The network for 'establishment or maintenance of apical basal cell polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment or maintenance of apical basal cell polarity

Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.

NameDescriptionProbabilityFunc Analog Organism
l(2)gllethal (2) giant larvae0.679
Rab5Rab-protein 50.571
Rab11Rab-protein 110.559
Sop2Suppressor of profilin 20.525
aPKCatypical protein kinase C0.481
frcfringe connection0.453
dlg1discs large 10.419
Cdc42CG12530 gene product from transcript CG12530-RA0.412
eyaeyes absent0.392
ChcClathrin heavy chain0.389
RalaRas-related protein0.388
par-1CG8201 gene product from transcript CG8201-RA0.343
cpacapping protein alpha0.302
trptransient receptor potential0.263
KhcKinesin heavy chain0.261
Syx5Syntaxin 50.252
par-6CG5884 gene product from transcript CG5884-RA0.230
sqhspaghetti squash0.182
Rac1CG2248 gene product from transcript CG2248-RA0.180
VangVan Gogh0.177
ShcSHC-adaptor protein0.176
Syx7Syntaxin 70.170
lkb1CG9374 gene product from transcript CG9374-RJ0.157
stanstarry night0.145
beta-Specbeta Spectrin0.125
JraJun-related antigen0.121
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.110
Dhc64CDynein heavy chain 64C0.108
VhaAC39Vacuolar H[+]-ATPase C39 subunit0.104
Arr2Arrestin 20.099
Sgt1CG9617 gene product from transcript CG9617-RA0.099
ric8aCG15797 gene product from transcript CG15797-RA0.098
sec23CG1250 gene product from transcript CG1250-RA0.097
Npc1aNiemann-Pick type C-1a0.094
DlicDynein light intermediate chain0.094
CG13144CG13144 gene product from transcript CG13144-RA0.090
Arp87CActin-related protein 87C0.090
Fas2Fasciclin 20.089
CG34168CG34168 gene product from transcript CG34168-RA0.079
Wnt4Wnt oncogene analog 40.078
alpha-Specalpha Spectrin0.070
HphHIF prolyl hydroxylase0.060
ovoCG6824 gene product from transcript CG6824-RE0.060
vps2CG14542 gene product from transcript CG14542-RA0.059
XpdXeroderma pigmentosum D0.057
vps24Charged multivesicular body protein 30.055
stumpsCG31317 gene product from transcript CG31317-RC0.054
bowlbrother of odd with entrails limited0.051
Nrx-IVNeurexin IV0.050
Vps28Vacuolar protein sorting 280.048
TSG101tumor suppressor protein 1010.048
UsfCG17592 gene product from transcript CG17592-RB0.047
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.047
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
gei-4Protein GEI-40.037
sur-5Protein SUR-50.029
C06G3.6Protein C06G3.60.022
nid-1Protein NID-10.021
mpk-1Protein MPK-10.017
par-6Protein PAR-60.017
lag-1Protein LAG-10.017
C03A3.2Protein C03A3.20.016
R10E4.9Protein R10E4.90.016
ykt-6Protein YKT-60.016
spl-1Protein SPL-10.016
dgn-1Protein DGN-10.015
CELE_T04H1.2Protein T04H1.20.011
C43H6.4Protein C43H6.40.010
sem-5Protein SEM-50.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
crb2acrumbs homolog 2a0.981
epb41l5erythrocyte membrane protein band 4.1 like 50.978
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.450
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.445
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.398
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.280
ythdf1YTH domain family, member 10.238
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.218
ilkintegrin linked kinase0.204
guca1cguanylate cyclase activator 1C0.198
crb2bcrumbs homolog 2b0.191
prkciprotein kinase C, iota0.176
ift88intraflagellar transport 88 homolog0.163
crb3bcrumbs homolog 3b0.130
pacsin3protein kinase C and casein kinase substrate in neurons 30.126
cdh2cadherin 2, neuronal0.125
lamb1alaminin, beta 1a0.120
crb1crumbs homolog 1 (Drosophila)0.116
pitpnbphosphotidylinositol transfer protein, beta0.115
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.112
dag1dystroglycan 10.093
crb3acrumbs homolog 3a0.092
kif7kinesin family member 70.084
kif17kinesin family member 170.083
mstnamyostatin a0.081
tbx2bT-box 2b0.075
tfectranscription factor EC0.068
ahcyl1S-adenosylhomocysteine hydrolase-like 10.067
prickle1aprickle-like 1 (Drosophila) a0.067
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.062
krt8keratin 80.058
spry2sprouty homolog 20.057
shdbSrc homology 2 domain containing transforming protein D, b0.056
lama1laminin, alpha 10.056
celsr2cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.055
pfn2profilin 20.055
mibmind bomb0.053
ehd1EH-domain containing 10.053
cplx4acomplexin 4a0.053
polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.052
stilTAL1 (SCL) interrupting locus0.052
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.049
crxcone-rod homeobox0.048
synj1synaptojanin 10.048
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.047
zfpl1zinc finger protein-like 10.047
gro2groucho 20.046
tpm1tropomyosin 1 (alpha)0.044
ephb4beph receptor B4b0.043
lrp2low density lipoprotein-related protein 20.043
nrg1neuregulin 10.042
acvr1bactivin A receptor, type IB0.041
pvrl1apoliovirus receptor-related 1a0.039
prnprs3prion protein, related sequence 30.038
rnd3aRho family GTPase 3a0.037
osr2odd-skipped related 2 (Drosophila)0.036
laptm4alysosomal-associated protein transmembrane 4 alpha0.036
casz1castor zinc finger 10.035
dynlt3dynein, light chain, Tctex-type 30.033
card14caspase recruitment domain family, member 140.033
rhpn2rhophilin, Rho GTPase binding protein 20.032
atp1a3bATPase, Na+/K+ transporting, alpha 3b polypeptide0.032
prkczprotein kinase C, zeta0.031
cntn1bcontactin 1b0.031
relv-rel reticuloendotheliosis viral oncogene homolog0.031
lsrlipolysis stimulated lipoprotein receptor0.031
cxadrcoxsackie virus and adenovirus receptor0.031
inhbaainhibin, beta Aa0.030
egr2bearly growth response 2b0.030
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.030
sp2sp2 transcription factor0.028
mxi1max interacting protein0.028
cdc73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.028
has2hyaluronan synthase 20.027
tob1atransducer of ERBB2, 1a0.027
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.026
grk7aG-protein-coupled receptor kinase 7a0.025
olfm1bolfactomedin 1b0.025
eya1eyes absent homolog 10.025
csadcysteine sulfinic acid decarboxylase0.024
gamtguanidinoacetate N-methyltransferase0.024
abca5ATP-binding cassette, sub-family A (ABC1), member 50.023
dlg1discs, large (Drosophila) homolog 10.023
gyltl1bglycosyltransferase-like 1b0.023
opn4x1opsin 4x10.023
skianuclear oncoprotein skia0.022
cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.022
nrp2bneuropilin 2b0.021
cldn12claudin 120.021
LOC100003514protein kinase C alpha type-like0.021
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
MAPTmicrotubule-associated protein tau0.997
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.991
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.990
DVL3dishevelled, dsh homolog 3 (Drosophila)0.979
RHOAras homolog gene family, member A0.964
LRRK2leucine-rich repeat kinase 20.958
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.941
EGFRepidermal growth factor receptor0.937
GDAguanine deaminase0.933
APCadenomatous polyposis coli0.907
DVL1dishevelled, dsh homolog 1 (Drosophila)0.899
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.885
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.847
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.825
ARHGAP1Rho GTPase activating protein 10.821
CNKSR2connector enhancer of kinase suppressor of Ras 20.804
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.787
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.779
CSNK1Ecasein kinase 1, epsilon0.776
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.763
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.759
PKP2plakophilin 20.748
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.734
SORBS3sorbin and SH3 domain containing 30.702
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.585
CD247CD247 molecule0.564
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.547
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.533
LATlinker for activation of T cells0.530
ARHGEF2Rho/Rac guanine nucleotide exchange factor (GEF) 20.524
PRKCZprotein kinase C, zeta0.500
IQGAP1IQ motif containing GTPase activating protein 10.489
JUPjunction plakoglobin0.483
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.470
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.447
CHMP1Achromatin modifying protein 1A0.443
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.442
GMFBglia maturation factor, beta0.441
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.409
INADLInaD-like (Drosophila)0.409
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.398
CD44CD44 molecule (Indian blood group)0.393
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.392
ACACAacetyl-CoA carboxylase alpha0.386
RHOCras homolog gene family, member C0.358
PRKCIprotein kinase C, iota0.332
CDH5cadherin 5, type 2 (vascular endothelium)0.321
MYH9myosin, heavy chain 9, non-muscle0.295
CEP250centrosomal protein 250kDa0.271
MARK2MAP/microtubule affinity-regulating kinase 20.270
CAPNS1calpain, small subunit 10.255
AXIN1axin 10.237
MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)0.237
PFN1profilin 10.235
ROD1ROD1 regulator of differentiation 1 (S. pombe)0.221
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.214
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.214
ROCK1Rho-associated, coiled-coil containing protein kinase 10.212
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.200
YAP1Yes-associated protein 10.197
TCEA2transcription elongation factor A (SII), 20.186
MCCmutated in colorectal cancers0.186
BTBD10BTB (POZ) domain containing 100.182
DCTN1dynactin 10.178
GSK3Bglycogen synthase kinase 3 beta0.173
CALM1calmodulin 1 (phosphorylase kinase, delta)0.166
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.154
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.150
CSNK1Dcasein kinase 1, delta0.149
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.149
TNS4tensin 40.147
ILKintegrin-linked kinase0.140
RAB21RAB21, member RAS oncogene family0.138
PKP4plakophilin 40.136
GLIS2GLIS family zinc finger 20.127
AP1G1adaptor-related protein complex 1, gamma 1 subunit0.124
ERBB2IPerbb2 interacting protein0.122
PSEN1presenilin 10.122
KRT18keratin 180.121
BADBCL2-associated agonist of cell death0.119
TRIP6thyroid hormone receptor interactor 60.118
EXOC5exocyst complex component 50.118
MARK1MAP/microtubule affinity-regulating kinase 10.118
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.116
RALGDSral guanine nucleotide dissociation stimulator0.115
DVL2dishevelled, dsh homolog 2 (Drosophila)0.109
EMP3epithelial membrane protein 30.108
STRN3striatin, calmodulin binding protein 30.106
ZNF512Bzinc finger protein 512B0.104
SAC3D1SAC3 domain containing 10.104
CTNND1catenin (cadherin-associated protein), delta 10.100
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.100
SHC1SHC (Src homology 2 domain containing) transforming protein 10.100
COBRA1cofactor of BRCA10.098
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.097
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dvl2dishevelled 2, dsh homolog (Drosophila)0.972
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.886
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.733
Ush1gUsher syndrome 1G homolog (human)0.547
Pax6paired box gene 60.454
Ascl1achaete-scute complex homolog 1 (Drosophila)0.452
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.441
Dvl3dishevelled 3, dsh homolog (Drosophila)0.425
Neurod1neurogenic differentiation 10.420
Foxa2forkhead box A20.397
Vangl1vang-like 1 (van gogh, Drosophila)0.385
Emx1empty spiracles homolog 1 (Drosophila)0.376
Ptk7PTK7 protein tyrosine kinase 70.338
Pax2paired box gene 20.333
Atoh7atonal homolog 7 (Drosophila)0.324
Ptpn11protein tyrosine phosphatase, non-receptor type 110.322
Vangl2vang-like 2 (van gogh, Drosophila)0.318
MecomMDS1 and EVI1 complex locus0.317
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.314
Neurog2neurogenin 20.301
Sox2SRY-box containing gene 20.294
Prph2peripherin 20.284
Otx2orthodenticle homolog 2 (Drosophila)0.283
Wdr1WD repeat domain 10.264
Shhsonic hedgehog0.258
Gdnfglial cell line derived neurotrophic factor0.254
Pou4f3POU domain, class 4, transcription factor 30.253
Hes5hairy and enhancer of split 5 (Drosophila)0.236
Lhx9LIM homeobox protein 90.215
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.209
Pitx2paired-like homeodomain transcription factor 20.207
Smad2MAD homolog 2 (Drosophila)0.206
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.179
Lhx1LIM homeobox protein 10.167
Rb1retinoblastoma 10.162
Myo6myosin VI0.158
Hoxa1homeobox A10.146
Ptprqprotein tyrosine phosphatase, receptor type, Q0.143
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.138
Tlx3T-cell leukemia, homeobox 30.134
Gata1GATA binding protein 10.131
Fgf8fibroblast growth factor 80.128
Sox11SRY-box containing gene 110.126
Bdnfbrain derived neurotrophic factor0.126
Neurod4neurogenic differentiation 40.121
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.109
Efna2ephrin A20.108
Osr1odd-skipped related 1 (Drosophila)0.108
Itgb1integrin beta 1 (fibronectin receptor beta)0.103
En1engrailed 10.102
Hand2heart and neural crest derivatives expressed transcript 20.099
Notch2Notch gene homolog 2 (Drosophila)0.098
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.096
Lhx3LIM homeobox protein 30.092
Lin7clin-7 homolog C (C. elegans)0.089
Rag2recombination activating gene 20.088
Emx2empty spiracles homolog 2 (Drosophila)0.085
Dab1disabled homolog 1 (Drosophila)0.083
Chukconserved helix-loop-helix ubiquitous kinase0.082
Ush1cUsher syndrome 1C homolog (human)0.081
Ptf1apancreas specific transcription factor, 1a0.080
Phox2bpaired-like homeobox 2b0.080
Onecut1one cut domain, family member 10.078
Foxg1forkhead box G10.077
Ptenphosphatase and tensin homolog0.077
Ilkintegrin linked kinase0.075
Celsr1cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)0.075
Gscgoosecoid homeobox0.074
Srrm4serine/arginine repetitive matrix 40.074
Prkczprotein kinase C, zeta0.072
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.071
2410004A20RikRIKEN cDNA 2410004A20 gene0.069
Pdx1pancreatic and duodenal homeobox 10.067
Crb1crumbs homolog 1 (Drosophila)0.065
Pou3f3POU domain, class 3, transcription factor 30.065
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.064
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.064
Arhgap1Rho GTPase activating protein 10.064
Smad1MAD homolog 1 (Drosophila)0.064
Foxj1forkhead box J10.063
Pou3f4POU domain, class 3, transcription factor 40.059
Insm1insulinoma-associated 10.059
Fstl1follistatin-like 10.059
Hoxd13homeobox D130.059
Ntf3neurotrophin 30.059
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.058
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.055
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.055
Rac1RAS-related C3 botulinum substrate 10.054
Grxcr1glutaredoxin, cysteine rich 10.053
Mobkl1bMOB1, Mps One Binder kinase activator-like 1B (yeast)0.052
Lamc1laminin, gamma 10.052
Smad4MAD homolog 4 (Drosophila)0.051
Cldn3claudin 30.050
Sp3trans-acting transcription factor 30.048
Cdh4cadherin 40.048
Pcdh15protocadherin 150.048
Nr5a1nuclear receptor subfamily 5, group A, member 10.047
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism