The network for 'negative regulation of small gtpase mediated signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of small gtpase mediated signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.

NameDescriptionProbabilityFunc Analog Organism
S6kIIRPS6-protein kinase-II0.397
dmdiminutive0.312
CG7928CG7928 gene product from transcript CG7928-RA0.195
scbscab0.183
Dsor1Downstream of raf10.176
NFATNFAT homolog0.173
CG5180CG5180 gene product from transcript CG5180-RB0.139
Pk61CProtein kinase 61C0.131
CG4813CG4813 gene product from transcript CG4813-RA0.117
Snr1Snf5-related 10.103
mbtmushroom bodies tiny0.101
Eip63EEcdysone-induced protein 63E0.097
Atg1Autophagy-specific gene 10.091
CG14667CG14667 gene product from transcript CG14667-RA0.086
wbwing blister0.081
Cdc42CG12530 gene product from transcript CG12530-RA0.078
Su(z)2Suppressor of zeste 20.074
hipkhomeodomain interacting protein kinase0.070
CG2662CG2662 gene product from transcript CG2662-RA0.070
vrivrille0.069
ShcSHC-adaptor protein0.069
SdcSyndecan0.064
Su(var)3-7Suppressor of variegation 3-70.061
rgrugose0.051
rodrough deal0.051
CTCFCG8591 gene product from transcript CG8591-RA0.051
lqfliquid facets0.051
CG9797CG9797 gene product from transcript CG9797-RA0.049
drprdraper0.047
AlyCG1101 gene product from transcript CG1101-RA0.047
mrimrityu0.047
aopanterior open0.046
C3GCG42328 gene product from transcript CG42328-RC0.042
Rho1CG8416 gene product from transcript CG8416-RB0.042
CG4424CG4424 gene product from transcript CG4424-RA0.039
CG8273CG8273 gene product from transcript CG8273-RA0.038
NetBNetrin-B0.037
CG11696CG11696 gene product from transcript CG11696-RA0.036
slikSterile20-like kinase0.035
robo3CG5423 gene product from transcript CG5423-RA0.035
Rab7Rab-protein 70.034
Akt1CG4006 gene product from transcript CG4006-RA0.032
kaykayak0.032
RanBPMRan-binding protein M0.031
AlkCG8250 gene product from transcript CG8250-RA0.030
CG9650CG9650 gene product from transcript CG9650-RG0.029
ckcrinkled0.028
CG16812CG16812 gene product from transcript CG16812-RA0.028
dupdouble parked0.028
CG8965CG8965 gene product from transcript CG8965-RA0.027
pucpuckered0.027
MBD-likeCG8208 gene product from transcript CG8208-RA0.026
tsgtwisted gastrulation0.026
jebjelly belly0.025
CG31961CG31961 gene product from transcript CG31961-RA0.025
B-H1BarH10.025
nrv1nervana 10.025
CG1792CG1792 gene product from transcript CG1792-RA0.025
CG15167CG15167 gene product from transcript CG15167-RA0.025
Smg5CG8954 gene product from transcript CG8954-RA0.024
swshort wing0.024
Myo31DFMyosin 31DF0.023
inscinscuteable0.023
wdbwiderborst0.023
CG10366CG10366 gene product from transcript CG10366-RA0.022
CG2129CG2129 gene product from transcript CG2129-RA0.022
enokenoki mushroom0.022
svpseven up0.022
cyccycle0.022
Mkp3Mitogen-activated protein kinase phosphatase 30.022
CG4730CG4730 gene product from transcript CG4730-RA0.021
AblAbl tyrosine kinase0.021
CG15601CG15601 gene product from transcript CG15601-RA0.021
CG14711CG14711 gene product from transcript CG14711-RA0.020
simjsimjang0.020
crolcrooked legs0.020
chicoCG5686 gene product from transcript CG5686-RB0.020
InRInsulin-like receptor0.020
rinrasputin0.019
LnkCG17367 gene product from transcript CG17367-RC0.019
CG6792CG6792 gene product from transcript CG6792-RA0.019
hanghangover0.019
pallpallbearer0.019
alphalphabet0.019
RavusCG15889 gene product from transcript CG15889-RA0.019
mysmyospheroid0.018
az2CG1605 gene product from transcript CG1605-RA0.018
Gem2Gemin20.018
pydpolychaetoid0.018
CG13367CG13367 gene product from transcript CG13367-RA0.018
cnocanoe0.018
ttktramtrack0.018
tutlturtle0.017
edechinoid0.017
FimFimbrin0.017
Rip11Rab11 interacting protein0.017
Cep135CG17081 gene product from transcript CG17081-RB0.017
Ets97DEts at 97D0.017
CG12424CG12424 gene product from transcript CG12424-RC0.017
l(1)G0232lethal (1) G02320.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
itgb1b.2integrin, beta 1b.20.983
itgb1bintegrin, beta 1b0.874
itgb1aintegrin, beta 1a0.740
lpar1lysophosphatidic acid receptor 10.495
itgb1b.1integrin, beta 1b.10.379
insrbinsulin receptor b0.364
akap12bA kinase (PRKA) anchor protein (gravin) 12b0.291
nf1aneurofibromin 1a0.278
igfbp6binsulin-like growth factor binding protein 6b0.218
hmcn1hemicentin 10.210
LOC567638hypothetical LOC5676380.203
mfn2mitofusin 20.179
igfbp6ainsulin-like growth factor binding protein 6a0.176
im:7136220im:71362200.167
whsc1Wolf-Hirschhorn syndrome candidate 10.152
trim33tripartite motif-containing 330.148
LOC100003330melanocortin-2 receptor accessory protein 2-like0.135
mtmr8myotubularin related protein 80.131
cbx2chromobox homolog 2 (Drosophila Pc class)0.128
ptger2aprostaglandin E receptor 2a (subtype EP2)0.111
kdm5clysine (K)-specific demethylase 5C0.110
ewsr1aEwing sarcoma breakpoint region 1a0.108
mc5rbmelanocortin 5b receptor0.105
marcksamyristoylated alanine rich protein kinase C substrate a0.105
disp1dispatched homolog 1 (Drosophila)0.103
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.102
akap8lA kinase (PRKA) anchor protein 8-like0.099
kpna4karyopherin alpha 4 (importin alpha 3)0.099
zgc:91976zgc:919760.099
zgc:101071zgc:1010710.092
cnot1CCR4-NOT transcription complex, subunit 10.091
usp1ubiquitin specific protease 10.090
lmnb1lamin B10.089
zgc:162126zgc:1621260.089
frem1aFras1 related extracellular matrix 1a0.083
b2mbeta-2-microglobulin0.082
si:ch211-184m19.1si:ch211-184m19.10.081
hmga1ahigh mobility group AT-hook 1a0.080
rif1RAP1 interacting factor homolog (yeast)0.074
si:ch211-152c2.3si:ch211-152c2.30.071
extl3exostoses (multiple)-like 30.069
wu:fi25h02wu:fi25h020.069
ext1bexostoses (multiple) 1b0.068
api5apoptosis inhibitor 50.068
tcea1transcription elongation factor A (SII), 10.066
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.065
pde10aphosphodiesterase 10A0.064
vcpvalosin containing protein0.063
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.062
rbb4retinoblastoma binding protein 40.058
tubg1tubulin, gamma 10.058
pkp2plakophilin 20.057
ppigpeptidyl-prolyl isomerase G (cyclophilin G)0.057
vgll4lvestigial like 4 like0.056
prrx1bpaired related homeobox 1b0.055
akt2v-akt murine thymoma viral oncogene homolog 20.055
ythdf1YTH domain family, member 10.054
hpd4-hydroxyphenylpyruvate dioxygenase0.054
prpf8pre-mRNA processing factor 80.053
mc5ramelanocortin 5a receptor0.053
tfdp1atranscription factor Dp-1, a0.053
mcm7MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)0.053
zgc:114199zgc:1141990.053
gatad2aGATA zinc finger domain containing 2A0.053
insrainsulin receptor a0.052
dopey1dopey family member 10.052
smtnbsmoothelin b0.051
rsrc2arginine/serine-rich coiled-coil 20.050
sfswapsplicing factor, suppressor of white-apricot homolog (Drosophila)0.050
arfgef1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.050
fgfrl1bfibroblast growth factor receptor-like 1b0.050
caprin1acell cycle associated protein 1a0.050
otud7bOTU domain containing 7B0.050
zgc:56306zgc:563060.049
fcho2FCH domain only 20.049
spred1sprouty-related, EVH1 domain containing 10.048
zgc:66440zgc:664400.048
srsf11serine/arginine-rich splicing factor 110.047
sh3pxd2bSH3 and PX domains 2B0.047
nf1bneurofibromin 1b0.046
vps39vacuolar protein sorting 39 homolog (S. cerevisiae)0.046
acin1aapoptotic chromatin condensation inducer 1a0.045
atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.045
atxn7l3ataxin 7-like 30.044
calcrlacalcitonin receptor-like a0.044
si:ch1073-351m12.1si:ch1073-351m12.10.044
lef1lymphocyte enhancer binding factor 10.043
zgc:55468zgc:554680.043
nup107nucleoporin 1070.043
rbm39aRNA binding motif protein 39a0.043
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 50.043
slc2a12solute carrier family 2 (facilitated glucose transporter), member 120.043
rrbp1ribosome binding protein 1 homolog (dog)0.043
zgc:85727zgc:857270.043
agtr2angiotensin II receptor, type 20.043
porP450 (cytochrome) oxidoreductase0.042
ptpraprotein tyrosine phosphatase, receptor type, A0.042
dedd1death effector domain-containing 10.042
wdr82WD repeat domain containing 820.041
znf711zinc finger protein 7110.041
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAPK1mitogen-activated protein kinase 10.995
MAPK14mitogen-activated protein kinase 140.985
HDAC1histone deacetylase 10.938
CBX5chromobox homolog 50.494
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.381
DUSP1dual specificity phosphatase 10.248
CBX1chromobox homolog 10.242
C19orf50chromosome 19 open reading frame 500.237
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.190
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.189
NCOA3nuclear receptor coactivator 30.150
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.141
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.137
MAPK3mitogen-activated protein kinase 30.133
RIN1Ras and Rab interactor 10.129
MAP2K1mitogen-activated protein kinase kinase 10.127
PDCD6IPprogrammed cell death 6 interacting protein0.114
GBP3guanylate binding protein 30.110
KIF1Bkinesin family member 1B0.099
KCTD10potassium channel tetramerisation domain containing 100.095
E2F6E2F transcription factor 60.092
DUSP3dual specificity phosphatase 30.084
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.081
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.075
MARCH5membrane-associated ring finger (C3HC4) 50.069
FHL2four and a half LIM domains 20.062
ARRB2arrestin, beta 20.061
DUSP7dual specificity phosphatase 70.055
ATF2activating transcription factor 20.052
SH3KBP1SH3-domain kinase binding protein 10.049
NCOA1nuclear receptor coactivator 10.045
PTPRRprotein tyrosine phosphatase, receptor type, R0.043
RPS6KA3ribosomal protein S6 kinase, 90kDa, polypeptide 30.038
GSK3Bglycogen synthase kinase 3 beta0.038
PEA15phosphoprotein enriched in astrocytes 150.038
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.038
NCOR2nuclear receptor corepressor 20.035
SPRY2sprouty homolog 2 (Drosophila)0.034
HDAC2histone deacetylase 20.033
RBBP4retinoblastoma binding protein 40.033
MBD3methyl-CpG binding domain protein 30.033
E2F4E2F transcription factor 4, p107/p130-binding0.032
YBX1Y box binding protein 10.029
RICTORRPTOR independent companion of MTOR, complex 20.029
ZFP36L1zinc finger protein 36, C3H type-like 10.029
LBRlamin B receptor0.028
RB1retinoblastoma 10.027
MTORmechanistic target of rapamycin (serine/threonine kinase)0.025
EGFRepidermal growth factor receptor0.025
RANBP3RAN binding protein 30.024
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.021
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.021
PCDH9protocadherin 90.021
PTPN7protein tyrosine phosphatase, non-receptor type 70.020
PRKCAprotein kinase C, alpha0.020
PPAP2Bphosphatidic acid phosphatase type 2B0.020
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.019
VPS24vacuolar protein sorting 24 homolog (S. cerevisiae)0.019
MAP2K4mitogen-activated protein kinase kinase 40.018
RHOBras homolog gene family, member B0.018
MBPmyelin basic protein0.017
STAMsignal transducing adaptor molecule (SH3 domain and ITAM motif) 10.017
ADNPactivity-dependent neuroprotector homeobox0.017
CSNK2A1casein kinase 2, alpha 1 polypeptide0.016
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.016
MED31mediator complex subunit 310.016
ITGB4integrin, beta 40.016
ATN1atrophin 10.015
RXRAretinoid X receptor, alpha0.015
IQGAP1IQ motif containing GTPase activating protein 10.014
HDAC5histone deacetylase 50.014
PTPRJprotein tyrosine phosphatase, receptor type, J0.014
RASA1RAS p21 protein activator (GTPase activating protein) 10.014
SOX4SRY (sex determining region Y)-box 40.013
BAIAP2BAI1-associated protein 20.013
EEF2Keukaryotic elongation factor-2 kinase0.013
XPO6exportin 60.013
HDAC6histone deacetylase 60.013
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.013
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)0.013
PXNpaxillin0.012
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.012
DUSP6dual specificity phosphatase 60.012
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.012
AKAP9A kinase (PRKA) anchor protein (yotiao) 90.012
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)0.011
AKT1S1AKT1 substrate 1 (proline-rich)0.011
C10orf116chromosome 10 open reading frame 1160.011
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.011
ARHGAP9Rho GTPase activating protein 90.011
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.011
KCTD13potassium channel tetramerisation domain containing 130.011
ATXN3ataxin 30.010
TOP2Btopoisomerase (DNA) II beta 180kDa0.010
OPA1optic atrophy 1 (autosomal dominant)0.010
RPS6KA1ribosomal protein S6 kinase, 90kDa, polypeptide 10.010
GATAD2BGATA zinc finger domain containing 2B0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
IRA1Ira1p0.172
CDC24Cdc24p0.147
GPB2Gpb2p0.129
PKC1Pkc1p0.088
CDC25Cdc25p0.087
ACK1Ack1p0.085
RHO1Rho1p0.080
MKK1Mkk1p0.066
ROM2Rom2p0.064
IRA2Ira2p0.063
SLG1Slg1p0.063
MDS3Mds3p0.058
FYV8Fyv8p0.055
GPR1Gpr1p0.055
CYR1Cyr1p0.051
SAC7Sac7p0.048
BEM2Bem2p0.036
RIM15Rim15p0.025
BEM3Bem3p0.025
SRD1Srd1p0.020
CYK3Cyk3p0.020
TAO3Tao3p0.019
YAR068Whypothetical protein0.019
LEU2Leu2p0.018
YOL038C-Ahypothetical protein0.018
MER1Mer1p0.018
SAK1Sak1p0.016
ARP10Arp10p0.016
PRS2Prs2p0.016
PEP5Pep5p0.016
YLR264C-Ahypothetical protein0.016
MSS11Mss11p0.016
PCL9Pcl9p0.015
YLR162Whypothetical protein0.015
SPL2Spl2p0.015
YNL058Chypothetical protein0.015
MKS1Mks1p0.015
ARG8Arg8p0.014
BST1Bst1p0.014
YBR013Chypothetical protein0.014
ICS2Ics2p0.013
ZPS1Zps1p0.013
YAR066Whypothetical protein0.013
CPD1Cpd1p0.013
AUA1Aua1p0.013
HPF1Hpf1p0.013
BRN1Brn1p0.013
TSC11Tsc11p0.013
ATP6Atp6p0.013
GIC2Gic2p0.013
HXT3Hxt3p0.012
YNL234Whypothetical protein0.012
CUP1-1Cup1-1p0.012
YLR042Chypothetical protein0.012
SPR6Spr6p0.012
HOR2Hor2p0.012
YOL013W-Ahypothetical protein0.012
YBR016Whypothetical protein0.012
FMT1Fmt1p0.011
SCM4Scm4p0.011
YKR017Chypothetical protein0.011
AVL9Avl9p0.011
BIT61Bit61p0.011
IML1Iml1p0.011
YIL151Chypothetical protein0.011
YPR157Whypothetical protein0.011
SGE1Sge1p0.011
IQG1Iqg1p0.011
UPS3Ups3p0.011
YPL066Whypothetical protein0.011
GYL1Gyl1p0.011
BAT2Bat2p0.011
YIL001Whypothetical protein0.011
ARE2Are2p0.011
UFO1Ufo1p0.011
PRM4Prm4p0.011
SSP1Ssp1p0.011
OPT2Opt2p0.011
RGD2Rgd2p0.010
GID7Gid7p0.010
PCL2Pcl2p0.010
IZH4Izh4p0.010
AAD6Aad6p0.010
TYE7Tye7p0.010
PMA2Pma2p0.010
YKR075Chypothetical protein0.010
PCT1Pct1p0.010
YLR040Chypothetical protein0.010
CHA1Cha1p0.010
BSC1Bsc1p0.010
YPL067Chypothetical protein0.010