The network for 'angiotensin activated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

angiotensin activated signaling pathway

The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription.

NameDescriptionProbabilityFunc Analog Organism
RLN3relaxin 30.994
TNKS2tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 20.907
TIMP3TIMP metallopeptidase inhibitor 30.809
SLC4A4solute carrier family 4, sodium bicarbonate cotransporter, member 40.575
ARRB1arrestin, beta 10.263
BDKRB1bradykinin receptor B10.149
SULT1B1sulfotransferase family, cytosolic, 1B, member 10.085
BDKRB2bradykinin receptor B20.080
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.064
EPB42erythrocyte membrane protein band 4.20.041
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.035
GLYATglycine-N-acyltransferase0.033
OVGP1oviductal glycoprotein 1, 120kDa0.032
ING2inhibitor of growth family, member 20.031
RHAGRh-associated glycoprotein0.030
AMPD1adenosine monophosphate deaminase 10.030
TLX1T-cell leukemia homeobox 10.030
ZNF273zinc finger protein 2730.029
MS4A12membrane-spanning 4-domains, subfamily A, member 120.027
ACEangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.027
KNG1kininogen 10.027
AGXTalanine-glyoxylate aminotransferase0.026
DAOD-amino-acid oxidase0.026
FABP1fatty acid binding protein 1, liver0.026
ALPIalkaline phosphatase, intestinal0.026
EEA1early endosome antigen 10.025
CST5cystatin D0.025
AHSPalpha hemoglobin stabilizing protein0.025
TSHBthyroid stimulating hormone, beta0.024
ENPP3ectonucleotide pyrophosphatase/phosphodiesterase 30.023
CPB2carboxypeptidase B2 (plasma)0.023
FZD9frizzled homolog 9 (Drosophila)0.023
GPR31G protein-coupled receptor 310.022
CEACAM8carcinoembryonic antigen-related cell adhesion molecule 80.022
PLEKHG6pleckstrin homology domain containing, family G (with RhoGef domain) member 60.022
C4BPAcomplement component 4 binding protein, alpha0.022
PNLIPRP1pancreatic lipase-related protein 10.022
CCR4chemokine (C-C motif) receptor 40.021
PDZD3PDZ domain containing 30.021
GPA33glycoprotein A33 (transmembrane)0.020
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 40.020
MAS1MAS1 oncogene0.020
HSD17B2hydroxysteroid (17-beta) dehydrogenase 20.020
TNNI2troponin I type 2 (skeletal, fast)0.020
KLK1kallikrein 10.020
DEFA4defensin, alpha 4, corticostatin0.020
ACANaggrecan0.020
XRN15'-3' exoribonuclease 10.019
PRRX2paired related homeobox 20.019
OTCornithine carbamoyltransferase0.019
SPATS1spermatogenesis associated, serine-rich 10.019
ATP10BATPase, class V, type 10B0.019
GPR12G protein-coupled receptor 120.019
NGBneuroglobin0.019
HBDhemoglobin, delta0.019
KIR2DS3killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 30.018
CLDN14claudin 140.018
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.018
RAXretina and anterior neural fold homeobox0.018
AGTangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.018
LIPClipase, hepatic0.018
BTNL3butyrophilin-like 30.018
RAB3IL1RAB3A interacting protein (rabin3)-like 10.018
PI15peptidase inhibitor 150.018
ERN2endoplasmic reticulum to nucleus signaling 20.017
EDN2endothelin 20.017
CTRCchymotrypsin C (caldecrin)0.017
MYOCmyocilin, trabecular meshwork inducible glucocorticoid response0.017
PADI4peptidyl arginine deiminase, type IV0.017
SSX5synovial sarcoma, X breakpoint 50.017
HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor0.017
AVPR2arginine vasopressin receptor 20.017
PDE6Aphosphodiesterase 6A, cGMP-specific, rod, alpha0.017
GYPBglycophorin B (MNS blood group)0.017
SARDHsarcosine dehydrogenase0.017
PAPD4PAP associated domain containing 40.017
BMXBMX non-receptor tyrosine kinase0.017
NOX1NADPH oxidase 10.017
PDCD1programmed cell death 10.016
ALOX15Barachidonate 15-lipoxygenase, type B0.016
KRT83keratin 830.016
CD177CD177 molecule0.016
PON1paraoxonase 10.016
PGCprogastricsin (pepsinogen C)0.016
STC1stanniocalcin 10.016
FABP2fatty acid binding protein 2, intestinal0.016
CCRN4LCCR4 carbon catabolite repression 4-like (S. cerevisiae)0.016
PON3paraoxonase 30.016
BPIbactericidal/permeability-increasing protein0.016
MAPK10mitogen-activated protein kinase 100.016
AQP8aquaporin 80.016
BCL2L14BCL2-like 14 (apoptosis facilitator)0.016
HAVCR1hepatitis A virus cellular receptor 10.015
CXCR1chemokine (C-X-C motif) receptor 10.015
SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 60.015
IL1RL2interleukin 1 receptor-like 20.015
CCL24chemokine (C-C motif) ligand 240.015
HSD17B3hydroxysteroid (17-beta) dehydrogenase 30.015
EPXeosinophil peroxidase0.015
VIPR1vasoactive intestinal peptide receptor 10.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Agtr1aangiotensin II receptor, type 1a0.996
Ren1renin 1 structural0.973
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.829
Leprleptin receptor0.665
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.434
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.278
Agtrapangiotensin II, type I receptor-associated protein0.201
Umoduromodulin0.192
Slc12a1solute carrier family 12, member 10.142
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.117
Nos3nitric oxide synthase 3, endothelial cell0.075
Aqp2aquaporin 20.071
Nr3c2nuclear receptor subfamily 3, group C, member 20.056
Ldlrlow density lipoprotein receptor0.050
Tgfbr2transforming growth factor, beta receptor II0.050
Wt1Wilms tumor 1 homolog0.050
Agtr2angiotensin II receptor, type 20.037
Ptgs1prostaglandin-endoperoxide synthase 10.032
Fbn1fibrillin 10.032
Nos2nitric oxide synthase 2, inducible0.028
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.026
Tgfb1transforming growth factor, beta 10.025
Cyp11b2cytochrome P450, family 11, subfamily b, polypeptide 20.022
Krtap13-1keratin associated protein 13-10.018
Loxlysyl oxidase0.017
Arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.016
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.016
Ptgs2prostaglandin-endoperoxide synthase 20.016
Robo2roundabout homolog 2 (Drosophila)0.016
Bdkrb2bradykinin receptor, beta 20.015
Meox1mesenchyme homeobox 10.014
Agtr1bangiotensin II receptor, type 1b0.014
2310010M20RikRIKEN cDNA 2310010M20 gene0.013
Nos1nitric oxide synthase 1, neuronal0.013
Clcn1chloride channel 10.013
Retret proto-oncogene0.013
Dysfdysferlin0.013
Aprtadenine phosphoribosyl transferase0.012
Prrt1proline-rich transmembrane protein 10.012
Bcl6bB-cell CLL/lymphoma 6, member B0.012
A4galtalpha 1,4-galactosyltransferase0.012
Fgf23fibroblast growth factor 230.011
Adcy6adenylate cyclase 60.011
Heylhairy/enhancer-of-split related with YRPW motif-like0.011
Olfr90olfactory receptor 900.011
Cpa3carboxypeptidase A3, mast cell0.011
Akr1b3aldo-keto reductase family 1, member B3 (aldose reductase)0.011
Npy2rneuropeptide Y receptor Y20.011
Tgfbr1transforming growth factor, beta receptor I0.011
Elnelastin0.011
Tas2r108taste receptor, type 2, member 1080.010
Rab44RAB44, member RAS oncogene family0.010
Uts2rurotensin 2 receptor0.010
Gm11567predicted gene 115670.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism