The network for 'icosanoid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

icosanoid metabolic process

The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.

NameDescriptionProbabilityFunc Analog Organism
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.858
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.853
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.814
NCF4neutrophil cytosolic factor 4, 40kDa0.791
DUSP1dual specificity phosphatase 10.676
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.664
COTL1coactosin-like 1 (Dictyostelium)0.516
MAPK1mitogen-activated protein kinase 10.468
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.436
ALDOAaldolase A, fructose-bisphosphate0.249
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.244
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.224
UBASH3Bubiquitin associated and SH3 domain containing B0.216
MAP2K4mitogen-activated protein kinase kinase 40.189
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.189
FADS2fatty acid desaturase 20.189
PDPK13-phosphoinositide dependent protein kinase-10.176
DHCR77-dehydrocholesterol reductase0.175
TICAM2toll-like receptor adaptor molecule 20.164
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.148
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.140
ALOX5arachidonate 5-lipoxygenase0.132
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.129
C8Acomplement component 8, alpha polypeptide0.121
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.118
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.116
C8Bcomplement component 8, beta polypeptide0.113
CYP4F3cytochrome P450, family 4, subfamily F, polypeptide 30.102
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.095
SCDstearoyl-CoA desaturase (delta-9-desaturase)0.086
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.078
ALOX12Barachidonate 12-lipoxygenase, 12R type0.073
EP300E1A binding protein p3000.073
GLYATglycine-N-acyltransferase0.067
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.067
XPO7exportin 70.066
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.064
CXCR4chemokine (C-X-C motif) receptor 40.060
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.056
ADH6alcohol dehydrogenase 6 (class V)0.055
AGXT2alanine--glyoxylate aminotransferase 20.054
MAPK8mitogen-activated protein kinase 80.053
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.051
MAT1Amethionine adenosyltransferase I, alpha0.050
CYP2A7cytochrome P450, family 2, subfamily A, polypeptide 70.048
CYBAcytochrome b-245, alpha polypeptide0.046
CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 110.046
C6complement component 60.046
F9coagulation factor IX0.046
MYD88myeloid differentiation primary response gene (88)0.046
OTCornithine carbamoyltransferase0.045
FETUBfetuin B0.044
G6PCglucose-6-phosphatase, catalytic subunit0.042
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.042
CXCL3chemokine (C-X-C motif) ligand 30.042
PRMT2protein arginine methyltransferase 20.042
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.041
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.040
KRT5keratin 50.039
UGT1A3UDP glucuronosyltransferase 1 family, polypeptide A30.039
HRGhistidine-rich glycoprotein0.038
AADACarylacetamide deacetylase (esterase)0.037
PRKCBprotein kinase C, beta0.037
LAMC3laminin, gamma 30.037
CPA3carboxypeptidase A3 (mast cell)0.036
APCSamyloid P component, serum0.035
TATtyrosine aminotransferase0.035
FABP1fatty acid binding protein 1, liver0.035
HALhistidine ammonia-lyase0.035
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.035
BHMTbetaine--homocysteine S-methyltransferase0.034
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 10.034
HLA-DPB1major histocompatibility complex, class II, DP beta 10.034
BLNKB-cell linker0.034
GSTA3glutathione S-transferase alpha 30.033
TRIM9tripartite motif containing 90.033
SULT2B1sulfotransferase family, cytosolic, 2B, member 10.031
CATcatalase0.031
MS4A2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.031
BTKBruton agammaglobulinemia tyrosine kinase0.030
CFHR4complement factor H-related 40.030
ALOX5AParachidonate 5-lipoxygenase-activating protein0.029
TNFAIP6tumor necrosis factor, alpha-induced protein 60.029
F13Bcoagulation factor XIII, B polypeptide0.029
NCF2neutrophil cytosolic factor 20.029
MASP2mannan-binding lectin serine peptidase 20.029
DPYSdihydropyrimidinase0.029
SLC25A1solute carrier family 25 (mitochondrial carrier; citrate transporter), member 10.029
ALOXE3arachidonate lipoxygenase 30.028
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.028
CAPGcapping protein (actin filament), gelsolin-like0.028
AKR1C4aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)0.027
DAOD-amino-acid oxidase0.027
SLC17A3solute carrier family 17 (sodium phosphate), member 30.027
ABCC3ATP-binding cassette, sub-family C (CFTR/MRP), member 30.027
KAT2BK(lysine) acetyltransferase 2B0.027
HPD4-hydroxyphenylpyruvate dioxygenase0.027
LECT2leukocyte cell-derived chemotaxin 20.027
PPIDpeptidylprolyl isomerase D0.026
HSD17B2hydroxysteroid (17-beta) dehydrogenase 20.026
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.898
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.880
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.844
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.708
Alox5arachidonate 5-lipoxygenase0.647
F9coagulation factor IX0.567
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.560
Cyp2c54cytochrome P450, family 2, subfamily c, polypeptide 540.547
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.545
Cyp2b9cytochrome P450, family 2, subfamily b, polypeptide 90.506
Cps1carbamoyl-phosphate synthetase 10.483
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.402
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.401
Akr1c6aldo-keto reductase family 1, member C60.398
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.380
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.368
Cyp3a13cytochrome P450, family 3, subfamily a, polypeptide 130.347
Cyp2f2cytochrome P450, family 2, subfamily f, polypeptide 20.322
Otcornithine transcarbamylase0.315
Il6interleukin 60.287
Cd14CD14 antigen0.273
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.267
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.264
Gstm1glutathione S-transferase, mu 10.262
Aadacarylacetamide deacetylase (esterase)0.247
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.244
Alox5aparachidonate 5-lipoxygenase activating protein0.244
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.241
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.237
Hrghistidine-rich glycoprotein0.225
Sult1d1sulfotransferase family 1D, member 10.220
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.220
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.205
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.204
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.199
Dmgdhdimethylglycine dehydrogenase precursor0.189
H2-Aahistocompatibility 2, class II antigen A, alpha0.177
Apohapolipoprotein H0.176
Ces1dcarboxylesterase 1D0.171
Sult1b1sulfotransferase family 1B, member 10.164
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.160
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.157
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.148
Hmgcs23-hydroxy-3-methylglutaryl-Coenzyme A synthase 20.144
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.142
F13bcoagulation factor XIII, beta subunit0.141
Ces2acarboxylesterase 2A0.138
Adh7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide0.138
Rdh7retinol dehydrogenase 70.136
TyrobpTYRO protein tyrosine kinase binding protein0.136
Ces1ccarboxylesterase 1C0.136
H2-DMahistocompatibility 2, class II, locus DMa0.129
Nr1i3nuclear receptor subfamily 1, group I, member 30.126
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.125
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.124
G6pcglucose-6-phosphatase, catalytic0.124
Cml2camello-like 20.120
CrpC-reactive protein, pentraxin-related0.120
Glyatglycine-N-acyltransferase0.118
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.116
Ptgs2prostaglandin-endoperoxide synthase 20.116
Mbl2mannose-binding lectin (protein C) 20.115
Albalbumin0.115
Akr1d1aldo-keto reductase family 1, member D10.113
Ugt3a2UDP glycosyltransferases 3 family, polypeptide A20.112
Aldh3a1aldehyde dehydrogenase family 3, subfamily A10.111
Tdo2tryptophan 2,3-dioxygenase0.107
Adamdec1ADAM-like, decysin 10.106
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.105
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.104
Pon1paraoxonase 10.103
C1qacomplement component 1, q subcomponent, alpha polypeptide0.103
H2-Ab1histocompatibility 2, class II antigen A, beta 10.103
Fmo3flavin containing monooxygenase 30.103
Lyz2lysozyme 20.103
Pahphenylalanine hydroxylase0.100
Slco1b2solute carrier organic anion transporter family, member 1b20.100
Prlrprolactin receptor0.100
Cdsncorneodesmosin0.099
Adh1alcohol dehydrogenase 1 (class I)0.099
Cyp2c68cytochrome P450, family 2, subfamily c, polypeptide 680.099
Pplperiplakin0.095
Bhmtbetaine-homocysteine methyltransferase0.092
Ugt2a3UDP glucuronosyltransferase 2 family, polypeptide A30.090
Abcc6ATP-binding cassette, sub-family C (CFTR/MRP), member 60.090
Platplasminogen activator, tissue0.090
Apoc4apolipoprotein C-IV0.088
Ptgesprostaglandin E synthase0.088
Orai1ORAI calcium release-activated calcium modulator 10.086
Capn9calpain 90.085
Keg1kidney expressed gene 10.085
Selpselectin, platelet0.084
Ces1gcarboxylesterase 1G0.084
Hgdhomogentisate 1, 2-dioxygenase0.083
Aldobaldolase B, fructose-bisphosphate0.083
Ugt2b34UDP glucuronosyltransferase 2 family, polypeptide B340.083
Mup3major urinary protein 30.082
Myd88myeloid differentiation primary response gene 880.082
H2-Eb1histocompatibility 2, class II antigen E beta0.079
Slc22a1solute carrier family 22 (organic cation transporter), member 10.079
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Akr1c18aldo-keto reductase family 1, member C180.559
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.514
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.497
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.471
Anxa5annexin A50.390
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.390
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.384
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.371
Reg3gregenerating islet-derived 3 gamma0.339
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.337
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.274
Ctdsp1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 10.272
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.270
A1i3alpha-1-inhibitor III0.254
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.247
RT1-DMbRT1 class II, locus DMb0.240
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.227
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.190
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.181
S100a11S100 calcium binding protein A11 (calizzarin)0.174
Defb4defensin beta 40.172
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.170
Cyp2b15cytochrome P450, family 2, subfamily b, polypeptide 150.170
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.169
Olr1696olfactory receptor 16960.151
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.135
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.133
Orm1orosomucoid 10.122
LOC100365112carboxylesterase-like0.122
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.121
Cyp2b2cytochrome P450, family 2, subfamily b, polypeptide 20.119
Slc14a2solute carrier family 14 (urea transporter), member 20.119
Casp1caspase 10.116
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.115
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.114
Aqp9aquaporin 90.110
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.106
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.102
Rxrgretinoid X receptor gamma0.098
Hckhemopoietic cell kinase0.096
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.093
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.092
Xdhxanthine dehydrogenase0.090
LOC494499LOC494499 protein0.087
Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 10.087
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.087
Il2rbinterleukin 2 receptor, beta0.086
Slc6a4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.079
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.078
S100a10S100 calcium binding protein A100.073
Slco1a1solute carrier organic anion transporter family, member 1a10.072
Opn1mwopsin 1 (cone pigments), medium-wave-sensitive0.071
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.067
Mettl7bmethyltransferase like 7B0.067
Krt4keratin 40.066
Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 20.064
Arl11ADP-ribosylation factor-like 110.064
Fgbfibrinogen beta chain0.064
Prlrprolactin receptor0.064
LOC100361547Cytochrome P450, family 2, subfamily c, polypeptide 7-like0.062
Gsta3glutathione S-transferase A30.062
Crygfcrystallin, gamma F0.062
Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.060
Qpctglutaminyl-peptide cyclotransferase0.060
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.059
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.059
Dhcr77-dehydrocholesterol reductase0.058
Gckrglucokinase (hexokinase 4) regulator0.058
Apoa2apolipoprotein A-II0.057
Fdxrferredoxin reductase0.057
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.057
Fasnfatty acid synthase0.056
Pspparotid secretory protein0.056
Rgs3regulator of G-protein signaling 30.055
Krt13keratin 130.055
Hspb1heat shock protein 10.054
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.054
Akr1c12aldo-keto reductase family 1, member C120.053
Srd5a1steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)0.053
Lgals3lectin, galactoside-binding, soluble, 30.052
Galnt5UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)0.052
Cps1carbamoyl-phosphate synthetase 10.052
Rag1recombination activating gene 10.051
RT1-DaRT1 class II, locus Da0.051
Hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.048
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.048
Cyp27a1cytochrome P450, family 27, subfamily a, polypeptide 10.048
Vimvimentin0.047
Gjb3gap junction protein, beta 30.047
Haao3-hydroxyanthranilate 3,4-dioxygenase0.047
Cd151CD151 molecule (Raph blood group)0.047
Kng2kininogen 20.046
Nmur2neuromedin U receptor 20.045
Serpinb3serine protease inhibitor B30.045
Azgp1alpha-2-glycoprotein 1, zinc-binding0.045
Slc22a7solute carrier family 22 (organic anion transporter), member 70.043
Ppargperoxisome proliferator-activated receptor gamma0.043
Cyp2d1cytochrome P450, family 2, subfamily d, polypeptide 10.041
F9coagulation factor IX0.040
Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 80.040
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism