The network for 'positive regulation of rab gtpase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of rab gtpase activity

Any process that activates or increases the activity of a GTPase of the Rab family.

NameDescriptionProbabilityFunc Analog Organism
GABARAPL1GABA(A) receptor-associated protein like 10.998
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.988
NUDT18nudix (nucleoside diphosphate linked moiety X)-type motif 180.978
CHD3chromodomain helicase DNA binding protein 30.974
BIN1bridging integrator 10.968
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.903
C19orf50chromosome 19 open reading frame 500.847
MYCBP2MYC binding protein 20.792
RAB4ARAB4A, member RAS oncogene family0.626
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.587
RAB3GAP1RAB3 GTPase activating protein subunit 1 (catalytic)0.557
PRKCZprotein kinase C, zeta0.441
RAB5ARAB5A, member RAS oncogene family0.416
PDPK13-phosphoinositide dependent protein kinase-10.399
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog0.391
EEA1early endosome antigen 10.357
VPS13Dvacuolar protein sorting 13 homolog D (S. cerevisiae)0.343
PNPLA6patatin-like phospholipase domain containing 60.316
CRTC2CREB regulated transcription coactivator 20.315
TSC2tuberous sclerosis 20.303
RAB3IPRAB3A interacting protein (rabin3)0.295
CELSR3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)0.272
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.263
NCKAP1NCK-associated protein 10.261
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.261
EZRezrin0.239
RAB3GAP2RAB3 GTPase activating protein subunit 2 (non-catalytic)0.233
RGS2regulator of G-protein signaling 2, 24kDa0.223
RAB3IL1RAB3A interacting protein (rabin3)-like 10.223
FAM82A2family with sequence similarity 82, member A20.216
KIAA0930KIAA09300.208
FRYLFRY-like0.205
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.199
LZTR1leucine-zipper-like transcription regulator 10.195
MINK1misshapen-like kinase 10.190
PLCG1phospholipase C, gamma 10.179
VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2)0.158
MPRIPmyosin phosphatase Rho interacting protein0.155
WBP2WW domain binding protein 20.154
KLC1kinesin light chain 10.150
EIF2S3eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa0.147
AKT1S1AKT1 substrate 1 (proline-rich)0.141
PIP5K1Cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma0.127
GGA3golgi-associated, gamma adaptin ear containing, ARF binding protein 30.126
RABEP1rabaptin, RAB GTPase binding effector protein 10.120
LMF2lipase maturation factor 20.115
PHF3PHD finger protein 30.115
CABIN1calcineurin binding protein 10.108
CARD11caspase recruitment domain family, member 110.106
TRAPPC2trafficking protein particle complex 20.102
NBR1neighbor of BRCA1 gene 10.101
ATG9AATG9 autophagy related 9 homolog A (S. cerevisiae)0.100
GDI1GDP dissociation inhibitor 10.100
FRMD6FERM domain containing 60.098
EPB41L3erythrocyte membrane protein band 4.1-like 30.098
ACAP3ArfGAP with coiled-coil, ankyrin repeat and PH domains 30.097
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.097
OSBPL3oxysterol binding protein-like 30.093
STRN4striatin, calmodulin binding protein 40.093
TSC1tuberous sclerosis 10.083
CICcapicua homolog (Drosophila)0.082
FXR2fragile X mental retardation, autosomal homolog 20.082
MICALL1MICAL-like 10.081
ATG14ATG14 autophagy related 14 homolog (S. cerevisiae)0.079
MYO9Bmyosin IXB0.079
GBF1golgi brefeldin A resistant guanine nucleotide exchange factor 10.076
ALS2amyotrophic lateral sclerosis 2 (juvenile)0.073
STBD1starch binding domain 10.072
DGKZdiacylglycerol kinase, zeta0.071
AP2A2adaptor-related protein complex 2, alpha 2 subunit0.070
TRAPPC10trafficking protein particle complex 100.067
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.066
LARP1La ribonucleoprotein domain family, member 10.064
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.062
RASSF1Ras association (RalGDS/AF-6) domain family member 10.061
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.060
GAKcyclin G associated kinase0.058
DCAF10DDB1 and CUL4 associated factor 100.058
CDK17cyclin-dependent kinase 170.058
RAB24RAB24, member RAS oncogene family0.058
PTPN3protein tyrosine phosphatase, non-receptor type 30.057
MYO18Amyosin XVIIIA0.056
NISCHnischarin0.056
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 10.056
IPO13importin 130.054
EML3echinoderm microtubule associated protein like 30.053
ROR1receptor tyrosine kinase-like orphan receptor 10.052
FAM65Afamily with sequence similarity 65, member A0.052
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.052
CAMTA2calmodulin binding transcription activator 20.051
RASSF5Ras association (RalGDS/AF-6) domain family member 50.050
SIN3BSIN3 homolog B, transcription regulator (yeast)0.050
CYTH4cytohesin 40.049
RPS6KA1ribosomal protein S6 kinase, 90kDa, polypeptide 10.048
RALGDSral guanine nucleotide dissociation stimulator0.048
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.048
VPS13Avacuolar protein sorting 13 homolog A (S. cerevisiae)0.047
RNPEPL1arginyl aminopeptidase (aminopeptidase B)-like 10.046
UBR5ubiquitin protein ligase E3 component n-recognin 50.046
CEP350centrosomal protein 350kDa0.046
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rme-4Protein RME-40.014
K10B4.3Protein K10B4.30.011
rpm-1Protein RPM-10.010
unc-71Protein UNC-710.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG8155CG8155 gene product from transcript CG8155-RA0.524
CG4552CG4552 gene product from transcript CG4552-RA0.170
synjsynaptojanin0.137
RalaRas-related protein0.105
CG6509CG6509 gene product from transcript CG6509-RB0.099
SCARCG4636 gene product from transcript CG4636-RA0.064
HphHIF prolyl hydroxylase0.063
HLH106Helix loop helix protein 1060.058
sec15CG7034 gene product from transcript CG7034-RA0.053
simasimilar0.051
l(2)k05819lethal (2) k058190.049
Vps35Vacuolar protein sorting 350.043
SmoxSmad on X0.041
jarjaguar0.041
CG15118CG15118 gene product from transcript CG15118-RC0.038
kenken and barbie0.036
staistathmin0.035
CalpBCalpain-B0.034
CG5798CG5798 gene product from transcript CG5798-RA0.031
Kap3Kinesin associated protein 30.029
CG1233CG1233 gene product from transcript CG1233-RB0.029
CG6194CG6194 gene product from transcript CG6194-RA0.028
TSG101tumor suppressor protein 1010.027
cdmcadmus0.027
ltlight0.026
EDTPEgg-derived tyrosine phosphatase0.021
CG10631CG10631 gene product from transcript CG10631-RA0.020
CG7158CG7158 gene product from transcript CG7158-RA0.019
lgslegless0.018
par-6CG5884 gene product from transcript CG5884-RA0.018
Rip11Rab11 interacting protein0.017
Eip75BEcdysone-induced protein 75B0.017
CG10254CG10254 gene product from transcript CG10254-RB0.017
Sra-1specifically Rac1-associated protein 10.017
bazbazooka0.017
SbfSET domain binding factor0.017
Klp68DKinesin-like protein at 68D0.017
cncinnabar0.016
CG3356CG3356 gene product from transcript CG3356-RA0.016
pkaapCG4132 gene product from transcript CG4132-RA0.015
CG2938CG2938 gene product from transcript CG2938-RB0.015
CG5087CG5087 gene product from transcript CG5087-RA0.015
Vti1CG3279 gene product from transcript CG3279-RA0.014
DlicDynein light intermediate chain0.013
CG33090CG33090 gene product from transcript CG33090-RB0.013
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.013
CG6454CG6454 gene product from transcript CG6454-RC0.013
pgant3polypeptide GalNAc transferase 30.013
CG5270CG5270 gene product from transcript CG5270-RB0.012
maskmultiple ankyrin repeats single KH domain0.012
rab3-GAPCG7061 gene product from transcript CG7061-RA0.012
CG11178CG11178 gene product from transcript CG11178-RA0.012
CG11055CG11055 gene product from transcript CG11055-RB0.011
CG11033CG11033 gene product from transcript CG11033-RB0.011
Eps-15Epidermal growth factor receptor pathway substrate clone 150.011
schlankCG3576 gene product from transcript CG3576-RB0.011
CG11247CG11247 gene product from transcript CG11247-RC0.011
wtswarts0.011
G9aCG2995 gene product from transcript CG2995-RA0.011
Syx7Syntaxin 70.011
CG10918CG10918 gene product from transcript CG10918-RA0.010
CG11526CG11526 gene product from transcript CG11526-RB0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Itsn1intersectin 1 (SH3 domain protein 1A)0.181
Zdhhc17zinc finger, DHHC domain containing 170.174
D15Ertd621eDNA segment, Chr 15, ERATO Doi 621, expressed0.104
Mkl1MKL (megakaryoblastic leukemia)/myocardin-like 10.078
Fnip1folliculin interacting protein 10.046
Pcnxl3pecanex-like 3 (Drosophila)0.038
Stag2stromal antigen 20.036
Tab2TGF-beta activated kinase 1/MAP3K7 binding protein 20.026
Ppp3caprotein phosphatase 3, catalytic subunit, alpha isoform0.024
Abtb1ankyrin repeat and BTB (POZ) domain containing 10.024
Fndc3afibronectin type III domain containing 3A0.022
Arhgap21Rho GTPase activating protein 210.022
Rab5aRAB5A, member RAS oncogene family0.021
Cpne3copine III0.020
Eps15epidermal growth factor receptor pathway substrate 150.020
Nckap1NCK-associated protein 10.020
Rbm7RNA binding motif protein 70.018
Glg1golgi apparatus protein 10.018
Iqsec1IQ motif and Sec7 domain 10.017
Copb1coatomer protein complex, subunit beta 10.016
Lamp2lysosomal-associated membrane protein 20.016
Rnf103ring finger protein 1030.016
Nek7NIMA (never in mitosis gene a)-related expressed kinase 70.016
Tjp1tight junction protein 10.016
Stxbp3asyntaxin binding protein 3A0.015
Golim4golgi integral membrane protein 40.014
Dnm1dynamin 10.014
Pitpnm1phosphatidylinositol transfer protein, membrane-associated 10.014
Ciccapicua homolog (Drosophila)0.014
Hivep1human immunodeficiency virus type I enhancer binding protein 10.014
Evi5ecotropic viral integration site 50.014
Cc2d1acoiled-coil and C2 domain containing 1A0.013
Vps35vacuolar protein sorting 350.013
Strn4striatin, calmodulin binding protein 40.013
Megf8multiple EGF-like-domains 80.013
March7membrane-associated ring finger (C3HC4) 70.012
Ap1b1adaptor protein complex AP-1, beta 1 subunit0.012
Golga4golgi autoantigen, golgin subfamily a, 40.011
Dennd4bDENN/MADD domain containing 4B0.011
Rdxradixin0.011
Phlpp1PH domain and leucine rich repeat protein phosphatase 10.011
Dlgap4discs, large homolog-associated protein 4 (Drosophila)0.011
Abcg2ATP-binding cassette, sub-family G (WHITE), member 20.011
Rock1Rho-associated coiled-coil containing protein kinase 10.011
Sh2d3cSH2 domain containing 3C0.011
Golph3golgi phosphoprotein 30.010
Sacm1lSAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)0.010
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Smg5Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)0.050
Pls3plastin 3 (T-isoform)0.022
Copb1coatomer protein complex, subunit beta 10.022
Adaradenosine deaminase, RNA-specific0.021
Eif3eeukaryotic translation initiation factor 3, subunit E0.019
Smek2SMEK homolog 2, suppressor of mek1 (Dictyostelium)0.018
Exoc5exocyst complex component 50.017
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.017
Lgals8lectin, galactoside-binding, soluble, 80.017
Nckap1NCK-associated protein 10.017
Tmem59transmembrane protein 590.014
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.013
Rab7aRAB7A, member RAS oncogene family0.013
Appamyloid beta (A4) precursor protein0.013
Clcn7chloride channel 70.013
Slc22a17solute carrier family 22, member 170.013
RGD621098similar to RIKEN cDNA D230025D16Rik0.013
Ulk1Unc-51 like kinase 1 (C. elegans)0.013
Zfp260zinc finger protein 2600.012
Snx2sorting nexin 20.012
RGD1565411similar to 2610317D23Rik protein0.012
Inpp4ainositol polyphosphate-4-phosphatase, type 10.012
Pi4k2aphosphatidylinositol 4-kinase type 2 alpha0.012
Sptlc1serine palmitoyltransferase, long chain base subunit 10.012
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.012
G3bp2GTPase activating protein (SH3 domain) binding protein 20.011
Mcf2lMCF.2 cell line derived transforming sequence-like0.011
Hp1bp3heterochromatin protein 1, binding protein 30.011
Ubr4ubiquitin protein ligase E3 component n-recognin 40.011
Mospd2motile sperm domain containing 20.011
Hk1hexokinase 10.011
Ampd2adenosine monophosphate deaminase 2 (isoform L)0.011
Brd2bromodomain containing 20.011
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.010
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.010
Unc13bunc-13 homolog B (C. elegans)0.010
Sash3SAM and SH3 domain containing 30.010
Nptnneuroplastin0.010
Lzts2leucine zipper, putative tumor suppressor 20.010
Cmpk1cytidine monophosphate (UMP-CMP) kinase 10.010
Arhgap5Rho GTPase activating protein 50.010
Stx2syntaxin 20.010
MaddMAP-kinase activating death domain0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism