The network for 'canonical wnt signaling pathway involved in cardiac muscle cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

canonical wnt signaling pathway involved in cardiac muscle cell fate commitment

The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin and contributing to cardiac muscle cell fate commitment. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.

NameDescriptionProbabilityFunc Analog Organism
NOTCH1notch 11.000
SPENspen homolog, transcriptional regulator (Drosophila)1.000
ATXN1Lataxin 1-like1.000
LRP6low density lipoprotein receptor-related protein 61.000
MAML1mastermind-like 1 (Drosophila)1.000
NCOR2nuclear receptor corepressor 21.000
FZD1frizzled homolog 1 (Drosophila)0.998
JAG1jagged 10.979
FGF18fibroblast growth factor 180.974
SNW1SNW domain containing 10.901
CIR1corepressor interacting with RBPJ, 10.873
WNT10Awingless-type MMTV integration site family, member 10A0.775
NOTCH3notch 30.712
LBX1ladybird homeobox 10.698
FZD8frizzled homolog 8 (Drosophila)0.674
WNT1wingless-type MMTV integration site family, member 10.577
PGRprogesterone receptor0.573
FGF3fibroblast growth factor 30.562
WNT3wingless-type MMTV integration site family, member 30.548
IHHIndian hedgehog0.534
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.516
WIF1WNT inhibitory factor 10.499
NOTCH2notch 20.450
SFRP1secreted frizzled-related protein 10.447
FGF4fibroblast growth factor 40.420
FGF8fibroblast growth factor 8 (androgen-induced)0.415
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.380
HES2hairy and enhancer of split 2 (Drosophila)0.376
SART1squamous cell carcinoma antigen recognized by T cells0.361
ATXN1ataxin 10.343
AQP5aquaporin 50.321
SHHsonic hedgehog0.283
MMP11matrix metallopeptidase 11 (stromelysin 3)0.267
RAXretina and anterior neural fold homeobox0.258
BHLHE23basic helix-loop-helix family, member e230.246
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.227
FOXF2forkhead box F20.217
ZNF830zinc finger protein 8300.217
CTNNBL1catenin, beta like 10.202
WNT4wingless-type MMTV integration site family, member 40.183
KIAA0174KIAA01740.181
HS3ST6heparan sulfate (glucosamine) 3-O-sulfotransferase 60.171
ACANaggrecan0.159
PPARAperoxisome proliferator-activated receptor alpha0.158
SOX21SRY (sex determining region Y)-box 210.158
DLX4distal-less homeobox 40.156
SOX1SRY (sex determining region Y)-box 10.145
MDFIMyoD family inhibitor0.141
FOXD3forkhead box D30.141
BMP8Abone morphogenetic protein 8a0.141
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.136
DRD4dopamine receptor D40.134
KDM5Alysine (K)-specific demethylase 5A0.134
FOXL1forkhead box L10.133
HOXC8homeobox C80.133
NPAS1neuronal PAS domain protein 10.132
FOXE1forkhead box E1 (thyroid transcription factor 2)0.128
SIX2SIX homeobox 20.128
TLX3T-cell leukemia homeobox 30.125
CDX1caudal type homeobox 10.121
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.115
WNT11wingless-type MMTV integration site family, member 110.114
VSTM2LV-set and transmembrane domain containing 2 like0.111
FAM46Afamily with sequence similarity 46, member A0.110
P2RX2purinergic receptor P2X, ligand-gated ion channel, 20.110
ENTPD2ectonucleoside triphosphate diphosphohydrolase 20.108
GDNFglial cell derived neurotrophic factor0.107
DLL1delta-like 1 (Drosophila)0.107
PAX8paired box 80.107
GSK3Bglycogen synthase kinase 3 beta0.106
WNT7Awingless-type MMTV integration site family, member 7A0.106
SIX5SIX homeobox 50.103
GUCA2Aguanylate cyclase activator 2A (guanylin)0.102
FZD2frizzled homolog 2 (Drosophila)0.097
C1QL1complement component 1, q subcomponent-like 10.095
HOXD13homeobox D130.095
JAG2jagged 20.094
EXOC3L2exocyst complex component 3-like 20.089
FZD10frizzled homolog 10 (Drosophila)0.087
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.087
POU3F1POU class 3 homeobox 10.085
PAX7paired box 70.082
NKX2-1NK2 homeobox 10.082
COL2A1collagen, type II, alpha 10.079
FIBCD1fibrinogen C domain containing 10.078
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.076
CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 10.075
HOXA11homeobox A110.075
WNT2wingless-type MMTV integration site family member 20.074
CRLF1cytokine receptor-like factor 10.073
FOXB1forkhead box B10.073
WNT6wingless-type MMTV integration site family, member 60.069
SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.069
HOXD9homeobox D90.067
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.066
WNT3Awingless-type MMTV integration site family, member 3A0.066
LMX1ALIM homeobox transcription factor 1, alpha0.066
BMP4bone morphogenetic protein 40.064
VSX1visual system homeobox 10.064
NKD2naked cuticle homolog 2 (Drosophila)0.063
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)0.281
Emx1empty spiracles homolog 1 (Drosophila)0.245
Shhsonic hedgehog0.219
Wnt3awingless-related MMTV integration site 3A0.091
Prrx2paired related homeobox 20.083
Notch2Notch gene homolog 2 (Drosophila)0.083
Ctnnb1catenin (cadherin associated protein), beta 10.048
Psen1presenilin 10.046
Otx2orthodenticle homolog 2 (Drosophila)0.034
Bmp4bone morphogenetic protein 40.028
Foxc1forkhead box C10.026
Fgfr2fibroblast growth factor receptor 20.026
Dll1delta-like 1 (Drosophila)0.023
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.022
Pax3paired box gene 30.021
Jag1jagged 10.020
Fgf8fibroblast growth factor 80.017
Hes1hairy and enhancer of split 1 (Drosophila)0.017
Col13a1collagen, type XIII, alpha 10.017
Foxc2forkhead box C20.016
Efna4ephrin A40.015
Umoduromodulin0.014
Tbx1T-box 10.014
Gli3GLI-Kruppel family member GLI30.014
Fgfr1fibroblast growth factor receptor 10.013
Lrp6low density lipoprotein receptor-related protein 60.013
Sox2SRY-box containing gene 20.012
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.012
Sox9SRY-box containing gene 90.012
Pitx2paired-like homeodomain transcription factor 20.012
Hand2heart and neural crest derivatives expressed transcript 20.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism