The network for 'negative regulation of reactive oxygen species metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of reactive oxygen species metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.

NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 10.958
MDM2Mdm2 p53 binding protein homolog (mouse)0.946
IRAK2interleukin-1 receptor-associated kinase 20.778
APOEapolipoprotein E0.573
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.570
IL10RAinterleukin 10 receptor, alpha0.342
HSPB8heat shock 22kDa protein 80.305
CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae)0.260
EP300E1A binding protein p3000.253
FBXO7F-box protein 70.239
MMP12matrix metallopeptidase 12 (macrophage elastase)0.234
MEOX1mesenchyme homeobox 10.209
CRYAAcrystallin, alpha A0.199
HSPB2heat shock 27kDa protein 20.194
NKX2-1NK2 homeobox 10.146
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.143
PPP5Cprotein phosphatase 5, catalytic subunit0.142
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.142
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.138
ZNF746zinc finger protein 7460.135
CRYBB2crystallin, beta B20.133
TRAF1TNF receptor-associated factor 10.125
MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)0.106
PINK1PTEN induced putative kinase 10.104
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)0.102
TGFB1transforming growth factor, beta 10.100
MYLK2myosin light chain kinase 20.090
CALCAcalcitonin-related polypeptide alpha0.087
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.086
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.085
CD320CD320 molecule0.080
RIPK2receptor-interacting serine-threonine kinase 20.076
CCL20chemokine (C-C motif) ligand 200.075
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.072
BAG3BCL2-associated athanogene 30.071
HSPB1heat shock 27kDa protein 10.070
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.070
CRYGCcrystallin, gamma C0.069
TRAF6TNF receptor-associated factor 60.068
MMP10matrix metallopeptidase 10 (stromelysin 2)0.066
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.065
CCL7chemokine (C-C motif) ligand 70.063
TRAF3TNF receptor-associated factor 30.060
KCTD1potassium channel tetramerisation domain containing 10.060
MAXMYC associated factor X0.059
TNFRSF9tumor necrosis factor receptor superfamily, member 90.059
THBS1thrombospondin 10.057
SP1Sp1 transcription factor0.056
THBS2thrombospondin 20.054
MEP1Ameprin A, alpha (PABA peptide hydrolase)0.054
MPDZmultiple PDZ domain protein0.053
HDAC6histone deacetylase 60.051
CDK6cyclin-dependent kinase 60.051
DLG2discs, large homolog 2 (Drosophila)0.050
SH3BP4SH3-domain binding protein 40.049
MMP13matrix metallopeptidase 13 (collagenase 3)0.048
HDAC1histone deacetylase 10.047
CXCL5chemokine (C-X-C motif) ligand 50.045
POLR2Jpolymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa0.045
TOLLIPtoll interacting protein0.045
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.043
SPAG9sperm associated antigen 90.042
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.042
EGR2early growth response 20.041
RB1retinoblastoma 10.040
SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.040
F2Rcoagulation factor II (thrombin) receptor0.040
SIRT5sirtuin 50.040
CXCL3chemokine (C-X-C motif) ligand 30.040
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)0.040
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.039
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.039
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.038
BBS1Bardet-Biedl syndrome 10.037
CAV2caveolin 20.036
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.034
MYOD1myogenic differentiation 10.034
CRYBA1crystallin, beta A10.034
KCNF1potassium voltage-gated channel, subfamily F, member 10.033
SIRT3sirtuin 30.033
C12orf4chromosome 12 open reading frame 40.033
SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.032
MMP11matrix metallopeptidase 11 (stromelysin 3)0.032
C2orf18chromosome 2 open reading frame 180.031
RAB26RAB26, member RAS oncogene family0.031
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.031
PAX7paired box 70.031
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.031
BECN1beclin 1, autophagy related0.030
NGFRnerve growth factor receptor0.030
STAT5Asignal transducer and activator of transcription 5A0.029
PTENphosphatase and tensin homolog0.029
ALDH2aldehyde dehydrogenase 2 family (mitochondrial)0.029
BBS10Bardet-Biedl syndrome 100.029
SIRT4sirtuin 40.028
HAGHhydroxyacylglutathione hydrolase0.028
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Hsp27Heat shock protein 270.906
Hsp23Heat shock protein 230.622
Hsp68Heat shock protein 680.545
Hsp26Heat shock protein 260.471
CycJCyclin J0.124
Hsp22Heat shock protein 220.121
Pink1PTEN-induced putative kinase 10.083
CG4461CG4461 gene product from transcript CG4461-RA0.043
Hsp67BbHeat shock gene 67Bb0.038
cdc14CG7134 gene product from transcript CG7134-RB0.036
HtrA2CG8464 gene product from transcript CG8464-RA0.034
CG15199CG15199 gene product from transcript CG15199-RA0.031
CG11327CG11327 gene product from transcript CG11327-RA0.030
laceCG4162 gene product from transcript CG4162-RA0.024
kermitCG11546 gene product from transcript CG11546-RB0.022
CG11391CG11391 gene product from transcript CG11391-RA0.020
Ant2Adenine nucleotide translocase 20.019
SdhBSuccinate dehydrogenase B0.019
CG10713CG10713 gene product from transcript CG10713-RA0.018
CG3568CG3568 gene product from transcript CG3568-RA0.017
X11LCG5675 gene product from transcript CG5675-RB0.016
Hsp83Heat shock protein 830.016
CG4603CG4603 gene product from transcript CG4603-RA0.016
CG4586CG4586 gene product from transcript CG4586-RA0.016
Pvf3PDGF- and VEGF-related factor 30.015
CG9472CG9472 gene product from transcript CG9472-RA0.015
rempAreduced mechanoreceptor potential A0.014
CG42360CG42360 gene product from transcript CG42360-RA0.014
LaspCG3849 gene product from transcript CG3849-RB0.014
CG9090CG9090 gene product from transcript CG9090-RA0.013
Hsp67BcHeat shock gene 67Bc0.012
CG14022CG14022 gene product from transcript CG14022-RA0.012
CG42369CG42369 gene product from transcript CG42369-RA0.012
p53CG33336 gene product from transcript CG33336-RB0.012
RASSF8CG5053 gene product from transcript CG5053-RA0.012
SP2637CG5473 gene product from transcript CG5473-RC0.012
CG8455CG8455 gene product from transcript CG8455-RA0.011
MarfMitochondrial assembly regulatory factor0.011
eIF4E-3CG8023 gene product from transcript CG8023-RA0.011
CG8818CG8818 gene product from transcript CG8818-RA0.011
fhfrataxin homolog0.010
DJ-1alphaCG6646 gene product from transcript CG6646-RA0.010
CG11368CG11368 gene product from transcript CG11368-RA0.010
TomTwin of m40.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.996
Trp63transformation related protein 630.560
Trim30dtripartite motif-containing 30D0.490
Ptenphosphatase and tensin homolog0.458
Shhsonic hedgehog0.295
Col1a1collagen, type I, alpha 10.285
Apcadenomatosis polyposis coli0.279
Mdm2transformed mouse 3T3 cell double minute 20.276
Gbx2gastrulation brain homeobox 20.159
Trim30atripartite motif-containing 30A0.156
Pnpla2patatin-like phospholipase domain containing 20.150
Leprleptin receptor0.146
Ikbkbinhibitor of kappaB kinase beta0.141
Pax6paired box gene 60.122
Pax3paired box gene 30.116
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.109
Esr1estrogen receptor 1 (alpha)0.106
Tlr4toll-like receptor 40.101
Ccl2chemokine (C-C motif) ligand 20.097
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.084
Mdm4transformed mouse 3T3 cell double minute 40.082
Rararetinoic acid receptor, alpha0.080
Stat3signal transducer and activator of transcription 30.079
Ctnnb1catenin (cadherin associated protein), beta 10.076
MaxMax protein0.075
Dmddystrophin, muscular dystrophy0.069
Chd7chromodomain helicase DNA binding protein 70.068
Fgfr2fibroblast growth factor receptor 20.066
Foxc2forkhead box C20.061
Emx2empty spiracles homolog 2 (Drosophila)0.058
Ptgs2prostaglandin-endoperoxide synthase 20.056
Ptpn11protein tyrosine phosphatase, non-receptor type 110.055
BrafBraf transforming gene0.053
Prlrprolactin receptor0.053
Kitkit oncogene0.045
Wasf2WAS protein family, member 20.043
Rb1retinoblastoma 10.042
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.040
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.040
Trim12atripartite motif-containing 12A0.039
Traf2TNF receptor-associated factor 20.038
Tbx1T-box 10.038
Ptrfpolymerase I and transcript release factor0.038
Arandrogen receptor0.036
Esr2estrogen receptor 2 (beta)0.036
Kiss1KiSS-1 metastasis-suppressor0.036
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.036
Atmataxia telangiectasia mutated homolog (human)0.036
Ahraryl-hydrocarbon receptor0.035
Myd88myeloid differentiation primary response gene 880.035
Brca2breast cancer 20.035
Ppargperoxisome proliferator activated receptor gamma0.034
Cdkn1bcyclin-dependent kinase inhibitor 1B0.034
Trp73transformation related protein 730.033
Notch1Notch gene homolog 1 (Drosophila)0.031
Parp14poly (ADP-ribose) polymerase family, member 140.031
Vhlvon Hippel-Lindau tumor suppressor0.030
Emx1empty spiracles homolog 1 (Drosophila)0.029
Ncoa3nuclear receptor coactivator 30.028
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.027
Irf9interferon regulatory factor 90.027
Tgfbr2transforming growth factor, beta receptor II0.027
Fgf10fibroblast growth factor 100.026
Hhathedgehog acyltransferase0.026
Hccsholocytochrome c synthetase0.026
Rarbretinoic acid receptor, beta0.026
Jag1jagged 10.026
Mfn2mitofusin 20.024
Amhr2anti-Mullerian hormone type 2 receptor0.024
En1engrailed 10.023
Tbx10T-box 100.023
Eya1eyes absent 1 homolog (Drosophila)0.023
Itgb1integrin beta 1 (fibronectin receptor beta)0.023
Oas1b2'-5' oligoadenylate synthetase 1B0.022
Foxc1forkhead box C10.022
Il6interleukin 60.022
TctaT-cell leukemia translocation altered gene0.022
Diablodiablo homolog (Drosophila)0.022
H2-M3histocompatibility 2, M region locus 30.021
Pyhin1pyrin and HIN domain family, member 10.021
Msx2homeobox, msh-like 20.021
Ccnd1cyclin D10.021
Il10interleukin 100.020
Cdkn2acyclin-dependent kinase inhibitor 2A0.020
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.020
Clcn5chloride channel 50.020
Trim34atripartite motif-containing 34A0.020
Isl1ISL1 transcription factor, LIM/homeodomain0.020
Sox9SRY-box containing gene 90.019
Hoxa1homeobox A10.019
Otx2orthodenticle homolog 2 (Drosophila)0.019
Sox2SRY-box containing gene 20.019
Meox2mesenchyme homeobox 20.019
Trim12ctripartite motif-containing 12C0.019
Ikbkginhibitor of kappaB kinase gamma0.019
Vegfavascular endothelial growth factor A0.019
Il6stinterleukin 6 signal transducer0.019
Nfkbiznuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.019
Lifleukemia inhibitory factor0.018
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hspb1heat shock protein 10.186
Hspa1aheat shock 70kD protein 1A0.134
Cryabcrystallin, alpha B0.106
Cd80Cd80 molecule0.038
Igtpinterferon gamma induced GTPase0.037
LOC100362108poly (ADP-ribose) polymerase family, member 100.036
RGD1309537similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A)0.026
Mybphmyosin binding protein H0.023
Olr1493olfactory receptor gene Olr14930.023
RradRas-related associated with diabetes0.022
Sstr1somatostatin receptor 10.021
Slc48a1solute carrier family 48 (heme transporter), member 10.020
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.020
Sp110SP110 nuclear body protein0.019
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.019
Stat1signal transducer and activator of transcription 10.019
Flncfilamin C, gamma0.019
Sod2superoxide dismutase 2, mitochondrial0.018
S100a6S100 calcium binding protein A60.018
Dlatdihydrolipoamide S-acetyltransferase0.018
Prrx1paired related homeobox 10.017
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.016
Mmp13matrix metallopeptidase 130.016
Pcdhga11protocadherin gamma subfamily A, 110.016
Fcer2Fc fragment of IgE, low affinity II, receptor for (CD23)0.016
RGD735029SEL1 domain containing protein RGD7350290.016
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.015
Hspd1heat shock protein 1 (chaperonin)0.015
CebpeCCAAT/enhancer binding protein (C/EBP), epsilon0.014
Fgf18fibroblast growth factor 180.014
Il2rainterleukin 2 receptor, alpha0.014
Chrngcholinergic receptor, nicotinic, gamma0.014
Muskmuscle, skeletal, receptor tyrosine kinase0.014
Nr5a2nuclear receptor subfamily 5, group A, member 20.014
Dhfrdihydrofolate reductase0.013
Ccng1cyclin G10.013
Shc3SHC (Src homology 2 domain containing) transforming protein 30.013
Col10a1collagen, type X, alpha 10.013
Il1r1interleukin 1 receptor, type I0.013
Il10interleukin 100.013
Ifi35interferon-induced protein 350.012
Myo9amyosin IXA0.012
Rcan2regulator of calcineurin 20.012
Serpinb7serpin peptidase inhibitor, clade B (ovalbumin), member 70.012
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.012
Rnf213ring finger protein 2130.011
Sh3tc1SH3 domain and tetratricopeptide repeats 10.011
Vom2r40vomeronasal 2 receptor, 400.011
Mmp7matrix metallopeptidase 70.011
RT1-M5RT1 class Ib, locus M50.011
Hprt1hypoxanthine phosphoribosyltransferase 10.011
Irf7interferon regulatory factor 70.011
Cd8bCD8b molecule0.011
Tpm1tropomyosin 1, alpha0.011
Mvpmajor vault protein0.011
Fgd4FYVE, RhoGEF and PH domain containing 40.010
Foxo1forkhead box O10.010
Pdk2pyruvate dehydrogenase kinase, isozyme 20.010
Bcl2B-cell CLL/lymphoma 20.010
Grprgastrin releasing peptide receptor0.010
Dnah1dynein, axonemal, heavy chain 10.010
Ier3immediate early response 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism