The network for 'gamete generation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

gamete generation

The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.

NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.717
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.217
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.159
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.159
MAGOHmago-nashi homolog, proliferation-associated (Drosophila)0.129
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.094
CREBBPCREB binding protein0.093
ATXN1ataxin 10.090
PABPC1poly(A) binding protein, cytoplasmic 10.085
ATF2activating transcription factor 20.074
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.071
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.071
SMAD3SMAD family member 30.071
CSNK2A1casein kinase 2, alpha 1 polypeptide0.069
ESR1estrogen receptor 10.065
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.062
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.052
EZH2enhancer of zeste homolog 2 (Drosophila)0.050
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.050
TCP1t-complex 10.050
SMURF1SMAD specific E3 ubiquitin protein ligase 10.050
SF3A2splicing factor 3a, subunit 2, 66kDa0.048
DNMT1DNA (cytosine-5-)-methyltransferase 10.047
RB1retinoblastoma 10.047
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.047
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.046
GSK3Bglycogen synthase kinase 3 beta0.045
BRCA1breast cancer 1, early onset0.044
U2AF1U2 small nuclear RNA auxiliary factor 10.043
SNRPD1small nuclear ribonucleoprotein D1 polypeptide 16kDa0.040
SNRPGsmall nuclear ribonucleoprotein polypeptide G0.038
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.038
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.038
TARDBPTAR DNA binding protein0.038
QKIquaking homolog, KH domain RNA binding (mouse)0.037
EGFRepidermal growth factor receptor0.035
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.035
BRCA2breast cancer 2, early onset0.035
SP1Sp1 transcription factor0.034
SSBSjogren syndrome antigen B (autoantigen La)0.034
SF3B1splicing factor 3b, subunit 1, 155kDa0.033
SNRPFsmall nuclear ribonucleoprotein polypeptide F0.033
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.031
U2AF2U2 small nuclear RNA auxiliary factor 20.031
CCT6Achaperonin containing TCP1, subunit 6A (zeta 1)0.030
APCadenomatous polyposis coli0.029
TNRC6Atrinucleotide repeat containing 6A0.029
CCT3chaperonin containing TCP1, subunit 3 (gamma)0.029
MAPK14mitogen-activated protein kinase 140.028
SNRPEsmall nuclear ribonucleoprotein polypeptide E0.027
CCT7chaperonin containing TCP1, subunit 7 (eta)0.027
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.027
EP300E1A binding protein p3000.027
CSNK2Bcasein kinase 2, beta polypeptide0.027
SRSF1serine/arginine-rich splicing factor 10.027
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.027
HNRNPKheterogeneous nuclear ribonucleoprotein K0.026
CALM1calmodulin 1 (phosphorylase kinase, delta)0.025
EIF3Heukaryotic translation initiation factor 3, subunit H0.025
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.025
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.024
HDAC1histone deacetylase 10.023
FLNAfilamin A, alpha0.023
PBKPDZ binding kinase0.023
EIF2C2eukaryotic translation initiation factor 2C, 20.023
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.023
WDR5WD repeat domain 50.023
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.023
RHOAras homolog gene family, member A0.022
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.022
CDK2cyclin-dependent kinase 20.022
MCM7minichromosome maintenance complex component 70.021
UBCubiquitin C0.021
EEDembryonic ectoderm development0.021
IQGAP1IQ motif containing GTPase activating protein 10.021
EIF3Beukaryotic translation initiation factor 3, subunit B0.020
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.020
CCT5chaperonin containing TCP1, subunit 5 (epsilon)0.020
GNB2L1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 10.020
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.019
EIF2C1eukaryotic translation initiation factor 2C, 10.019
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.019
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.019
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.019
PNNpinin, desmosome associated protein0.019
SNRPD3small nuclear ribonucleoprotein D3 polypeptide 18kDa0.019
JUNjun proto-oncogene0.018
FGFR1fibroblast growth factor receptor 10.018
PRKCZprotein kinase C, zeta0.018
HNRNPUL1heterogeneous nuclear ribonucleoprotein U-like 10.018
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.018
AHSA1AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)0.018
SRSF2serine/arginine-rich splicing factor 20.018
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.018
RPS6ribosomal protein S60.018
JAG1jagged 10.018
CSNK1Ecasein kinase 1, epsilon0.018
MPRIPmyosin phosphatase Rho interacting protein0.018
BCL3B-cell CLL/lymphoma 30.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pha-4Protein PHA-40.985
cgh-1Protein CGH-10.983
goa-1Protein GOA-10.978
vab-3Protein VAB-30.971
let-502Protein LET-5020.966
lag-1Protein LAG-10.949
eef-1A.1Protein EEF-1A.10.946
mat-3Protein MAT-30.942
par-5Protein PAR-50.936
prp-8Protein PRP-80.935
npp-1Protein NPP-10.928
gld-1Protein GLD-10.925
sem-5Protein SEM-50.916
gpr-1Protein GPR-10.913
gls-1Protein GLS-10.909
egl-45Protein EGL-450.900
W05F2.3Protein W05F2.30.895
mex-5Protein MEX-50.894
dao-5Protein DAO-50.890
cye-1Protein CYE-10.884
klp-15Protein KLP-150.872
npp-7Protein NPP-70.869
egg-6Protein EGG-60.868
suf-1Protein SUF-10.854
rpt-5Protein RPT-50.841
cbd-1Protein CBD-10.837
unc-57Protein UNC-570.835
mbk-2Protein MBK-20.829
spdl-1Protein SPDL-10.826
xpo-1Protein XPO-10.819
tbb-2Protein TBB-20.818
ruvb-1Protein RUVB-10.816
klp-16Protein KLP-160.810
scc-1Protein SCC-10.809
rpb-2Protein RPB-20.808
F33D11.10Protein F33D11.100.808
CELE_C12D8.1Protein C12D8.10.805
sma-6Protein SMA-60.804
ima-3Protein IMA-30.800
mom-2Protein MOM-20.797
gpr-2Protein GPR-20.796
gex-3Protein GEX-30.792
cyk-4Protein CYK-40.788
csn-1Protein CSN-10.787
tbb-1Protein TBB-10.768
rnp-6Protein RNP-60.766
rpa-2Protein RPA-20.764
dsh-2Protein DSH-20.763
taf-5Protein TAF-50.761
rsp-1Protein RSP-10.756
attf-2Protein ATTF-20.756
rpa-1Protein RPA-10.751
vit-6Protein VIT-60.751
wago-4Protein WAGO-40.748
asd-1Protein ASD-10.747
yif-1Protein YIF-10.744
zif-1Protein ZIF-10.736
msp-36Protein MSP-360.733
unc-60Protein UNC-600.730
lin-13Protein LIN-130.728
T28D9.1Protein T28D9.10.725
hil-2Protein HIL-20.722
sel-10Protein SEL-100.720
spt-5Protein SPT-50.711
snr-3Protein SNR-30.709
mcm-2Protein MCM-20.701
rsp-6Protein RSP-60.697
dnj-12Protein DNJ-120.695
hsp-1Protein HSP-10.694
prp-3Protein PRP-30.690
cdc-26Protein CDC-260.689
ztf-7Protein ZTF-70.685
kin-2Protein KIN-20.685
ife-1Protein IFE-10.684
him-3Protein HIM-30.684
vha-8Protein VHA-80.683
cin-4Protein CIN-40.682
mpk-1Protein MPK-10.678
unc-32Protein UNC-320.677
tag-72Protein TAG-720.675
cfim-2Protein CFIM-20.674
mei-2Protein MEI-20.674
mdf-2Protein MDF-20.666
hcp-3Protein HCP-30.656
syx-4Protein SYX-40.655
rpl-3Protein RPL-30.655
cks-1Protein CKS-10.653
zen-4Protein ZEN-40.650
vab-1Protein VAB-10.646
F54C9.9Protein F54C9.90.646
cra-1Protein CRA-10.645
rme-2Protein RME-20.645
puf-6Protein PUF-60.640
snr-4Protein SNR-40.639
rsa-1Protein RSA-10.638
tba-2Protein TBA-20.636
cdc-37Protein CDC-370.632
skr-2Protein SKR-20.628
ubq-1Protein UBQ-10.625
apg-1Protein APG-10.623
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
piwil1piwi-like 1 (Drosophila)0.967
ptch2patched 20.964
tp53tumor protein p530.910
nanos3nanos homolog 30.884
piwil2piwi-like 2 (Drosophila)0.772
gli1GLI-Kruppel family member 10.742
lamc1laminin, gamma 10.711
robo3roundabout homolog 30.641
pbx4pre-B-cell leukemia transcription factor 40.580
smad1MAD homolog 1 (Drosophila)0.575
brca2breast cancer 2, early onset0.539
her6hairy-related 60.464
hhiphedgehog interacting protein0.461
hoxb1bhomeo box B1b0.442
bmp4bone morphogenetic protein 40.437
fanclFanconi anemia, complementation group L0.434
ptch1patched 10.397
sox9aSRY-box containing gene 9a0.377
snrpd3lsmall nuclear ribonucleoprotein D3 polypeptide, like0.351
tfap2atranscription factor AP-2 alpha0.347
e2f5E2F transcription factor 50.336
tdrd1tudor domain containing 10.318
foxi1forkhead box I10.318
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.315
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.310
bmp2bbone morphogenetic protein 2b0.308
khdrbs1aKH domain containing, RNA binding, signal transduction associated 1a0.305
fzd7bfrizzled homolog 7b0.302
nop58NOP58 ribonucleoprotein homolog (yeast)0.290
paqr8progestin and adipoQ receptor family member VIII0.283
wnt11wingless-type MMTV integration site family, member 110.278
kitakit receptor a0.276
dlatdihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)0.270
shhasonic hedgehog a0.268
bmpr1bbbone morphogenetic protein receptor, type 1bb0.254
sart3squamous cell carcinoma antigen recognised by T cells 30.241
ybx1Y box binding protein 10.238
zff9zinc finger protein 90.227
fn1fibronectin 10.223
sf1splicing factor 10.211
per3period homolog 3 (Drosophila)0.209
lmx1b.2LIM homeobox transcription factor 1, beta 20.209
orgoogenesis-related gene0.206
wnt1wingless-type MMTV integration site family, member 10.200
tuba1ltubulin, alpha 1, like0.197
ckmacreatine kinase, muscle a0.193
eng2aengrailed 2a0.193
six4bsine oculis homeobox homolog 4b0.189
cct6achaperonin containing TCP1, subunit 6A (zeta 1)0.189
notch3notch homolog 30.189
foxa2forkhead box A20.186
sox2SRY-box containing gene 20.181
neo1neogenin 10.173
pcdh19protocadherin 190.166
gdf9growth differentiation factor 90.166
rhoabras homolog gene family, member Ab0.165
cct7chaperonin containing TCP1, subunit 7 (eta)0.165
sap18sin3-associated polypeptide0.165
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.162
col8a1acollagen, type VIII, alpha 1a0.162
celf1cugbp, Elav-like family member 10.162
pabpc1apoly A binding protein, cytoplasmic 1 a0.162
aldh1a2aldehyde dehydrogenase 1 family, member A20.161
gng3guanine nucleotide binding protein (G protein), gamma 30.160
lef1lymphocyte enhancer binding factor 10.153
eif3ceukaryotic translation initiation factor 3, subunit C0.152
igfbp3insulin-like growth factor binding protein 30.148
wt1awilms tumor 1a0.143
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.143
hoxa2bhomeo box A2b0.143
eif2s1eukaryotic translation initiation factor 2, subunit 1 alpha0.142
myf5myogenic factor 50.140
igf1rbinsulin-like growth factor 1b receptor0.140
eif1beukaryotic translation initiation factor 1B0.139
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.138
ranras-related nuclear protein0.138
whsc1Wolf-Hirschhorn syndrome candidate 10.138
mmp2matrix metalloproteinase 20.137
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.137
otx1borthodenticle homolog 1b0.136
dag1dystroglycan 10.133
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.133
gdf6agrowth differentiation factor 6a0.130
mef2dmyocyte enhancer factor 2d0.130
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.129
myd88myeloid differentiation primary response gene (88)0.129
pitx2paired-like homeodomain transcription factor 20.125
mybl2myeloblastosis oncogene-like 20.124
smad5MAD homolog 5 (Drosophila)0.122
mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.122
flot1bflotillin 1b0.121
sox9bSRY-box containing gene 9b0.121
harshistidyl-tRNA synthetase0.121
sox32SRY-box containing gene 320.120
cx43.4connexin 43.40.120
smosmoothened homolog (Drosophila)0.119
tgfbr2transforming growth factor, beta receptor II0.118
pax2apaired box gene 2a0.117
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Top2atopoisomerase (DNA) II alpha0.184
Kifc1kinesin family member C10.119
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.107
Id3inhibitor of DNA binding 30.098
Acvr1activin A receptor, type I0.098
Lbrlamin B receptor0.098
Hspa1aheat shock 70kD protein 1A0.096
Actbactin, beta0.093
Plaurplasminogen activator, urokinase receptor0.093
Tra2btransformer 2 beta homolog (Drosophila)0.089
Pebp1phosphatidylethanolamine binding protein 10.088
Sh3gl2SH3-domain GRB2-like 20.088
Myh9myosin, heavy chain 9, non-muscle0.087
Nab1Ngfi-A binding protein 10.087
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.087
Rap1bRAP1B, member of RAS oncogene family0.087
Cdk2cyclin dependent kinase 20.083
Fkbp4FK506 binding protein 40.082
Cd44Cd44 molecule0.080
Slc22a7solute carrier family 22 (organic anion transporter), member 70.079
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.079
Ctxn1cortexin 10.078
Plauplasminogen activator, urokinase0.076
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.075
Lphn1latrophilin 10.074
Actn4actinin alpha 40.073
Pcnaproliferating cell nuclear antigen0.072
Olr1700olfactory receptor 17000.072
Eef2eukaryotic translation elongation factor 20.072
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.071
Tecrtrans-2,3-enoyl-CoA reductase0.071
Runx1runt-related transcription factor 10.070
Hnrpdheterogeneous nuclear ribonucleoprotein D0.070
Prkcdprotein kinase C, delta0.069
Tcf12transcription factor 120.069
Mapk3mitogen activated protein kinase 30.069
Gipgastric inhibitory polypeptide0.069
Grin3aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A0.067
Fth1ferritin, heavy polypeptide 10.067
Dlg3discs, large homolog 3 (Drosophila)0.067
Litaflipopolysaccharide-induced TNF factor0.065
Sumo1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.065
Casp2caspase 20.064
Rcn2reticulocalbin 2, EF-hand calcium binding domain0.064
Grm5glutamate receptor, metabotropic 50.063
Ccr1chemokine (C-C motif) receptor 10.063
LOC100360150eukaryotic translation elongation factor 1 alpha 20.063
Snap25synaptosomal-associated protein 250.062
Ppil4peptidylprolyl isomerase (cyclophilin)-like 40.062
Anxa4annexin A40.062
Id1inhibitor of DNA binding 10.062
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.062
Cckbrcholecystokinin B receptor0.061
Kcnk1potassium channel, subfamily K, member 10.061
Metmet proto-oncogene0.061
Ptprcprotein tyrosine phosphatase, receptor type, C0.060
Hdac2histone deacetylase 20.060
Il1binterleukin 1 beta0.060
Dusp1dual specificity phosphatase 10.060
Usf2upstream transcription factor 2, c-fos interacting0.059
Gstp1glutathione S-transferase pi 10.059
Slc16a8solute carrier family 16, member 8 (monocarboxylic acid transporter 3)0.059
Id2inhibitor of DNA binding 20.059
Prl4a1prolactin family 4, subfamily a, member 10.058
Gnmtglycine N-methyltransferase0.058
Pld2phospholipase D20.057
Rplp0ribosomal protein, large, P00.057
LOC290595hypothetical gene supported by AF1520020.057
Snrpbsmall nuclear ribonucleoprotein polypeptides B and B10.056
Icam1intercellular adhesion molecule 10.056
Adam7ADAM metallopeptidase domain 70.056
Hnrnpabheterogeneous nuclear ribonucleoprotein A/B0.056
LOC679840similar to germinal histone H4 gene0.056
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.056
Slc24a2solute carrier family 24 (sodium/potassium/calcium exchanger), member 20.055
Ccl4chemokine (C-C motif) ligand 40.055
Ccl3chemokine (C-C motif) ligand 30.055
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.055
Sp4Sp4 transcription factor0.055
Fgfr2fibroblast growth factor receptor 20.055
Arl5aADP-ribosylation factor-like 5A0.055
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.054
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.053
Rhoaras homolog gene family, member A0.053
Sellselectin L0.053
Olr1493olfactory receptor gene Olr14930.053
Ppap2aphosphatidic acid phosphatase type 2A0.053
Serpina3mserine (or cysteine) proteinase inhibitor, clade A, member 3M0.053
Pou2f3POU class 2 homeobox 30.052
Flt1FMS-related tyrosine kinase 10.052
Zranb2zinc finger, RAN-binding domain containing 20.052
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.052
Gata6GATA binding protein 60.052
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.052
Prkaa1protein kinase, AMP-activated, alpha 1 catalytic subunit0.051
Prps1phosphoribosyl pyrophosphate synthetase 10.051
Ccnd3cyclin D30.051
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism