The network for 'ectodermal placode formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ectodermal placode formation

The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.

NameDescriptionProbabilityFunc Analog Organism
HDAC1histone deacetylase 10.998
HDAC2histone deacetylase 20.958
SP1Sp1 transcription factor0.900
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.780
ARRB1arrestin, beta 10.731
VEGFAvascular endothelial growth factor A0.606
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.546
GSK3Bglycogen synthase kinase 3 beta0.444
SIN3ASIN3 homolog A, transcription regulator (yeast)0.380
MBD3methyl-CpG binding domain protein 30.362
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.316
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.272
HNF4Ahepatocyte nuclear factor 4, alpha0.261
FGFR1fibroblast growth factor receptor 10.261
POU5F1POU class 5 homeobox 10.241
BMP1bone morphogenetic protein 10.215
YY1YY1 transcription factor0.204
BZW1basic leucine zipper and W2 domains 10.199
DKK1dickkopf homolog 1 (Xenopus laevis)0.174
HCFC1host cell factor C1 (VP16-accessory protein)0.158
NCF2neutrophil cytosolic factor 20.152
SMAD7SMAD family member 70.137
NKX2-1NK2 homeobox 10.136
SALL2sal-like 2 (Drosophila)0.127
FOXD3forkhead box D30.121
CAV1caveolin 1, caveolae protein, 22kDa0.109
MDFIMyoD family inhibitor0.104
WNT3Awingless-type MMTV integration site family, member 3A0.085
HNF1AHNF1 homeobox A0.084
SMAD3SMAD family member 30.083
KCTD1potassium channel tetramerisation domain containing 10.080
LRRK2leucine-rich repeat kinase 20.077
DVL3dishevelled, dsh homolog 3 (Drosophila)0.077
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.075
CXCR5chemokine (C-X-C motif) receptor 50.074
PTPN11protein tyrosine phosphatase, non-receptor type 110.067
HRGhistidine-rich glycoprotein0.066
MSX2msh homeobox 20.066
RBBP4retinoblastoma binding protein 40.064
EYA2eyes absent homolog 2 (Drosophila)0.062
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.061
SH3BP4SH3-domain binding protein 40.061
LRP6low density lipoprotein receptor-related protein 60.057
WWP2WW domain containing E3 ubiquitin protein ligase 20.056
GAB1GRB2-associated binding protein 10.055
EDARectodysplasin A receptor0.051
GLIS2GLIS family zinc finger 20.049
NCF4neutrophil cytosolic factor 4, 40kDa0.049
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.049
NCF1neutrophil cytosolic factor 10.048
TMOD3tropomodulin 3 (ubiquitous)0.047
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.046
PAX6paired box 60.046
SMAD1SMAD family member 10.043
BCL11BB-cell CLL/lymphoma 11B (zinc finger protein)0.043
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.039
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.039
DCTN2dynactin 2 (p50)0.036
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.036
GNASGNAS complex locus0.035
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.035
MT1Ametallothionein 1A0.035
MAP3K5mitogen-activated protein kinase kinase kinase 50.035
APCadenomatous polyposis coli0.034
RCOR1REST corepressor 10.034
DVL2dishevelled, dsh homolog 2 (Drosophila)0.033
PGFplacental growth factor0.032
CDV3CDV3 homolog (mouse)0.031
NUCB1nucleobindin 10.031
MBD2methyl-CpG binding domain protein 20.030
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.030
MTA3metastasis associated 1 family, member 30.030
HEMGNhemogen0.030
JUPjunction plakoglobin0.029
PPIL4peptidylprolyl isomerase (cyclophilin)-like 40.029
NEK6NIMA (never in mitosis gene a)-related kinase 60.029
GNG2guanine nucleotide binding protein (G protein), gamma 20.029
SIM2single-minded homolog 2 (Drosophila)0.029
DLX2distal-less homeobox 20.029
SOX5SRY (sex determining region Y)-box 50.029
ZBTB17zinc finger and BTB domain containing 170.028
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.028
MPZL1myelin protein zero-like 10.027
SOX7SRY (sex determining region Y)-box 70.027
NR0B2nuclear receptor subfamily 0, group B, member 20.027
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.027
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.026
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.026
INHBAinhibin, beta A0.025
TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)0.025
PPT1palmitoyl-protein thioesterase 10.024
GSK3Aglycogen synthase kinase 3 alpha0.024
CDK2AP1cyclin-dependent kinase 2 associated protein 10.023
GNMTglycine N-methyltransferase0.023
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.023
SOX13SRY (sex determining region Y)-box 130.023
CATcatalase0.023
HNF1BHNF1 homeobox B0.023
AXIN2axin 20.022
LYPD3LY6/PLAUR domain containing 30.022
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sox2SRY-box containing gene 20.948
foxi1forkhead box I10.933
fgf8afibroblast growth factor 8 a0.926
tbx1T-box 10.925
dlx4bdistal-less homeobox gene 4b0.897
eya1eyes absent homolog 10.895
ndr2nodal-related 20.875
fgf3fibroblast growth factor 30.854
bmp4bone morphogenetic protein 40.803
dlx3bdistal-less homeobox gene 3b0.799
fgf17fibroblast growth factor 170.751
six4bsine oculis homeobox homolog 4b0.742
dlx4adistal-less homeobox gene 4a0.724
foxa2forkhead box A20.706
tp63tumor protein p630.645
foxa3forkhead box A30.641
admpanti-dorsalizing morphogenic protein0.628
ephb4beph receptor B4b0.625
bmp2bbone morphogenetic protein 2b0.623
sfrp1asecreted frizzled-related protein 1a0.613
flhfloating head0.553
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.537
gata2aGATA-binding protein 2a0.517
snai1bsnail homolog 1b (Drosophila)0.510
cdx4caudal type homeo box transcription factor 40.498
dkk1bdickkopf 1b0.480
gbx2gastrulation brain homeo box 20.455
dlx2bdistal-less homeobox gene 2b0.448
pax8paired box gene 80.438
rargaretinoic acid receptor gamma a0.437
wnt2wingless-type MMTV integration site family member 20.435
wnt1wingless-type MMTV integration site family, member 10.422
dharmadharma0.375
osr1odd-skipped related 1 (Drosophila)0.370
jag2jagged 20.363
msxcmuscle segment homeobox C0.356
tfap2atranscription factor AP-2 alpha0.330
spry2sprouty homolog 20.328
fzd7afrizzled homolog 7a0.328
kitakit receptor a0.325
bmp2abone morphogenetic protein 2a0.312
pitx2paired-like homeodomain transcription factor 20.303
cdh2cadherin 2, neuronal0.291
wnt3wingless-type MMTV integration site family, member 30.284
msxdmuscle segment homeobox D0.281
hmx4H6 family homeobox 40.269
msxbmuscle segment homeobox B0.266
hmx1H6 homeo box 10.260
otx1aorthodenticle homolog 1a0.260
lmx1b.1LIM homeobox transcription factor 1, beta 10.260
wnt4awingless-type MMTV integration site family, member 4a0.255
foxj1aforkhead box J1a0.250
ctsl1bcathepsin L, 1 b0.238
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.220
gata3GATA-binding protein 30.220
unc5bunc-5 homolog B (C. elegans)0.213
wif1wnt inhibitory factor 10.205
wnt8bwingless-type MMTV integration site family, member 8b0.205
sp5lSp5 transcription factor-like0.186
wnt5bwingless-type MMTV integration site family, member 5b0.185
crestincrestin0.184
nr2e1nuclear receptor subfamily 2, group E, member 10.180
si:ch211-173o4.2si:ch211-173o4.20.174
foxc1aforkhead box C1a0.173
twist3twist30.165
sox3SRY-box containing gene 30.158
spry4sprouty (Drosophila) homolog 40.148
dlx2adistal-less homeobox gene 2a0.143
tbx6T-box gene 60.140
fn1fibronectin 10.140
map2k4amitogen-activated protein kinase kinase 4a0.139
nog1noggin 10.139
lhx5LIM homeobox 50.132
otx1borthodenticle homolog 1b0.130
lef1lymphocyte enhancer binding factor 10.128
ntn1bnetrin 1b0.127
her3hairy-related 30.126
sox1aSRY-box containing gene 1a0.122
grhl2bgrainyhead-like 2b (Drosophila)0.121
wnt3awingless-type MMTV integration site family, member 3A0.121
lhx6LIM homeobox 60.120
emx3empty spiracles homeobox 30.120
fgf8bfibroblast growth factor 8 b0.120
wnt7bbwingless-type MMTV integration site family, member 7Bb0.115
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.114
gbx1gastrulation brain homeobox 10.108
hmx3homeo box (H6 family) 30.107
pitx3paired-like homeodomain transcription factor 30.107
otx2orthodenticle homolog 20.105
zfyve26zinc finger, FYVE domain containing 260.102
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.102
nrp2aneuropilin 2a0.101
vcanbversican b0.101
shhbsonic hedgehog b0.099
wnt11rwingless-type MMTV integration site family, member 11, related0.099
fgfrl1bfibroblast growth factor receptor-like 1b0.099
her5hairy-related 50.098
dlcdeltaC0.098
foxi3aforkhead box I3a0.097
gcm2glial cells missing homolog 2 (Drosophila)0.097
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
grogroucho0.450
eyaeyes absent0.251
tshteashirt0.213
hthhomothorax0.210
smosmoothened0.205
MedMedea0.131
Stat92ESignal-transducer and activator of transcription protein at 92E0.113
cicubitus interruptus0.111
dppdecapentaplegic0.071
ciccapicua0.067
slp1sloppy paired 10.055
mirrmirror0.054
dvedefective proventriculus0.053
sosine oculis0.050
nubnubbin0.048
Su(z)12CG8013 gene product from transcript CG8013-RA0.046
PclPolycomblike0.046
lgslegless0.044
Syx1ASyntaxin 1A0.043
toytwin of eyeless0.042
saxsaxophone0.041
DfdDeformed0.040
miramiranda0.040
tiotiptop0.040
ttvtout-velu0.039
prdpaired0.036
gsbgooseberry0.035
18w18 wheeler0.034
dshdishevelled0.031
bowlbrother of odd with entrails limited0.030
shnschnurri0.030
ovoCG6824 gene product from transcript CG6824-RE0.029
TlToll0.027
armarmadillo0.027
panpangolin0.025
grngrain0.024
nkdnaked cuticle0.024
ftfat0.024
trctricornered0.023
danrdistal antenna-related0.023
arrarrow0.021
tuptailup0.021
porporcupine0.021
OptixCG18455 gene product from transcript CG18455-RA0.020
discodisconnected0.019
opaodd paired0.019
ActbetaActivin-beta0.018
btdbuttonhead0.017
hipkhomeodomain interacting protein kinase0.017
pumpumilio0.017
cv-ccrossveinless c0.016
fs(1)hfemale sterile (1) homeotic0.016
DoaDarkener of apricot0.016
srpserpent0.016
elavembryonic lethal abnormal vision0.016
captcapulet0.016
exdextradenticle0.015
dockdreadlocks0.015
hpohippo0.015
enengrailed0.015
spensplit ends0.014
stwlstonewall0.014
spdosanpodo0.014
thsthisbe0.014
indintermediate neuroblasts defective0.013
hhhedgehog0.013
trxtrithorax0.013
twitwist0.013
bazbazooka0.013
konkon-tiki0.013
AntpAntennapedia0.012
wgwingless0.012
snksnake0.012
jarjaguar0.012
CG8486CG8486 gene product from transcript CG8486-RE0.012
ifinflated0.012
simsingle-minded0.011
PoxnPox neuro0.011
gsb-ngooseberry-neuro0.011
tsltorso-like0.011
caupcaupolican0.011
emsempty spiracles0.011
pdm2POU domain protein 20.011
SoxNSoxNeuro0.011
hkbhuckebein0.011
Hr46Hormone receptor-like in 460.011
Fas3Fasciclin 30.011
UbxUltrabithorax0.011
HmgcrHMG Coenzyme A reductase0.011
putpunt0.011
kek1kekkon-10.011
pcxpecanex0.011
RfxCG6312 gene product from transcript CG6312-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.996
Otx2orthodenticle homolog 2 (Drosophila)0.985
Tcfap2atranscription factor AP-2, alpha0.888
Sox2SRY-box containing gene 20.887
Pax2paired box gene 20.883
Pax3paired box gene 30.870
Prrx1paired related homeobox 10.830
Fgf8fibroblast growth factor 80.824
Gli3GLI-Kruppel family member GLI30.817
Eya1eyes absent 1 homolog (Drosophila)0.785
Pitx2paired-like homeodomain transcription factor 20.704
Foxg1forkhead box G10.636
Fgf3fibroblast growth factor 30.532
Shhsonic hedgehog0.524
Tbx3T-box 30.495
Hand1heart and neural crest derivatives expressed transcript 10.494
Bmp4bone morphogenetic protein 40.481
Gbx2gastrulation brain homeobox 20.481
Ctnnb1catenin (cadherin associated protein), beta 10.433
Sox11SRY-box containing gene 110.389
Msx2homeobox, msh-like 20.356
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.339
Alx1ALX homeobox 10.315
Lrp6low density lipoprotein receptor-related protein 60.311
Dok2docking protein 20.310
Hoxa1homeobox A10.302
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.302
Alx4aristaless-like homeobox 40.296
Pitx1paired-like homeodomain transcription factor 10.272
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.239
Dlx5distal-less homeobox 50.230
Lmx1aLIM homeobox transcription factor 1 alpha0.225
Nodalnodal0.196
Rargretinoic acid receptor, gamma0.194
Hoxd13homeobox D130.191
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.177
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.171
Sall4sal-like 4 (Drosophila)0.165
Hmx3H6 homeobox 30.163
Msx1homeobox, msh-like 10.152
Fgf10fibroblast growth factor 100.152
Lef1lymphoid enhancer binding factor 10.150
Smad6MAD homolog 6 (Drosophila)0.144
NanogNanog homeobox0.138
Runx2runt related transcription factor 20.136
Isl1ISL1 transcription factor, LIM/homeodomain0.131
Zeb1zinc finger E-box binding homeobox 10.128
Pou3f3POU domain, class 3, transcription factor 30.128
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.124
Smosmoothened homolog (Drosophila)0.116
Otx1orthodenticle homolog 1 (Drosophila)0.116
Pax6paired box gene 60.109
Bdnfbrain derived neurotrophic factor0.108
Dok1docking protein 10.107
Col2a1collagen, type II, alpha 10.106
Ptenphosphatase and tensin homolog0.105
Pou5f1POU domain, class 5, transcription factor 10.104
Chd7chromodomain helicase DNA binding protein 70.101
Bmp7bone morphogenetic protein 70.098
Gata3GATA binding protein 30.095
Tcfap2ctranscription factor AP-2, gamma0.095
Gscgoosecoid homeobox0.095
Snai1snail homolog 1 (Drosophila)0.094
Vangl2vang-like 2 (van gogh, Drosophila)0.092
Sall3sal-like 3 (Drosophila)0.088
Zic3zinc finger protein of the cerebellum 30.088
Foxc1forkhead box C10.087
Gsk3bglycogen synthase kinase 3 beta0.087
Wnt1wingless-related MMTV integration site 10.081
Foxh1forkhead box H10.080
Rarbretinoic acid receptor, beta0.078
En2engrailed 20.077
Dlx1distal-less homeobox 10.073
Sox3SRY-box containing gene 30.071
Lrp5low density lipoprotein receptor-related protein 50.066
Pax9paired box gene 90.065
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.063
Alx3aristaless-like homeobox 30.059
Tbx15T-box 150.058
Hes1hairy and enhancer of split 1 (Drosophila)0.058
Foxa2forkhead box A20.057
Hoxa13homeobox A130.057
Neurod1neurogenic differentiation 10.057
Tbx10T-box 100.055
Ece1endothelin converting enzyme 10.054
Nognoggin0.054
Grb2growth factor receptor bound protein 20.054
Sim1single-minded homolog 1 (Drosophila)0.054
Tbx2T-box 20.054
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.053
Hoxb1homeobox B10.052
Hspg2perlecan (heparan sulfate proteoglycan 2)0.050
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.049
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.047
Plxnd1plexin D10.047
Sin3atranscriptional regulator, SIN3A (yeast)0.046
Lhx1LIM homeobox protein 10.045
Wnt3awingless-related MMTV integration site 3A0.045
Ptk2PTK2 protein tyrosine kinase 20.045
Tbx5T-box 50.044
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism