The network for 'negative regulation of secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor0.976
ANXA1annexin A10.903
MPDZmultiple PDZ domain protein0.894
IGF1Rinsulin-like growth factor 1 receptor0.873
INSRinsulin receptor0.808
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.807
SNAP23synaptosomal-associated protein, 23kDa0.649
MED15mediator complex subunit 150.641
GRB10growth factor receptor-bound protein 100.636
AXLAXL receptor tyrosine kinase0.617
PTPN1protein tyrosine phosphatase, non-receptor type 10.575
GABBR1gamma-aminobutyric acid (GABA) B receptor, 10.572
SMN1survival of motor neuron 1, telomeric0.552
CRHR1corticotropin releasing hormone receptor 10.543
KCNE1potassium voltage-gated channel, Isk-related family, member 10.533
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.488
APPamyloid beta (A4) precursor protein0.487
ADORA2Aadenosine A2a receptor0.467
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.428
FOXD3forkhead box D30.422
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.413
S100A10S100 calcium binding protein A100.392
PILRApaired immunoglobin-like type 2 receptor alpha0.392
LIN7Blin-7 homolog B (C. elegans)0.387
SSTR3somatostatin receptor 30.365
PTAFRplatelet-activating factor receptor0.359
CRHcorticotropin releasing hormone0.351
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.336
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.335
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.334
HLA-Gmajor histocompatibility complex, class I, G0.334
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.299
STX4syntaxin 40.291
MAPTmicrotubule-associated protein tau0.290
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.281
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.274
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.263
LRRK2leucine-rich repeat kinase 20.244
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.240
IL1R1interleukin 1 receptor, type I0.240
IL1Binterleukin 1, beta0.239
KLHL3kelch-like 3 (Drosophila)0.225
STX6syntaxin 60.216
CSKc-src tyrosine kinase0.213
SIGLEC7sialic acid binding Ig-like lectin 70.210
IL22RA1interleukin 22 receptor, alpha 10.209
CXCL2chemokine (C-X-C motif) ligand 20.209
TREM1triggering receptor expressed on myeloid cells 10.205
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.199
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.180
IRS1insulin receptor substrate 10.174
PTPN6protein tyrosine phosphatase, non-receptor type 60.174
IL10RAinterleukin 10 receptor, alpha0.172
PMLpromyelocytic leukemia0.170
APOC1apolipoprotein C-I0.169
NOS1APnitric oxide synthase 1 (neuronal) adaptor protein0.166
IRS2insulin receptor substrate 20.158
STX11syntaxin 110.150
CHRNA4cholinergic receptor, nicotinic, alpha 40.145
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.145
MUC1mucin 1, cell surface associated0.145
SSTR2somatostatin receptor 20.144
JAG1jagged 10.142
TEKTEK tyrosine kinase, endothelial0.141
TRAF1TNF receptor-associated factor 10.137
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.134
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.131
RNF11ring finger protein 110.129
SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 30.127
CHMP1Achromatin modifying protein 1A0.127
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.123
GOLGA2golgin A20.122
CACNA1Hcalcium channel, voltage-dependent, T type, alpha 1H subunit0.121
DRD2dopamine receptor D20.118
ANXA7annexin A70.118
PRKCAprotein kinase C, alpha0.114
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 10.113
VAC14Vac14 homolog (S. cerevisiae)0.107
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.107
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.104
JAK3Janus kinase 30.104
IL22RA2interleukin 22 receptor, alpha 20.103
TFF1trefoil factor 10.103
KSR1kinase suppressor of ras 10.101
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.099
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.099
C19orf50chromosome 19 open reading frame 500.097
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.096
APBA3amyloid beta (A4) precursor protein-binding, family A, member 30.094
HK3hexokinase 3 (white cell)0.093
NR4A3nuclear receptor subfamily 4, group A, member 30.092
ACTBactin, beta0.092
MTNR1Amelatonin receptor 1A0.088
MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 60.087
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.086
IL6Rinterleukin 6 receptor0.085
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
fabp11afatty acid binding protein 11a0.463
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.412
nf1aneurofibromin 1a0.404
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.303
anxa1bannexin A1b0.228
igf3insulin-like growth factor 30.219
hcrthypocretin (orexin) neuropeptide precursor0.191
foxa3forkhead box A30.187
aplp2amyloid beta (A4) precursor-like protein 20.180
per2period homolog 2 (Drosophila)0.176
il8interleukin 80.168
cry3cryptochrome 30.154
tnfatumor necrosis factor a (TNF superfamily, member 2)0.143
cyp1b1cytochrome P450, family 1, subfamily B, polypeptide 10.142
cnr1cannabinoid receptor 10.139
ncam2neural cell adhesion molecule 20.129
slc17a7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 70.128
tefthyrotroph embryonic factor0.122
nf1bneurofibromin 1b0.121
dao.2D-amino-acid oxidase 20.119
otpaorthopedia homolog a0.117
nlgn1neuroligin 10.115
syne1aspectrin repeat containing, nuclear envelope 1a0.114
notch3notch homolog 30.110
avplarginine vasopressin-like0.108
baxabcl2-associated X protein, a0.101
thtyrosine hydroxylase0.099
icn2ictacalcin 20.098
mchr1amelanin-concentrating hormone receptor 1a0.097
egfraepidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)0.093
dab1adisabled homolog 1a (Drosophila)0.093
bnc2basonuclin 20.091
cldn2claudin 20.090
dmrt3adoublesex and mab-3 related transcription factor 3a0.089
mstnamyostatin a0.089
ptgs2aprostaglandin-endoperoxide synthase 2a0.088
bhlhe41basic helix-loop-helix family, member e410.083
restRE1-silencing transcription factor0.082
psen1presenilin 10.075
col5a3bcollagen type V alpha-3b0.074
tshbthyroid stimulating hormone, beta subunit0.074
fgfr3fibroblast growth factor receptor 30.073
fabp2fatty acid binding protein 2, intestinal0.073
hif1alhypoxia-inducible factor 1, alpha subunit, like0.070
olig1oligodendrocyte lineage transcription factor 10.070
csnk1dbcasein kinase 1, delta b0.070
htra1aHtrA serine peptidase 1a0.068
gsdfgonadal somatic cell derived factor0.067
col7a1lcollagen type VII alpha 1-like0.067
hcrtr2hypocretin (orexin) receptor 20.067
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 50.067
fshrfollicle stimulating hormone receptor0.067
fabp11bfatty acid binding protein 11b0.066
bsk146brain specific kinase 1460.065
prdm5PR domain containing 50.065
gna12guanine nucleotide binding protein (G protein) alpha 120.064
znf395bzinc finger protein 395b0.064
gcm2glial cells missing homolog 2 (Drosophila)0.064
inhbabinhibin, beta Ab0.063
ptger2aprostaglandin E receptor 2a (subtype EP2)0.063
hspb6heat shock protein, alpha-crystallin-related, b60.063
gpiaglucose phosphate isomerase a0.062
ptgs1prostaglandin-endoperoxide synthase 10.062
appaamyloid beta (A4) precursor protein a0.059
drd2ldopamine receptor D2 like0.058
hsd17b1hydroxysteroid (17-beta) dehydrogenase 10.057
duoxdual oxidase0.056
figlafactor in the germline alpha0.056
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.056
ptrfbpolymerase I and transcript release factor b0.056
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.055
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.053
hspb11heat shock protein, alpha-crystallin-related, b110.053
sepw1selenoprotein W, 10.052
spns2spinster homolog 2 (Drosophila)0.052
cry1acryptochrome 1a0.052
mpp2bmembrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2b)0.052
card14caspase recruitment domain family, member 140.052
prok2prokineticin 20.051
slc25a27solute carrier family 25, member 270.051
abhd2aabhydrolase domain containing 2a0.050
tuba8l3tubulin, alpha 8 like 30.050
nog2noggin 20.050
otx5orthodenticle homolog 50.050
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.050
nme5non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)0.049
pdx1pancreatic and duodenal homeobox 10.049
ppp4cbprotein phosphatase 4 (formerly X), catalytic subunit b0.049
mapk7mitogen-activated protein kinase 70.049
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Octbeta2RCG33976 gene product from transcript CG33976-RA0.032
CaMKIICalcium/calmodulin-dependent protein kinase II0.014
IppInositol polyphosphate 1-phosphatase0.013
Drep-2DNA fragmentation factor-related protein 20.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.962
Drd2dopamine receptor D20.942
Nos2nitric oxide synthase 2, inducible0.910
Esr1estrogen receptor 1 (alpha)0.837
Leprleptin receptor0.787
Socs1suppressor of cytokine signaling 10.693
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.670
Insrinsulin receptor0.664
Tnftumor necrosis factor0.655
Clockcircadian locomotor output cycles kaput0.604
Pax8paired box gene 80.597
MefvMediterranean fever0.572
Nos1nitric oxide synthase 1, neuronal0.555
Nr3c1nuclear receptor subfamily 3, group C, member 10.511
Arntlaryl hydrocarbon receptor nuclear translocator-like0.494
Cd80CD80 antigen0.489
Pdcd1programmed cell death 10.446
Ppargperoxisome proliferator activated receptor gamma0.444
Ifnginterferon gamma0.444
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.411
Il1r1interleukin 1 receptor, type I0.408
Phox2bpaired-like homeobox 2b0.398
Adrb3adrenergic receptor, beta 30.398
Fshrfollicle stimulating hormone receptor0.392
Ccr2chemokine (C-C motif) receptor 20.386
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.381
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.368
Atoh7atonal homolog 7 (Drosophila)0.364
Inhbainhibin beta-A0.361
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.351
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.323
Htr45 hydroxytryptamine (serotonin) receptor 40.313
Lhx3LIM homeobox protein 30.306
Oprm1opioid receptor, mu 10.300
Irf5interferon regulatory factor 50.292
Ccl2chemokine (C-C motif) ligand 20.288
Cd160CD160 antigen0.279
Adrb1adrenergic receptor, beta 10.271
Esr2estrogen receptor 2 (beta)0.257
Apoeapolipoprotein E0.256
Gata6GATA binding protein 60.254
Itgaxintegrin alpha X0.247
Ccl4chemokine (C-C motif) ligand 40.245
LOC100048884novel member of the major urinary protein (Mup) gene family0.236
Il1binterleukin 1 beta0.234
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.230
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.225
Ptgs2prostaglandin-endoperoxide synthase 20.225
Ern2endoplasmic reticulum (ER) to nucleus signalling 20.224
Pnpla2patatin-like phospholipase domain containing 20.224
S100a5S100 calcium binding protein A50.222
Pitx3paired-like homeodomain transcription factor 30.220
Cxcr2chemokine (C-X-C motif) receptor 20.209
S1pr2sphingosine-1-phosphate receptor 20.209
Rxraretinoid X receptor alpha0.207
Fpr-rs3formyl peptide receptor, related sequence 30.206
Plauplasminogen activator, urokinase0.203
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.201
Sstr4somatostatin receptor 40.201
Pdgfbplatelet derived growth factor, B polypeptide0.197
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.191
Saa4serum amyloid A 40.189
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.186
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.186
Gpr33G protein-coupled receptor 330.182
Arandrogen receptor0.178
Ptpn12protein tyrosine phosphatase, non-receptor type 120.177
Trpv1transient receptor potential cation channel, subfamily V, member 10.172
Ntf3neurotrophin 30.171
Ccl3chemokine (C-C motif) ligand 30.171
Nos3nitric oxide synthase 3, endothelial cell0.170
Pkm2pyruvate kinase, muscle0.169
Nkx2-3NK2 transcription factor related, locus 3 (Drosophila)0.169
Isl1ISL1 transcription factor, LIM/homeodomain0.168
Mup5major urinary protein 50.165
Trpc4transient receptor potential cation channel, subfamily C, member 40.162
Pramel7preferentially expressed antigen in melanoma like 70.161
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.160
Gata4GATA binding protein 40.159
BtkBruton agammaglobulinemia tyrosine kinase0.156
Il1ainterleukin 1 alpha0.156
Inpp5dinositol polyphosphate-5-phosphatase D0.155
Sstr3somatostatin receptor 30.155
Il1rl1interleukin 1 receptor-like 10.152
Notch1Notch gene homolog 1 (Drosophila)0.151
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.150
Rasal1RAS protein activator like 1 (GAP1 like)0.149
Lag3lymphocyte-activation gene 30.148
Fut1fucosyltransferase 10.148
Cckbrcholecystokinin B receptor0.145
Adora2aadenosine A2a receptor0.145
Tgfb1transforming growth factor, beta 10.142
Bglapbone gamma carboxyglutamate protein0.142
Nf1neurofibromatosis 10.137
Ighimmunoglobulin heavy chain complex0.136
Bdkrb1bradykinin receptor, beta 10.134
Lamp2lysosomal-associated membrane protein 20.134
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a10S100 calcium binding protein A100.225
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.225
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.154
Anxa5annexin A50.152
Nr4a3nuclear receptor subfamily 4, group A, member 30.134
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.128
Olr226olfactory receptor 2260.119
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.119
Gucy2dguanylate cyclase 2d0.098
Prlhrprolactin releasing hormone receptor0.093
Reg3gregenerating islet-derived 3 gamma0.093
Trhr2thyrotropin releasing hormone receptor 20.093
Mc5rmelanocortin 5 receptor0.090
Pspparotid secretory protein0.087
Slc6a7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.086
Arpc1bactin related protein 2/3 complex, subunit 1B0.083
Cx3cr1chemokine (C-X3-C motif) receptor 10.082
Hcrtr1hypocretin (orexin) receptor 10.078
Col10a1collagen, type X, alpha 10.076
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.075
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.073
Grm5glutamate receptor, metabotropic 50.073
Itgb1integrin, beta 10.072
Prph2peripherin 20.072
Htr65-hydroxytryptamine (serotonin) receptor 60.071
Celsr3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.070
S100a11S100 calcium binding protein A11 (calizzarin)0.070
Clstn3calsyntenin 30.069
Cacng4calcium channel, voltage-dependent, gamma subunit 40.069
Chrm2cholinergic receptor, muscarinic 20.067
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.066
Syn1synapsin I0.064
Prl2a1Prolactin family 2, subfamily a, member 10.061
Anxa2annexin A20.060
Rgs9regulator of G-protein signaling 90.060
Prkcgprotein kinase C, gamma0.059
Ptger2prostaglandin E receptor 2 (subtype EP2)0.059
Fgd4FYVE, RhoGEF and PH domain containing 40.059
Gata4GATA binding protein 40.058
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.058
S100a6S100 calcium binding protein A60.058
Rap1bRAP1B, member of RAS oncogene family0.057
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.057
Adcy5adenylate cyclase 50.057
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.056
Grm7glutamate receptor, metabotropic 70.055
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.055
Avparginine vasopressin0.053
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.053
Rab11aRAB11a, member RAS oncogene family0.052
Fam65afamily with sequence similarity 65, member A0.052
Syn3synapsin III0.052
Fam38bfamily with sequence similarity 38, member B0.051
Slc4a3solute carrier family 4 (anion exchanger), member 30.051
Csn3casein kappa0.051
Cmklr1chemokine-like receptor 10.051
Galr3galanin receptor 30.050
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.049
Atxn1ataxin 10.049
Lgals3lectin, galactoside-binding, soluble, 30.049
Serpinb6aserine (or cysteine) peptidase inhibitor, clade B, member 6a0.048
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.048
Ccl2chemokine (C-C motif) ligand 20.048
Notch3Notch homolog 3 (Drosophila)0.047
Iappislet amyloid polypeptide0.047
Csrnp2cysteine-serine-rich nuclear protein 20.047
Ccbp2chemokine binding protein 20.047
Flt1FMS-related tyrosine kinase 10.046
Pla2g5phospholipase A2, group V0.046
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.046
RGD1310262hypothetical LOC3046500.045
Arandrogen receptor0.045
Gng7guanine nucleotide binding protein (G protein), gamma 70.045
Fgf16fibroblast growth factor 160.045
Gfi1growth factor independent 1 transcription repressor0.044
Sstr3somatostatin receptor 30.044
Glp1rglucagon-like peptide 1 receptor0.044
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.043
Il4interleukin 40.043
Adora2aadenosine A2a receptor0.043
Myadmmyeloid-associated differentiation marker0.042
Strnstriatin, calmodulin binding protein0.042
Necab2N-terminal EF-hand calcium binding protein 20.042
Phexphosphate regulating endopeptidase homolog, X-linked0.042
Cdkn2bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.041
Nkx6-1NK6 homeobox 10.041
Sox17SRY (sex determining region Y)-box 170.041
Il13interleukin 130.041
Unc5aunc-5 homolog A (C. elegans)0.041
Casq2calsequestrin 2 (cardiac muscle)0.041
Csf1colony stimulating factor 1 (macrophage)0.041
Hand1heart and neural crest derivatives expressed 10.041
Adora1adenosine A1 receptor0.040
Npy5rneuropeptide Y receptor Y50.040
Tacr1tachykinin receptor 10.040
Teddm1transmembrane epididymal protein 10.040
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism