The network for 'establishment of monopolar cell polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment of monopolar cell polarity

The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis.

NameDescriptionProbabilityFunc Analog Organism
fzfrizzled0.972
rokRho-kinase0.917
Rab23CG2108 gene product from transcript CG2108-RA0.490
pkprickle0.463
frtzfritz0.446
VangVan Gogh0.372
dshdishevelled0.241
enaenabled0.240
RalaRas-related protein0.235
Cdc42CG12530 gene product from transcript CG12530-RA0.197
POSHPlenty of SH3s0.193
fngfringe0.168
Ptp69DProtein tyrosine phosphatase 69D0.161
pumpumilio0.154
crbcrumbs0.139
ininturned0.135
fjfour-jointed0.130
CG32556CG32556 gene product from transcript CG32556-RB0.129
snsinged0.123
G-ialpha65AG protein alphai subunit 65A0.107
frcfringe connection0.107
LIMK1LIM-kinase10.103
G-oalpha47AG protein oalpha 47A0.073
dsdachsous0.071
ckcrinkled0.067
trctricornered0.066
wdbwiderborst0.065
PknProtein kinase related to protein kinase N0.064
ttktramtrack0.061
aPKCatypical protein kinase C0.051
p120ctnAdherens junction protein p1200.051
par-1CG8201 gene product from transcript CG8201-RA0.045
alpha-Man-IIbCG4606 gene product from transcript CG4606-RA0.044
Wnt4Wnt oncogene analog 40.039
dlg1discs large 10.037
MtlMig-2-like0.034
mtsmicrotubule star0.033
coracoracle0.032
dbodiablo0.032
flrflare0.031
Cip4CG15015 gene product from transcript CG15015-RA0.030
Mes2CG11100 gene product from transcript CG11100-RB0.029
sktlskittles0.028
dxdeltex0.027
tshteashirt0.026
sanoserrano0.025
dgodiego0.024
ovoCG6824 gene product from transcript CG6824-RE0.023
exexpanded0.022
CG4030CG4030 gene product from transcript CG4030-RA0.021
CG42251CG42251 gene product from transcript CG42251-RC0.020
gishgilgamesh0.019
mwhmultiple wing hairs0.018
sec23CG1250 gene product from transcript CG1250-RA0.017
hipkhomeodomain interacting protein kinase0.017
Pak3CG14895 gene product from transcript CG14895-RA0.017
fyfuzzy0.017
msnmisshapen0.017
SerSerrate0.017
Btk29ABtk family kinase at 29A0.017
ftfat0.016
twftwinfilin0.016
TolloCG6890 gene product from transcript CG6890-RA0.016
rinrasputin0.015
WASpCG1520 gene product from transcript CG1520-RA0.015
stanstarry night0.015
tsrtwinstar0.015
Rac1CG2248 gene product from transcript CG2248-RA0.014
CG3125CG3125 gene product from transcript CG3125-RA0.014
Alg-2Apoptosis-linked gene-20.013
Upf1CG1559 gene product from transcript CG1559-RA0.013
JhI-21CG12317 gene product from transcript CG12317-RB0.013
beta-Specbeta Spectrin0.013
kermitCG11546 gene product from transcript CG11546-RB0.013
kluklumpfuss0.013
numbCG3779 gene product from transcript CG3779-RB0.012
CG4968CG4968 gene product from transcript CG4968-RA0.012
Eb1CG3265 gene product from transcript CG3265-RF0.012
Vrp1Verprolin 10.012
SoxNSoxNeuro0.012
nctnicastrin0.012
Cul-5Cullin-50.011
bazbazooka0.011
lkb1CG9374 gene product from transcript CG9374-RJ0.011
Rho1CG8416 gene product from transcript CG8416-RB0.011
Klp64DKinesin-like protein at 64D0.011
CG3563CG3563 gene product from transcript CG3563-RA0.011
MntCG13316 gene product from transcript CG13316-RD0.011
CG3508CG3508 gene product from transcript CG3508-RB0.010
CG31687CG31687 gene product from transcript CG31687-RA0.010
Vhlvon Hippel-Lindau0.010
otkoff-track0.010
PtenCG5671 gene product from transcript CG5671-RB0.010
sshslingshot0.010
ShcSHC-adaptor protein0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh2cadherin 2, neuronal0.758
crb2acrumbs homolog 2a0.733
mibmind bomb0.323
prkciprotein kinase C, iota0.273
pax2apaired box gene 2a0.189
epb41l5erythrocyte membrane protein band 4.1 like 50.155
ift88intraflagellar transport 88 homolog0.134
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.133
lama1laminin, alpha 10.124
fgf8afibroblast growth factor 8 a0.118
cdh1cadherin 1, epithelial0.111
lamb1alaminin, beta 1a0.104
synj1synaptojanin 10.078
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.072
notch1anotch homolog 1a0.068
lamc1laminin, gamma 10.068
ckap5cytoskeleton associated protein 50.064
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.060
tp53tumor protein p530.059
vangl2vang-like 2 (van gogh, Drosophila)0.056
scn1bbsodium channel, voltage-gated, type I, beta b0.053
pbx4pre-B-cell leukemia transcription factor 40.052
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.051
pkd2polycystic kidney disease 20.046
mitfamicrophthalmia-associated transcription factor a0.046
wacaWW domain containing adaptor with coiled-coil a0.044
foxd3forkhead box D30.044
dspadesmoplakin a0.040
nrp1aneuropilin 1a0.039
eya1eyes absent homolog 10.038
axin1axin 10.037
zeb2azinc finger E-box binding homeobox 2a0.036
lrrc6leucine rich repeat containing 60.035
lrp2low density lipoprotein-related protein 20.033
dvl3dishevelled, dsh homolog 3 (Drosophila)0.031
alcamaactivated leukocyte cell adhesion molecule a0.031
wu:fb54a03wu:fb54a030.031
oepone-eyed pinhead0.031
foxj1bforkhead box J1b0.030
osr2odd-skipped related 2 (Drosophila)0.030
krt18keratin 180.030
guca1cguanylate cyclase activator 1C0.030
sox10SRY-box containing gene 100.029
pcdh2acprotocadherin 2 alpha c0.028
kif17kinesin family member 170.026
ctnnb1catenin (cadherin-associated protein), beta 10.026
acvr1bactivin A receptor, type IB0.025
pou4f1POU domain, class 4, transcription factor 10.024
flrfleer0.023
dvl2dishevelled, dsh homolog 2 (Drosophila)0.023
nrxn1aneurexin 1a0.022
celsr2cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.022
perpPERP, TP53 apoptosis effector0.022
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.021
hnf1bbHNF1 homeobox Bb0.021
ttnatitin a0.021
shhasonic hedgehog a0.020
trpm7transient receptor potential cation channel, subfamily M, member 70.020
smad5MAD homolog 5 (Drosophila)0.020
ythdf1YTH domain family, member 10.020
pard3par-3 partitioning defective 3 homolog (C. elegans)0.020
dag1dystroglycan 10.020
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.020
wnt5bwingless-type MMTV integration site family, member 5b0.020
cdh23cadherin-like 230.020
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.019
tpp1tripeptidyl peptidase I0.019
gab1GRB2-associated binding protein 10.019
gpr98G protein-coupled receptor 980.019
anxa5bannexin A5b0.018
jupjunction plakoglobin0.018
epcamepithelial cell adhesion molecule0.018
dlg1discs, large (Drosophila) homolog 10.017
slc45a2solute carrier family 45, member 20.017
zgc:66100zgc:661000.017
gmdsGDP-mannose 4,6-dehydratase0.017
ap1b1adaptor-related protein complex 1, beta 1 subunit0.017
plp1bproteolipid protein 1b0.016
nadl1.2neural adhesion molecule L1.20.016
pou2f1bPOU class 2 homeobox 1b0.016
si:ch211-166a6.5si:ch211-166a6.50.016
rhovras homolog gene family, member V0.016
celsr1acadherin EGF LAG seven-pass G-type receptor 1a0.015
gdf6agrowth differentiation factor 6a0.015
cadm2acell adhesion molecule 2a0.015
nsfaN-ethylmaleimide-sensitive factor a0.015
dzip1DAZ interacting protein 10.015
ptk2.1protein tyrosine kinase 2a0.015
fxr2fragile X mental retardation, autosomal homolog 20.015
mical3flavoprotein oxidoreductase MICAL30.015
rb1retinoblastoma 10.015
entpd3ectonucleoside triphosphate diphosphohydrolase 30.015
ftr82finTRIM family, member 820.015
clrn1clarin 10.015
pogzapogo transposable element with ZNF domain a0.014
terttelomerase reverse transcriptase0.014
dicer1Dicer1, Dcr-1 homolog (Drosophila)0.014
fbn2bfibrillin 2b0.014
ptf1apancreas specific transcription factor, 1a0.014
hdac1histone deacetylase 10.013
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Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
DVL3dishevelled, dsh homolog 3 (Drosophila)0.877
APCadenomatous polyposis coli0.860
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.849
LRRK2leucine-rich repeat kinase 20.847
AXIN1axin 10.529
CNKSR2connector enhancer of kinase suppressor of Ras 20.514
DVL1dishevelled, dsh homolog 1 (Drosophila)0.261
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.222
CSNK1Ecasein kinase 1, epsilon0.214
ZNF512Bzinc finger protein 512B0.211
JAM2junctional adhesion molecule 20.177
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.173
SMAD3SMAD family member 30.159
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.149
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.131
CEP164centrosomal protein 164kDa0.120
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.115
VCLvinculin0.105
PKP4plakophilin 40.104
TJP2tight junction protein 2 (zona occludens 2)0.086
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.079
KIAA1377KIAA13770.072
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.071
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.066
STRN3striatin, calmodulin binding protein 30.060
PSEN1presenilin 10.053
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.050
MCCmutated in colorectal cancers0.048
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.048
CSNK1Dcasein kinase 1, delta0.044
WT1Wilms tumor 10.039
CDH5cadherin 5, type 2 (vascular endothelium)0.038
ZFYVE9zinc finger, FYVE domain containing 90.037
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.036
PXNpaxillin0.036
SYVN1synovial apoptosis inhibitor 1, synoviolin0.036
ENGendoglin0.033
PPP1R12Aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.032
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.031
C9orf100chromosome 9 open reading frame 1000.031
GANgigaxonin0.031
CREBBPCREB binding protein0.031
HSPG2heparan sulfate proteoglycan 20.030
JAM3junctional adhesion molecule 30.028
CTGFconnective tissue growth factor0.027
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.025
F11RF11 receptor0.025
SFNstratifin0.025
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.025
BAHD1bromo adjacent homology domain containing 10.025
GLIS2GLIS family zinc finger 20.023
MEX3Cmex-3 homolog C (C. elegans)0.022
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.022
PIK3CBphosphoinositide-3-kinase, catalytic, beta polypeptide0.021
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.021
AHNAKAHNAK nucleoprotein0.021
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.020
ARHGAP5Rho GTPase activating protein 50.019
ZMYND8zinc finger, MYND-type containing 80.019
TSC22D1TSC22 domain family, member 10.019
PLCB3phospholipase C, beta 3 (phosphatidylinositol-specific)0.018
LRP6low density lipoprotein receptor-related protein 60.018
TIFATRAF-interacting protein with forkhead-associated domain0.018
BTRCbeta-transducin repeat containing0.018
NKD2naked cuticle homolog 2 (Drosophila)0.018
MAP2K6mitogen-activated protein kinase kinase 60.018
MYST2MYST histone acetyltransferase 20.018
MYH10myosin, heavy chain 10, non-muscle0.017
TAOK1TAO kinase 10.017
TJP1tight junction protein 1 (zona occludens 1)0.017
CTNND2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)0.017
FLNAfilamin A, alpha0.016
SHOC2soc-2 suppressor of clear homolog (C. elegans)0.015
ITGA4integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)0.015
USH1CUsher syndrome 1C (autosomal recessive, severe)0.015
TRIP6thyroid hormone receptor interactor 60.015
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.014
RNF2ring finger protein 20.014
PNMA2paraneoplastic antigen MA20.014
TLN1talin 10.014
LLGL1lethal giant larvae homolog 1 (Drosophila)0.014
SAC3D1SAC3 domain containing 10.013
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.013
TNFAIP8L1tumor necrosis factor, alpha-induced protein 8-like 10.013
MARK2MAP/microtubule affinity-regulating kinase 20.013
UBE3Aubiquitin protein ligase E3A0.013
C16orf48chromosome 16 open reading frame 480.013
PCGF2polycomb group ring finger 20.013
MYO6myosin VI0.013
AP2M1adaptor-related protein complex 2, mu 1 subunit0.013
RANBP2RAN binding protein 20.012
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.012
AP1M1adaptor-related protein complex 1, mu 1 subunit0.012
PITX1paired-like homeodomain 10.012
MDM4Mdm4 p53 binding protein homolog (mouse)0.012
RAB5BRAB5B, member RAS oncogene family0.012
PNMA1paraneoplastic antigen MA10.012
DBN1drebrin 10.012
FERMT2fermitin family member 20.012
FHOD3formin homology 2 domain containing 30.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Dvl2dishevelled 2, dsh homolog (Drosophila)1.000
Vangl2vang-like 2 (van gogh, Drosophila)0.999
Dvl3dishevelled 3, dsh homolog (Drosophila)0.995
Vangl1vang-like 1 (van gogh, Drosophila)0.991
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.958
Neurod1neurogenic differentiation 10.924
Ascl1achaete-scute complex homolog 1 (Drosophila)0.896
Pax6paired box gene 60.878
Neurog2neurogenin 20.826
Vegfavascular endothelial growth factor A0.691
Ldb3LIM domain binding 30.527
Neurod4neurogenic differentiation 40.494
Sox11SRY-box containing gene 110.356
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.355
Itga3integrin alpha 30.341
Lmx1bLIM homeobox transcription factor 1 beta0.324
Sox2SRY-box containing gene 20.303
Emx1empty spiracles homolog 1 (Drosophila)0.264
Ptk7PTK7 protein tyrosine kinase 70.262
Prkczprotein kinase C, zeta0.239
Dab1disabled homolog 1 (Drosophila)0.191
Cdh23cadherin 23 (otocadherin)0.189
Otx2orthodenticle homolog 2 (Drosophila)0.179
MecomMDS1 and EVI1 complex locus0.151
Shhsonic hedgehog0.137
Lamb1laminin B10.136
Gdnfglial cell line derived neurotrophic factor0.133
Onecut1one cut domain, family member 10.131
Neurog3neurogenin 30.118
Nkd1naked cuticle 1 homolog (Drosophila)0.107
Myh10myosin, heavy polypeptide 10, non-muscle0.101
Gata1GATA binding protein 10.098
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.098
Zeb1zinc finger E-box binding homeobox 10.090
Tlx3T-cell leukemia, homeobox 30.076
Ptk2PTK2 protein tyrosine kinase 20.073
Dact3dapper homolog 3, antagonist of beta-catenin (xenopus)0.072
Inainternexin neuronal intermediate filament protein, alpha0.072
Ush1gUsher syndrome 1G homolog (human)0.072
Insm1insulinoma-associated 10.071
Nr2e1nuclear receptor subfamily 2, group E, member 10.067
Pou4f3POU domain, class 4, transcription factor 30.067
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.066
Foxg1forkhead box G10.065
Pou4f2POU domain, class 4, transcription factor 20.060
Tcf3transcription factor 30.059
Atoh7atonal homolog 7 (Drosophila)0.056
Pou3f3POU domain, class 3, transcription factor 30.056
Zic3zinc finger protein of the cerebellum 30.054
Prph2peripherin 20.053
Nhlh1nescient helix loop helix 10.051
Foxa2forkhead box A20.049
Sim2single-minded homolog 2 (Drosophila)0.049
Hsf1heat shock factor 10.049
Arxaristaless related homeobox0.048
Kiss1KiSS-1 metastasis-suppressor0.048
Cldn3claudin 30.047
Plcg2phospholipase C, gamma 20.045
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.044
Srrm4serine/arginine repetitive matrix 40.042
Msx1homeobox, msh-like 10.038
Gpc3glypican 30.036
Foxf2forkhead box F20.034
Nphs2nephrosis 2 homolog, podocin (human)0.034
Celsr1cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)0.034
Cd151CD151 antigen0.032
Ptf1apancreas specific transcription factor, 1a0.031
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.031
Tbx2T-box 20.031
Snai1snail homolog 1 (Drosophila)0.030
Gscgoosecoid homeobox0.030
Prkcbprotein kinase C, beta0.029
Foxj1forkhead box J10.029
Cd19CD19 antigen0.029
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.029
Sav1salvador homolog 1 (Drosophila)0.029
Mks1Meckel syndrome, type 10.028
Pitx1paired-like homeodomain transcription factor 10.028
Smurf2SMAD specific E3 ubiquitin protein ligase 20.027
Pdx1pancreatic and duodenal homeobox 10.027
Arrb2arrestin, beta 20.027
Col4a1collagen, type IV, alpha 10.026
Lepleptin0.026
Dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.026
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.026
Hoxb4homeobox B40.026
Tcf21transcription factor 210.025
Irs3insulin receptor substrate 30.025
Igf2bp1insulin-like growth factor 2 mRNA binding protein 10.024
Akt1thymoma viral proto-oncogene 10.024
Kif3akinesin family member 3A0.024
Gnrh1gonadotropin releasing hormone 10.023
Vcanversican0.023
Notonotochord homolog (Xenopus laevis)0.023
Gpsm3G-protein signalling modulator 3 (AGS3-like, C. elegans)0.023
Tgif2TGFB-induced factor homeobox 20.023
Lhx6LIM homeobox protein 60.023
Ighimmunoglobulin heavy chain complex0.022
Gli2GLI-Kruppel family member GLI20.022
Cnn1calponin 10.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism