The network for 'negative regulation of alpha beta t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of alpha beta t cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.

NameDescriptionProbabilityFunc Analog Organism
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 61.000
PILRApaired immunoglobin-like type 2 receptor alpha0.998
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.997
CCR5chemokine (C-C motif) receptor 50.994
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.983
IL4Rinterleukin 4 receptor0.973
TFF1trefoil factor 10.958
DRD2dopamine receptor D20.953
CCL4chemokine (C-C motif) ligand 40.930
PTPN6protein tyrosine phosphatase, non-receptor type 60.912
HK3hexokinase 3 (white cell)0.872
SIGLEC7sialic acid binding Ig-like lectin 70.853
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.827
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.824
CCR1chemokine (C-C motif) receptor 10.813
IL1Binterleukin 1, beta0.765
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.713
CD2APCD2-associated protein0.712
IL2RGinterleukin 2 receptor, gamma0.668
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.627
CXCL9chemokine (C-X-C motif) ligand 90.582
IL8interleukin 80.579
CCL22chemokine (C-C motif) ligand 220.572
CCL13chemokine (C-C motif) ligand 130.551
CXCL10chemokine (C-X-C motif) ligand 100.546
CCL5chemokine (C-C motif) ligand 50.541
TRAF1TNF receptor-associated factor 10.539
DPP4dipeptidyl-peptidase 40.484
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.440
CCL7chemokine (C-C motif) ligand 70.393
CD33CD33 molecule0.388
NEDD9neural precursor cell expressed, developmentally down-regulated 90.361
TNFSF14tumor necrosis factor (ligand) superfamily, member 140.334
TNFRSF9tumor necrosis factor receptor superfamily, member 90.307
FCN1ficolin (collagen/fibrinogen domain containing) 10.307
SIN3ASIN3 homolog A, transcription regulator (yeast)0.297
IL1RNinterleukin 1 receptor antagonist0.292
SIGLEC9sialic acid binding Ig-like lectin 90.277
CCL8chemokine (C-C motif) ligand 80.245
CCR7chemokine (C-C motif) receptor 70.244
CCL3chemokine (C-C motif) ligand 30.230
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.227
CD300CCD300c molecule0.213
NLRP3NLR family, pyrin domain containing 30.209
TYMPthymidine phosphorylase0.202
CYTH4cytohesin 40.197
SLAMF8SLAM family member 80.195
VSIG4V-set and immunoglobulin domain containing 40.190
CEACAM3carcinoembryonic antigen-related cell adhesion molecule 30.184
IL4interleukin 40.182
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.171
CD86CD86 molecule0.156
CCR4chemokine (C-C motif) receptor 40.156
CXCL13chemokine (C-X-C motif) ligand 130.150
PCDH9protocadherin 90.146
LILRB4leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 40.138
CCL2chemokine (C-C motif) ligand 20.135
IFNGinterferon, gamma0.133
CD40CD40 molecule, TNF receptor superfamily member 50.132
TNFtumor necrosis factor0.130
LILRA3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 30.128
TREM1triggering receptor expressed on myeloid cells 10.127
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.123
EBI3Epstein-Barr virus induced 30.122
AQP9aquaporin 90.121
CXCL3chemokine (C-X-C motif) ligand 30.120
EPORerythropoietin receptor0.116
IL10interleukin 100.116
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.115
FPR3formyl peptide receptor 30.114
PIK3R5phosphoinositide-3-kinase, regulatory subunit 50.113
PTAFRplatelet-activating factor receptor0.110
CCR3chemokine (C-C motif) receptor 30.110
CCL11chemokine (C-C motif) ligand 110.110
LAIR1leukocyte-associated immunoglobulin-like receptor 10.109
SKIv-ski sarcoma viral oncogene homolog (avian)0.108
SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi10.106
CXCL2chemokine (C-X-C motif) ligand 20.105
LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 50.103
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.100
SELEselectin E0.099
MARCOmacrophage receptor with collagenous structure0.099
CCL3L3chemokine (C-C motif) ligand 3-like 30.095
SIGLEC10sialic acid binding Ig-like lectin 100.094
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.094
CCL19chemokine (C-C motif) ligand 190.093
RNF11ring finger protein 110.093
FPR2formyl peptide receptor 20.093
TRADDTNFRSF1A-associated via death domain0.092
AOAHacyloxyacyl hydrolase (neutrophil)0.091
CCL21chemokine (C-C motif) ligand 210.090
SIRPAsignal-regulatory protein alpha0.090
IL6interleukin 6 (interferon, beta 2)0.088
CH25Hcholesterol 25-hydroxylase0.086
CXCL5chemokine (C-X-C motif) ligand 50.083
C2complement component 20.080
CD80CD80 molecule0.079
NOD2nucleotide-binding oligomerization domain containing 20.079
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Stat3signal transducer and activator of transcription 30.989
Gli3GLI-Kruppel family member GLI30.985
Tnftumor necrosis factor0.919
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.852
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.830
Myd88myeloid differentiation primary response gene 880.735
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.695
Il6stinterleukin 6 signal transducer0.562
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.559
Rc3h1RING CCCH (C3H) domains 10.520
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.448
Ifnginterferon gamma0.414
Jak2Janus kinase 20.355
Leprleptin receptor0.350
Cyldcylindromatosis (turban tumor syndrome)0.296
Ltalymphotoxin A0.277
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.250
Traf6TNF receptor-associated factor 60.245
FasFas (TNF receptor superfamily member 6)0.240
Ror2receptor tyrosine kinase-like orphan receptor 20.231
Gli2GLI-Kruppel family member GLI20.230
Zeb1zinc finger E-box binding homeobox 10.223
Il6interleukin 60.211
Ptenphosphatase and tensin homolog0.204
Pthlhparathyroid hormone-like peptide0.182
Socs1suppressor of cytokine signaling 10.182
Socs3suppressor of cytokine signaling 30.179
Cd40CD40 antigen0.170
S1pr2sphingosine-1-phosphate receptor 20.168
Fgf10fibroblast growth factor 100.157
Ighimmunoglobulin heavy chain complex0.133
Map3k14mitogen-activated protein kinase kinase kinase 140.133
Ikzf1IKAROS family zinc finger 10.130
Ren1renin 1 structural0.118
Bcl3B-cell leukemia/lymphoma 30.117
Il4interleukin 40.112
Foxp3forkhead box P30.111
Ctnnb1catenin (cadherin associated protein), beta 10.104
Fgfr2fibroblast growth factor receptor 20.099
Stat5asignal transducer and activator of transcription 5A0.098
Batf3basic leucine zipper transcription factor, ATF-like 30.090
Rnf11ring finger protein 110.090
Kitkit oncogene0.090
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.085
Stat6signal transducer and activator of transcription 60.084
Ptpn11protein tyrosine phosphatase, non-receptor type 110.079
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.077
Fgfr3fibroblast growth factor receptor 30.076
Nos2nitric oxide synthase 2, inducible0.071
Egfrepidermal growth factor receptor0.064
Zbtb37zinc finger and BTB domain containing 370.063
Ptch1patched homolog 10.060
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.057
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.056
Il1r1interleukin 1 receptor, type I0.055
Fgf9fibroblast growth factor 90.055
Ccl2chemokine (C-C motif) ligand 20.055
Trpv1transient receptor potential cation channel, subfamily V, member 10.054
Rac1RAS-related C3 botulinum substrate 10.053
Il2rginterleukin 2 receptor, gamma chain0.052
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.049
Stat5bsignal transducer and activator of transcription 5B0.049
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.048
Sh2b2SH2B adaptor protein 20.048
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.046
Plcg1phospholipase C, gamma 10.046
Foxn1forkhead box N10.046
Traf2TNF receptor-associated factor 20.044
Twist2twist homolog 2 (Drosophila)0.044
Sox9SRY-box containing gene 90.041
Cul5cullin 50.041
Tax1bp1Tax1 (human T-cell leukemia virus type I) binding protein 10.041
Smad6MAD homolog 6 (Drosophila)0.041
Atp11cATPase, class VI, type 11C0.040
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.038
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.038
Shhsonic hedgehog0.037
Prdm1PR domain containing 1, with ZNF domain0.036
Rc3h2ring finger and CCCH-type zinc finger domains 20.036
Il2rbinterleukin 2 receptor, beta chain0.036
Trp53transformation related protein 530.034
Il10rainterleukin 10 receptor, alpha0.033
Rag1recombination activating gene 10.033
Pim1proviral integration site 10.032
Grb10growth factor receptor bound protein 100.030
Il3rainterleukin 3 receptor, alpha chain0.030
Tnfaip3tumor necrosis factor, alpha-induced protein 30.029
Fesfeline sarcoma oncogene0.029
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.028
Tmem64transmembrane protein 640.027
Neurog3neurogenin 30.027
TcraT-cell receptor alpha chain0.026
Bdkrb2bradykinin receptor, beta 20.026
Acvrl1activin A receptor, type II-like 10.025
Rps6ka3ribosomal protein S6 kinase polypeptide 30.025
Cd40lgCD40 ligand0.025
Bmp7bone morphogenetic protein 70.025
Pcsk5proprotein convertase subtilisin/kexin type 50.025
Socs5suppressor of cytokine signaling 50.024
Irf5interferon regulatory factor 50.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Madcam1mucosal vascular addressin cell adhesion molecule 10.036
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.028
Chrna7cholinergic receptor, nicotinic, alpha 70.028
Ceacam3carcinoembryonic antigen-related cell adhesion molecule 30.025
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.022
Olr442olfactory receptor 4420.018
Hsd17b3hydroxysteroid (17-beta) dehydrogenase 30.017
Gjb4gap junction protein, beta 40.017
Dsppdentin sialophosphoprotein0.016
Gja5gap junction protein, alpha 50.014
Adrb3adrenergic, beta-3-, receptor0.014
Slc22a13solute carrier family 22 (organic anion transporter), member 130.014
Crhr2corticotropin releasing hormone receptor 20.013
Avparginine vasopressin0.012
Pacs1phosphofurin acidic cluster sorting protein 10.012
Opn1swopsin 1 (cone pigments), short-wave-sensitive0.012
Dlg4discs, large homolog 4 (Drosophila)0.010
Olr1493olfactory receptor gene Olr14930.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism