The network for 'dna endoreduplication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna endoreduplication

Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.

NameDescriptionProbabilityFunc Analog Organism
slp1sloppy paired 10.776
DpDP transcription factor0.727
Mcm10Sensitized chromosome inheritance modifier 190.680
Mcm2Minichromosome maintenance 20.639
Orc2Origin recognition complex subunit 20.626
jumujumeau0.507
dupdouble parked0.485
CG9772CG9772 gene product from transcript CG9772-RB0.346
hdhumpty dumpty0.333
Mcm5Minichromosome maintenance 50.279
SlbpStem-loop binding protein0.269
gsbgooseberry0.251
CDC45LCG3658 gene product from transcript CG3658-RA0.249
dntdoughnut on 20.212
CycECyclin E0.192
picpiccolo0.187
nejnejire0.173
tostosca0.173
twitwist0.172
tlltailless0.169
HmrHybrid male rescue0.167
CG13350CG13350 gene product from transcript CG13350-RA0.165
Ndc80CG9938 gene product from transcript CG9938-RA0.156
rodrough deal0.154
tintinman0.153
nkdnaked cuticle0.152
cdc16CG6759 gene product from transcript CG6759-RA0.151
slp2sloppy paired 20.145
pds5CG17509 gene product from transcript CG17509-RA0.141
E(bx)Enhancer of bithorax0.139
bynbrachyenteron0.137
Top2Topoisomerase 20.136
dpadisc proliferation abnormal0.130
kniknirps0.128
Orc5Origin recognition complex subunit 50.127
CG14869CG14869 gene product from transcript CG14869-RB0.125
Rca1Regulator of cyclin A10.120
btlbreathless0.104
RnrLRibonucleoside diphosphate reductase large subunit0.102
NotumCG13076 gene product from transcript CG13076-RB0.102
hkbhuckebein0.101
Klp61FKinesin-like protein at 61F0.096
Traf4TNF-receptor-associated factor 40.092
tldtolloid0.091
YetiCG40218 gene product from transcript CG40218-RA0.086
ph-dpolyhomeotic distal0.085
oddodd skipped0.082
latlatheo0.081
chicoCG5686 gene product from transcript CG5686-RB0.078
asf1anti-silencing factor 10.069
mip120Myb-interacting protein 1200.067
Nuf2CG8902 gene product from transcript CG8902-RA0.060
CG9316CG9316 gene product from transcript CG9316-RA0.060
Btk29ABtk family kinase at 29A0.059
mus209mutagen-sensitive 2090.059
Caf1-105CG12892 gene product from transcript CG12892-RA0.058
gtgiant0.057
CG3407CG3407 gene product from transcript CG3407-RA0.056
mus101mutagen-sensitive 1010.056
skpACG16983 gene product from transcript CG16983-RD0.056
fnefound in neurons0.055
l(2)05714lethal (2) 057140.054
Mcm6Minichromosome maintenance 60.053
DNApol-alpha60DNA polymerase alpha 60kD0.051
BCL7-likeCG17252 gene product from transcript CG17252-RA0.047
DNApol-alpha73DNA polymerase alpha 73kD0.047
ctaconcertina0.046
CG3430CG3430 gene product from transcript CG3430-RA0.046
pluplutonium0.046
enengrailed0.045
ribribbon0.044
pathpathetic0.044
Ets97DEts at 97D0.043
CG3508CG3508 gene product from transcript CG3508-RB0.042
Orc6Origin recognition complex subunit 60.041
lunaCG33473 gene product from transcript CG33473-RB0.037
Cks30ACyclin-dependent kinase subunit 30A0.037
HLH54FCG5005 gene product from transcript CG5005-RA0.037
piwiCG6122 gene product from transcript CG6122-RA0.036
chmchameau0.036
rad50CG6339 gene product from transcript CG6339-RD0.036
jebjelly belly0.036
CG14937CG14937 gene product from transcript CG14937-RA0.034
egeagle0.034
Mcm3Minichromosome maintenance 30.033
hephemipterous0.033
Kmn1kinetochore Mis12-Ndc80 network component 10.032
exexpanded0.032
Top1Topoisomerase 10.032
nebnebbish0.031
toctoucan0.031
cmetCENP-meta0.031
runrunt0.029
Cdk4Cyclin-dependent kinase 40.029
Rab23CG2108 gene product from transcript CG2108-RA0.028
CycACyclin A0.028
kek5kekkon50.028
Trf2TATA box binding protein-related factor 20.028
CG5792CG5792 gene product from transcript CG5792-RA0.027
CG5694CG5694 gene product from transcript CG5694-RA0.027
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
CDK2cyclin-dependent kinase 20.441
RB1retinoblastoma 10.398
SMC1Astructural maintenance of chromosomes 1A0.238
CCNE1cyclin E10.091
MCM2minichromosome maintenance complex component 20.061
RBL1retinoblastoma-like 1 (p107)0.058
TFDP2transcription factor Dp-2 (E2F dimerization partner 2)0.032
E2F7E2F transcription factor 70.030
TFDP1transcription factor Dp-10.030
ORC1origin recognition complex, subunit 10.028
WAPALwings apart-like homolog (Drosophila)0.027
E2F8E2F transcription factor 80.025
RAD21RAD21 homolog (S. pombe)0.021
RBBP8retinoblastoma binding protein 80.021
SKP2S-phase kinase-associated protein 2 (p45)0.019
MCM7minichromosome maintenance complex component 70.018
RBL2retinoblastoma-like 2 (p130)0.016
E2F1E2F transcription factor 10.015
ORC6origin recognition complex, subunit 60.014
MCM6minichromosome maintenance complex component 60.014
CDT1chromatin licensing and DNA replication factor 10.012
CDC6cell division cycle 6 homolog (S. cerevisiae)0.012
MCMBPminichromosome maintenance complex binding protein0.011
MCM3minichromosome maintenance complex component 30.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)1.000
Smc1astructural maintenance of chromosomes 1A0.991
Ccne1cyclin E10.947
E2f1E2F transcription factor 10.922
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.915
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.900
Cdk2cyclin-dependent kinase 20.840
Foxa2forkhead box A20.813
Arid1bAT rich interactive domain 1B (SWI-like)0.799
Cdca5cell division cycle associated 50.697
Mdm2transformed mouse 3T3 cell double minute 20.646
Ccna2cyclin A20.619
Smc3structural maintenace of chromosomes 30.566
Mecp2methyl CpG binding protein 20.554
Ccnfcyclin F0.533
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.530
Rbl1retinoblastoma-like 1 (p107)0.501
Rrm2ribonucleotide reductase M20.491
Tfdp2transcription factor Dp 20.485
Rad21RAD21 homolog (S. pombe)0.467
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.456
Mybl2myeloblastosis oncogene-like 20.452
Lig1ligase I, DNA, ATP-dependent0.374
Chaf1bchromatin assembly factor 1, subunit B (p60)0.368
Orc1origin recognition complex, subunit 10.367
Rad51RAD51 homolog (S. cerevisiae)0.366
Cdt1chromatin licensing and DNA replication factor 10.359
Plk1polo-like kinase 1 (Drosophila)0.333
Cbx5chromobox homolog 5 (Drosophila HP1a)0.329
Foxm1forkhead box M10.318
Polepolymerase (DNA directed), epsilon0.311
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.307
Incenpinner centromere protein0.297
Rb1retinoblastoma 10.288
Nbnnibrin0.277
Cdca7lcell division cycle associated 7 like0.276
Aurkbaurora kinase B0.273
Chek1checkpoint kinase 1 homolog (S. pombe)0.257
E2f8E2F transcription factor 80.254
Rcc1regulator of chromosome condensation 10.253
Gtse1G two S phase expressed protein 10.247
Gfi1growth factor independent 10.246
Tcf19transcription factor 190.242
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.224
Exo1exonuclease 10.223
Cdc7cell division cycle 7 (S. cerevisiae)0.219
BlnkB-cell linker0.218
Rad51ap1RAD51 associated protein 10.211
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.201
Mcm6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)0.195
StilScl/Tal1 interrupting locus0.190
Timelesstimeless homolog (Drosophila)0.190
Ncaphnon-SMC condensin I complex, subunit H0.185
Dtldenticleless homolog (Drosophila)0.182
Ccne2cyclin E20.182
Melkmaternal embryonic leucine zipper kinase0.175
Pkdccprotein kinase domain containing, cytoplasmic0.172
Dna2DNA replication helicase 2 homolog (yeast)0.170
Rmnd5arequired for meiotic nuclear division 5 homolog A (S. cerevisiae)0.165
Dok1docking protein 10.165
Mki67antigen identified by monoclonal antibody Ki 670.163
Birc5baculoviral IAP repeat-containing 50.162
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.162
Sgol1shugoshin-like 1 (S. pombe)0.156
Brca1breast cancer 10.154
Dkk1dickkopf homolog 1 (Xenopus laevis)0.153
BlmBloom syndrome, RecQ helicase-like0.149
DbpD site albumin promoter binding protein0.147
Kitlkit ligand0.139
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.139
Rad50RAD50 homolog (S. cerevisiae)0.135
Lmnb1lamin B10.132
Foxa1forkhead box A10.132
Gmnngeminin0.129
Brca2breast cancer 20.125
Sass6spindle assembly 6 homolog (C. elegans)0.118
Iqgap3IQ motif containing GTPase activating protein 30.118
Hellshelicase, lymphoid specific0.117
Rfc5replication factor C (activator 1) 50.114
Pinx1PIN2/TERF1 interacting, telomerase inhibitor 10.114
Wdhd1WD repeat and HMG-box DNA binding protein 10.113
Nr1d2nuclear receptor subfamily 1, group D, member 20.110
Pola1polymerase (DNA directed), alpha 10.109
Hlfhepatic leukemia factor0.109
Hoxa5homeobox A50.108
Cdk1cyclin-dependent kinase 10.106
Prc1protein regulator of cytokinesis 10.105
Cdca4cell division cycle associated 40.103
Kif11kinesin family member 110.100
Ccdc99coiled-coil domain containing 990.099
A930001N09RikRIKEN cDNA A930001N09 gene0.098
Hmga2high mobility group AT-hook 20.097
Sp3trans-acting transcription factor 30.096
Fam111afamily with sequence similarity 111, member A0.095
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.092
Smad2MAD homolog 2 (Drosophila)0.090
Tk1thymidine kinase 10.089
Gsg2germ cell-specific gene 20.088
Ranbp9RAN binding protein 90.085
Trip13thyroid hormone receptor interactor 130.083
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism