The network for 'negative regulation of stem cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of stem cell differentiation

Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.

NameDescriptionProbabilityFunc Analog Organism
NOTCH1notch 10.972
JAG1jagged 10.927
POU5F1POU class 5 homeobox 10.773
NOTCH3notch 30.725
ARandrogen receptor0.690
NKX2-1NK2 homeobox 10.593
TBX5T-box 50.589
PAX8paired box 80.543
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.482
NOTCH2notch 20.336
JAG2jagged 20.319
CREBBPCREB binding protein0.305
AXIN1axin 10.304
DLL1delta-like 1 (Drosophila)0.288
CAV1caveolin 1, caveolae protein, 22kDa0.221
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.218
RFWD2ring finger and WD repeat domain 20.204
TP73tumor protein p730.180
MAP3K5mitogen-activated protein kinase kinase kinase 50.159
LRRK2leucine-rich repeat kinase 20.151
TWIST2twist homolog 2 (Drosophila)0.140
NR4A1nuclear receptor subfamily 4, group A, member 10.139
CTNNBIP1catenin, beta interacting protein 10.124
FOXD3forkhead box D30.124
PDX1pancreatic and duodenal homeobox 10.119
FZD1frizzled homolog 1 (Drosophila)0.105
MAML1mastermind-like 1 (Drosophila)0.103
GATA4GATA binding protein 40.102
CDX2caudal type homeobox 20.094
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.086
FGF3fibroblast growth factor 30.084
SMAD1SMAD family member 10.083
HNF1AHNF1 homeobox A0.079
ATN1atrophin 10.077
WDYHV1WDYHV motif containing 10.072
FZD8frizzled homolog 8 (Drosophila)0.068
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.065
GFI1Bgrowth factor independent 1B transcription repressor0.065
MNX1motor neuron and pancreas homeobox 10.062
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.062
FBLN1fibulin 10.060
TBX1T-box 10.058
SOCS1suppressor of cytokine signaling 10.056
WT1Wilms tumor 10.056
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.055
BBS10Bardet-Biedl syndrome 100.054
SIM2single-minded homolog 2 (Drosophila)0.054
SOX2SRY (sex determining region Y)-box 20.054
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.054
LBX1ladybird homeobox 10.052
BBS1Bardet-Biedl syndrome 10.052
REV3LREV3-like, catalytic subunit of DNA polymerase zeta (yeast)0.051
HES2hairy and enhancer of split 2 (Drosophila)0.047
WNT10Awingless-type MMTV integration site family, member 10A0.046
NCOA2nuclear receptor coactivator 20.045
HNF4Ahepatocyte nuclear factor 4, alpha0.045
FOXA2forkhead box A20.043
PAX7paired box 70.042
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.042
GEMIN6gem (nuclear organelle) associated protein 60.042
TBX2T-box 20.041
WWP2WW domain containing E3 ubiquitin protein ligase 20.041
AMOTL1angiomotin like 10.040
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.040
SOX1SRY (sex determining region Y)-box 10.039
CEP164centrosomal protein 164kDa0.038
C9orf100chromosome 9 open reading frame 1000.038
INHBBinhibin, beta B0.035
NEUROG3neurogenin 30.035
REPS2RALBP1 associated Eps domain containing 20.034
TAL1T-cell acute lymphocytic leukemia 10.034
RUNX1runt-related transcription factor 10.033
PYYpeptide YY0.033
BHLHE23basic helix-loop-helix family, member e230.033
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.032
APCadenomatous polyposis coli0.031
HNF1BHNF1 homeobox B0.031
WDR5WD repeat domain 50.029
FGF8fibroblast growth factor 8 (androgen-induced)0.029
KRTAP4-12keratin associated protein 4-120.028
FOXO1forkhead box O10.028
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.028
PITX1paired-like homeodomain 10.028
ADAM9ADAM metallopeptidase domain 90.027
FOXE1forkhead box E1 (thyroid transcription factor 2)0.027
PPP2R2Cprotein phosphatase 2, regulatory subunit B, gamma0.027
EGFL7EGF-like-domain, multiple 70.026
HOXB13homeobox B130.026
NKX6-1NK6 homeobox 10.026
LHX1LIM homeobox 10.026
GATA5GATA binding protein 50.026
CALCAcalcitonin-related polypeptide alpha0.025
RAXretina and anterior neural fold homeobox0.025
LRP6low density lipoprotein receptor-related protein 60.025
FHL1four and a half LIM domains 10.024
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
foxj1aforkhead box J1a0.895
pax8paired box gene 80.835
jag1bjagged 1b0.679
fzd7afrizzled homolog 7a0.610
etv2ets variant gene 20.506
rfx2regulatory factor X, 2 (influences HLA class II expression)0.438
pax2apaired box gene 2a0.406
jag2jagged 20.404
osr2odd-skipped related 2 (Drosophila)0.391
wt1awilms tumor 1a0.391
gata6GATA-binding protein 60.383
spry4sprouty (Drosophila) homolog 40.352
tbx2aT-box gene 2a0.302
wnt8bwingless-type MMTV integration site family, member 8b0.282
wnt1wingless-type MMTV integration site family, member 10.281
hhexhematopoietically expressed homeobox0.276
notch3notch homolog 30.273
bmp4bone morphogenetic protein 40.245
hoxb1ahomeo box B1a0.238
hoxd11ahomeo box D11a0.212
notch2notch homolog 20.192
wacaWW domain containing adaptor with coiled-coil a0.181
lmx1b.1LIM homeobox transcription factor 1, beta 10.177
gata3GATA-binding protein 30.174
lhx1aLIM homeobox 1a0.168
foxa3forkhead box A30.164
pou3f3bPOU class 3 homeobox 3b0.163
ascl1aachaete-scute complex-like 1a (Drosophila)0.162
sox3SRY-box containing gene 30.161
smg7Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)0.161
wnt11rwingless-type MMTV integration site family, member 11, related0.159
crabp2bcellular retinoic acid binding protein 2, b0.158
vsx2visual system homeobox 20.157
pea3ETS-domain transcription factor pea30.153
wnt2bbwingless-type MMTV integration site family, member 2Bb0.149
dvl3dishevelled, dsh homolog 3 (Drosophila)0.146
vcanaversican a0.144
eya1eyes absent homolog 10.134
hnf1bbHNF1 homeobox Bb0.131
epha4aeph receptor A4a0.129
nkx2.3NK2 transcription factor related 30.127
mnx1motor neuron and pancreas homeobox 10.126
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.126
wnt4awingless-type MMTV integration site family, member 4a0.124
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.121
gdnfglial cell derived neurotrophic factor0.117
wnt5bwingless-type MMTV integration site family, member 5b0.116
bmp2bbone morphogenetic protein 2b0.116
fgf3fibroblast growth factor 30.115
rarabretinoic acid receptor, alpha b0.115
ism1isthmin 10.113
wt1bwilms tumor 1b0.113
neo1neogenin 10.113
tpbgltrophoblast glycoprotein-like0.113
cdh1cadherin 1, epithelial0.112
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.110
tll1tolloid-like 10.105
tmem2transmembrane protein 20.105
gbx2gastrulation brain homeo box 20.102
fgf17fibroblast growth factor 170.102
hoxc8ahomeo box C8a0.099
tjp1tight junction protein 1 (zona occludens 1)0.099
ncs1aneuronal calcium sensor 1a0.097
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.096
gli2aGLI-Kruppel family member GLI2a0.096
ccdc40coiled-coil domain containing 400.093
fn1fibronectin 10.092
barhl1.2BarH-like 1.20.091
hoxb1bhomeo box B1b0.090
lsrlipolysis stimulated lipoprotein receptor0.089
foxi1forkhead box I10.087
otpborthopedia homolog b0.085
il17rdinterleukin 17 receptor D0.084
gbx1gastrulation brain homeobox 10.083
foxn4forkhead box N40.083
ythdf1YTH domain family, member 10.082
hoxd3ahomeo box D3a0.082
cldn5aclaudin 5a0.082
fli1afriend leukemia integration 1a0.081
hmx3homeo box (H6 family) 30.081
flrt3fibronectin leucine rich transmembrane 30.080
clic4chloride intracellular channel 40.079
sp5lSp5 transcription factor-like0.079
insm1ainsulinoma-associated 1a0.078
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.078
sim1asingle-minded homolog 1a (Drosophila)0.077
fn1bfibronectin 1b0.077
axin2axin 2 (conductin, axil)0.076
gyltl1bglycosyltransferase-like 1b0.076
lhx1bLIM homeobox 1b0.075
ef1ETS-related factor10.074
hnf1baHNF1 homeobox Ba0.074
slc38a3solute carrier family 38, member 30.072
klf4aKruppel-like transcription factor 4a0.071
neurod4neurogenic differentiation 40.070
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
E(spl)Enhancer of split0.964
HLHmdeltaE(spl) region transcript mdelta0.847
HLHm7E(spl) region transcript m70.804
HLHmgammaE(spl) region transcript mgamma0.764
HLHmbetaE(spl) region transcript mbeta0.407
HLHm5E(spl) region transcript m50.402
HLHm3E(spl) region transcript m30.291
TomTwin of m40.187
cicubitus interruptus0.185
ftzfushi tarazu0.093
malphaE(spl) region transcript malpha0.081
slp1sloppy paired 10.047
m4E(spl) region transcript m40.032
m2E(spl) region transcript m20.027
amosabsent MD neurons and olfactory sensilla0.019
HLH54FCG5005 gene product from transcript CG5005-RA0.019
NotumCG13076 gene product from transcript CG13076-RB0.017
fz2frizzled 20.015
TolloCG6890 gene product from transcript CG6890-RA0.013
gcmglial cells missing0.013
taptarget of Poxn0.012
CG14869CG14869 gene product from transcript CG14869-RB0.011
kirrekin of irre0.011
mxcmulti sex combs0.010
nkdnaked cuticle0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Vangl2vang-like 2 (van gogh, Drosophila)0.998
Fgfr2fibroblast growth factor receptor 20.997
Shhsonic hedgehog0.995
Dvl3dishevelled 3, dsh homolog (Drosophila)0.941
Gli3GLI-Kruppel family member GLI30.938
Bmp7bone morphogenetic protein 70.888
Foxc1forkhead box C10.873
Otx2orthodenticle homolog 2 (Drosophila)0.835
Tbx1T-box 10.828
Pitx2paired-like homeodomain transcription factor 20.804
Emx1empty spiracles homolog 1 (Drosophila)0.803
Eya1eyes absent 1 homolog (Drosophila)0.787
Bmp4bone morphogenetic protein 40.719
Gdf5growth differentiation factor 50.649
Fgf8fibroblast growth factor 80.633
Sox2SRY-box containing gene 20.620
Wnt3awingless-related MMTV integration site 3A0.585
Hand1heart and neural crest derivatives expressed transcript 10.578
Rargretinoic acid receptor, gamma0.528
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.501
Fgfr1fibroblast growth factor receptor 10.472
Pax3paired box gene 30.459
Jag1jagged 10.450
Foxc2forkhead box C20.442
Yap1yes-associated protein 10.418
Sfrp2secreted frizzled-related protein 20.416
Msx1homeobox, msh-like 10.387
Dvl2dishevelled 2, dsh homolog (Drosophila)0.348
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.345
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.298
Hes1hairy and enhancer of split 1 (Drosophila)0.293
Tcfap2atranscription factor AP-2, alpha0.287
Hoxd13homeobox D130.271
Alx4aristaless-like homeobox 40.270
Vangl1vang-like 1 (van gogh, Drosophila)0.240
Wwtr1WW domain containing transcription regulator 10.226
Notch2Notch gene homolog 2 (Drosophila)0.213
Emx2empty spiracles homolog 2 (Drosophila)0.207
Lef1lymphoid enhancer binding factor 10.201
Dkk1dickkopf homolog 1 (Xenopus laevis)0.197
Foxg1forkhead box G10.195
Notch1Notch gene homolog 1 (Drosophila)0.192
Pax8paired box gene 80.190
Psen1presenilin 10.187
Fgfr3fibroblast growth factor receptor 30.184
Vegfavascular endothelial growth factor A0.174
Pbx1pre B-cell leukemia transcription factor 10.170
Gas1growth arrest specific 10.167
Foxf1aforkhead box F1a0.164
Msx2homeobox, msh-like 20.161
Alx3aristaless-like homeobox 30.160
Hes3hairy and enhancer of split 3 (Drosophila)0.157
JunJun oncogene0.154
Rspo2R-spondin 2 homolog (Xenopus laevis)0.143
FosFBJ osteosarcoma oncogene0.138
Ern2endoplasmic reticulum (ER) to nucleus signalling 20.136
Gpc3glypican 30.135
Dlx5distal-less homeobox 50.127
Dusp1dual specificity phosphatase 10.125
Chd7chromodomain helicase DNA binding protein 70.123
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.121
Gscgoosecoid homeobox0.119
Tbx15T-box 150.118
Dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.114
Hoxa2homeobox A20.109
Pax6paired box gene 60.108
Hnf1bHNF1 homeobox B0.106
Lhx3LIM homeobox protein 30.103
Tgfbr2transforming growth factor, beta receptor II0.100
Dll1delta-like 1 (Drosophila)0.098
Tbx3T-box 30.097
Klf6Kruppel-like factor 60.097
Dll4delta-like 4 (Drosophila)0.095
Smosmoothened homolog (Drosophila)0.093
Hand2heart and neural crest derivatives expressed transcript 20.092
Gli2GLI-Kruppel family member GLI20.088
Efnb1ephrin B10.088
Ephb3Eph receptor B30.087
Gata4GATA binding protein 40.086
Prrx1paired related homeobox 10.085
Barx2BarH-like homeobox 20.084
Ece1endothelin converting enzyme 10.084
Gata6GATA binding protein 60.083
Otx1orthodenticle homolog 1 (Drosophila)0.082
JunbJun-B oncogene0.081
Pax2paired box gene 20.080
Btg2B-cell translocation gene 2, anti-proliferative0.079
Tcf21transcription factor 210.076
Foxe1forkhead box E10.074
Lrp6low density lipoprotein receptor-related protein 60.074
Crb3crumbs homolog 3 (Drosophila)0.073
Lhx1LIM homeobox protein 10.072
Tead1TEA domain family member 10.072
Wnt5awingless-related MMTV integration site 5A0.067
Hoxa1homeobox A10.063
Tead3TEA domain family member 30.063
Fgf3fibroblast growth factor 30.062
Alx1ALX homeobox 10.060
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism