The network for 'cellular response to histamine' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to histamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

NameDescriptionProbabilityFunc Analog Organism
RHOAras homolog gene family, member A0.910
GAS7growth arrest-specific 70.784
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.709
CKAP2Lcytoskeleton associated protein 2-like0.588
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.565
GRIK1glutamate receptor, ionotropic, kainate 10.550
SLC24A2solute carrier family 24 (sodium/potassium/calcium exchanger), member 20.536
SLC17A6solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 60.530
GLRA1glycine receptor, alpha 10.427
UGT2B7UDP glucuronosyltransferase 2 family, polypeptide B70.421
OPRK1opioid receptor, kappa 10.407
GPC5glypican 50.355
GABRA1gamma-aminobutyric acid (GABA) A receptor, alpha 10.333
GRIA1glutamate receptor, ionotropic, AMPA 10.314
GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 40.305
GABRA3gamma-aminobutyric acid (GABA) A receptor, alpha 30.288
CDH8cadherin 8, type 20.276
GABRQgamma-aminobutyric acid (GABA) receptor, theta0.276
SV2Csynaptic vesicle glycoprotein 2C0.263
RIMS2regulating synaptic membrane exocytosis 20.245
DDX25DEAD (Asp-Glu-Ala-Asp) box polypeptide 250.236
GLRA3glycine receptor, alpha 30.233
ELAVL2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)0.220
SLC12A5solute carrier family 12 (potassium/chloride transporter), member 50.210
HTR2A5-hydroxytryptamine (serotonin) receptor 2A0.207
CACNG3calcium channel, voltage-dependent, gamma subunit 30.191
NEUROD2neurogenic differentiation 20.190
GABRA5gamma-aminobutyric acid (GABA) A receptor, alpha 50.182
SNTG1syntrophin, gamma 10.182
CCKBRcholecystokinin B receptor0.175
KCNJ3potassium inwardly-rectifying channel, subfamily J, member 30.174
ASXL2additional sex combs like 2 (Drosophila)0.160
KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 30.156
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 20.152
NRXN1neurexin 10.151
SLC1A6solute carrier family 1 (high affinity aspartate/glutamate transporter), member 60.148
GABRR1gamma-aminobutyric acid (GABA) receptor, rho 10.147
RIT2Ras-like without CAAX 20.145
SYT13synaptotagmin XIII0.144
GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 20.141
DCCdeleted in colorectal carcinoma0.138
NKAPNFKB activating protein0.137
GLRA2glycine receptor, alpha 20.134
SMURF1SMAD specific E3 ubiquitin protein ligase 10.133
DRD5dopamine receptor D50.127
GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 10.125
STIM2stromal interaction molecule 20.123
ADAM18ADAM metallopeptidase domain 180.118
SLITRK3SLIT and NTRK-like family, member 30.117
PEX5Lperoxisomal biogenesis factor 5-like0.115
PIGRpolymeric immunoglobulin receptor0.113
STXBP5Lsyntaxin binding protein 5-like0.110
ARHGAP1Rho GTPase activating protein 10.109
PRKCGprotein kinase C, gamma0.103
GRM1glutamate receptor, metabotropic 10.102
GRIA2glutamate receptor, ionotropic, AMPA 20.100
NPYneuropeptide Y0.098
SERPINI2serpin peptidase inhibitor, clade I (pancpin), member 20.095
RGS7regulator of G-protein signaling 70.094
UBQLN1ubiquilin 10.094
PDCD7programmed cell death 70.093
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)0.093
UBQLN4ubiquilin 40.091
CACNB4calcium channel, voltage-dependent, beta 4 subunit0.089
SCN2Asodium channel, voltage-gated, type II, alpha subunit0.088
DAB1disabled homolog 1 (Drosophila)0.087
CDH18cadherin 18, type 20.087
NEUROD1neurogenic differentiation 10.086
RALYLRALY RNA binding protein-like0.083
PKD2polycystic kidney disease 2 (autosomal dominant)0.082
TEX15testis expressed 150.082
ATP2B3ATPase, Ca++ transporting, plasma membrane 30.078
MCF2MCF.2 cell line derived transforming sequence0.078
RIMS1regulating synaptic membrane exocytosis 10.078
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.078
GRIA4glutamate receptor, ionotrophic, AMPA 40.077
C6orf10chromosome 6 open reading frame 100.077
GPR12G protein-coupled receptor 120.076
FMNL2formin-like 20.076
AKAP5A kinase (PRKA) anchor protein 50.075
GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 20.073
CALB1calbindin 1, 28kDa0.072
PROL1proline rich, lacrimal 10.072
SEMG1semenogelin I0.072
VSTM2AV-set and transmembrane domain containing 2A0.071
GPR22G protein-coupled receptor 220.071
IFNA5interferon, alpha 50.071
CDH10cadherin 10, type 2 (T2-cadherin)0.070
CNKSR2connector enhancer of kinase suppressor of Ras 20.070
NELL1NEL-like 1 (chicken)0.069
GRM3glutamate receptor, metabotropic 30.068
RIMBP2RIMS binding protein 20.068
DAAM1dishevelled associated activator of morphogenesis 10.068
GRIA3glutamate receptor, ionotrophic, AMPA 30.066
SLCO1A2solute carrier organic anion transporter family, member 1A20.064
GNG4guanine nucleotide binding protein (G protein), gamma 40.064
B3GALT5UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 50.063
RLFrearranged L-myc fusion0.063
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.062
NTNG1netrin G10.062
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gabrb2gamma-aminobutyric acid (GABA) A receptor, subunit beta 20.999
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.918
Grid1glutamate receptor, ionotropic, delta 10.902
Gabra1gamma-aminobutyric acid (GABA) A receptor, subunit alpha 10.865
Gabra5gamma-aminobutyric acid (GABA) A receptor, subunit alpha 50.742
Gabrg2gamma-aminobutyric acid (GABA) A receptor, subunit gamma 20.726
Nxph1neurexophilin 10.484
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.449
B3galt1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 10.429
Gabrg1gamma-aminobutyric acid (GABA) A receptor, subunit gamma 10.405
Gabra2gamma-aminobutyric acid (GABA) A receptor, subunit alpha 20.396
Gad2glutamic acid decarboxylase 20.336
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.248
Slc12a5solute carrier family 12, member 50.243
Gria4glutamate receptor, ionotropic, AMPA4 (alpha 4)0.156
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.154
En2engrailed 20.139
Cnr1cannabinoid receptor 1 (brain)0.124
Cdh9cadherin 90.106
Trhrthyrotropin releasing hormone receptor0.091
Rit2Ras-like without CAAX 20.078
Gabrb1gamma-aminobutyric acid (GABA) A receptor, subunit beta 10.076
Fgf14fibroblast growth factor 140.073
Hcn1hyperpolarization-activated, cyclic nucleotide-gated K+ 10.071
Grm8glutamate receptor, metabotropic 80.068
Adcyap1adenylate cyclase activating polypeptide 10.066
Cdh10cadherin 100.063
Neurod6neurogenic differentiation 60.063
Gabrg3gamma-aminobutyric acid (GABA) A receptor, subunit gamma 30.061
Camk4calcium/calmodulin-dependent protein kinase IV0.059
Mgat4cmannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)0.058
Odz1odd Oz/ten-m homolog 1 (Drosophila)0.056
Grik2glutamate receptor, ionotropic, kainate 2 (beta 2)0.056
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)0.053
Kcns2K+ voltage-gated channel, subfamily S, 20.053
GsbsG substrate0.052
Grid2glutamate receptor, ionotropic, delta 20.052
Calb1calbindin 10.050
Pgrprogesterone receptor0.050
Kcnc1potassium voltage gated channel, Shaw-related subfamily, member 10.048
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.046
Gdap1ganglioside-induced differentiation-associated-protein 10.045
BrafBraf transforming gene0.043
Neto1neuropilin (NRP) and tolloid (TLL)-like 10.041
Gabra3gamma-aminobutyric acid (GABA) A receptor, subunit alpha 30.041
En1engrailed 10.041
Plcb1phospholipase C, beta 10.040
Dync1i1dynein cytoplasmic 1 intermediate chain 10.040
Syn2synapsin II0.039
Cdh8cadherin 80.039
Npy2rneuropeptide Y receptor Y20.037
Upp2uridine phosphorylase 20.037
Scn1asodium channel, voltage-gated, type I, alpha0.036
Thrbthyroid hormone receptor beta0.035
Slitrk6SLIT and NTRK-like family, member 60.035
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.035
Nxph2neurexophilin 20.035
Gad1glutamic acid decarboxylase 10.034
Svaseminal vesicle antigen0.034
Fam84afamily with sequence similarity 84, member A0.034
Mid1midline 10.034
NapbN-ethylmaleimide sensitive fusion protein attachment protein beta0.034
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.032
Hrkharakiri, BCL2 interacting protein (contains only BH3 domain)0.031
Ncam2neural cell adhesion molecule 20.031
Slc4a7solute carrier family 4, sodium bicarbonate cotransporter, member 70.030
Slc1a6solute carrier family 1 (high affinity aspartate/glutamate transporter), member 60.029
B3galt2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 20.029
Mmp16matrix metallopeptidase 160.029
Folh1folate hydrolase0.027
Nap1l2nucleosome assembly protein 1-like 20.027
Col19a1collagen, type XIX, alpha 10.027
Cntn4contactin 40.026
Adra2cadrenergic receptor, alpha 2c0.025
Epha3Eph receptor A30.025
Syt1synaptotagmin I0.025
Ceacam11carcinoembryonic antigen-related cell adhesion molecule 110.025
Cer1cerberus 1 homolog (Xenopus laevis)0.025
Rgs7regulator of G protein signaling 70.024
1810030J14RikRIKEN cDNA 1810030J14 gene0.024
Tbr1T-box brain gene 10.024
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.024
Zic3zinc finger protein of the cerebellum 30.024
Rasgrp1RAS guanyl releasing protein 10.023
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.023
Tac2tachykinin 20.023
Oprl1opioid receptor-like 10.023
Npy1rneuropeptide Y receptor Y10.023
Cacna1dcalcium channel, voltage-dependent, L type, alpha 1D subunit0.023
Dsc3desmocollin 30.023
Rfpl4ret finger protein-like 40.023
Gpr12G-protein coupled receptor 120.023
Dmp1dentin matrix protein 10.023
Ptprrprotein tyrosine phosphatase, receptor type, R0.021
Neurod1neurogenic differentiation 10.021
Gjd2gap junction protein, delta 20.021
Vstm2aV-set and transmembrane domain containing 2A0.021
Slc6a15solute carrier family 6 (neurotransmitter transporter), member 150.021
Kcnh1potassium voltage-gated channel, subfamily H (eag-related), member 10.021
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.953
Fgf14fibroblast growth factor 140.866
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.752
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.636
Nxph1neurexophilin 10.626
Gabra4gamma-aminobutyric acid (GABA) A receptor, alpha 40.583
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.524
Gria4glutamate receptor, ionotrophic, AMPA 40.469
Camk4calcium/calmodulin-dependent protein kinase IV0.425
Gad2glutamate decarboxylase 20.417
Cnksr2connector enhancer of kinase suppressor of Ras 20.395
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.308
Unc13cunc-13 homolog C (C. elegans)0.297
Drd1adopamine receptor D1A0.274
Hapln1hyaluronan and proteoglycan link protein 10.269
Grm7glutamate receptor, metabotropic 70.236
Aqp4aquaporin 40.226
Kcnv1potassium channel, subfamily V, member 10.209
Cntn1contactin 10.207
Nrcamneuronal cell adhesion molecule0.200
Ccbp2chemokine binding protein 20.196
Csn3casein kappa0.161
Slc5a5solute carrier family 5 (sodium iodide symporter), member 50.136
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.135
Gabrg2gamma-aminobutyric acid (GABA) A receptor, gamma 20.128
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.116
Gabrb3gamma-aminobutyric acid (GABA) A receptor, beta 30.103
Cntn4contactin 40.099
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.098
Cntn6contactin 60.096
Cdh6cadherin 60.091
Olr1469olfactory receptor Olr14690.089
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.081
Chrna2cholinergic receptor, nicotinic, alpha 2 (neuronal)0.081
Gabrb2gamma-aminobutyric acid (GABA) A receptor, beta 20.080
Rasgrp1RAS guanyl releasing protein 1 (calcium and DAG-regulated)0.077
Neurod1neurogenic differentiation 10.076
Opcmlopioid binding protein/cell adhesion molecule-like0.073
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.073
Lrrc7leucine rich repeat containing 70.072
Rgs8regulator of G-protein signaling 80.071
Syt7synaptotagmin VII0.070
Folh1folate hydrolase 10.069
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.068
Syt9synaptotagmin IX0.067
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.067
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.067
Dgkbdiacylglycerol kinase, beta0.066
Cnr1cannabinoid receptor 1 (brain)0.065
Gria2glutamate receptor, ionotropic, AMPA 20.064
Ceacam3carcinoembryonic antigen-related cell adhesion molecule 30.064
Gcm1glial cells missing homolog 1 (Drosophila)0.063
Rin1Ras and Rab interactor 10.063
Kcnt1potassium channel, subfamily T, member 10.062
Drd2dopamine receptor D20.062
Vom2r31vomeronasal 2 receptor, 310.060
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.060
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.060
Avparginine vasopressin0.052
Grm1glutamate receptor, metabotropic 10.052
Cx3cr1chemokine (C-X3-C motif) receptor 10.050
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.050
Kalrnkalirin, RhoGEF kinase0.050
Psg29pregnancy-specific glycoprotein 290.049
Htr2a5-hydroxytryptamine (serotonin) receptor 2A0.048
Cml3camello-like 30.047
Neflneurofilament, light polypeptide0.047
Gabra2gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 20.047
Kcnj9potassium inwardly-rectifying channel, subfamily J, member 90.046
Slco1a5solute carrier organic anion transporter family, member 1a50.046
Syt4synaptotagmin IV0.046
Gja6gap junction protein, alpha 60.046
Cntn3contactin 3 (plasmacytoma associated)0.045
Mogmyelin oligodendrocyte glycoprotein0.045
Oprl1opiate receptor-like 10.043
Sstr2somatostatin receptor 20.042
Foxg1forkhead box G10.042
Prph2peripherin 20.042
Gng7guanine nucleotide binding protein (G protein), gamma 70.041
Hpcal4hippocalcin-like 40.041
Necab1N-terminal EF-hand calcium binding protein 10.040
Rit2Ras-like without CAAX 20.040
Grm4glutamate receptor, metabotropic 40.040
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.040
Camk1gcalcium/calmodulin-dependent protein kinase IG0.039
Sh3gl2SH3-domain GRB2-like 20.039
Pmchpro-melanin-concentrating hormone0.038
Hrh2histamine receptor H 20.037
Giprgastric inhibitory polypeptide receptor0.036
Prkcgprotein kinase C, gamma0.036
Cyp11b3cytochrome P450, family 11, subfamily b, polypeptide 30.036
Snap91synaptosomal-associated protein 910.035
Kcnb2potassium voltage gated channel, Shab-related subfamily, member 20.035
Hoxa1homeo box A10.035
Omgoligodendrocyte-myelin glycoprotein0.034
Nrsn1neurensin 10.034
Htr5a5-hydroxytryptamine (serotonin) receptor 5A0.034
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism