The network for 'erbb signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

erbb signaling pathway

A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
phlpole hole0.907
Rac1CG2248 gene product from transcript CG2248-RA0.884
ShcSHC-adaptor protein0.746
SosSon of sevenless0.701
RhebCG1081 gene product from transcript CG1081-RA0.687
Gap1GTPase-activating protein 10.662
drkdownstream of receptor kinase0.644
Dsor1Downstream of raf10.629
Socs36ESuppressor of cytokine signaling at 36E0.547
argosCG4531 gene product from transcript CG4531-RA0.546
CblCG7037 gene product from transcript CG7037-RB0.539
cnkconnector enhancer of ksr0.526
cindrCIN85 and CD2AP orthologue0.518
Vps25Vacuolar protein sorting 250.447
DadDaughters against dpp0.405
C3GCG42328 gene product from transcript CG42328-RC0.394
S6kIIRPS6-protein kinase-II0.337
PtenCG5671 gene product from transcript CG5671-RB0.319
Gp150CG5820 gene product from transcript CG5820-RA0.315
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.305
NFATNFAT homolog0.286
Mkp3Mitogen-activated protein kinase phosphatase 30.270
Nedd4CG42279 gene product from transcript CG42279-RJ0.265
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.253
dosdaughter of sevenless0.247
PknProtein kinase related to protein kinase N0.233
hipkhomeodomain interacting protein kinase0.208
snostrawberry notch0.206
maskmultiple ankyrin repeats single KH domain0.200
slmbsupernumerary limbs0.199
Rab7Rab-protein 70.191
aopanterior open0.172
Tao-1CG14217 gene product from transcript CG14217-RF0.170
WnkCG7177 gene product from transcript CG7177-RA0.161
MrtfMyocardin-related transcription factor0.161
l(2)gd1lethal (2) giant discs 10.161
amosabsent MD neurons and olfactory sensilla0.154
PvrPDGF- and VEGF-receptor related0.139
sinaseven in absentia0.138
Ten-mTenascin major0.136
Rab5Rab-protein 50.133
Pvf1PDGF- and VEGF-related factor 10.133
vavCG7893 gene product from transcript CG7893-RB0.130
Vps36Vacuolar protein sorting 360.130
JraJun-related antigen0.127
ksrkinase suppressor of ras0.124
MarfMitochondrial assembly regulatory factor0.120
Sema-1aCG18405 gene product from transcript CG18405-RD0.108
p130CASCG1212 gene product from transcript CG1212-RA0.107
Akt1CG4006 gene product from transcript CG4006-RA0.105
bossbride of sevenless0.103
vps2CG14542 gene product from transcript CG14542-RA0.101
ash2absent, small, or homeotic discs 20.099
mbcmyoblast city0.097
CG1021CG1021 gene product from transcript CG1021-RE0.093
RagACG11968 gene product from transcript CG11968-RA0.093
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
let-60Protein LET-600.628
eps-8Protein EPS-80.188
mek-2Protein MEK-20.168
ajm-1Protein AJM-10.109
akt-1Protein AKT-10.074
egl-15Protein EGL-150.069
egl-30Protein EGL-300.065
rbr-2Protein RBR-20.055
vab-1Protein VAB-10.055
egl-27Protein EGL-270.045
C11E4.6Protein C11E4.60.044
egl-8Protein EGL-80.036
lst-1Protein LST-10.031
pept-3Protein PEPT-30.030
R03H10.2Protein R03H10.20.024
inx-1Protein INX-10.024
M02B1.3Protein M02B1.30.023
egl-26Protein EGL-260.022
alg-1Protein ALG-10.021
emo-1Protein EMO-10.021
gpb-1Protein GPB-10.020
sem-5Protein SEM-50.020
cmd-1Protein CMD-10.020
CELE_H28G03.1Protein H28G03.10.020
pqe-1Protein PQE-10.020
mca-2Protein MCA-20.020
daf-11Protein DAF-110.019
csnk-1Protein CSNK-10.018
mig-6Protein MIG-60.018
ina-1Protein INA-10.018
lag-1Protein LAG-10.018
clr-1Protein CLR-10.018
vab-3Protein VAB-30.017
ykt-6Protein YKT-60.017
emb-5Protein EMB-50.017
sel-8Protein SEL-80.015
fln-2Protein FLN-20.015
sma-1Protein SMA-10.015
miz-1Protein MIZ-10.015
egl-13Protein EGL-130.014
CELE_C10C6.6Protein C10C6.60.014
CELE_F52E1.9Protein F52E1.90.014
clc-3Protein CLC-30.014
soc-2Protein SOC-20.013
unc-115Protein UNC-1150.013
bar-1Protein BAR-10.013
wwp-1Protein WWP-10.013
plc-1Protein PLC-10.013
ZK512.4Protein ZK512.40.013
ZK1127.6Protein ZK1127.60.012
dmd-7Protein DMD-70.012
vab-10Protein VAB-100.012
egl-38Protein EGL-380.012
K06A9.1Protein K06A9.10.012
mpk-1Protein MPK-10.012
vav-1Protein VAV-10.012
lin-2Protein LIN-20.012
dpy-23Protein DPY-230.012
frm-8Protein FRM-80.012
C55B6.1Protein C55B6.10.012
spc-1Protein SPC-10.011
pat-3Protein PAT-30.011
rab-30Protein RAB-300.011
trcs-2Protein TRCS-20.011
F09C8.2Protein F09C8.20.011
sdpn-1Protein SDPN-10.011
C43H6.1Protein C43H6.10.010
zfp-3Protein ZFP-30.010
lam-2Protein LAM-20.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.999
EGFRepidermal growth factor receptor0.988
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.964
SHC1SHC (Src homology 2 domain containing) transforming protein 10.613
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.609
PTPN1protein tyrosine phosphatase, non-receptor type 10.562
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.481
APPamyloid beta (A4) precursor protein0.399
GHRgrowth hormone receptor0.303
CALM1calmodulin 1 (phosphorylase kinase, delta)0.302
DLG1discs, large homolog 1 (Drosophila)0.299
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.294
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.281
PTPN11protein tyrosine phosphatase, non-receptor type 110.271
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.245
PTK2PTK2 protein tyrosine kinase 20.208
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.187
CTNND1catenin (cadherin-associated protein), delta 10.170
GAB1GRB2-associated binding protein 10.165
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.139
NCOR1nuclear receptor corepressor 10.137
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.136
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.129
DLG4discs, large homolog 4 (Drosophila)0.129
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.123
DUSP1dual specificity phosphatase 10.122
ARID1AAT rich interactive domain 1A (SWI-like)0.108
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.107
MUC1mucin 1, cell surface associated0.104
STAMBPSTAM binding protein0.103
PDCD6IPprogrammed cell death 6 interacting protein0.100
SPRR2Asmall proline-rich protein 2A0.099
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.096
MAP2K1mitogen-activated protein kinase kinase 10.096
GRB2growth factor receptor-bound protein 20.093
UBE3Aubiquitin protein ligase E3A0.092
PTPN23protein tyrosine phosphatase, non-receptor type 230.092
ESR1estrogen receptor 10.091
ARID1BAT rich interactive domain 1B (SWI1-like)0.090
TSG101tumor susceptibility gene 1010.089
PTPRJprotein tyrosine phosphatase, receptor type, J0.088
RASA1RAS p21 protein activator (GTPase activating protein) 10.085
ARHGAP1Rho GTPase activating protein 10.076
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.076
GDAguanine deaminase0.073
MAP3K11mitogen-activated protein kinase kinase kinase 110.070
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.067
ABI2abl-interactor 20.065
DSG2desmoglein 20.064
LATlinker for activation of T cells0.062
YES1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.060
PRKCAprotein kinase C, alpha0.060
ARHGAP5Rho GTPase activating protein 50.059
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.059
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.058
EIF4A3eukaryotic translation initiation factor 4A30.058
PTENphosphatase and tensin homolog0.058
LTBP4latent transforming growth factor beta binding protein 40.056
IRS1insulin receptor substrate 10.054
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.054
CAV1caveolin 1, caveolae protein, 22kDa0.053
TFF1trefoil factor 10.052
NCK1NCK adaptor protein 10.051
LRRK2leucine-rich repeat kinase 20.051
NOTCH1notch 10.050
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.050
MAP3K5mitogen-activated protein kinase kinase kinase 50.050
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.048
SH3KBP1SH3-domain kinase binding protein 10.046
CD28CD28 molecule0.045
TOM1L1target of myb1 (chicken)-like 10.045
VAV1vav 1 guanine nucleotide exchange factor0.045
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.045
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.044
SH3GL3SH3-domain GRB2-like 30.043
CAV2caveolin 20.043
SORBS3sorbin and SH3 domain containing 30.043
CSNK1G3casein kinase 1, gamma 30.042
MAPK1mitogen-activated protein kinase 10.041
PBKPDZ binding kinase0.041
SOS1son of sevenless homolog 1 (Drosophila)0.039
SRCIN1SRC kinase signaling inhibitor 10.039
YAP1Yes-associated protein 10.039
CLASP1cytoplasmic linker associated protein 10.038
METmet proto-oncogene (hepatocyte growth factor receptor)0.038
REREarginine-glutamic acid dipeptide (RE) repeats0.038
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.037
FBLN1fibulin 10.037
EPORerythropoietin receptor0.036
RIN1Ras and Rab interactor 10.035
SH2D3ASH2 domain containing 3A0.035
SOCS1suppressor of cytokine signaling 10.035
EPS15epidermal growth factor receptor pathway substrate 150.034
ATN1atrophin 10.034
HDAC4histone deacetylase 40.034
PTPRAprotein tyrosine phosphatase, receptor type, A0.034
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptpn11protein tyrosine phosphatase, non-receptor type 110.988
Itgb1integrin beta 1 (fibronectin receptor beta)0.959
Grb2growth factor receptor bound protein 20.950
Inpp5dinositol polyphosphate-5-phosphatase D0.887
Leprleptin receptor0.879
Appamyloid beta (A4) precursor protein0.728
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.679
Egfrepidermal growth factor receptor0.642
Fgfr2fibroblast growth factor receptor 20.633
Nf1neurofibromatosis 10.579
Shc1src homology 2 domain-containing transforming protein C10.573
Prnpprion protein0.511
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.490
Retret proto-oncogene0.471
Nr3c1nuclear receptor subfamily 3, group C, member 10.468
Notch1Notch gene homolog 1 (Drosophila)0.453
Isl1ISL1 transcription factor, LIM/homeodomain0.444
Psen1presenilin 10.421
CblCasitas B-lineage lymphoma0.402
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.326
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.314
Ptenphosphatase and tensin homolog0.301
Dab1disabled homolog 1 (Drosophila)0.294
Stat3signal transducer and activator of transcription 30.281
Ctnnb1catenin (cadherin associated protein), beta 10.268
Mdm2transformed mouse 3T3 cell double minute 20.255
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.250
Ptk2PTK2 protein tyrosine kinase 20.240
Bdnfbrain derived neurotrophic factor0.237
Vav2vav 2 oncogene0.224
BlnkB-cell linker0.220
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.214
SrcRous sarcoma oncogene0.197
Nrg1neuregulin 10.192
Jak2Janus kinase 20.187
BtkBruton agammaglobulinemia tyrosine kinase0.182
Ntf3neurotrophin 30.165
Pax6paired box gene 60.163
Vav1vav 1 oncogene0.161
Notch2Notch gene homolog 2 (Drosophila)0.159
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.149
Cdkn1bcyclin-dependent kinase inhibitor 1B0.149
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.140
Hspg2perlecan (heparan sulfate proteoglycan 2)0.140
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.140
Dlg4discs, large homolog 4 (Drosophila)0.135
Tgfbr1transforming growth factor, beta receptor I0.134
Usp8ubiquitin specific peptidase 80.132
Il6stinterleukin 6 signal transducer0.128
WasWiskott-Aldrich syndrome homolog (human)0.116
Vegfavascular endothelial growth factor A0.116
Trp53transformation related protein 530.115
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.113
Crklv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.110
Phox2bpaired-like homeobox 2b0.108
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.108
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.105
Plcg1phospholipase C, gamma 10.104
Phox2apaired-like homeobox 2a0.101
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.092
Dlg1discs, large homolog 1 (Drosophila)0.088
Pdgfbplatelet derived growth factor, B polypeptide0.087
Prkcbprotein kinase C, beta0.087
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.086
Rac1RAS-related C3 botulinum substrate 10.086
Arid1aAT rich interactive domain 1A (SWI-like)0.085
Tbx3T-box 30.085
Rassf5Ras association (RalGDS/AF-6) domain family member 50.085
Sox10SRY-box containing gene 100.084
Gab2growth factor receptor bound protein 2-associated protein 20.084
Npc1Niemann Pick type C10.083
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.083
Dok1docking protein 10.078
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.078
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.076
Tgfbr2transforming growth factor, beta receptor II0.076
L1camL1 cell adhesion molecule0.075
Fgfr3fibroblast growth factor receptor 30.075
Nos3nitric oxide synthase 3, endothelial cell0.075
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.074
Ptgs2prostaglandin-endoperoxide synthase 20.073
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.071
Dll4delta-like 4 (Drosophila)0.070
Alx3aristaless-like homeobox 30.070
Atf2activating transcription factor 20.069
Hras1Harvey rat sarcoma virus oncogene 10.067
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.067
Gab1growth factor receptor bound protein 2-associated protein 10.066
Prkceprotein kinase C, epsilon0.066
CrebbpCREB binding protein0.059
Sp1trans-acting transcription factor 10.059
Itga3integrin alpha 30.059
Metmet proto-oncogene0.057
Vav3vav 3 oncogene0.057
Efnb2ephrin B20.057
Hhexhematopoietically expressed homeobox0.057
Sos1son of sevenless homolog 1 (Drosophila)0.056
Cd22CD22 antigen0.056
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Grb2growth factor receptor bound protein 20.632
Sgk1serum/glucocorticoid regulated kinase 10.156
Sirpasignal-regulatory protein alpha0.148
Ptpn6protein tyrosine phosphatase, non-receptor type 60.125
Egfrepidermal growth factor receptor0.125
Atp6v1b2ATPase, H transporting, lysosomal V1 subunit B20.099
Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.058
NsfN-ethylmaleimide-sensitive factor0.057
Shc1SHC (Src homology 2 domain containing) transforming protein 10.053
Hk1hexokinase 10.052
Litaflipopolysaccharide-induced TNF factor0.049
Prkcdprotein kinase C, delta0.047
Cd86CD86 molecule0.047
Ptafrplatelet-activating factor receptor0.045
Pfn1profilin 10.044
Ptprsprotein tyrosine phosphatase, receptor type, S0.044
RGD1308350similar to hypothetical protein MGC132510.042
Grip1glutamate receptor interacting protein 10.042
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.041
Ube2hubiquitin-conjugating enzyme E2H0.040
Muc4mucin 4, cell surface associated0.040
Cxcr4chemokine (C-X-C motif) receptor 40.039
Il2rbinterleukin 2 receptor, beta0.039
Plcg2phospholipase C, gamma 20.038
Rin1Ras and Rab interactor 10.033
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.033
Pld2phospholipase D20.032
Lcp2lymphocyte cytosolic protein 20.030
Inpp5dinositol polyphosphate-5-phosphatase D0.029
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.028
Pitpnaphosphatidylinositol transfer protein, alpha0.028
Ap2b1adaptor-related protein complex 2, beta 1 subunit0.027
Il1ainterleukin 1 alpha0.027
Metmet proto-oncogene0.027
Klf9Kruppel-like factor 90.027
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.026
Stk10serine/threonine kinase 100.026
Dab2disabled homolog 2 (Drosophila)0.026
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.026
Gfi1growth factor independent 1 transcription repressor0.025
Ptprcprotein tyrosine phosphatase, receptor type, C0.025
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.025
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.024
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.023
Ciitaclass II, major histocompatibility complex, transactivator0.023
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.023
Tnftumor necrosis factor (TNF superfamily, member 2)0.023
Foxs1forkhead box S10.023
Bdkrb2bradykinin receptor B20.022
Apba3amyloid beta (A4) precursor protein-binding, family A, member 30.022
Rab21RAB21, member RAS oncogene family0.022
Efhd2EF-hand domain family, member D20.022
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.022
PVRpoliovirus receptor0.022
Fmnl1formin-like 10.022
Gpr173G-protein coupled receptor 1730.021
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.021
Lhx5LIM homeobox 50.021
Smad1SMAD family member 10.021
Rhoaras homolog gene family, member A0.021
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.021
Hpcal4hippocalcin-like 40.020
Ttyh3tweety homolog 3 (Drosophila)0.020
Anxa2annexin A20.020
GraspGRP1 (general receptor for phosphoinositides 1)-associated scaffold protein0.020
Ifrd1interferon-related developmental regulator 10.020
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.019
Gata2GATA binding protein 20.019
Fosl2fos-like antigen 20.019
Hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.019
Cd38CD38 molecule0.019
Cpne5copine V0.019
Fgf5fibroblast growth factor 50.019
Dchs1dachsous 1 (Drosophila)0.019
Arf3ADP-ribosylation factor 30.019
Mapre1microtubule-associated protein, RP/EB family, member 10.019
Slc6a9solute carrier family 6 (neurotransmitter transporter, glycine), member 90.018
Irf1interferon regulatory factor 10.018
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.018
Rab7aRAB7A, member RAS oncogene family0.018
F2rl1coagulation factor II (thrombin) receptor-like 10.018
Epha2Eph receptor A20.018
Fgd2FYVE, RhoGEF and PH domain containing 20.018
Il2rginterleukin 2 receptor, gamma0.017
Sorbs1sorbin and SH3 domain containing 10.017
Cadm1cell adhesion molecule 10.017
Jak1Janus kinase 10.017
Vav1vav 1 guanine nucleotide exchange factor0.017
Cd37CD37 molecule0.017
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.016
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.016
Rhobras homolog gene family, member B0.016
Sash3SAM and SH3 domain containing 30.016
Cd40CD40 molecule, TNF receptor superfamily member 50.016
Adora2aadenosine A2a receptor0.016
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.016
Itpr3inositol 1,4,5-triphosphate receptor, type 30.016
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism