The network for 'notch signaling involved in heart development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

notch signaling involved in heart development

The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time.

NameDescriptionProbabilityFunc Analog Organism
NOTCH1notch 11.000
NOTCH3notch 31.000
JAG1jagged 11.000
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.998
NOTCH2notch 20.892
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.880
XIAPX-linked inhibitor of apoptosis0.779
DLL1delta-like 1 (Drosophila)0.715
JAG2jagged 20.691
GFI1Bgrowth factor independent 1B transcription repressor0.677
MAML1mastermind-like 1 (Drosophila)0.658
JUBjub, ajuba homolog (Xenopus laevis)0.374
NOTCH2NLnotch 2 N-terminal like0.136
EGFL7EGF-like-domain, multiple 70.092
EGR1early growth response 10.062
KDM1Alysine (K)-specific demethylase 1A0.044
FBLN1fibulin 10.043
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.033
ATN1atrophin 10.021
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.017
HEY1hairy/enhancer-of-split related with YRPW motif 10.016
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.013
SPENspen homolog, transcriptional regulator (Drosophila)0.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)1.000
Psen1presenilin 10.962
Dll1delta-like 1 (Drosophila)0.934
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.862
Chd7chromodomain helicase DNA binding protein 70.711
Notch2Notch gene homolog 2 (Drosophila)0.603
Fgfr1fibroblast growth factor receptor 10.189
Pitx2paired-like homeodomain transcription factor 20.157
Gata4GATA binding protein 40.102
Meox2mesenchyme homeobox 20.076
Jag1jagged 10.076
Pax3paired box gene 30.070
Vangl2vang-like 2 (van gogh, Drosophila)0.066
Foxc1forkhead box C10.065
Psen2presenilin 20.058
LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase0.056
Efnb2ephrin B20.056
Vegfavascular endothelial growth factor A0.051
Ctnnb1catenin (cadherin associated protein), beta 10.050
Rb1retinoblastoma 10.047
Rxraretinoid X receptor alpha0.045
Hes1hairy and enhancer of split 1 (Drosophila)0.045
Tbx1T-box 10.038
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.032
Itgb1integrin beta 1 (fibronectin receptor beta)0.032
Dll4delta-like 4 (Drosophila)0.032
Hspg2perlecan (heparan sulfate proteoglycan 2)0.032
Nos3nitric oxide synthase 3, endothelial cell0.031
Tgfb2transforming growth factor, beta 20.028
Egfl7EGF-like domain 70.025
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.025
Foxc2forkhead box C20.025
Lama5laminin, alpha 50.023
Ptf1apancreas specific transcription factor, 1a0.021
Fgf8fibroblast growth factor 80.016
Fgfr2fibroblast growth factor receptor 20.014
Hey2hairy/enhancer-of-split related with YRPW motif 20.013
Cdkn1bcyclin-dependent kinase inhibitor 1B0.013
Zfpm2zinc finger protein, multitype 20.012
NrarpNotch-regulated ankyrin repeat protein0.012
Efnb1ephrin B10.012
Ptk7PTK7 protein tyrosine kinase 70.011
Shhsonic hedgehog0.010
Pax1paired box gene 10.010
Neurl1aneuralized homolog 1A (Drosophila)0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism