The network for 'regulation of leukocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of leukocyte activation

Any process that modulates the frequency, rate, or extent of leukocyte activation.

NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
LCKlymphocyte-specific protein tyrosine kinase1.000
SYKspleen tyrosine kinase0.998
CAV1caveolin 1, caveolae protein, 22kDa0.996
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.992
GRB2growth factor receptor-bound protein 20.992
PTPN6protein tyrosine phosphatase, non-receptor type 60.987
PTPN1protein tyrosine phosphatase, non-receptor type 10.986
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.982
SHC1SHC (Src homology 2 domain containing) transforming protein 10.977
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.967
IL4Rinterleukin 4 receptor0.963
BIRC3baculoviral IAP repeat containing 30.943
FYNFYN oncogene related to SRC, FGR, YES0.916
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.888
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.883
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.880
ICAM1intercellular adhesion molecule 10.861
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.847
TRAF1TNF receptor-associated factor 10.821
HLA-Bmajor histocompatibility complex, class I, B0.797
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.793
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.782
BTN3A1butyrophilin, subfamily 3, member A10.746
BCL2B-cell CLL/lymphoma 20.731
AXLAXL receptor tyrosine kinase0.731
TGIF1TGFB-induced factor homeobox 10.730
HLA-Fmajor histocompatibility complex, class I, F0.730
B2Mbeta-2-microglobulin0.728
LTAlymphotoxin alpha (TNF superfamily, member 1)0.716
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.716
RIPK2receptor-interacting serine-threonine kinase 20.715
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.712
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.711
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.710
FGFR2fibroblast growth factor receptor 20.703
CTLA4cytotoxic T-lymphocyte-associated protein 40.695
CD80CD80 molecule0.693
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.681
HLA-DMBmajor histocompatibility complex, class II, DM beta0.678
EGFRepidermal growth factor receptor0.659
CCR7chemokine (C-C motif) receptor 70.653
IRF4interferon regulatory factor 40.646
BTKBruton agammaglobulinemia tyrosine kinase0.643
CD2CD2 molecule0.632
HLA-Emajor histocompatibility complex, class I, E0.627
BIDBH3 interacting domain death agonist0.623
SLAMF1signaling lymphocytic activation molecule family member 10.614
PLCG1phospholipase C, gamma 10.583
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.581
SH2D1ASH2 domain containing 1A0.574
TNFRSF9tumor necrosis factor receptor superfamily, member 90.570
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.544
HLA-Cmajor histocompatibility complex, class I, C0.543
MYD88myeloid differentiation primary response gene (88)0.542
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.540
CD28CD28 molecule0.534
CCL22chemokine (C-C motif) ligand 220.531
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.531
SIGLEC7sialic acid binding Ig-like lectin 70.527
PMLpromyelocytic leukemia0.520
CXCL9chemokine (C-X-C motif) ligand 90.520
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.519
CD86CD86 molecule0.517
PAX3paired box 30.510
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.509
BCL2L1BCL2-like 10.509
CD6CD6 molecule0.505
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.505
IRAK1interleukin-1 receptor-associated kinase 10.497
BTN3A3butyrophilin, subfamily 3, member A30.484
HLA-Amajor histocompatibility complex, class I, A0.484
IL1R1interleukin 1 receptor, type I0.482
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.481
BLNKB-cell linker0.474
SOCS3suppressor of cytokine signaling 30.471
NCK1NCK adaptor protein 10.459
PTPRCprotein tyrosine phosphatase, receptor type, C0.451
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.450
TFF1trefoil factor 10.424
SMAD7SMAD family member 70.423
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.420
CCL4chemokine (C-C motif) ligand 40.411
ABI1abl-interactor 10.410
CCR5chemokine (C-C motif) receptor 50.407
HLA-Gmajor histocompatibility complex, class I, G0.404
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.396
IL16interleukin 16 (lymphocyte chemoattractant factor)0.392
VAV1vav 1 guanine nucleotide exchange factor0.379
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.378
TNFAIP3tumor necrosis factor, alpha-induced protein 30.368
FYBFYN binding protein0.366
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.364
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.359
TNFtumor necrosis factor0.349
CCL2chemokine (C-C motif) ligand 20.343
CD247CD247 molecule0.343
IL4interleukin 40.342
BTN3A2butyrophilin, subfamily 3, member A20.341
CCL13chemokine (C-C motif) ligand 130.341
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-BaRT1 class II, locus Ba0.778
Ptprcprotein tyrosine phosphatase, receptor type, C0.632
Cd5Cd5 molecule0.522
RT1-BbRT1 class II, locus Bb0.367
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.307
Reg3bregenerating islet-derived 3 beta0.304
RT1-DaRT1 class II, locus Da0.301
Cd2Cd2 molecule0.298
Csf1colony stimulating factor 1 (macrophage)0.233
Ptafrplatelet-activating factor receptor0.189
Calcrlcalcitonin receptor-like0.174
Cd247Cd247 molecule0.172
Cd4Cd4 molecule0.165
Spnsialophorin0.164
LOC100361571keratin associated protein 1-3-like0.161
Flt1FMS-related tyrosine kinase 10.154
Hdac7histone deacetylase 70.152
Il17rainterleukin 17 receptor A0.142
Anxa2annexin A20.141
Sdc3syndecan 30.139
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.138
RT1-Db1RT1 class II, locus Db10.135
Gzmkgranzyme K0.131
Nr5a2nuclear receptor subfamily 5, group A, member 20.126
Ptger4prostaglandin E receptor 4 (subtype EP4)0.126
RT1-DMbRT1 class II, locus DMb0.118
Cfpcomplement factor properdin0.115
Cd44Cd44 molecule0.115
Lyz2lysozyme 20.113
Ciitaclass II, major histocompatibility complex, transactivator0.112
Lef1lymphoid enhancer binding factor 10.112
Wipf1WAS/WASL interacting protein family, member 10.111
Arhgap4Rho GTPase activating protein 40.110
Il6interleukin 60.109
Dnase1l3deoxyribonuclease 1-like 30.109
Ccr5chemokine (C-C motif) receptor 50.108
Tp53tumor protein p530.106
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.105
Il1r1interleukin 1 receptor, type I0.104
Vipvasoactive intestinal peptide0.099
RGD1304644similar to RIKEN cDNA 2310046K010.099
Cd3gCD3 molecule, gamma0.099
Pla2g10phospholipase A2, group X0.098
Syt8synaptotagmin VIII0.098
Socs3suppressor of cytokine signaling 30.096
Apbb1ipamyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein0.095
Clec4a1C-type lectin domain family 4, member a10.093
Ltalymphotoxin alpha (TNF superfamily, member 1)0.092
Gfra2GDNF family receptor alpha 20.092
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.089
Hckhemopoietic cell kinase0.088
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.088
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.088
Cybbcytochrome b-245, beta polypeptide0.084
Il9rinterleukin 9 receptor0.084
FaslgFas ligand (TNF superfamily, member 6)0.084
Grin2aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.083
Ptger2prostaglandin E receptor 2 (subtype EP2)0.079
Ppyr1pancreatic polypeptide receptor 10.076
Lrg1leucine-rich alpha-2-glycoprotein 10.076
Alox5arachidonate 5-lipoxygenase0.075
Itgb7integrin, beta 70.074
Cd53Cd53 molecule0.071
Aspgasparaginase homolog (S. cerevisiae)0.071
Reg1aregenerating islet-derived 1 alpha0.069
Csn1s1casein alpha s10.069
Il2rginterleukin 2 receptor, gamma0.069
Itgadintegrin, alpha D0.068
Cxcr5chemokine (C-X-C motif) receptor 50.068
Psd4pleckstrin and Sec7 domain containing 40.067
Tshbthyroid stimulating hormone, beta0.066
Slfn2schlafen 20.066
Tbxas1thromboxane A synthase 1, platelet0.065
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.065
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.065
Arhgap25Rho GTPase activating protein 250.065
NrarpNotch-regulated ankyrin repeat protein0.065
Olr1078olfactory receptor 10780.064
Scn11asodium channel, voltage-gated, type XI, alpha0.063
Rassf5Ras association (RalGDS/AF-6) domain family member 50.063
Reg3gregenerating islet-derived 3 gamma0.063
Casp1caspase 10.063
Notch3Notch homolog 3 (Drosophila)0.063
Cd37CD37 molecule0.062
Tgfbr2transforming growth factor, beta receptor II0.062
Mmp10matrix metallopeptidase 100.062
Atp2b4ATPase, Ca++ transporting, plasma membrane 40.061
Bcanbrevican0.059
Map4k1mitogen activated protein kinase kinase kinase kinase 10.059
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.058
Cd38CD38 molecule0.058
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.057
Leprleptin receptor0.057
Tgfbr3transforming growth factor, beta receptor III0.056
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.055
Ncr1natural cytotoxicity triggering receptor 10.055
Bin2bridging integrator 20.055
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.054
Pecam1platelet/endothelial cell adhesion molecule 10.054
Cd40lgCD40 ligand0.053
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism