The network for 'positive regulation of leukocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of leukocyte activation

Any process that activates or increases the frequency, rate, or extent of leukocyte activation.

NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase1.000
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.997
SYKspleen tyrosine kinase0.996
PTPN6protein tyrosine phosphatase, non-receptor type 60.990
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.990
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.979
INSRinsulin receptor0.973
GRB2growth factor receptor-bound protein 20.967
CAV1caveolin 1, caveolae protein, 22kDa0.943
BCL2B-cell CLL/lymphoma 20.920
HLA-Fmajor histocompatibility complex, class I, F0.908
CD80CD80 molecule0.871
HLA-Gmajor histocompatibility complex, class I, G0.847
PTPN1protein tyrosine phosphatase, non-receptor type 10.842
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.842
HLA-Bmajor histocompatibility complex, class I, B0.802
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.788
B2Mbeta-2-microglobulin0.780
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.775
HLA-DMBmajor histocompatibility complex, class II, DM beta0.774
LATlinker for activation of T cells0.752
IL1R1interleukin 1 receptor, type I0.748
HLA-Cmajor histocompatibility complex, class I, C0.704
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.697
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.697
HLA-Amajor histocompatibility complex, class I, A0.678
HLA-Emajor histocompatibility complex, class I, E0.657
CXCL9chemokine (C-X-C motif) ligand 90.653
CREBBPCREB binding protein0.652
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.647
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.640
SH3KBP1SH3-domain kinase binding protein 10.635
IL2RBinterleukin 2 receptor, beta0.607
ICAM1intercellular adhesion molecule 10.595
PTPRCprotein tyrosine phosphatase, receptor type, C0.591
CCL5chemokine (C-C motif) ligand 50.577
FASFas (TNF receptor superfamily, member 6)0.573
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.565
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.563
SH3BP2SH3-domain binding protein 20.552
PMLpromyelocytic leukemia0.539
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.527
CD86CD86 molecule0.526
HLA-DRB5major histocompatibility complex, class II, DR beta 50.526
STAT4signal transducer and activator of transcription 40.520
CCR7chemokine (C-C motif) receptor 70.517
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.501
CDK2cyclin-dependent kinase 20.494
BCL2L1BCL2-like 10.492
IL4Rinterleukin 4 receptor0.468
CTLA4cytotoxic T-lymphocyte-associated protein 40.466
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.459
BTN3A1butyrophilin, subfamily 3, member A10.455
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.452
SHC1SHC (Src homology 2 domain containing) transforming protein 10.413
TICAM2toll-like receptor adaptor molecule 20.409
CCL22chemokine (C-C motif) ligand 220.395
CASP8caspase 8, apoptosis-related cysteine peptidase0.386
SIGLEC7sialic acid binding Ig-like lectin 70.384
CXCL2chemokine (C-X-C motif) ligand 20.377
CD247CD247 molecule0.376
CCR5chemokine (C-C motif) receptor 50.376
HCKhemopoietic cell kinase0.373
BLNKB-cell linker0.370
NCOR2nuclear receptor corepressor 20.366
RUNX1runt-related transcription factor 10.365
CCL4chemokine (C-C motif) ligand 40.359
IL2RGinterleukin 2 receptor, gamma0.359
ABI1abl-interactor 10.357
ESR1estrogen receptor 10.352
IL1Binterleukin 1, beta0.351
LIN9lin-9 homolog (C. elegans)0.341
CXCL10chemokine (C-X-C motif) ligand 100.338
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.331
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.327
FGFR2fibroblast growth factor receptor 20.326
TNFRSF9tumor necrosis factor receptor superfamily, member 90.310
TGIF1TGFB-induced factor homeobox 10.310
RXRAretinoid X receptor, alpha0.307
NLRC4NLR family, CARD domain containing 40.307
GBAglucosidase, beta, acid0.305
PLCG1phospholipase C, gamma 10.297
TLR2toll-like receptor 20.291
BTN3A2butyrophilin, subfamily 3, member A20.286
IFNGinterferon, gamma0.283
IRF4interferon regulatory factor 40.276
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.274
HDAC9histone deacetylase 90.274
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.272
GAS7growth arrest-specific 70.271
IL10interleukin 100.265
ZAP70zeta-chain (TCR) associated protein kinase 70kDa0.262
LST1leukocyte specific transcript 10.257
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.250
CD28CD28 molecule0.242
PTENphosphatase and tensin homolog0.239
CD1CCD1c molecule0.238
CARD11caspase recruitment domain family, member 110.238
CCL13chemokine (C-C motif) ligand 130.231
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
RT1-BaRT1 class II, locus Ba0.787
RT1-DaRT1 class II, locus Da0.374
Cd5Cd5 molecule0.336
Ptprcprotein tyrosine phosphatase, receptor type, C0.307
Cd37CD37 molecule0.288
Cd3gCD3 molecule, gamma0.272
RT1-Db1RT1 class II, locus Db10.256
Rassf5Ras association (RalGDS/AF-6) domain family member 50.193
Casp1caspase 10.191
Cd247Cd247 molecule0.190
Il9rinterleukin 9 receptor0.184
Il2rbinterleukin 2 receptor, beta0.176
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.157
Ccr5chemokine (C-C motif) receptor 50.143
Itgb7integrin, beta 70.121
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.121
LOC100364854similar to RIKEN cDNA A430107P09 gene-like0.105
Cxcr3chemokine (C-X-C motif) receptor 30.104
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.104
Csf1colony stimulating factor 1 (macrophage)0.097
Cybbcytochrome b-245, beta polypeptide0.094
Gzmkgranzyme K0.092
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.092
Cd53Cd53 molecule0.091
Dnase1l3deoxyribonuclease 1-like 30.087
Cd48Cd48 molecule0.086
Socs3suppressor of cytokine signaling 30.082
Map3k3mitogen activated protein kinase kinase kinase 30.082
Klrd1killer cell lectin-like receptor, subfamily D, member 10.081
Cd4Cd4 molecule0.080
Cd40lgCD40 ligand0.075
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.075
Il13interleukin 130.074
Syt8synaptotagmin VIII0.074
Ptger4prostaglandin E receptor 4 (subtype EP4)0.072
TcrbT-cell receptor beta chain0.070
Cd38CD38 molecule0.069
Tgfbr3transforming growth factor, beta receptor III0.068
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.068
Zic1Zic family member 1 (odd-paired homolog, Drosophila)0.068
Lim2lens intrinsic membrane protein 20.066
Il1binterleukin 1 beta0.064
Sirpasignal-regulatory protein alpha0.064
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.064
Il2rginterleukin 2 receptor, gamma0.063
Igh-6immunoglobulin heavy chain 60.063
Icosinducible T-cell co-stimulator0.062
Fgbfibrinogen beta chain0.060
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.060
Nkg7natural killer cell group 7 sequence0.057
Arhgap4Rho GTPase activating protein 40.057
Tgfbr2transforming growth factor, beta receptor II0.055
Rab3il1RAB3A interacting protein (rabin3)-like 10.055
Ptafrplatelet-activating factor receptor0.054
Itgadintegrin, alpha D0.054
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.053
RT1-BbRT1 class II, locus Bb0.053
Cpa3carboxypeptidase A3, mast cell0.053
Psd4pleckstrin and Sec7 domain containing 40.051
Ucnurocortin0.051
Il1r1interleukin 1 receptor, type I0.051
Scn11asodium channel, voltage-gated, type XI, alpha0.051
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.050
Vipvasoactive intestinal peptide0.049
Cd86CD86 molecule0.049
Cd2Cd2 molecule0.049
Ciitaclass II, major histocompatibility complex, transactivator0.048
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.048
Latlinker for activation of T cells0.047
Ncanneurocan0.046
Cfpcomplement factor properdin0.043
Olr1078olfactory receptor 10780.043
Cmklr1chemokine-like receptor 10.043
Fam26ffamily with sequence similarity 26, member F0.041
Plinperilipin0.040
Alox5arachidonate 5-lipoxygenase0.040
Olr1500olfactory receptor 15000.040
FaslgFas ligand (TNF superfamily, member 6)0.038
Pecam1platelet/endothelial cell adhesion molecule 10.038
Spnsialophorin0.038
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.037
Fgfr2fibroblast growth factor receptor 20.036
Hdac7histone deacetylase 70.036
Slc7a9solute carrier family 7 (cationic amino acid transporter, y+ system), member 90.035
Ccl5chemokine (C-C motif) ligand 50.035
Il10interleukin 100.035
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.034
Il13ra2interleukin 13 receptor, alpha 20.034
Pou2af1POU class 2 associating factor 10.034
Pspparotid secretory protein0.033
RT1-DMbRT1 class II, locus DMb0.033
Batf3basic leucine zipper transcription factor, ATF-like 30.033
Hckhemopoietic cell kinase0.033
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.033
Cd79bCd79b molecule, immunoglobulin-associated beta0.032
LOC100361706lambda-chain C1-region-like0.032
Il1rl1interleukin 1 receptor-like 10.032
Cxcr5chemokine (C-X-C motif) receptor 50.032
Kynukynureninase (L-kynurenine hydrolase)0.032
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.031
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism