The network for 't cell receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

t cell receptor signaling pathway

A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.

NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase1.000
LATlinker for activation of T cells0.996
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.996
SYKspleen tyrosine kinase0.995
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.995
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.992
GRB2growth factor receptor-bound protein 20.984
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.983
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.975
FYNFYN oncogene related to SRC, FGR, YES0.903
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.878
CD80CD80 molecule0.869
VAV1vav 1 guanine nucleotide exchange factor0.869
PTPN1protein tyrosine phosphatase, non-receptor type 10.811
CTLA4cytotoxic T-lymphocyte-associated protein 40.802
BTN3A2butyrophilin, subfamily 3, member A20.759
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.650
BLNKB-cell linker0.645
BTN3A3butyrophilin, subfamily 3, member A30.625
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.625
TRAF3TNF receptor-associated factor 30.604
TRAF6TNF receptor-associated factor 60.564
CD247CD247 molecule0.503
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.473
PTPN6protein tyrosine phosphatase, non-receptor type 60.432
FYBFYN binding protein0.416
GHRgrowth hormone receptor0.402
BTN3A1butyrophilin, subfamily 3, member A10.399
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.389
TFF1trefoil factor 10.385
PLCG1phospholipase C, gamma 10.384
BIRC3baculoviral IAP repeat containing 30.378
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.339
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.316
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.293
CARD11caspase recruitment domain family, member 110.291
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.290
SH2D1ASH2 domain containing 1A0.282
CD40CD40 molecule, TNF receptor superfamily member 50.281
MAPK1mitogen-activated protein kinase 10.279
SHC1SHC (Src homology 2 domain containing) transforming protein 10.272
SPRR2Asmall proline-rich protein 2A0.255
APPamyloid beta (A4) precursor protein0.252
SH3BP2SH3-domain binding protein 20.232
RNF31ring finger protein 310.207
PRKCQprotein kinase C, theta0.174
ADAM15ADAM metallopeptidase domain 150.159
TNFAIP3tumor necrosis factor, alpha-induced protein 30.154
TRAF1TNF receptor-associated factor 10.136
MAPK3mitogen-activated protein kinase 30.113
SOS1son of sevenless homolog 1 (Drosophila)0.109
C9orf89chromosome 9 open reading frame 890.109
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.106
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.104
PSEN1presenilin 10.096
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.094
NUMBLnumb homolog (Drosophila)-like0.093
RIPK2receptor-interacting serine-threonine kinase 20.092
BTN2A2butyrophilin, subfamily 2, member A20.091
SMURF1SMAD specific E3 ubiquitin protein ligase 10.090
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.088
SH3KBP1SH3-domain kinase binding protein 10.082
PHYHIPLphytanoyl-CoA 2-hydroxylase interacting protein-like0.081
CD2CD2 molecule0.075
MED28mediator complex subunit 280.073
STRADASTE20-related kinase adaptor alpha0.071
BIRC2baculoviral IAP repeat containing 20.071
SNAP23synaptosomal-associated protein, 23kDa0.071
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.069
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.068
HDAC7histone deacetylase 70.067
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.066
TRIM32tripartite motif containing 320.061
EGFRepidermal growth factor receptor0.060
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.056
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.056
SQSTM1sequestosome 10.051
SLASrc-like-adaptor0.049
TRAF5TNF receptor-associated factor 50.049
GRAP2GRB2-related adaptor protein 20.045
HCKhemopoietic cell kinase0.045
IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase0.043
PDCD6IPprogrammed cell death 6 interacting protein0.041
TANKTRAF family member-associated NFKB activator0.041
SMURF2SMAD specific E3 ubiquitin protein ligase 20.039
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.039
PTK2BPTK2B protein tyrosine kinase 2 beta0.039
METmet proto-oncogene (hepatocyte growth factor receptor)0.039
PSEN2presenilin 2 (Alzheimer disease 4)0.037
UBASH3Bubiquitin associated and SH3 domain containing B0.037
MICAMHC class I polypeptide-related sequence A0.036
SHC3SHC (Src homology 2 domain containing) transforming protein 30.036
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.035
PILRApaired immunoglobin-like type 2 receptor alpha0.034
BTKBruton agammaglobulinemia tyrosine kinase0.033
MAP2K1mitogen-activated protein kinase kinase 10.033
PTK2PTK2 protein tyrosine kinase 20.033
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.032
NCK1NCK adaptor protein 10.031
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.030
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Latlinker for activation of T cells1.000
Ikzf1IKAROS family zinc finger 10.999
Inpp5dinositol polyphosphate-5-phosphatase D0.998
Ptprcprotein tyrosine phosphatase, receptor type, C0.998
Il2rginterleukin 2 receptor, gamma chain0.995
Lcklymphocyte protein tyrosine kinase0.993
Foxp3forkhead box P30.992
Tnftumor necrosis factor0.992
Map3k14mitogen-activated protein kinase kinase kinase 140.991
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.991
TcraT-cell receptor alpha chain0.991
Cd247CD247 antigen0.972
ItkIL2-inducible T-cell kinase0.961
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.942
Gata4GATA binding protein 40.915
FasFas (TNF receptor superfamily member 6)0.905
Ifnginterferon gamma0.896
Tnfaip3tumor necrosis factor, alpha-induced protein 30.894
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.893
FynFyn proto-oncogene0.883
Ltalymphotoxin A0.869
Cd19CD19 antigen0.827
Flt1FMS-like tyrosine kinase 10.815
Il2rbinterleukin 2 receptor, beta chain0.812
CblCasitas B-lineage lymphoma0.802
Ccr1chemokine (C-C motif) receptor 10.802
Icosinducible T-cell co-stimulator0.778
Lyz2lysozyme 20.757
Ccr2chemokine (C-C motif) receptor 20.757
Cd4CD4 antigen0.728
Stat3signal transducer and activator of transcription 30.718
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.705
Grb2growth factor receptor bound protein 20.662
Il7rinterleukin 7 receptor0.619
Cd80CD80 antigen0.616
Il2interleukin 20.613
Jak2Janus kinase 20.605
Notch1Notch gene homolog 1 (Drosophila)0.585
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.566
Ccr6chemokine (C-C motif) receptor 60.538
Ltblymphotoxin B0.531
Cd22CD22 antigen0.525
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.523
Cd40CD40 antigen0.518
Cd44CD44 antigen0.502
Cdh5cadherin 50.499
Cxcl13chemokine (C-X-C motif) ligand 130.481
Il4interleukin 40.477
Cd8aCD8 antigen, alpha chain0.463
Casp8caspase 80.427
Itgalintegrin alpha L0.426
Il27rainterleukin 27 receptor, alpha0.417
Dok1docking protein 10.416
Prdm1PR domain containing 1, with ZNF domain0.416
WasWiskott-Aldrich syndrome homolog (human)0.415
Zap70zeta-chain (TCR) associated protein kinase0.413
Vav1vav 1 oncogene0.405
Plcg1phospholipase C, gamma 10.381
Ccr7chemokine (C-C motif) receptor 70.376
Shc1src homology 2 domain-containing transforming protein C10.360
Zfpm2zinc finger protein, multitype 20.353
Prkcdprotein kinase C, delta0.349
Klrd1killer cell lectin-like receptor, subfamily D, member 10.346
Relreticuloendotheliosis oncogene0.342
Foxn1forkhead box N10.338
Igkimmunoglobulin kappa chain complex0.328
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.314
Myo1fmyosin IF0.304
Pdcd1programmed cell death 10.304
Cd6CD6 antigen0.290
Il1r1interleukin 1 receptor, type I0.289
Fcgr2bFc receptor, IgG, low affinity IIb0.287
Socs1suppressor of cytokine signaling 10.287
Acvrl1activin A receptor, type II-like 10.280
Smad4MAD homolog 4 (Drosophila)0.277
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.276
Irf4interferon regulatory factor 40.272
Cd86CD86 antigen0.270
Map3k7mitogen-activated protein kinase kinase kinase 70.266
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.260
S1pr2sphingosine-1-phosphate receptor 20.243
Ccl3chemokine (C-C motif) ligand 30.240
Tnip1TNFAIP3 interacting protein 10.239
Il10interleukin 100.239
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.235
Cd28CD28 antigen0.231
Rag2recombination activating gene 20.228
Ccl2chemokine (C-C motif) ligand 20.223
Ighimmunoglobulin heavy chain complex0.223
Cd3eCD3 antigen, epsilon polypeptide0.216
Itgaxintegrin alpha X0.214
Ciitaclass II transactivator0.214
Slamf6SLAM family member 60.211
Rc3h1RING CCCH (C3H) domains 10.202
Cd8b1CD8 antigen, beta chain 10.200
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.198
Hrhairless0.196
Card11caspase recruitment domain family, member 110.195
Cd7CD7 antigen0.194
Cd2CD2 antigen0.192
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cd247Cd247 molecule0.205
Stk10serine/threonine kinase 100.136
Sash3SAM and SH3 domain containing 30.130
Tnfrsf14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.121
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.120
Cd2Cd2 molecule0.120
TcrbT-cell receptor beta chain0.107
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.085
Cd3gCD3 molecule, gamma0.074
Ccl5chemokine (C-C motif) ligand 50.068
Ptpn18protein tyrosine phosphatase, non-receptor type 180.062
Cd37CD37 molecule0.061
Cd3dCD3 molecule, delta0.056
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.054
Klrd1killer cell lectin-like receptor, subfamily D, member 10.049
Cd8aCD8a molecule0.048
Arhgap4Rho GTPase activating protein 40.046
Lcp2lymphocyte cytosolic protein 20.043
Dock8dedicator of cytokinesis 80.041
Adrb2adrenergic, beta-2-, receptor, surface0.040
Stat4signal transducer and activator of transcription 40.038
Igh-6immunoglobulin heavy chain 60.036
Il2rbinterleukin 2 receptor, beta0.036
Prf1perforin 1 (pore forming protein)0.035
Ets1v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)0.033
Il2rginterleukin 2 receptor, gamma0.032
Ctsecathepsin E0.032
Icosinducible T-cell co-stimulator0.030
Map4k1mitogen activated protein kinase kinase kinase kinase 10.029
Cd3eCD3 molecule, epsilon0.028
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.026
Il7rinterleukin 7 receptor0.025
Sh2d1aSH2 domain protein 1A0.025
Bin2bridging integrator 20.025
Sorbs1sorbin and SH3 domain containing 10.024
Prkcbprotein kinase C, beta0.024
Epsti1epithelial stromal interaction 1 (breast)0.023
Serpinb6bserine (or cysteine) peptidase inhibitor, clade B, member 6b0.023
Arrb2arrestin, beta 20.023
GrapGRB2-related adaptor protein0.023
Otud5OTU domain containing 50.022
Spnsialophorin0.022
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.022
Inpp5dinositol polyphosphate-5-phosphatase D0.022
Fam26ffamily with sequence similarity 26, member F0.022
Cxcr4chemokine (C-X-C motif) receptor 40.022
FynFYN oncogene related to SRC, FGR, YES0.022
Ptprcapprotein tyrosine phosphatase, receptor type, C-associated protein0.022
Aif1allograft inflammatory factor 10.021
Dgkadiacylglycerol kinase, alpha0.021
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.021
Ptprsprotein tyrosine phosphatase, receptor type, S0.020
P2ry10purinergic receptor P2Y, G-protein coupled, 100.020
Hcsthematopoietic cell signal transducer0.020
Mca32mast cell antigen 320.019
Ptpn7protein tyrosine phosphatase, non-receptor type 70.019
Traf3ip3TRAF3 interacting protein 30.019
Hckhemopoietic cell kinase0.019
Stap1signal transducing adaptor family member 10.019
Prkchprotein kinase C, eta0.018
Cdc2l6cell division cycle 2-like 6 (CDK8-like)0.018
Ralav-ral simian leukemia viral oncogene homolog A (ras related)0.018
LOC363326hypothetical LOC3633260.018
Ciitaclass II, major histocompatibility complex, transactivator0.018
Slfn2schlafen 20.018
Elmo2engulfment and cell motility 20.018
Evi2aecotropic viral integration site 2A0.018
Coro1acoronin, actin binding protein 1A0.017
Nkg7natural killer cell group 7 sequence0.017
Gzmagranzyme A0.017
UgcgUDP-glucose ceramide glucosyltransferase0.017
Zap70zeta-chain (TCR) associated protein kinase0.017
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.017
Glg1golgi apparatus protein 10.017
Tpm3tropomyosin 3, gamma0.017
Plcg2phospholipase C, gamma 20.017
Myo1emyosin IE0.017
St13suppression of tumorigenicity 130.016
RT1-BaRT1 class II, locus Ba0.016
Casp1caspase 10.016
Man2c1mannosidase, alpha, class 2C, member 10.016
Baz1abromodomain adjacent to zinc finger domain, 1A0.016
Map4microtubule-associated protein 40.016
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.016
Slc27a1solute carrier family 27 (fatty acid transporter), member 10.016
CremcAMP responsive element modulator0.015
Vdac1voltage-dependent anion channel 10.015
Dnajc14DnaJ (Hsp40) homolog, subfamily C, member 140.015
Dd25hypothetical protein Dd250.015
Nrp1neuropilin 10.015
Atp2a3ATPase, Ca++ transporting, ubiquitous0.015
Gimap4GTPase, IMAP family member 40.015
Dennd3DENN/MADD domain containing 30.015
Phemxpan hematopoietic expression0.015
Lrmplymphoid-restricted membrane protein0.015
Plekho1pleckstrin homology domain containing, family O member 10.015
TxkTXK tyrosine kinase0.014
Ccr5chemokine (C-C motif) receptor 50.014
Latlinker for activation of T cells0.014
Dctn4dynactin 40.014
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism