The network for 'positive regulation of striated muscle cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of striated muscle cell differentiation

Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.

NameDescriptionProbabilityFunc Analog Organism
SRFserum response factor (c-fos serum response element-binding transcription factor)1.000
NOTCH1notch 10.915
HDAC4histone deacetylase 40.772
BMPR1Abone morphogenetic protein receptor, type IA0.768
BCL2L1BCL2-like 10.631
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.615
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.594
EP300E1A binding protein p3000.578
FNBP1Lformin binding protein 1-like0.553
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.437
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.349
BMPR1Bbone morphogenetic protein receptor, type IB0.291
MEF2Amyocyte enhancer factor 2A0.216
JAG1jagged 10.192
RARAretinoic acid receptor, alpha0.190
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.188
RPTORregulatory associated protein of MTOR, complex 10.174
FZD1frizzled homolog 1 (Drosophila)0.152
SPENspen homolog, transcriptional regulator (Drosophila)0.147
IL4interleukin 40.144
CREBBPCREB binding protein0.136
DPP4dipeptidyl-peptidase 40.134
ANKFY1ankyrin repeat and FYVE domain containing 10.130
HNF4Ahepatocyte nuclear factor 4, alpha0.102
MKL1megakaryoblastic leukemia (translocation) 10.092
H3F3CH3 histone, family 3C0.089
IL4Rinterleukin 4 receptor0.085
NCOR2nuclear receptor corepressor 20.076
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.069
RXRAretinoid X receptor, alpha0.068
NCOA1nuclear receptor coactivator 10.066
KAT2BK(lysine) acetyltransferase 2B0.065
FSTL1follistatin-like 10.063
IL2RGinterleukin 2 receptor, gamma0.057
NCOA6nuclear receptor coactivator 60.056
LRRK2leucine-rich repeat kinase 20.050
ZHX1zinc fingers and homeoboxes 10.048
HDAC9histone deacetylase 90.047
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.045
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.045
PIAS1protein inhibitor of activated STAT, 10.034
MAP2K3mitogen-activated protein kinase kinase 30.033
SMAD7SMAD family member 70.033
ARandrogen receptor0.029
LRP6low density lipoprotein receptor-related protein 60.028
MYOGmyogenin (myogenic factor 4)0.027
MAP2K6mitogen-activated protein kinase kinase 60.023
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.023
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.022
MEF2Cmyocyte enhancer factor 2C0.021
MYOD1myogenic differentiation 10.021
TRIP10thyroid hormone receptor interactor 100.020
DUSP1dual specificity phosphatase 10.020
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.020
NCOA3nuclear receptor coactivator 30.019
MED31mediator complex subunit 310.019
SMAD1SMAD family member 10.018
IQGAP1IQ motif containing GTPase activating protein 10.017
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.014
NR5A2nuclear receptor subfamily 5, group A, member 20.014
PTRFpolymerase I and transcript release factor0.013
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.013
NR2F2nuclear receptor subfamily 2, group F, member 20.013
MKL2MKL/myocardin-like 20.012
RBM4BRNA binding motif protein 4B0.012
NOTCH3notch 30.012
FZD8frizzled homolog 8 (Drosophila)0.012
ESR1estrogen receptor 10.011
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.011
BCL2L11BCL2-like 11 (apoptosis facilitator)0.010
CUX1cut-like homeobox 10.010
NR4A1nuclear receptor subfamily 4, group A, member 10.010
ESR2estrogen receptor 2 (ER beta)0.010
DEPTORDEP domain containing MTOR-interacting protein0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
aldh1a2aldehyde dehydrogenase 1 family, member A20.989
myf5myogenic factor 50.872
ptch2patched 20.831
shhasonic hedgehog a0.760
fgf8afibroblast growth factor 8 a0.692
hspb1heat shock protein, alpha-crystallin-related, 10.538
myod1myogenic differentiation 10.529
pcdh8protocadherin 80.483
cxcr4bchemokine (C-X-C motif), receptor 4b0.389
epha4aeph receptor A4a0.368
sox9aSRY-box containing gene 9a0.281
osr1odd-skipped related 1 (Drosophila)0.274
bmp2bbone morphogenetic protein 2b0.267
cdh2cadherin 2, neuronal0.264
hsp90a.1heat shock protein 90-alpha 10.259
pax2apaired box gene 2a0.256
foxa2forkhead box A20.235
egr2bearly growth response 2b0.212
ntn2netrin 20.212
prdm1aPR domain containing 1a, with ZNF domain0.203
mespbmesoderm posterior b0.202
fgf3fibroblast growth factor 30.179
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.179
lef1lymphocyte enhancer binding factor 10.147
ndr2nodal-related 20.145
stac3SH3 and cysteine rich domain 30.143
her1hairy-related 10.138
bmp4bone morphogenetic protein 40.137
hand2heart and neural crest derivatives expressed transcript 20.129
trpv4transient receptor potential cation channel, subfamily V, member 40.122
trpm7transient receptor potential cation channel, subfamily M, member 70.121
gli1GLI-Kruppel family member 10.113
fstafollistatin a0.105
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.103
pwp2hPWP2 periodic tryptophan protein homolog (yeast)0.099
pitx3paired-like homeodomain transcription factor 30.099
foxd3forkhead box D30.099
fabp11afatty acid binding protein 11a0.094
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.092
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.088
gpiaglucose phosphate isomerase a0.086
sesn1sestrin 10.083
wnt5bwingless-type MMTV integration site family, member 5b0.082
nr4a2bnuclear receptor subfamily 4, group A, member 2b0.080
bhlhe40basic helix-loop-helix family, member e400.078
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.078
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.077
rspo3R-spondin 3 homolog (Xenopus laevis)0.077
wlswntless homolog (Drosophila)0.077
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.076
sox2SRY-box containing gene 20.076
tgfbitransforming growth factor, beta-induced0.074
pitx2paired-like homeodomain transcription factor 20.073
trpv6transient receptor potential cation channel, subfamily V, member 60.072
mespamesoderm posterior a0.067
mapk3mitogen-activated protein kinase 30.066
gngt2bguanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b0.066
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.063
wnt7bawingless-type MMTV integration site family, member 7Ba0.062
acta1bactin, alpha 1b, skeletal muscle0.062
dusp6dual specificity phosphatase 60.062
edn1endothelin 10.062
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.061
smyhc1slow myosin heavy chain 10.060
pcdh18bprotocadherin 18b0.059
fn1fibronectin 10.055
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.055
mapk1mitogen-activated protein kinase 10.054
gro2groucho 20.054
nr5a2nuclear receptor subfamily 5, group A, member 20.054
tmem38atransmembrane protein 38A0.052
tbx2bT-box 2b0.052
actc1bactin, alpha, cardiac muscle 1b0.051
cxcr4achemokine (C-X-C motif) receptor 4a0.051
h1mlinker histone H1M0.051
fancd2Fanconi anemia, complementation group D20.051
spata2spermatogenesis associated 20.050
mapk14amitogen-activated protein kinase 14a0.050
aplnraapelin receptor a0.049
gle1GLE1 RNA export mediator homolog (yeast)0.048
her7hairy and enhancer of split related-70.047
appl2adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 20.047
mesp2mesoderm posterior 2 homolog (mouse)0.046
snx5sorting nexin 50.046
tnnt1troponin T1, skeletal, slow0.045
lmx1b.1LIM homeobox transcription factor 1, beta 10.045
snai1asnail homolog 1a (Drosophila)0.045
ppargperoxisome proliferator activated receptor gamma0.044
arpc1bactin related protein 2/3 complex, subunit 1B0.044
ihhaIndian hedgehog homolog a0.044
wnt8awingless-type MMTV integration site family, member 8a0.043
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.020
Mekk1CG7717 gene product from transcript CG7717-RB0.017
InRInsulin-like receptor0.014
dallydivision abnormally delayed0.013
MadMothers against dpp0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.988
Pitx1paired-like homeodomain transcription factor 10.932
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.809
Rxraretinoid X receptor alpha0.785
Pitx2paired-like homeodomain transcription factor 20.728
Foxc1forkhead box C10.721
Pax3paired box gene 30.704
Bcl2B-cell leukemia/lymphoma 20.575
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.562
Gata4GATA binding protein 40.550
Mapk14mitogen-activated protein kinase 140.539
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.516
Ccl7chemokine (C-C motif) ligand 70.500
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.488
Foxc2forkhead box C20.479
Efnb2ephrin B20.436
Vegfavascular endothelial growth factor A0.435
Tbx3T-box 30.433
BaxBCL2-associated X protein0.413
Gli2GLI-Kruppel family member GLI20.405
Nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.374
Meox2mesenchyme homeobox 20.371
Thrathyroid hormone receptor alpha0.362
Ccl2chemokine (C-C motif) ligand 20.335
Fgfr2fibroblast growth factor receptor 20.334
Ntf3neurotrophin 30.329
Pax2paired box gene 20.283
Ror2receptor tyrosine kinase-like orphan receptor 20.282
Ptenphosphatase and tensin homolog0.279
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.276
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.271
Gja5gap junction protein, alpha 50.250
Cxcr4chemokine (C-X-C motif) receptor 40.243
Fgf10fibroblast growth factor 100.223
Tbx1T-box 10.222
Cxcl1chemokine (C-X-C motif) ligand 10.214
Mef2cmyocyte enhancer factor 2C0.207
Hoxa1homeobox A10.192
Isl1ISL1 transcription factor, LIM/homeodomain0.184
Pou5f1POU domain, class 5, transcription factor 10.180
Otx2orthodenticle homolog 2 (Drosophila)0.175
Wt1Wilms tumor 1 homolog0.171
Pax8paired box gene 80.170
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.170
Dll4delta-like 4 (Drosophila)0.170
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.158
Ptrfpolymerase I and transcript release factor0.150
Foxg1forkhead box G10.149
Pax1paired box gene 10.148
Gdnfglial cell line derived neurotrophic factor0.147
Bdnfbrain derived neurotrophic factor0.140
Gli3GLI-Kruppel family member GLI30.140
Hdac4histone deacetylase 40.137
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.135
Il1binterleukin 1 beta0.135
Lmx1bLIM homeobox transcription factor 1 beta0.128
Socs1suppressor of cytokine signaling 10.127
Cxcl2chemokine (C-X-C motif) ligand 20.115
Chd7chromodomain helicase DNA binding protein 70.113
Efna1ephrin A10.112
Ifnginterferon gamma0.112
Sox9SRY-box containing gene 90.111
Il1rninterleukin 1 receptor antagonist0.110
Sall4sal-like 4 (Drosophila)0.110
Rarbretinoic acid receptor, beta0.109
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.105
Hdac7histone deacetylase 70.103
Zeb1zinc finger E-box binding homeobox 10.101
Efna2ephrin A20.100
Runx2runt related transcription factor 20.097
Dmddystrophin, muscular dystrophy0.097
Cyp26c1cytochrome P450, family 26, subfamily c, polypeptide 10.096
Cxcl13chemokine (C-X-C motif) ligand 130.092
Phox2bpaired-like homeobox 2b0.092
Mapk11mitogen-activated protein kinase 110.092
Map3k14mitogen-activated protein kinase kinase kinase 140.088
Ikzf3IKAROS family zinc finger 30.087
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.086
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.083
Hey2hairy/enhancer-of-split related with YRPW motif 20.082
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.081
Foxp2forkhead box P20.081
Notch1Notch gene homolog 1 (Drosophila)0.080
Ptpn11protein tyrosine phosphatase, non-receptor type 110.079
Gata6GATA binding protein 60.079
Zfpm2zinc finger protein, multitype 20.078
Stat6signal transducer and activator of transcription 60.077
Col13a1collagen, type XIII, alpha 10.074
Prrx1paired related homeobox 10.073
Wnt9bwingless-type MMTV integration site 9B0.072
Nos1nitric oxide synthase 1, neuronal0.069
Nr2f2nuclear receptor subfamily 2, group F, member 20.069
Gzmkgranzyme K0.068
Tgfb2transforming growth factor, beta 20.068
Phox2apaired-like homeobox 2a0.067
Tlx3T-cell leukemia, homeobox 30.067
Nr5a1nuclear receptor subfamily 5, group A, member 10.064
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism