The network for 'negative regulation of cell matrix adhesion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell matrix adhesion

Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
HOXB5homeobox B50.442
TGFB1transforming growth factor, beta 10.387
ABI2abl-interactor 20.294
FKBP1AFK506 binding protein 1A, 12kDa0.238
DLG1discs, large homolog 1 (Drosophila)0.171
BMP2bone morphogenetic protein 20.166
PTPN1protein tyrosine phosphatase, non-receptor type 10.154
HOXA10homeobox A100.133
INADLInaD-like (Drosophila)0.132
PLAUplasminogen activator, urokinase0.114
SMAD7SMAD family member 70.093
HOXB6homeobox B60.075
ENGendoglin0.073
HOXB7homeobox B70.072
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.069
SNX33sorting nexin 330.054
HOXB3homeobox B30.052
HOXA5homeobox A50.052
HOXA4homeobox A40.045
ACVR1activin A receptor, type I0.044
GDF5growth differentiation factor 50.042
HOXA7homeobox A70.037
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.036
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.036
SH3PXD2ASH3 and PX domains 2A0.035
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.034
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.033
BCAR1breast cancer anti-estrogen resistance 10.031
FAF1Fas (TNFRSF6) associated factor 10.031
SH3D19SH3 domain containing 190.030
PLATplasminogen activator, tissue0.030
SNX9sorting nexin 90.029
SDC2syndecan 20.027
PCDH9protocadherin 90.026
PTK2PTK2 protein tyrosine kinase 20.026
HOXC6homeobox C60.024
TGFB3transforming growth factor, beta 30.024
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.024
HOXA6homeobox A60.023
HOXC10homeobox C100.023
WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 10.023
PRKG1protein kinase, cGMP-dependent, type I0.022
SRCIN1SRC kinase signaling inhibitor 10.021
TGFBR1transforming growth factor, beta receptor 10.021
HOXA2homeobox A20.020
HOXB9homeobox B90.020
PACSIN3protein kinase C and casein kinase substrate in neurons 30.019
FN1fibronectin 10.019
HAP1huntingtin-associated protein 10.017
LIN7Alin-7 homolog A (C. elegans)0.017
LIMK1LIM domain kinase 10.016
EPS8epidermal growth factor receptor pathway substrate 80.015
TNK2tyrosine kinase, non-receptor, 20.014
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.014
PTPN11protein tyrosine phosphatase, non-receptor type 110.013
YAP1Yes-associated protein 10.013
ZMYND11zinc finger, MYND-type containing 110.013
HOXA11homeobox A110.013
GYPCglycophorin C (Gerbich blood group)0.012
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.012
HOXA3homeobox A30.012
FASLGFas ligand (TNF superfamily, member 6)0.012
MAPK8mitogen-activated protein kinase 80.012
PTPN12protein tyrosine phosphatase, non-receptor type 120.011
NRP1neuropilin 10.011
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.011
HOXC9homeobox C90.011
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.011
HOXC4homeobox C40.010
HOXB2homeobox B20.010
SMAD6SMAD family member 60.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sirpasignal-regulatory protein alpha0.092
Inpp5dinositol polyphosphate-5-phosphatase D0.050
Tgfb1transforming growth factor, beta 10.047
Ptpn6protein tyrosine phosphatase, non-receptor type 60.045
Nedd4neural precursor cell expressed, developmentally down-regulated 40.042
Dock8dedicator of cytokinesis 80.036
Plaurplasminogen activator, urokinase receptor0.035
Il2rginterleukin 2 receptor, gamma0.034
Cd37CD37 molecule0.033
Cald1caldesmon 10.031
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.027
Cd86CD86 molecule0.026
Il1binterleukin 1 beta0.023
Tcf4transcription factor 40.023
Il2rbinterleukin 2 receptor, beta0.023
Casp1caspase 10.022
Ptprcprotein tyrosine phosphatase, receptor type, C0.021
Sykspleen tyrosine kinase0.021
Mafbv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)0.021
Ier5limmediate early response 5-like0.020
Neurl3neuralized homolog 3 (Drosophila)0.020
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.019
Cd3gCD3 molecule, gamma0.019
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.018
Ccl4chemokine (C-C motif) ligand 40.018
RGD1311493similar to CG13379-PA0.017
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.017
Cfpcomplement factor properdin0.016
Vcanversican0.016
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.016
C5ar1complement component 5a receptor 10.016
Calcrlcalcitonin receptor-like0.016
RGD1308350similar to hypothetical protein MGC132510.015
Cdcp1CUB domain containing protein 10.015
Myo1gmyosin IG0.015
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.015
Plcg2phospholipase C, gamma 20.015
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.015
Arhgap25Rho GTPase activating protein 250.014
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.014
Ptprsprotein tyrosine phosphatase, receptor type, S0.014
Plekpleckstrin0.014
Prkchprotein kinase C, eta0.014
Itpr3inositol 1,4,5-triphosphate receptor, type 30.014
Irs1insulin receptor substrate 10.014
Lcp2lymphocyte cytosolic protein 20.014
Ptpn7protein tyrosine phosphatase, non-receptor type 70.014
Ptafrplatelet-activating factor receptor0.014
Wbp4WW domain binding protein 4 (formin binding protein 21)0.014
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.014
Castcalpastatin0.013
Rock2Rho-associated coiled-coil containing protein kinase 20.013
Ccl5chemokine (C-C motif) ligand 50.013
Klrd1killer cell lectin-like receptor, subfamily D, member 10.013
Wdr26WD repeat domain 260.013
RT1-DMaRT1 class II, locus DMa0.013
Anxa4annexin A40.013
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.013
Cybbcytochrome b-245, beta polypeptide0.013
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.013
Jak1Janus kinase 10.013
LOC24906RoBo-10.012
Cd3dCD3 molecule, delta0.012
Marcksmyristoylated alanine rich protein kinase C substrate0.012
Tmem106atransmembrane protein 106A0.012
Piglphosphatidylinositol glycan anchor biosynthesis, class L0.012
Bak1BCL2-antagonist/killer 10.012
Slc15a3solute carrier family 15, member 30.012
Plauplasminogen activator, urokinase0.012
Ptpn18protein tyrosine phosphatase, non-receptor type 180.012
Anpepalanyl (membrane) aminopeptidase0.012
Fgfr1Fibroblast growth factor receptor 10.012
Ptpreprotein tyrosine phosphatase, receptor type, E0.012
Irs3insulin receptor substrate 30.012
Ctsecathepsin E0.012
Col12a1collagen, type XII, alpha 10.012
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.011
Acp5acid phosphatase 5, tartrate resistant0.011
Prkcdprotein kinase C, delta0.011
F2rl1coagulation factor II (thrombin) receptor-like 10.011
Glg1golgi apparatus protein 10.011
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.011
Hmha1histocompatibility (minor) HA-10.011
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.011
Cux1cut-like homeobox 10.011
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.011
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.011
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.011
Pja2praja 2, RING-H2 motif containing0.011
Ripk3receptor-interacting serine-threonine kinase 30.011
Jdp2Jun dimerization protein 20.011
Lphn2latrophilin 20.011
Ehd4EH-domain containing 40.011
Jak2Janus kinase 20.011
Fam26ffamily with sequence similarity 26, member F0.011
Bst1bone marrow stromal cell antigen 10.010
Lamb2laminin, beta 20.010
Egr2early growth response 20.010
Aggf1angiogenic factor with G patch and FHA domains 10.010
Sash3SAM and SH3 domain containing 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism