Protein PAC-10.013
gpr-2Protein GPR-20.013
mel-11Protein MEL-110.013
ntl-4Protein NTL-40.013
lin-53Protein LIN-530.013
C49H3.9Protein C49H3.90.013
F33D11.10Protein F33D11.100.012
W09D10.1Protein W09D10.10.012
szy-20Protein SZY-200.012
htz-1Protein HTZ-10.012
R11A8.7Protein R11A8.70.012
rpt-5Protein RPT-50.012
hat-1Protein HAT-10.012
CELE_R11H6.2Protein R11H6.20.012
mcm-2Protein MCM-20.012
air-2Protein AIR-20.012
lin-23Protein LIN-230.012
his-64Protein HIS-640.012
F12F6.1Protein F12F6.10.011
knl-3Protein KNL-30.011
csn-5Protein CSN-50.011
pcn-1Protein PCN-10.011
hcp-1Protein HCP-10.011
rpn-6.1Protein RPN-6.10.011
F25B3.6Protein F25B3.60.011
F31D4.2Protein F31D4.20.011
hpo-10Protein HPO-100.011
abu-13Protein ABU-130.011
npl-4.1Protein NPL-4.10.011
gpr-1Protein GPR-10.011
cyb-1Protein CYB-10.011
csn-4Protein CSN-40.011
cids-2Protein CIDS-20.011
T22F3.2Protein T22F3.20.011
bmk-1Protein BMK-10.011
CELE_C24H12.5Protein C24H12.50.011
F28C10.3Protein F28C10.30.011
cul-1Protein CUL-10.011
H03E18.1Protein H03E18.10.011
ptp-3Protein PTP-30.011
hgrs-1Protein HGRS-10.010
CELE_ZK1025.3Protein ZK1025.30.010
Y55F3BR.8Protein Y55F3BR.80.010
csc-1Protein CSC-10.010
rnp-5Protein RNP-50.010
snr-2Protein SNR-20.010
T19C3.2Protein T19C3.20.010
hmp-1Protein HMP-10.010
air-1Protein AIR-10.010
prp-21Protein PRP-210.010
mes-6Protein MES-60.010
sax-3Protein SAX-30.010
T12B3.4Protein T12B3.40.010
rfl-1Protein RFL-10.010
hda-3Protein HDA-30.010
lin-49Protein LIN-490.010
R07B1.5Protein R07B1.50.010
T23B3.1Protein T23B3.10.010
CELE_F52C6.3Protein F52C6.30.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.938
ANAPC4anaphase promoting complex subunit 40.653
ANAPC7anaphase promoting complex subunit 70.423
CDC27cell division cycle 27 homolog (S. cerevisiae)0.392
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.363
RB1retinoblastoma 10.299
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.227
ANAPC5anaphase promoting complex subunit 50.196
CDK2cyclin-dependent kinase 20.162
CCT8chaperonin containing TCP1, subunit 8 (theta)0.152
DAXXdeath-domain associated protein0.141
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.127
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.126
TP53tumor protein p530.121
BRCA2breast cancer 2, early onset0.119
CCNA2cyclin A20.112
CHAF1Achromatin assembly factor 1, subunit A (p150)0.106
CD2BP2CD2 (cytoplasmic tail) binding protein 20.104
ZNF263zinc finger protein 2630.086
PSEN1presenilin 10.078
TRIM39tripartite motif containing 390.075
ASF1AASF1 anti-silencing function 1 homolog A (S. cerevisiae)0.072
HIPK2homeodomain interacting protein kinase 20.072
GABARAPL1GABA(A) receptor-associated protein like 10.069
SMAD2SMAD family member 20.061
SYVN1synovial apoptosis inhibitor 1, synoviolin0.060
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.059
TPBGtrophoblast glycoprotein0.058
CCNB1cyclin B10.058
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.053
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.052
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.051
CDC20cell division cycle 20 homolog (S. cerevisiae)0.051
FXR2fragile X mental retardation, autosomal homolog 20.049
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.049
MED15mediator complex subunit 150.046
TRAF6TNF receptor-associated factor 60.046
NBR1neighbor of BRCA1 gene 10.045
ARIH2ariadne homolog 2 (Drosophila)0.044
MAP3K5mitogen-activated protein kinase kinase kinase 50.044
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.043
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.042
BAG2BCL2-associated athanogene 20.042
C19orf39chromosome 19 open reading frame 390.042
GFI1Bgrowth factor independent 1B transcription repressor0.041
CBX1chromobox homolog 10.041
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.039
CASC5cancer susceptibility candidate 50.039
CREBBPCREB binding protein0.039
PLK1polo-like kinase 10.039
SQSTM1sequestosome 10.038
SKP2S-phase kinase-associated protein 2 (p45)0.038
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.037
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.036
ZNF207zinc finger protein 2070.034
OTUB1OTU domain, ubiquitin aldehyde binding 10.034
CKS1BCDC28 protein kinase regulatory subunit 1B0.034
STX5syntaxin 50.034
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.032
VCPvalosin containing protein0.032
CDC6cell division cycle 6 homolog (S. cerevisiae)0.032
CCND1cyclin D10.032
TOR1Atorsin family 1, member A (torsin A)0.032
ANAPC11anaphase promoting complex subunit 110.031
GABARAPL2GABA(A) receptor-associated protein-like 20.031
MED1mediator complex subunit 10.030
COPS8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)0.030
UHRF2ubiquitin-like with PHD and ring finger domains 20.030
MDC1mediator of DNA-damage checkpoint 10.029
GABARAPGABA(A) receptor-associated protein0.029
HUWE1HECT, UBA and WWE domain containing 10.029
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.028
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.028
TP53BP1tumor protein p53 binding protein 10.028
MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 60.028
BIRC5baculoviral IAP repeat containing 50.027
TOR1AIP2torsin A interacting protein 20.027
TYRP1tyrosinase-related protein 10.027
FLNBfilamin B, beta0.026
SP100SP100 nuclear antigen0.026
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.026
CDC37cell division cycle 37 homolog (S. cerevisiae)0.026
MYST1MYST histone acetyltransferase 10.026
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.025
CBX5chromobox homolog 50.025
FASFas (TNF receptor superfamily, member 6)0.025
SRIsorcin0.024
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.024
LMNAlamin A/C0.024
ATMINATM interactor0.024
PSEN2presenilin 2 (Alzheimer disease 4)0.024
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.024
PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 100.024
BTBD2BTB (POZ) domain containing 20.023
UBCubiquitin C0.023
BCL2L1BCL2-like 10.023
FANCD2Fanconi anemia, complementation group D20.023
TRIM32tripartite motif containing 320.023
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.023
TERF2IPtelomeric repeat binding factor 2, interacting protein0.022
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.986
Gli3GLI-Kruppel family member GLI30.718
Pax2paired box gene 20.661
Ctnnb1catenin (cadherin associated protein), beta 10.618
Fgfr2fibroblast growth factor receptor 20.607
Foxc1forkhead box C10.483
Rb1retinoblastoma 10.473
Cdk1cyclin-dependent kinase 10.383
Wnt3awingless-related MMTV integration site 3A0.332
Shhsonic hedgehog0.304
Lhx1LIM homeobox protein 10.273
Notch1Notch gene homolog 1 (Drosophila)0.260
Ccnb1cyclin B10.254
Gli2GLI-Kruppel family member GLI20.253
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.250
Ncoa3nuclear receptor coactivator 30.248
Ptenphosphatase and tensin homolog0.235
Bmp7bone morphogenetic protein 70.194
Kif22kinesin family member 220.158
Ccne1cyclin E10.158
Emx2empty spiracles homolog 2 (Drosophila)0.152
Sox9SRY-box containing gene 90.146
SkilSKI-like0.145
Bmp4bone morphogenetic protein 40.142
Mdm2transformed mouse 3T3 cell double minute 20.140
Cdk2cyclin-dependent kinase 20.136
Ccna2cyclin A20.126
Ptch1patched homolog 10.122
Emx1empty spiracles homolog 1 (Drosophila)0.121
Dkk1dickkopf homolog 1 (Xenopus laevis)0.120
Ccnb2cyclin B20.115
Setdb1SET domain, bifurcated 10.115
Pax8paired box gene 80.111
Ror2receptor tyrosine kinase-like orphan receptor 20.108
Birc5baculoviral IAP repeat-containing 50.105
Trp73transformation related protein 730.104
Notch2Notch gene homolog 2 (Drosophila)0.096
Pthlhparathyroid hormone-like peptide0.095
Socs1suppressor of cytokine signaling 10.084
Prc1protein regulator of cytokinesis 10.081
Ncstnnicastrin0.080
Sgol2shugoshin-like 2 (S. pombe)0.079
Lrp6low density lipoprotein receptor-related protein 60.078
C330027C09RikRIKEN cDNA C330027C09 gene0.077
Wnt4wingless-related MMTV integration site 40.077
Otx2orthodenticle homolog 2 (Drosophila)0.077
Smosmoothened homolog (Drosophila)0.076
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.072
Ccne2cyclin E20.071
Nuf2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.070
Rarbretinoic acid receptor, beta0.066
Otx1orthodenticle homolog 1 (Drosophila)0.064
Cdca8cell division cycle associated 80.064
Efna4ephrin A40.064
DaxxFas death domain-associated protein0.063
Kif20akinesin family member 20A0.063
Amhr2anti-Mullerian hormone type 2 receptor0.063
Fgf8fibroblast growth factor 80.061
Hoxd13homeobox D130.060
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.059
Sgol1shugoshin-like 1 (S. pombe)0.058
Tbrachyury0.058
Tbx1T-box 10.057
Lin9lin-9 homolog (C. elegans)0.056
Usp1ubiquitin specific peptidase 10.055
Naa38N(alpha)-acetyltransferase 38, NatC auxiliary subunit0.055
Spag5sperm associated antigen 50.053
Fgfr3fibroblast growth factor receptor 30.051
Aimp1aminoacyl tRNA synthetase complex-interacting multifunctional protein 10.049
Hmgb2high mobility group box 20.047
Pcnaproliferating cell nuclear antigen0.046
Ube2cubiquitin-conjugating enzyme E2C0.046
Cks2CDC28 protein kinase regulatory subunit 20.046
Wnt1wingless-related MMTV integration site 10.046
Klklotho0.046
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.043
Zfp219zinc finger protein 2190.041
Cops4COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)0.041
Gdnfglial cell line derived neurotrophic factor0.040
Col2a1collagen, type II, alpha 10.040
Rargretinoic acid receptor, gamma0.039
Pax3paired box gene 30.038
Bcl2B-cell leukemia/lymphoma 20.038
Suz12suppressor of zeste 12 homolog (Drosophila)0.038
Fzd10frizzled homolog 10 (Drosophila)0.038
Fgfr1fibroblast growth factor receptor 10.037
Arandrogen receptor0.037
Msx2homeobox, msh-like 20.036
Ooepoocyte expressed protein homolog (dog)0.035
Trp63transformation related protein 630.035
En1engrailed 10.034
Mki67antigen identified by monoclonal antibody Ki 670.034
Nognoggin0.033
Arid1bAT rich interactive domain 1B (SWI-like)0.033
Smc4structural maintenance of chromosomes 40.033
Msx1homeobox, msh-like 10.033
Mdm4transformed mouse 3T3 cell double minute 40.033
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.032
Hmmrhyaluronan mediated motility receptor (RHAMM)0.032
BrafBraf transforming gene0.031
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MAD2Mad2p0.702
CDC20Cdc20p0.535
CDC55Cdc55p0.501
PPH22Pph22p0.480
PPH21Pph21p0.441
SLI15Sli15p0.432
HHF2Hhf2p0.324
MAD1Mad1p0.310
BUB1Bub1p0.308
CHL4Chl4p0.297
RTS1Rts1p0.266
MAD3Mad3p0.258
PPZ1Ppz1p0.204
YPI1Ypi1p0.192
CTF3Ctf3p0.187
NBL1Nbl1p0.173
GIP2Gip2p0.168
KIP1Kip1p0.163
CTF13Ctf13p0.163
BUB3Bub3p0.140
SLK19Slk19p0.119
ECO1Eco1p0.109
IML3Iml3p0.104
MTW1Mtw1p0.100
PIG2Pig2p0.098
TID3Tid3p0.067
DSN1Dsn1p0.058
SDS22Sds22p0.057
FMP48Fmp48p0.056
CIN8Cin8p0.053
ZDS1Zds1p0.053
CHL1Chl1p0.052
TIP41Tip41p0.048
CSL4Csl4p0.046
GLC7Glc7p0.045
PCL10Pcl10p0.045
MLC1Mlc1p0.044
CDC28Cdc28p0.043
CSE4Cse4p0.043
SKP1Skp1p0.041
PTI1Pti1p0.039
MCM21Mcm21p0.039
RAD23Rad23p0.038
CBF1Cbf1p0.038
SPC110Spc110p0.037
SPC24Spc24p0.037
RPT6Rpt6p0.037
GLG1Glg1p0.037
YML053Chypothetical protein0.035
VIK1Vik1p0.034
STU1Stu1p0.034
NSL1Nsl1p0.034
STD1Std1p0.033
UFD2Ufd2p0.032
CBF2Cbf2p0.032
RPT1Rpt1p0.032
SPT15Spt15p0.030
YIL151Chypothetical protein0.030
SPO12Spo12p0.029
TOR2Tor2p0.029
MIF2Mif2p0.029
YLR264C-Ahypothetical protein0.028
TPD3Tpd3p0.028
GSY1Gsy1p0.028
RAD53Rad53p0.028
STB2Stb2p0.027
TAF6Taf6p0.027
SRD1Srd1p0.027
YLR162Whypothetical protein0.026
YOL038C-Ahypothetical protein0.026
LEU2Leu2p0.025
PSK1Psk1p0.025
YNL144Chypothetical protein0.025
PRS2Prs2p0.025
RPN14Rpn14p0.025
NDD1Ndd1p0.025
MCM22Mcm22p0.025
TPI1Tpi1p0.025
TAF10Taf10p0.024
SPL2Spl2p0.024
SPO14Spo14p0.024
HST3Hst3p0.024
HIR1Hir1p0.023
SKM1Skm1p0.023
ADH2Adh2p0.023
CHA1Cha1p0.023
SUR1Sur1p0.023
YBR296C-Ahypothetical protein0.023
WSS1Wss1p0.023
RPT2Rpt2p0.023
MER1Mer1p0.023
NTO1Nto1p0.022
VHS3Vhs3p0.022
CIN1Cin1p0.022
RPT4Rpt4p0.022
HTB1Htb1p0.022
RAD54Rad54p0.022
YIR035Chypothetical protein0.022
BCK2Bck2p0.022
MF(ALPHA)2Mf(alpha)2p0.022