The network for 'positive regulation of leukocyte chemotaxis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of leukocyte chemotaxis

Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.

NameDescriptionProbabilityFunc Analog Organism
CCR5chemokine (C-C motif) receptor 50.999
CXCL9chemokine (C-X-C motif) ligand 90.995
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.984
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.982
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.981
CCL5chemokine (C-C motif) ligand 50.976
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.964
CCL4chemokine (C-C motif) ligand 40.957
VEGFAvascular endothelial growth factor A0.940
CCR1chemokine (C-C motif) receptor 10.931
AXLAXL receptor tyrosine kinase0.913
S100BS100 calcium binding protein B0.901
CXCL10chemokine (C-X-C motif) ligand 100.857
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.848
S100A14S100 calcium binding protein A140.815
S100A16S100 calcium binding protein A160.793
CCR7chemokine (C-C motif) receptor 70.789
PDIA3protein disulfide isomerase family A, member 30.785
IFNGinterferon, gamma0.783
NRP1neuropilin 10.760
S100A1S100 calcium binding protein A10.759
CCL22chemokine (C-C motif) ligand 220.742
CCL2chemokine (C-C motif) ligand 20.739
CXCL11chemokine (C-X-C motif) ligand 110.622
DPP4dipeptidyl-peptidase 40.617
CCL19chemokine (C-C motif) ligand 190.595
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.561
CXCL13chemokine (C-X-C motif) ligand 130.519
CCL8chemokine (C-C motif) ligand 80.515
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.490
CCL13chemokine (C-C motif) ligand 130.489
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.479
CCL7chemokine (C-C motif) ligand 70.468
CCR2chemokine (C-C motif) receptor 20.463
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.456
PLAUplasminogen activator, urokinase0.427
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.415
S100A6S100 calcium binding protein A60.409
IL2RBinterleukin 2 receptor, beta0.409
ABI2abl-interactor 20.400
PLATplasminogen activator, tissue0.365
PLAURplasminogen activator, urokinase receptor0.335
HCKhemopoietic cell kinase0.329
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.314
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.312
MMP12matrix metallopeptidase 12 (macrophage elastase)0.312
IL8interleukin 80.308
COL4A1collagen, type IV, alpha 10.306
PLEKpleckstrin0.302
FYNFYN oncogene related to SRC, FGR, YES0.299
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.295
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.292
CCR4chemokine (C-C motif) receptor 40.287
IL2RGinterleukin 2 receptor, gamma0.262
CCL3chemokine (C-C motif) ligand 30.250
CXCR4chemokine (C-X-C motif) receptor 40.246
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.242
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.236
IL1Binterleukin 1, beta0.224
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.216
CYBBcytochrome b-245, beta polypeptide0.208
CCL11chemokine (C-C motif) ligand 110.207
C2complement component 20.207
CXCR6chemokine (C-X-C motif) receptor 60.206
TNFtumor necrosis factor0.206
CAV1caveolin 1, caveolae protein, 22kDa0.205
SNX9sorting nexin 90.203
VCAM1vascular cell adhesion molecule 10.199
IL7Rinterleukin 7 receptor0.187
CCL20chemokine (C-C motif) ligand 200.177
IL6interleukin 6 (interferon, beta 2)0.174
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.156
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.153
SLAMF7SLAM family member 70.152
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.152
PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)0.152
PTPRAprotein tyrosine phosphatase, receptor type, A0.146
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.145
AQP9aquaporin 90.143
SLAMF8SLAM family member 80.139
TGFB1transforming growth factor, beta 10.133
CLEC7AC-type lectin domain family 7, member A0.123
IRF4interferon regulatory factor 40.123
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.122
FYBFYN binding protein0.121
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.121
CTNND1catenin (cadherin-associated protein), delta 10.118
VCANversican0.116
NCF2neutrophil cytosolic factor 20.116
FN1fibronectin 10.113
LAIR1leukocyte-associated immunoglobulin-like receptor 10.113
COL1A1collagen, type I, alpha 10.112
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.111
IL18RAPinterleukin 18 receptor accessory protein0.108
FCGR3BFc fragment of IgG, low affinity IIIb, receptor (CD16b)0.107
DLG1discs, large homolog 1 (Drosophila)0.106
IGFBP5insulin-like growth factor binding protein 50.106
DNM1dynamin 10.105
LST1leukocyte specific transcript 10.103
LATlinker for activation of T cells0.102
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh5cadherin 50.426
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.332
fli1afriend leukemia integration 1a0.289
etv2ets variant gene 20.205
sox7SRY-box containing gene 70.174
tie2endothelium-specific receptor tyrosine kinase 20.165
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.143
plxnd1plexin D10.123
osr1odd-skipped related 1 (Drosophila)0.098
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.096
efnb2aephrin B2a0.088
tie1endothelium-specific receptor tyrosine kinase 10.083
tll1tolloid-like 10.081
cntn2contactin 20.060
bnc2basonuclin 20.058
dll4delta-like 4 (Drosophila)0.053
wu:fv91b12wu:fv91b120.052
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.051
procprotein C (inactivator of coagulation factors Va and VIIIa)0.049
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.047
ltkleukocyte tyrosine kinase0.044
vegfaavascular endothelial growth factor Aa0.044
kitakit receptor a0.039
hspg2heparan sulfate proteoglycan 20.037
epas1bendothelial PAS domain protein 1b0.036
emilin1aelastin microfibril interfacer 1a0.034
nrp1aneuropilin 1a0.034
postnperiostin, osteoblast specific factor0.033
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.032
gfi1.1growth factor independent 1.10.030
mmp17amatrix metallopeptidase 17a0.030
podxlpodocalyxin-like0.029
calcrlacalcitonin receptor-like a0.029
col12a1collagen, type XII, alpha 10.029
si:ch211-173o4.2si:ch211-173o4.20.028
myod1myogenic differentiation 10.028
lyzlysozyme0.028
myf5myogenic factor 50.028
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.027
f2rcoagulation factor II (thrombin) receptor0.027
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.027
emp2epithelial membrane protein 20.026
wt1bwilms tumor 1b0.026
si:ch211-235f6.2si:ch211-235f6.20.026
ccbe1collagen and calcium binding EGF domains 10.026
col5a1procollagen, type V, alpha 10.025
klf2aKruppel-like factor 2a0.025
runx1runt-related transcription factor 10.025
sema3dsemaphorin 3d0.024
bmp4bone morphogenetic protein 40.024
mcambmelanoma cell adhesion molecule b0.023
ccr9bchemokine (C-C motif) receptor 9b0.023
fmnl2aformin-like 2a0.023
tgfb3transforming growth factor, beta 30.022
si:ch73-60e21.1si:ch73-60e21.10.022
plce1phospholipase C, epsilon 10.022
ntn4netrin 40.022
stab2stabilin 20.022
mitfamicrophthalmia-associated transcription factor a0.022
st8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.021
sulf1sulfatase 10.021
gpr182G protein-coupled receptor 1820.021
dab2disabled homolog 2 (Drosophila)0.020
kitlgakit ligand a0.020
sfrp2secreted frizzled-related protein 20.020
si:dkey-261h17.1si:dkey-261h17.10.020
jag1ajagged 1a0.020
LOC553366hypothetical protein LOC5533660.019
vegfcvascular endothelial growth factor c0.019
pmelapremelanosome protein a0.019
cmybtranscription factor cmyb0.019
sc:d812sc:d8120.019
arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.018
fgf20afibroblast growth factor 20a0.018
ptgs1prostaglandin-endoperoxide synthase 10.018
atp6v0d1ATPase, H+ transporting, V0 subunit D isoform 10.018
aplnrbapelin receptor b0.018
spon2bspondin 2b, extracellular matrix protein0.018
tal1T-cell acute lymphocytic leukemia 10.017
renrenin0.017
mrc1amannose receptor, C type 1a0.017
si:dkey-12o15.1si:dkey-12o15.10.017
tgfbr2transforming growth factor, beta receptor II0.017
rhagRhesus blood group-associated glycoprotein0.017
mapk15mitogen-activated protein kinase 150.017
matn4matrilin 40.017
tp63tumor protein p630.016
ptk6aPTK6 protein tyrosine kinase 6a0.016
csf1racolony stimulating factor 1 receptor, a0.016
ca15acarbonic anhydrase XV a0.016
pax7bpaired box gene 7b0.016
masp2mannan-binding lectin serine peptidase 20.016
ccl25bchemokine (C-C motif) ligand 25b0.016
nf1bneurofibromin 1b0.016
ip6k2inositol hexaphosphate kinase 20.016
cbfbcore-binding factor, beta subunit0.016
wtipWilms tumor 1 interacting protein0.015
spon2aspondin 2a, extracellular matrix protein0.015
egr2bearly growth response 2b0.015
ext1bexostoses (multiple) 1b0.015
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl2chemokine (C-C motif) ligand 20.996
Cxcl10chemokine (C-X-C motif) ligand 100.924
Il6interleukin 60.695
Ccl4chemokine (C-C motif) ligand 40.658
Il1binterleukin 1 beta0.628
Cxcl2chemokine (C-X-C motif) ligand 20.541
Cd14CD14 molecule0.524
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.437
RT1-BaRT1 class II, locus Ba0.387
Il1ainterleukin 1 alpha0.379
Ccl7chemokine (C-C motif) ligand 70.359
Ccl3chemokine (C-C motif) ligand 30.350
Il2rginterleukin 2 receptor, gamma0.338
TcrbT-cell receptor beta chain0.137
Cd53Cd53 molecule0.127
Hckhemopoietic cell kinase0.109
Il8rbinterleukin 8 receptor, beta0.098
Ccr5chemokine (C-C motif) receptor 50.097
RT1-DaRT1 class II, locus Da0.092
Icam1intercellular adhesion molecule 10.089
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.088
Nkg7natural killer cell group 7 sequence0.080
RT1-BbRT1 class II, locus Bb0.080
Elk3ELK3, ETS-domain protein0.073
Ccl20chemokine (C-C motif) ligand 200.073
Fosl1fos-like antigen 10.072
Ptger4prostaglandin E receptor 4 (subtype EP4)0.069
Plekpleckstrin0.069
Plauplasminogen activator, urokinase0.068
MrgprfMAS-related GPR, member F0.067
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.065
Il2rbinterleukin 2 receptor, beta0.064
Thbdthrombomodulin0.063
Reg3gregenerating islet-derived 3 gamma0.059
Casp1caspase 10.055
Cd68Cd68 molecule0.053
Ccr2chemokine (C-C motif) receptor 20.053
Cd37CD37 molecule0.051
Igsf6immunoglobulin superfamily, member 60.051
Laptm5lysosomal protein transmembrane 50.048
Ptprcprotein tyrosine phosphatase, receptor type, C0.047
Socs3suppressor of cytokine signaling 30.046
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.045
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.039
Cd83CD83 molecule0.039
Calcrlcalcitonin receptor-like0.039
Ubdubiquitin D0.039
Reg3bregenerating islet-derived 3 beta0.035
Rhojras homolog gene family, member J0.033
Col12a1collagen, type XII, alpha 10.033
Edn1endothelin 10.032
TyrobpTyro protein tyrosine kinase binding protein0.032
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.030
Klrd1killer cell lectin-like receptor, subfamily D, member 10.030
Jak1Janus kinase 10.030
Seleselectin E0.030
Fcn1ficolin (collagen/fibrinogen domain containing) 10.029
Gzmbgranzyme B0.029
F2rl2coagulation factor II (thrombin) receptor-like 20.029
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.028
Il1rninterleukin 1 receptor antagonist0.028
Slco2b1solute carrier organic anion transporter family, member 2b10.028
Ly86lymphocyte antigen 860.028
Rab20RAB20, member RAS oncogene family0.027
Xcl1chemokine (C motif) ligand 10.027
Gzmkgranzyme K0.026
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.026
Cd86CD86 molecule0.025
F2rl1coagulation factor II (thrombin) receptor-like 10.025
Pld4phospholipase D family, member 40.024
Neurl3neuralized homolog 3 (Drosophila)0.024
Cd8aCD8a molecule0.023
Ptgs2prostaglandin-endoperoxide synthase 20.023
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.023
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.023
F13a1coagulation factor XIII, A1 polypeptide0.022
Cd69Cd69 molecule0.022
Timp3TIMP metallopeptidase inhibitor 30.022
Mmp3matrix metallopeptidase 30.020
Iappislet amyloid polypeptide0.019
Cxcl11chemokine (C-X-C motif) ligand 110.019
S1pr2sphingosine-1-phosphate receptor 20.019
Cd4Cd4 molecule0.019
Cd44Cd44 molecule0.018
Timp1TIMP metallopeptidase inhibitor 10.017
Tfpi2tissue factor pathway inhibitor 20.017
Metmet proto-oncogene0.016
Arl5cADP-ribosylation factor-like 5C0.016
Itgadintegrin, alpha D0.016
ArhgdibRho, GDP dissociation inhibitor (GDI) beta0.016
Tmem88transmembrane protein 880.016
Sellselectin L0.015
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.015
Ngfnerve growth factor (beta polypeptide)0.015
Ly6cLy6-C antigen0.014
Cfdcomplement factor D (adipsin)0.014
Fgfr2fibroblast growth factor receptor 20.014
Mmp12matrix metallopeptidase 120.013
Slpisecretory leukocyte peptidase inhibitor0.013
Ch25hcholesterol 25-hydroxylase0.013
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism