The network for 'somatostatin receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

somatostatin receptor signaling pathway

The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
MPDZmultiple PDZ domain protein1.000
SSTR2somatostatin receptor 20.957
SSTR3somatostatin receptor 30.947
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.445
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.404
KCNF1potassium voltage-gated channel, subfamily F, member 10.361
CHRNA4cholinergic receptor, nicotinic, alpha 40.326
GPRASP1G protein-coupled receptor associated sorting protein 10.265
PNOCprepronociceptin0.144
SHANK1SH3 and multiple ankyrin repeat domains 10.130
DRD2dopamine receptor D20.122
OR2AG1olfactory receptor, family 2, subfamily AG, member 10.113
CORTcortistatin0.092
FSCN2fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)0.070
NTSR1neurotensin receptor 1 (high affinity)0.068
SOX1SRY (sex determining region Y)-box 10.067
NEURLneuralized homolog (Drosophila)0.051
GIPgastric inhibitory polypeptide0.048
CALYcalcyon neuron-specific vesicular protein0.048
OXToxytocin, prepropeptide0.048
HTR2A5-hydroxytryptamine (serotonin) receptor 2A0.046
THtyrosine hydroxylase0.045
NGBneuroglobin0.045
RHBDL1rhomboid, veinlet-like 1 (Drosophila)0.045
GRM5glutamate receptor, metabotropic 50.044
SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.043
ZFR2zinc finger RNA binding protein 20.043
GCGRglucagon receptor0.043
GJA4gap junction protein, alpha 4, 37kDa0.043
GRM1glutamate receptor, metabotropic 10.042
GHRHRgrowth hormone releasing hormone receptor0.042
PRM2protamine 20.040
CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.040
KCNK13potassium channel, subfamily K, member 130.039
VGFVGF nerve growth factor inducible0.038
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.038
DKK4dickkopf homolog 4 (Xenopus laevis)0.038
NKPD1NTPase, KAP family P-loop domain containing 10.037
INSL3insulin-like 3 (Leydig cell)0.036
CACNA1Bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.036
OPCMLopioid binding protein/cell adhesion molecule-like0.035
KLK15kallikrein-related peptidase 150.034
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.033
PAX8paired box 80.033
ADRA1Dadrenergic, alpha-1D-, receptor0.033
IL17Binterleukin 17B0.033
CCKBRcholecystokinin B receptor0.032
OPRD1opioid receptor, delta 10.031
CCL1chemokine (C-C motif) ligand 10.031
VSTM2AV-set and transmembrane domain containing 2A0.031
SLC30A3solute carrier family 30 (zinc transporter), member 30.031
ADM2adrenomedullin 20.031
NEUROD2neurogenic differentiation 20.030
SLC1A7solute carrier family 1 (glutamate transporter), member 70.029
EMX1empty spiracles homeobox 10.028
CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunit0.028
IL27interleukin 270.028
CEACAM3carcinoembryonic antigen-related cell adhesion molecule 30.028
PRKCGprotein kinase C, gamma0.028
NTN3netrin 30.027
NKX2-8NK2 homeobox 80.027
PLEKHA2pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 20.027
MTNR1Amelatonin receptor 1A0.027
GHSRgrowth hormone secretagogue receptor0.027
SHHsonic hedgehog0.027
FCER2Fc fragment of IgE, low affinity II, receptor for (CD23)0.027
AVPR1Barginine vasopressin receptor 1B0.027
TLX2T-cell leukemia homeobox 20.027
LHBluteinizing hormone beta polypeptide0.026
OPRL1opiate receptor-like 10.026
GP2glycoprotein 2 (zymogen granule membrane)0.026
ADAM11ADAM metallopeptidase domain 110.026
WSCD2WSC domain containing 20.026
SSTsomatostatin0.025
UTS2Rurotensin 2 receptor0.025
MAGmyelin associated glycoprotein0.025
S1PR5sphingosine-1-phosphate receptor 50.025
CRHR1corticotropin releasing hormone receptor 10.025
DAGLAdiacylglycerol lipase, alpha0.025
GNB3guanine nucleotide binding protein (G protein), beta polypeptide 30.025
PAEPprogestagen-associated endometrial protein0.025
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)0.024
NR5A1nuclear receptor subfamily 5, group A, member 10.023
CRXcone-rod homeobox0.023
KCNJ3potassium inwardly-rectifying channel, subfamily J, member 30.023
KCNK4potassium channel, subfamily K, member 40.023
POU2F2POU class 2 homeobox 20.023
PRAMEF12PRAME family member 120.023
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.022
GJC2gap junction protein, gamma 2, 47kDa0.022
AMNamnionless homolog (mouse)0.022
SYNGR4synaptogyrin 40.022
KCNJ4potassium inwardly-rectifying channel, subfamily J, member 40.022
CELA2Achymotrypsin-like elastase family, member 2A0.022
HTR3A5-hydroxytryptamine (serotonin) receptor 3A0.022
P2RX6purinergic receptor P2X, ligand-gated ion channel, 60.022
CA10carbonic anhydrase X0.022
FOXN1forkhead box N10.022
KISS1KiSS-1 metastasis-suppressor0.021
HTR45-hydroxytryptamine (serotonin) receptor 40.021
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cckbrcholecystokinin B receptor0.949
Esr1estrogen receptor 1 (alpha)0.643
Drd2dopamine receptor D20.611
Nr5a1nuclear receptor subfamily 5, group A, member 10.583
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.563
Chrm1cholinergic receptor, muscarinic 1, CNS0.542
Sncbsynuclein, beta0.542
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.524
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.498
Fshrfollicle stimulating hormone receptor0.468
Rgs9regulator of G-protein signaling 90.456
Gnrhrgonadotropin releasing hormone receptor0.427
Sez6seizure related gene 60.381
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.348
Pgrprogesterone receptor0.346
Alkanaplastic lymphoma kinase0.343
Gabrg3gamma-aminobutyric acid (GABA) A receptor, subunit gamma 30.337
Kiss1KiSS-1 metastasis-suppressor0.336
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.303
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.298
Adra2cadrenergic receptor, alpha 2c0.295
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.293
Edaectodysplasin-A0.292
Plcb1phospholipase C, beta 10.281
Htr45 hydroxytryptamine (serotonin) receptor 40.272
Trhthyrotropin releasing hormone0.272
Oxtoxytocin0.257
Gpr27G protein-coupled receptor 270.252
Syn2synapsin II0.250
Esr2estrogen receptor 2 (beta)0.233
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.232
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.217
Cnr1cannabinoid receptor 1 (brain)0.210
Sstr1somatostatin receptor 10.209
Rnf112ring finger protein 1120.208
Tacr1tachykinin receptor 10.200
Epha6Eph receptor A60.196
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.196
Kcns2K+ voltage-gated channel, subfamily S, 20.195
Lhx3LIM homeobox protein 30.182
Grin2cglutamate receptor, ionotropic, NMDA2C (epsilon 3)0.174
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.166
Crhr1corticotropin releasing hormone receptor 10.161
Cplx2complexin 20.154
Grid2glutamate receptor, ionotropic, delta 20.153
Syt2synaptotagmin II0.151
Htr75-hydroxytryptamine (serotonin) receptor 70.151
Gpr3G-protein coupled receptor 30.141
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.138
Lhbluteinizing hormone beta0.136
Cntn3contactin 30.127
Gpr12G-protein coupled receptor 120.125
Sstr2somatostatin receptor 20.124
Htr3a5-hydroxytryptamine (serotonin) receptor 3A0.123
Cplx1complexin 10.123
Ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.121
BC089491cDNA sequence BC0894910.121
Ptpn5protein tyrosine phosphatase, non-receptor type 50.116
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.115
Slc22a12solute carrier family 22 (organic anion/cation transporter), member 120.114
Cgaglycoprotein hormones, alpha subunit0.114
Kcna6potassium voltage-gated channel, shaker-related, subfamily, member 60.110
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.103
Gastgastrin0.102
Hrh1histamine receptor H10.102
Trpc5transient receptor potential cation channel, subfamily C, member 50.100
Mc3rmelanocortin 3 receptor0.100
Lepleptin0.099
Sstr4somatostatin receptor 40.099
Zp1zona pellucida glycoprotein 10.098
Arnt2aryl hydrocarbon receptor nuclear translocator 20.095
Gpr83G protein-coupled receptor 830.095
Hrkharakiri, BCL2 interacting protein (contains only BH3 domain)0.095
Grid1glutamate receptor, ionotropic, delta 10.094
Neurod2neurogenic differentiation 20.093
Gad2glutamic acid decarboxylase 20.092
Oprk1opioid receptor, kappa 10.091
Drd3dopamine receptor D30.090
Prop1paired like homeodomain factor 10.088
Kcnd1potassium voltage-gated channel, Shal-related family, member 10.087
Srcin1SRC kinase signaling inhibitor 10.086
Hoxd13homeobox D130.083
Grin2dglutamate receptor, ionotropic, NMDA2D (epsilon 4)0.081
Slc2a5solute carrier family 2 (facilitated glucose transporter), member 50.080
Cntn4contactin 40.079
Syt1synaptotagmin I0.077
SeboxSEBOX homeobox0.076
Cacna1bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.075
Rit2Ras-like without CAAX 20.070
Tcl1b1T-cell leukemia/lymphoma 1B, 10.070
Fgf10fibroblast growth factor 100.069
Zfp92zinc finger protein 920.069
Cacna1ecalcium channel, voltage-dependent, R type, alpha 1E subunit0.069
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.069
Syt6synaptotagmin VI0.068
Nptx2neuronal pentraxin 20.067
Hrh3histamine receptor H30.067
Kcnab3potassium voltage-gated channel, shaker-related subfamily, beta member 30.067
Lhx9LIM homeobox protein 90.065
Fam164cfamily with sequence similarity 164, member C0.065
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Sstr1somatostatin receptor 10.694
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.601
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.524
Htr75-hydroxytryptamine (serotonin) receptor 70.484
Nmbrneuromedin B receptor0.429
Chrna7cholinergic receptor, nicotinic, alpha 70.401
Grm6glutamate receptor, metabotropic 60.393
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.376
Chrna3cholinergic receptor, nicotinic, alpha 30.372
RGD1564664similar to LOC387763 protein0.366
Avpr1barginine vasopressin receptor 1B0.358
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.348
Calcrcalcitonin receptor0.328
Oprl1opiate receptor-like 10.296
Cckbrcholecystokinin B receptor0.280
Hrh3histamine receptor H30.264
Chrna4cholinergic receptor, nicotinic, alpha 40.246
Grm8glutamate receptor, metabotropic 80.241
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.231
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.227
Gpr83G protein-coupled receptor 830.224
Grm1glutamate receptor, metabotropic 10.223
Hpcahippocalcin0.218
Cacna1icalcium channel, voltage-dependent, T type, alpha 1I subunit0.215
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.209
Grprgastrin releasing peptide receptor0.199
B3gat1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)0.185
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.173
Scnn1gsodium channel, nonvoltage-gated 1, gamma0.160
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.153
Glra1glycine receptor, alpha 10.151
FevFEV (ETS oncogene family)0.148
Sstr2somatostatin receptor 20.136
Ompolfactory marker protein0.135
Pmfbp1polyamine modulated factor 1 binding protein 10.135
Bcanbrevican0.129
Clstn3calsyntenin 30.125
Sypsynaptophysin0.119
Fgf14fibroblast growth factor 140.118
Drd1adopamine receptor D1A0.118
Nrg1neuregulin 10.115
Ncanneurocan0.114
Grpgastrin releasing peptide0.111
Neurog3neurogenin 30.111
Olr416olfactory receptor 4160.107
Oprk1opioid receptor, kappa 10.106
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.102
Thtyrosine hydroxylase0.101
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.100
Gckglucokinase0.099
Slc6a7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.095
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.094
Vom2r53vomeronasal 2 receptor, 530.093
Dusp4dual specificity phosphatase 40.092
Snap91synaptosomal-associated protein 910.090
Glp1rglucagon-like peptide 1 receptor0.088
Gjb5gap junction protein, beta 50.086
Rgs9regulator of G-protein signaling 90.085
Kcnj9potassium inwardly-rectifying channel, subfamily J, member 90.085
CartptCART prepropeptide0.084
Hcrthypocretin0.079
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.079
Il24interleukin 240.078
Olr442olfactory receptor 4420.078
Shank2SH3 and multiple ankyrin repeat domains 20.077
Chrm5cholinergic receptor, muscarinic 50.075
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.073
Fgf2fibroblast growth factor 20.072
Ccr3chemokine (C-C motif) receptor 30.072
Serp2stress-associated endoplasmic reticulum protein family member 20.072
Gpr1G protein-coupled receptor 10.072
Uhmk1U2AF homology motif (UHM) kinase 10.071
Prlprolactin0.071
Crhbpcorticotropin releasing hormone binding protein0.071
Cyp11b1cytochrome P450, family 11, subfamily b, polypeptide 10.070
Nrlneural retina leucine zipper0.070
Ifna1interferon-alpha 10.070
Nxph1neurexophilin 10.069
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.069
FaslgFas ligand (TNF superfamily, member 6)0.065
Syn2synapsin II0.065
Dlx5distal-less homeobox 50.065
Syt4synaptotagmin IV0.062
Cpb1carboxypeptidase B1 (tissue)0.061
Prph2peripherin 20.061
Gnrhrgonadotropin releasing hormone receptor0.060
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.060
Adam3aADAM metallopeptidase domain 3A (cyritestin 1)0.060
Trpc5transient receptor potential cation channel, subfamily C, member 50.060
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.060
Kif6kinesin family member 60.060
LOC246267resection-induced TPI (rs11)0.059
Ptger2prostaglandin E receptor 2 (subtype EP2)0.058
Il1rninterleukin 1 receptor antagonist0.058
Necab2N-terminal EF-hand calcium binding protein 20.058
Chrnb3cholinergic receptor, nicotinic, beta 30.057
Il4interleukin 40.056
Sorcs3sortilin-related VPS10 domain containing receptor 30.056
Gng7guanine nucleotide binding protein (G protein), gamma 70.056
Syt2synaptotagmin II0.055
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism